CN102389594B - Portable blood purifying system - Google Patents

Portable blood purifying system Download PDF

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Publication number
CN102389594B
CN102389594B CN201110221144.6A CN201110221144A CN102389594B CN 102389594 B CN102389594 B CN 102389594B CN 201110221144 A CN201110221144 A CN 201110221144A CN 102389594 B CN102389594 B CN 102389594B
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communicated
transfusion
tube
venous
pressure sensor
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CN201110221144.6A
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Chinese (zh)
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CN102389594A (en
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周晓明
高大勇
刘驰
裴莹莹
赵刚
丁卫平
黄昱
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黄昱
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Abstract

The invention relates to a portable blood purifying system, which comprises a high throughput dialyzer with an arterial duct, a venous duct, a washing liquid tube and a transfusion tube; the arterial duct is in turn connected in series with an arterial valve, an arterial pressure sensor and a blood pump; the venous duct is in turn connected in series with a venous valve, a venous temperature sensor, a venous bubble detector and a venous pressure sensor, so that an external circulation unit is formed; the washing liquid tube is connected in series with a pre-charging valve and is communicated with a washing liquid container; the transfusion tube is in turn connected in series with a temperature controller, a transfusion tube bubble collector and a transfusion pump, and is communicated with a waste liquid container, so that a waste liquid processing unit is formed; and the system also comprises a transfusion pump, a temperature control device, a transfusion tube, a gating valve and a first transfusion branch and a second transfusion tube branch, so that a transfusion unit is formed. The system is simplified in structure and convenient to carry; and the system is suitable for patients to do short-time dialysis for several times or night dialysis treatment at home as household treatment equipment, so that toxin tolerance of dialysis patients during dialysis period is relieved while medical cost is reduced.

Description

Portable blood purifying system
Technical field
The invention belongs to technical field of medical instruments, be specifically related to a kind of for giving treatment to the medical apparatus and instruments for unconventional dialysis of acute and chronic renal failure, multiple organ failure, MOF, serious drug and toxic poisoning, i.e. a kind of blood purification system.
Background technology
Renal failure and uremia are very general critical illness all worldwide.According to U.S.'s kidney database displaying, the whole America in 2005, there is the end-stage renal failure patient who exceedes 450,000.In China, according to the incomplete statistics of Chinese nephropathy association, need at present the uremic patient for the treatment of nearly more than 1,000,000.
At present, applied main method is treated for dialysis by renal failure and uremia, comprises hemodialysis and peritoneal dialysis.Hemodialysis have the toxin of removing fully, be suitable for the advantages such as prolonged application, be to apply clinically maximum Therapeutic Method.In blood dialysis, needing the key equipment of application is haemodialysis control unit, and modern haemodialysis control unit is in order to realize good therapeutic effect, and version is all very complicated.Usually, hemodialysis mainly comprises the parts such as dialysate supply unit, automatic monitoring system and extracorporeal blood circulation system.Dialysate supply unit comprises dynamical system and temperature-controlling system, and the former can automatic preparation electrolyte content approach the sterile dialysis liquid of human body, and the negative pressure of dialysis fluid circuit is provided; The main Maintenance dialysis liquid of the latter constant temperature is supplied with.Automatic monitoring device carries out safely arranging in order to guarantee the extracorporeal circulation of blood of dialysis procedure, generally by dialysis solution and blood flow rate regulator control system, dialysate concentration monitoring system, sound pulse pressure monitor system, leak the parts such as blood monitor system and form.
Device structure based on complicated and work process, hemodialysis function is removed the toxin in uremic patient body more effectively.But haemodialysis control unit and the pattern for the treatment of accordingly still have larger drawback at present, are mainly reflected in:
1) purification efficiency is low.The cardinal principle of haemodialysis control unit treatment is that the toxin in blood spreads to dialysis fluid side gradually under the concentration difference of film both sides drives.Modern dialysis process can efficiently be removed the micromolecule toxin in blood, but obviously not enough to the removal efficiency of the crucial middle molecule toxins in carbamide disease patient body.In order to reach sufficient detoxifying effect, general each dialysis treatment need to reach more than 120 liters cleanout fluid.
