CN108114333A - Apparatus for purifying blood, blood purification system and its pre- punching method - Google Patents
Apparatus for purifying blood, blood purification system and its pre- punching method Download PDFInfo
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- CN108114333A CN108114333A CN201611067626.XA CN201611067626A CN108114333A CN 108114333 A CN108114333 A CN 108114333A CN 201611067626 A CN201611067626 A CN 201611067626A CN 108114333 A CN108114333 A CN 108114333A
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- pipeline
- fliud flushing
- pipe
- blood
- dialyzate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
- A61M1/3644—Mode of operation
- A61M1/365—Mode of operation through membranes, e.g. by inverted trans-membrane pressure [TMP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
- A61M1/3659—Cannulae pertaining to extracorporeal circulation
- A61M1/3661—Cannulae pertaining to extracorporeal circulation for haemodialysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/12—Blood circulatory system
Abstract
The present invention provides a kind of apparatus for purifying blood, blood purification system and its pre- punching method, apparatus for purifying blood include blood purification and and pipeline assembly, blood purification includes housing, input port and delivery outlet, the both ends of housing are respectively arranged with the first adsorbent filled chamber and the second adsorbent filled chamber, first adsorbent filled chamber is equipped with arterial end blood mouth, vein end blood mouth is equipped on second adsorbent filled chamber, input port is used to input dialyzate or pre- fliud flushing, delivery outlet is used to input dialyzate or the pre- fliud flushing of output, arterial end blood mouth and vein end blood mouth are used to export pre- fliud flushing.Pipeline assembly includes artery connecting tube, Connect of Vein pipe, dialyzate connecting tube, pre- fliud flushing input pipe, pre- fliud flushing efferent duct.This case is simple in structure and stability and high efficiency, avoids pre- fliud flushing and rushes in advance from top to down and carry the problem of absorbent particles enter dialysis membrane.
Description
Technical field
The present invention relates to field of blood purification more particularly to a kind of apparatus for purifying blood, blood purification system and blood are net
The pre- punching method of change system.
Background technology
Blood perfusion device is mainly by adsorbing the difficult permeability uremic toxins such as parathormone of uremia patient's body
（PTH）, leptin, 2 microglobulins of β（β2‐MG）, feritin, angiotensins etc., for treating Uremic complications, such as renal bone
Disease, heterotopic calcification, amyloidosis, carpal tunnel syndrome, malnutrition, intractable hypertension, cardiovascular complication etc..It is clinical at present
Dialysis treatment is carried out to uremic patient frequently with dialyzer and perfusion device series connection.Series connection treatment is first blood perfusion and dialyzer
Joint dialysis 2 it is small when after, then remove perfusion device merely dialysis 2 it is small when.Although such dialysis treatment mode can reduce uremia
Complication for patients shape, can play certain positive effect, but be frequently encountered in practical operation at the defects of compensating for simple dialysis
Some technical problems, such as：Since blood perfusion device is connected with dialyzers in series, when rushing in advance, pre- fliud flushing will first pass through blood perfusion
Then device finally flows into waste liquid bumping bag by the road into dialyzer again.During if blood perfusion device rushes in advance, even if having
Micro resin wear will also result in ventilative device and block etc., if come off resin by pipeline enter blood samples of patients will cause it is more dangerous
Happen.Furthermore it needs perfusion device removing simple dialyzer dialysis after when dialyzer, perfusion device cascade dialysis 2 are small, tear open
It is bacterium in air, micro- except dialyzer connection end and patients with hemodialysis's tube end must expose in air during pipeline
Dirt etc., which is easily entered by open end in dialyzer and transducer potector, to be polluted or infects, and unnecessary wound is caused to patient
Evil.
Although the connecting line for being not required to dismounting proposed in the patents such as CN203315422U and CN203469105U can solve
The certainly above problem.But using the road that during entire blood purification treatment, blood samples of patients cycles in vitro during pipeline connection
Footpath is long, increases blood with there is the probability that collarium border contacts, increases the burden of patient, increase potential security risk.
The content of the invention
The first object of the present invention is to provide a kind of simple in structure and stability and high efficiency apparatus for purifying blood.
The second object of the present invention is to provide a kind of simple in structure and stability and high efficiency blood purification system.
The third object of the present invention is to provide the pre- punching method of a kind of simple in structure and stability and high efficiency blood purification system.