2) treatment cost is high.The generally preparation online in therapeutic process of dialysis solution in hemodialysis, therefore needs complicated dialysate supply unit in haemodialysis control unit, approach the sterile dialysis liquid of human body to realize automatic preparation electrolyte content.And in order to guarantee security of operation, in haemodialysis control unit, also need to set up concentration monitoring and mismatch warning, to prevent the dialysis solution that mismatches that machine and man-made fault cause to occur.Complicated system structure causes equipment cost high.On the other hand, in blood dialysis, need to expend a large amount of dialysis solution, thereby cause the use cost of equipment also high.And in order to meet water for dialysis needs, hemodialysis requires to be equipped with complicated water treatment facilities, has further improved the treatment cost of hemodialysis.In the U.S., the expense of only treating for end-stage renal failure once use for 2000 is up to 14,200,000,000 dollars.And in China, a hemodialysis in hospital per capita year medical expense is about 6 to 100,000 yuan, high expense causes a lot of patients to can not get effectively treatment and death.
3) quality of life of patients is poor.Existing haemodialysis control unit build is huge, and needs large-scale water purification system support, therefore the using area of equipment has been proposed to very high requirement.Therefore, the main still so-called dialysis center hemodialysis (In-center hemodialysis) of current hemodialysis mode, patient goes to hospital's dialysis center, dialyses weekly 2~3 times, dialyses 4~6 hours at every turn.Loaded down with trivial details so round treatment meeting severe jamming patient's routine work and life, reduce patient's life quality, and long-term treatment meeting easily makes patient produce mental maladjustment.According to statistics, up to 27% hemodialysis patients, there is suicidal tendency.
Based on the existing above problem of existing haemodialysis control unit, the present invention is devoted to apply new method and designs to improve therapeutic quality, reduce treatment cost and improve quality of life of patients.
Summary of the invention
The problem that blood purification efficiency is low, treatment cost is high, quality of life of patients is poor existing in order to solve existing haemodialysis control unit and treatment pattern accordingly, the invention provides that a kind of therapeutic quality is high, treatment cost is low and improves the Portable blood purifying system of quality of life of patients.
The technical solution that realizes above-mentioned purpose is as follows:
Portable blood purifying system comprises during high flux hemodialysis device 4, and the inner chamber entrance 401 of described during high flux hemodialysis device 4 is being communicated with one end of ductus arteriosus 100, from the other end, ductus arteriosus, connecting successively tremulous pulse valve 101, arterial pressure sensor 103 and blood pump 104; The inner chamber outlet 402 of during high flux hemodialysis device 4 is being communicated with one end of venous duct 110, from the other end, venous duct, connecting successively venous valving 109, vein temperature sensor 108, vein bubble detector 107, venous pressure sensor 106, constituting body outer circulation unit; In described arterial pressure sensor 103 and venous pressure sensor 106, be respectively equipped with bubble trap;
The exocoel entrance 403 of described during high flux hemodialysis device 4 is being communicated with one end of cleanout fluid pipe, and the other end of cleanout fluid pipe is being communicated with soda liquor container 201, and soda liquor container 201 is provided with cleanout fluid weight sensor 202, the Prefill valve 306 of connecting on cleanout fluid pipe; The outlet of soda liquor container 201 is being communicated with one end of tube for transfusion 200, and the other end of tube for transfusion 200 is being communicated with the first port of the sluice valve 206 of infusing, the temperature controller 203 of connecting successively on tube for transfusion 200, tube for transfusion bubble trap 204 and infusion pump 205; The second port of transfusion sluice valve 206 is being communicated with one end of the first tube for transfusion branch road 210, and the other end of the first tube for transfusion branch road 210 is being communicated with venous duct 110 between the inner chamber outlet 402 of during high flux hemodialysis device and the import of venous pressure sensor 106 by tee T; The 3rd port of transfusion sluice valve 206 is being communicated with one end of the second tube for transfusion branch road 220, and the other end of the second tube for transfusion branch road 220 is being communicated with the ductus arteriosus 100 between tremulous pulse valve 101 and arterial pressure sensor 103 by tee T;
The exocoel outlet 404 of during high flux hemodialysis device 4 is being communicated with one end of sewer pipe, the other end of sewer pipe is being communicated with waste fluid container 301, waste fluid container 301 is provided with waste liquid weight sensor 302, on sewer pipe, connecting blood leak detector 305, waste liquid pressure transducer 304, ultrafiltrate pump 303, waste liquid pressure transducer 304 is provided with pressure transducer.
The exocoel entrance 403 of described during high flux hemodialysis device 4 is being communicated with the first port of waste liquid sluice valve 307, the second port of waste liquid sluice valve 307 is being communicated with soda liquor container 201, the 3rd port of waste liquid sluice valve 307 is being communicated with one end of regenerating tube, the other end of regenerating tube is being communicated with the outlet of waste fluid container 301, the regenerating tube from waste fluid container 301 outlets, connecting successively adsorber 310, sterilizing filter 309, regenerative pump 308.
Described temperature controller 203 is electric heating heater.
On described arterial pressure sensor 103, venous pressure sensor 106 and waste liquid pressure transducer 304 with bubble trap.
Described blood pump 104, infusion pump 205 and ultrafiltrate pump 303 are peristaltic pump, and rotating speed is accurately adjustable.
Described tremulous pulse valve 101, venous valving 109 and Prefill valve 306 are two-way grip pipe valve, and transfusion sluice valve 206 and waste liquid sluice valve 307 are three-dimensional pinch valve.
The present invention can realize two kinds of functions: pure hemofiltration and hemodiafiltration.When the present invention realizes hemodiafiltration function, transfusion unit comprises the elements such as bottled or packed aseptic cleanout fluid, infusion pump, tube for transfusion, sluice valve, wherein tube for transfusion is connected with ductus arteriosus and the venous duct of extracorporeal blood circulation system respectively through sluice valve, by equipment sluice valve state, can select flexibly front dilution (" first ultrafiltration after perfusion ") or rear dilution (" first ultrafiltration after perfusion "); Liquid waste processing unit comprises the elements such as ultrafiltrate pump, sewer pipe, cleanout fluid regenerating unit and waste fluid container, and waste liquid is adsorbed purification at adsorber under the driving of pump, enters during high flux hemodialysis device or filter and continues to purge away the poison in one's blood with the effect of dialysis.When the present invention realizes pure hemofiltration function, ultrafiltrate directly forms waste collection in waste fluid container.
Under two kinds of mode of operations, the present invention has all adopted the method for following a kind of non-invasive measurement and coutroi velocity: by reading the weight change of the measured cleanout fluid of weight sensor and waste liquid, feedback control cleanout fluid and waste liquid flow velocity, and indirectly control net ultrafiltration amount.
At transfusion unit, temperature controller of the present invention is a kind of electric heating heater, to realize the cleanout fluid heating of non-invasive.In temperature controller inside, wash liquid stream is through the liquid bag of a special shape, and in this liquid bag back-shaped flowing, in flow process, by the silica gel thermostat of heating, heated gradually.
Cleanout fluid regeneration sector in system comprises adsorber 310, regenerative pump 308 and the sterilizing filter 309 of adsorbents such as containing active carbon, resin.Carry out self-cleaning waste liquid and under the driving of regenerative pump 308, enter adsorber 310 and be adsorbed purification, become regeneration dialysis solution and reenter during high flux hemodialysis device, with the effect of dialysing, continue to remove the micromolecule toxin in blood.
By above design, the relative haemodialysis control unit of the present invention has advantages of following several respects:
1) in having efficiently, micromolecule Dusuqing removing solid capacity, blood purification efficiency obviously improves.
2) treat required cleanout fluid and greatly reduce, each treatment only need to be less than the cleanout fluid of 8 liters, makes system break away from the dependence to water correction plant on the one hand, and treatment cost also reduces greatly.
3) system is moved cleanout fluid used and can be prepared in advance, and without systems such as the online compounding system of complicated dialysis solution and corresponding concentration measurement and controls, device structure is simplified greatly, operational reliability and safety also relative raising.
4) system running is simple, and without complicated specialty operation, patient can independently treat.Intelligence control system in system can arrive patient's physiological data remote transmission dialysis monitoring center, thereby effectively ensures treatment safety and treatment curative effect.