In order to realize the first object of the present invention, the present invention provides a kind of apparatus for purifying blood, including blood purification and
Pipeline assembly, blood purification include housing, and housing forms hollow chamber, dialysis membrane, dialysis membrane both ends point are filled in chamber
It is not fixed in the cavity by the first adhesive layer and the second adhesive layer, input is provided on the outer wall of the opposite housing of dialysis membrane
Mouth and delivery outlet, housing both ends are respectively arranged with the first adsorbent filled chamber and the second adsorbent filled chamber, and the first adsorbent is filled out
It fills on room and is provided with arterial end blood mouth, the second adsorbent filled chamber is equipped with vein end blood mouth, and dialysis membrane is hollow fiber conduit, shell
Surround pre- fliud flushing chamber between body, the first adhesive layer, the second adhesive layer and hollow fiber conduit outside, input port and delivery outlet in advance
Fliud flushing chamber connects, and for inputting pre- fliud flushing, arterial end blood mouth and vein end blood mouth are used to export pre- fliud flushing for input port or delivery outlet；
Pipeline assembly includes artery connecting tube, Connect of Vein pipe, dialyzate connecting tube, pre- fliud flushing input pipe, pre- fliud flushing efferent duct, artery
The first end of connecting tube is connected with arterial end blood mouth, and the first end of Connect of Vein pipe is connected with vein end blood mouth, dialyzate connection
The first end of pipe is connected with input port or delivery outlet, and the first end of pre- fliud flushing input pipe is connected with artery connecting tube, and pre- fliud flushing is defeated
The second end for entering pipe is connected with dialyzate connecting tube, and the first end of pre- fliud flushing efferent duct is connected with artery connecting tube, and pre- fliud flushing is defeated
The second end of outlet pipe is connected with Connect of Vein pipe.
By said program as it can be seen that by the apparatus for purifying blood of this case, pre- fliud flushing enters pre- fliud flushing chamber, leads to membrane pressure
Effect is infiltrated through in hollow fiber conduit, and along in hollow fiber conduit into arterial end end cap and/or vein end end cap and right
First adsorbent and/or the second adsorbent therein are rushed in advance, are then then exhausted from.Pre- fliud flushing in the prior art is solved to first pass through
Adsorbent rushes adsorbent in advance, and the pre- fliud flushing with granule foreign for breaking through adsorbent in advance enters back into asking for dialysis membrane
Topic enters dialysis membrane so as to which pre- fliud flushing be avoided to carry particle；Simultaneously also without dismounting or access pipeline so that extracorporal circulatory system institute
It needs blood few, improves the comfort level of patient, especially for the less patient of the smaller total blood volume of build.On the other hand treat
When, without adjusting the break-make of pipeline or changing the flow direction of blood, the operation for making medical staff is more convenient, avoids because of behaviour
Risk caused by slipping up improves the security stability of blood purification system.
Further scheme is that the both ends of pre- fliud flushing input pipe are connected respectively by threeway and artery connecting tube, dialyzate
Connection is taken over, the both ends of pre- fliud flushing efferent duct are connected respectively by threeway with artery connecting tube, Connect of Vein pipe, pre- fliud flushing output
The first end of pipe is between the first end of pre- fliud flushing input pipe and arterial end blood mouth；Artery connecting tube is exported positioned at pre- fliud flushing
Pipe clamp is provided on position between the first end of pipe and the first end of pre- fliud flushing input pipe；Connect of Vein pipe is positioned at pre- fliud flushing
Pipe clamp is provided on position between efferent duct and vein end blood mouth；It is respectively equipped on pre- fliud flushing input pipe and pre- fliud flushing efferent duct
Pipe clamp.
Further scheme is, the both ends of pre- fliud flushing input pipe respectively by cock-type threeway and artery connecting tube, thoroughly
The connection of liquid connecting tube is analysed, the both ends of pre- fliud flushing efferent duct pass through cock-type threeway and artery connecting tube, Connect of Vein Guan Lian respectively
It connects, the first end of pre- fliud flushing efferent duct is between the first end of pre- fliud flushing input pipe and arterial end blood mouth.