5) relatively traditional haemodialysis control unit, structure of the present invention is simplified greatly, can move easily, and be easy to carry.The present invention can be used as therapeutic equipment at home, is more suitable for patient's repeatedly dialysis in short-term or nocturnal dialysis treatment at home, reduces the toxin tolerance of dialysis patient in dialysis interval when reducing medical care cost.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Fig. 2 is the structural representation with cleanout fluid regeneration module.
In above-mentioned figure, 100 ductus arteriosuss, 101 tremulous pulse valves, 102 tee Ts, 103 arterial pressure sensor, 104 blood pumps, 105 tee Ts, 106 venous pressure sensor, 107 vein bubble detectors, 108 vein temperature sensors, 109 tremulous pulse valves, 110 venous ductes, 200 tube for transfusions, 201 soda liquor containers, 202 cleanout fluid weight sensors, 203 temperature control equipments, 204 tube for transfusion bubble traps, 205 infusion pump, 206 tube for transfusion sluice valves, 210 tube for transfusion branch roads, 220 tube for transfusion branch roads, 301 waste fluid containers, 302 waste liquid weight sensors, 303 ultrafiltrate pumps, 304 waste liquid pressure transducer and pressure transducers, 305 blood leak detectors, 306 Prefill valves, 307 sewer pipe sluice valves, 4 during high flux hemodialysis devices, the inner chamber entrance of 401 during high flux hemodialysis devices, the exocoel outlet of 402 during high flux hemodialysis devices, the exocoel entrance of 403 during high flux hemodialysis devices, the exocoel outlet of 404 during high flux hemodialysis devices.
The specific embodiment
Below in conjunction with accompanying drawing, by embodiment, the present invention is further described.
Embodiment:
Referring to Fig. 1, Portable blood purifying system comprises during high flux hemodialysis device 4, the inner chamber entrance 401 of during high flux hemodialysis device 4 is being communicated with one end of ductus arteriosus 100, from the other end, ductus arteriosus, connecting successively tremulous pulse valve 101, arterial pressure sensor 103 and blood pump 104; The inner chamber outlet 402 of during high flux hemodialysis device 4 is being communicated with one end of venous duct 110, from the other end, venous duct, connecting successively venous valving 109, vein temperature sensor 108, vein bubble detector 107, venous pressure sensor 106, constituting body outer circulation unit; In arterial pressure sensor 103 and venous pressure sensor 106, be separately installed with bubble trap;
The exocoel entrance 403 of during high flux hemodialysis device 4 is being communicated with one end of cleanout fluid pipe, and the other end of cleanout fluid pipe is being communicated with soda liquor container 201, and cleanout fluid weight sensor 202 is installed on soda liquor container 201, the Prefill valve 306 of connecting on cleanout fluid pipe; The outlet of soda liquor container 201 is being communicated with one end of tube for transfusion 200, and the other end of tube for transfusion 200 is being communicated with the first port of the sluice valve 206 of infusing, the temperature controller 203 of connecting successively on tube for transfusion 200, tube for transfusion bubble trap 204 and infusion pump 205; The second port of transfusion sluice valve 206 is being communicated with one end of the first tube for transfusion branch road 210, and the other end of the first tube for transfusion branch road 210 is being communicated with venous duct 110 between the inner chamber outlet 402 of during high flux hemodialysis device and the import of venous pressure sensor 106 by tee T; The 3rd port of transfusion sluice valve 206 is being communicated with one end of the second tube for transfusion branch road 220, and the other end of the second tube for transfusion branch road 220 is being communicated with the ductus arteriosus 100 between tremulous pulse valve 101 and arterial pressure sensor 103 by tee T;
The exocoel outlet 404 of during high flux hemodialysis device 4 is being communicated with one end of sewer pipe, the other end of sewer pipe is being communicated with waste fluid container 301, waste liquid weight sensor 302 is installed on waste fluid container 301, on sewer pipe, connecting blood leak detector 305, waste liquid pressure transducer 304, ultrafiltrate pump 303, be provided with bubble trap on waste liquid pressure transducer 304.
Referring to Fig. 2, the exocoel entrance 403 of during high flux hemodialysis device 4 is being communicated with the first port of waste liquid sluice valve 307, the second port of waste liquid sluice valve 307 is being communicated with soda liquor container 201, the 3rd port of waste liquid sluice valve 307 is being communicated with one end of regenerating tube, the other end of regenerating tube is being communicated with the outlet of waste fluid container 301, the regenerating tube from waste fluid container 301 outlets, connecting successively adsorber 310, sterilizing filter 309, regenerative pump 308; This part of mechanism forms cleanout fluid regeneration sector.
During high flux hemodialysis device 4 models are the APS series Asahi Chemical Industry polysulfone membrane hemodialyzer of Japanese Asahi Kasei medical treatment apparatus Co., Ltd..
Temperature controller 203 is electric heating heater, product type: the ANIMEC AM-2S Fluid Warmer(U.S.).
Arterial pressure sensor 103, venous pressure sensor 106 and waste liquid pressure transducer 304 comprise bubble trap, and sensor hardware passes through air measured pressure value, and does not directly contact with liquid.
Blood pump 104, infusion pump 205 and ultrafiltrate pump 303 are all peristaltic pump, and the pump housing does not directly contact with tube fluid.
Tremulous pulse valve 101, venous valving 109 and Prefill valve 306 are two-way grip pipe valve, and transfusion sluice valve 206 and waste liquid sluice valve 307 are three-dimensional pinch valve.
Pure hemofiltration mode of operation is as follows:
As shown in Figure 1, the ductus arteriosus 100 of system and venous duct 110 are connected respectively to tremulous pulse and the vein of human body.In blood circulation unit 1, arterial blood, through tremulous pulse valve 101, tee T 102 and arterial pressure sensor 103, is pumped into the inner chamber entrance 401 of during high flux hemodialysis device 4 by blood pump 104 in vitro.Blood is flowed out by the inner chamber outlet 402 of during high flux hemodialysis device 4, through vein tee T 105, venous pressure sensor 106, vein bubble detector 107, temperature sensor 108, venous valving 109, by venous duct 110, flows back to human body.
In transfusion unit, sterile dialysis liquid by tube for transfusion 200 flow through temperature controller 203, tube for transfusion pressure transducer 204, pumps into extracorporeal circulation of blood by infusion pump 205 from soda liquor container 201.The decanting point of cleanout fluid has two kinds of selections.Wherein, cleanout fluid injects ductus arteriosus 100 to be mixed with blood, is called i.e. " the first ultrafiltration after dilution " of front dilution; And cleanout fluid injection venous duct 110 mixes with blood, be called i.e. " the diluting after first ultrafiltration " of rear dilution.
In liquid waste processing unit, ultrafiltrate flows out and forms waste liquids from the exocoel outlet 404 of during high flux hemodialysis device under the driving of ultrafiltrate pump 305, and flow through successively blood leak detector 305, waste liquid pressure transducer 304 of waste liquid flows back to waste fluid container 301.Wherein, waste liquid pressure transducer 304 is for the detection of transmembrane pressure.
In soda liquor container 201 and waste fluid container 301, the weight of liquid is measured by cleanout fluid weight sensor 202 and waste liquid weight sensor 302 respectively, with the flow velocity of feedback control cleanout fluid and waste liquid, and the indirect speed of accurately controlling perfusion and ultrafiltration.
Hemodiafiltration mode of operation is as follows:
Under this mode of operation, the extracorporeal circulation of blood unit of system and transfusion unit are identical with under pure hemofiltration pattern.Institute's difference is, has increased the elements such as adsorber 310 and regenerative pump 308, as shown in Figure 2 in liquid waste processing unit.The waste liquid flowing out from the exocoel outlet 404 of during high flux hemodialysis device enters waste fluid container 301, in the driving of regenerative pump 308, be lowered to adsorber 310, spent solution regeneration is dialysis solution, then through sterilizing filter 309, from the exocoel entrance 403 of during high flux hemodialysis device and during high flux hemodialysis device 4, reenters during high flux hemodialysis device 4.The most of toxin containing in waste liquid in adsorber 310 is adsorbed agent absorption, and in regeneration dialysis solution after treatment, content of toxins, far below blood, therefore especially can continue to diffuse to dialysis fluid side at the toxin of during high flux hemodialysis device 4 inner blood sides.In addition, by controlling regenerative pump 310 and ultrafiltrate pump 303, make waste liquid flow velocity be greater than regeneration dialysate flow rate, can realize continuous Ultrafiltration, system continues to remove the toxin in blood by the mode of dialysis filtration.