Further scheme is the first end of pre- fliud flushing input pipe, pre- fliud flushing efferent duct first end and artery connecting tube
It is connected by cock-type four-way, pre- fliud flushing input pipe second end is connected by cock-type threeway with pre- fliud flushing connecting tube, pre- fliud flushing
Efferent duct second end is connected by cock-type threeway with Connect of Vein pipe.
Therefore for the break-make between pipeline, four way plug valve can be used carry out commutation with threeway plug valve and connect,
Its is easy to operate, and stability is high.Pass through the setting of dialyzate connecting tube, dialyzate input pipe and dialyzate efferent duct so that pre-
Detaching pipelines are not required after punching, need to only pass through corresponding on-off line operation, effectively reduce the risk of pollution or infection, carry
High stable reliability.It is connected by pre- fliud flushing efferent duct between arterial end blood mouth and vein end blood mouth so that inhaled in pre- punching first
At attached dose, pre- fliud flushing can flow out from arterial end blood mouth and import duct of Arantius discharge, in the second adsorbent of punching in advance, block pre- punching
Liquid efferent duct can be compatible with existing Clinical practice Medical Devices, save new Medical Devices development cost.
Further scheme is that the second end of artery connecting tube is equipped with the first block, and the second end of Connect of Vein pipe is set
There is the second block, the second end of dialyzate connecting tube is equipped with the 3rd block；Artery connecting tube is included positioned at pre- fliud flushing input pipe
Second pipe between the first pipeline between first end and the first block, the first end positioned at pre- fliud flushing efferent duct and arterial end blood mouth
Road, the 9th pipeline between the first end of pre- fliud flushing input pipe and the first end of pre- fliud flushing efferent duct；Connect of Vein pipe bag
Include the 5th pipeline between vein end blood mouth and the second end of pre- fliud flushing efferent duct, positioned at pre- fliud flushing efferent duct second end and
The 6th pipeline between second block；Dialyzate connecting tube is included between pre- fliud flushing input pipe and input port/delivery outlet
The 8th pipeline between 7th pipeline, the second end positioned at pre- fliud flushing input pipe and the 3rd block；Pre- fliud flushing input pipe is the 3rd
Pipeline；Pre- fliud flushing efferent duct is the 4th pipeline.
Further scheme is that the second end of artery connecting tube is equipped with the first block, and the second end of Connect of Vein pipe is set
There is the second block, the second end of dialyzate connecting tube is equipped with the 3rd block；Artery connecting tube is included positioned at cock-type four-way and the
The first pipeline between one block, the second pipeline between cock-type four-way and arterial end blood mouth；Vein end connecting tube bag
Include the 5th pipeline between vein end blood mouth and the second end of pre- fliud flushing efferent duct, the second end positioned at pre- fliud flushing efferent duct
The 6th pipeline between the second block；Dialyzate connecting tube is included positioned at second end and the input port of pre- fliud flushing input pipe/defeated
The 8th pipeline between the 7th pipeline between outlet, the second end positioned at pre- fliud flushing input pipe and the 3rd block；Pre- fliud flushing is defeated
Enter tri- pipelines of Guan Wei；Pre- fliud flushing efferent duct is the 4th pipeline.
In order to realize the second object of the present invention, the present invention provides a kind of blood purification system, including appointing in said program
One apparatus for purifying blood；Artery connecting tube is connected with arterial, and Connect of Vein pipe is connected with duct of Arantius, dialyzate connecting tube with
Dialyzate input pipe connects, the delivery outlet is connected with the dialyzate efferent duct；Or the dialyzate connecting tube and dialyzate
Efferent duct connects, and the input port is connected with dialyzate input pipe；Dialyzate input pipe and dialyzate efferent duct respectively with dialysis
Liquid storage device connects.
By said program as it can be seen that by the blood purification system of this case, pre- fliud flushing enters pre- fliud flushing chamber, leads to membrane pressure
Effect is infiltrated through in hollow fiber conduit, and along in hollow fiber conduit into arterial end end cap and/or vein end end cap and right
First adsorbent and/or the second adsorbent therein are rushed in advance, are then then exhausted from.Pre- fliud flushing in the prior art is solved to first pass through
Adsorbent rushes adsorbent in advance, and the pre- fliud flushing with granule foreign for breaking through adsorbent in advance enters back into asking for dialysis membrane
Topic enters dialysis membrane so as to which pre- fliud flushing be avoided to carry particle；Simultaneously also without dismounting or access pipeline so that extracorporal circulatory system institute
It needs blood few, improves the comfort level of patient, especially for the less patient of the smaller total blood volume of build.On the other hand treat
When, without adjusting the break-make of pipeline or changing the flow direction of blood, the operation for making medical staff is more convenient, avoids because of behaviour
Risk caused by slipping up improves the security stability of blood purification system.
In order to realize the third object of the present invention, the present invention provides a kind of pre- punching method of blood purification system, and blood is net
Change system uses the blood purification system of any of the above-described；
Pre- punching method includes：
First break-make step, by arterial and the first pipeline connection, the first pipeline and the 3rd pipeline connection, the 3rd pipeline and the 7th
Pipeline connection；By the second pipeline and the 4th pipeline connection, the first pipeline and the second pipeline, the 4th pipeline are blocked, by the 4th pipe
Road and the 6th pipeline connection block the 5th pipeline and the 6th pipeline；
First rushes step in advance, and pre- fliud flushing is inputted from arterial, and pre- fliud flushing passes through the first pipeline, the 3rd pipeline, the 7th pipeline successively,
Into pre- fliud flushing chamber and infiltrate into dialysis membrane, then through the first adsorbent, the second pipeline and the 4th pipeline in arterial end end cap
It is exported afterwards from the 6th pipeline to duct of Arantius, is finally discharged from duct of Arantius, complete the pre- punching to the first adsorbent；
Second break-make step, by arterial and the first pipeline connection, the first pipeline and the 3rd pipeline connection, the 3rd pipeline and the 7th
Pipeline connection；First pipeline blocks respectively with the second pipeline, the 4th pipeline, the 4th pipeline and the 6th pipeline is blocked, by the 5th
Pipeline and the 6th pipeline connection；
Second rushes step in advance, and pre- fliud flushing is inputted from arterial, and pre- fliud flushing passes through the first pipeline, the 3rd pipeline, the 7th pipeline successively,
Into pre- fliud flushing chamber and infiltrate into dialysis membrane, through in vein end end cap the second adsorbent, after the 5th pipeline from the 6th pipe
Road is exported to duct of Arantius, is finally discharged from duct of Arantius, is completed the pre- punching to the second adsorbent；
3rd break-make step blocks the first pipeline and the second pipeline, the 4th pipeline；3rd pipeline and the 7th pipeline and the 8th pipe
Roadlock breaks；By the second pipeline and the 4th pipeline connection, the 4th pipeline and the 6th pipeline connection, the 5th pipeline and the 6th pipeline connect
It is logical, the 7th pipeline and the 8th pipeline connection；
3rd rushes step in advance, and dialyzate enters from the 8th pipeline, will be in pre- fliud flushing chamber by the 7th pipeline into pre- fliud flushing chamber
A pre- fliud flushing part is remained out of dialysis membrane through the first adsorbent, arterial end blood mouth, the second pipeline, the 4th pipe in artery end cap
Road exports to duct of Arantius from the 6th pipeline, is finally discharged from duct of Arantius；Another part is out of dialysis membrane through in vein end cap second
Adsorbent is exported to duct of Arantius through the 5th pipeline, the 6th pipeline, finally discharged from duct of Arantius.
In order to realize the third object of the present invention, the present invention also provides a kind of pre- punching method of blood purification system, blood
Cleaning system uses above-mentioned blood purification system；
Pre- punching method includes：
First break-make step, by arterial and the first pipeline connection, the first pipeline and the 3rd pipeline connection, the 3rd pipeline and the 7th
Pipeline connection；By the second pipeline and the 4th pipeline connection, the first pipeline and the second pipeline, the 4th pipeline are blocked, by the 4th pipe
Road and the 6th pipeline connection；By the 5th pipeline and the 6th pipeline connection；
First rushes step in advance, inputs pre- fliud flushing from arterial, pre- fliud flushing is by the first pipeline, the 3rd pipeline, the 7th pipeline, entrance
Pre- fliud flushing chamber is infiltrated into dialysis membrane；The pre- fliud flushing of a portion is from by the first adsorbent, the second pipe in arterial end end cap
It is exported behind road and the 4th pipeline from the 6th pipeline to duct of Arantius, is finally discharged from duct of Arantius, complete the pre- punching to the first adsorbent；
The pre- fliud flushing of another part, through the second adsorbent in vein end cap, is exported through the 5th pipeline, the 6th pipeline to vein out of dialysis membrane
Pipe finally discharges from duct of Arantius, completes the pre- punching to the second adsorbent；
Second break-make step blocks the first pipeline and the second pipeline, the 4th pipeline；3rd pipeline and the 7th pipeline and the 8th pipe
Roadlock breaks；By the second pipeline and the 4th pipeline connection, the 4th pipeline and the 6th pipeline connection, the 5th pipeline and the 6th pipeline connect
It is logical, the 7th pipeline and the 8th pipeline connection；
Second rushes step in advance, and dialyzate enters from the 8th pipeline, will be in pre- fliud flushing chamber by the 7th pipeline into pre- fliud flushing chamber
A pre- fliud flushing part is remained out of dialysis membrane through the first adsorbent, arterial end blood mouth, the second pipeline, the 4th pipe in artery end cap
Road exports to duct of Arantius from the 6th pipeline, is finally discharged from duct of Arantius；Another part is out of dialysis membrane through in vein end cap second
Adsorbent is exported to duct of Arantius through the 5th pipeline, the 6th pipeline, finally discharged from duct of Arantius.