Claims (4)

1. Portable blood purifying system, comprise during high flux hemodialysis device (4), it is characterized in that, the inner chamber entrance (401) of described during high flux hemodialysis device (4) is being communicated with one end of ductus arteriosus (100), the tremulous pulse valve (101) of connecting successively ductus arteriosus from the other end, arterial pressure sensor (103) and blood pump (104); The inner chamber outlet (402) of during high flux hemodialysis device (4) is being communicated with one end of venous duct (110), from the other end, venous duct, connecting successively venous valving (109), vein temperature sensor (108), vein bubble detector (107), venous pressure sensor (106), constituting body outer circulation unit; In described arterial pressure sensor (103) and venous pressure sensor (106), be respectively equipped with bubble trap;
The exocoel entrance (403) of described during high flux hemodialysis device (4) is being communicated with one end of cleanout fluid pipe, the other end of cleanout fluid pipe is being communicated with soda liquor container (201), soda liquor container (201) is provided with cleanout fluid weight sensor (202), the Prefill valve (306) of connecting on cleanout fluid pipe; The outlet of soda liquor container (201) is being communicated with one end of tube for transfusion (200), the other end of tube for transfusion (200) is being communicated with the first port of transfusion sluice valve (206), the temperature controller (203) of connecting successively on tube for transfusion (200), tube for transfusion bubble trap (204) and infusion pump (205); The second port of transfusion sluice valve (206) is being communicated with one end of the first tube for transfusion branch road (210), and the inner chamber that the other end of the first tube for transfusion branch road (210) is being communicated with during high flux hemodialysis device by tee T exports venous duct (110) between (402) and the import of venous pressure sensor (106); The 3rd port of transfusion sluice valve (206) is being communicated with one end of the second tube for transfusion branch road (220), and the other end of the second tube for transfusion branch road (220) is being communicated with the ductus arteriosus (100) between tremulous pulse valve (101) and arterial pressure sensor (103) by tee T;
The exocoel outlet (404) of during high flux hemodialysis device (4) is being communicated with one end of sewer pipe; the other end of sewer pipe is being communicated with waste fluid container (301); waste fluid container (301) is provided with waste liquid weight sensor (302); on sewer pipe, connecting blood leak detector (305), waste liquid pressure transducer (304), ultrafiltrate pump (303), waste liquid pressure transducer (304) is provided with pressure transducer;
The exocoel entrance (403) of described during high flux hemodialysis device (4) is being communicated with the first port of waste liquid sluice valve (307), the second port of waste liquid sluice valve (307) is being communicated with soda liquor container (201), the 3rd port of waste liquid sluice valve (307) is being communicated with one end of regenerating tube, the other end of regenerating tube is being communicated with the outlet of waste fluid container (301), the regenerating tube from waste fluid container (301) outlet, connecting successively adsorber (310), sterilizing filter (309), regenerative pump (308).
2. Portable blood purifying system according to claim 1, is characterized in that: described temperature controller (203) is electric heating heater.
3. Portable blood purifying system according to claim 1, is characterized in that: described arterial pressure sensor (103), venous pressure sensor (106) and waste liquid pressure transducer (304) are upper with bubble trap.
4. Portable blood purifying system according to claim 1, is characterized in that: described blood pump (104), infusion pump (205) and ultrafiltrate pump (303) are peristaltic pump.
CN201110221144.6A 2011-08-04 2011-08-04 Portable blood purifying system CN102389594B (en)

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CN103585684A (en) * 2013-11-27 2014-02-19 电子科技大学 Separate-type extracorporeal circulation system
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CN105709291B (en) * 2016-01-07 2018-12-04 王贵霞 A kind of Intelligent blood diafiltration device
CN106641707A (en) * 2016-10-08 2017-05-10 中国矿业大学 Efficient self-pressurized metering liquid nitrogen pump
US10272187B2 (en) * 2017-02-22 2019-04-30 Fresenius Medical Care Holdings, Inc. System and methods for dialyzer flow rates estimation using measured dialyzer pressures
CN107929838B (en) * 2017-11-15 2020-12-25 青岛市市立医院 Hemodialysis device for nephrology department

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