Therefore the pre- punching method for the blood purification system for passing through this case, pre- fliud flushing enter pre- fliud flushing chamber, pass through membrane pressure
The effect of difference is infiltrated through in hollow fiber conduit, and is entered along in hollow fiber conduit in arterial end end cap and/or vein end end cap
And the first adsorbent therein and/or the second adsorbent are rushed in advance, then it is then exhausted from.It is first to solve pre- fliud flushing in the prior art
Adsorbent is rushed in advance by adsorbent, and the pre- fliud flushing with granule foreign for breaking through adsorbent in advance enters back into dialysis membrane
Problem enters dialysis membrane so as to which pre- fliud flushing be avoided to carry particle；Simultaneously also without dismounting or access pipeline so that extracorporal circulatory system
Required blood is few, improves the comfort level of patient, especially for the less patient of the smaller total blood volume of build.On the other hand control
During treatment, without adjust pipeline break-make or change blood flow direction, the operation for making medical staff is more convenient, avoid because
Risk caused by operation error improves the security stability of blood purification system.
Description of the drawings
Fig. 1 is the structure diagram of blood purification first embodiment of the present invention.
Fig. 2 is the structure diagram of blood purification system first embodiment of the present invention.
Fig. 3 is the structure diagram of blood purification system second embodiment of the present invention.
Fig. 4 is the structure diagram of blood purification second embodiment of the present invention.
Fig. 5 is the structure diagram of blood purification system 3rd embodiment of the present invention.
Fig. 6 is the structure diagram of blood purification system fourth embodiment of the present invention.
Fig. 7 is the structure diagram of apparatus for purifying blood first embodiment of the present invention.
Fig. 8 is the structure diagram of apparatus for purifying blood second embodiment of the present invention.
Fig. 9 is the structure diagram of apparatus for purifying blood 3rd embodiment of the present invention.
Figure 10 is the structure diagram of the 5th embodiment of blood purification system of the present invention.
Figure 11 is the structure diagram of blood purification system sixth embodiment of the present invention.
The invention will be further described with reference to the accompanying drawings and embodiments.
Specific embodiment
Blood purification first embodiment：
With reference to Fig. 1, Fig. 1 is the structure diagram of blood purification 1, and blood purification 1 includes housing, input port 17 and delivery outlet
16, housing includes shell 11, arterial end end cap 12, vein end end cap 13, and shell 11 sets and forms hollow cavity in a tubular form,
Dialysis membrane 111 is filled in cavity, dialysis membrane 111 is hollow fiber conduit, and dialysis membrane 111 is by the first adhesive layer 112 and the second envelope
Glue-line 113 is fixed on the cavity both ends in housing 11, and hollow fiber conduit penetrates adhesive layer so that the hollow tube of hollow fiber conduit with
The outer space connection of adhesive layer, then make the cavity of shell 11, the first adhesive layer 112 and the second adhesive layer 113 inside, in
Pre- fliud flushing chamber or dialysate chamber are surrounded between the outside of hollow fiber pipe.
Arterial end end cap 12 is set in bottomed tube, and the cavity hatch of arterial end end cap 12 is set towards dialysis membrane 111, is moved
The bottom wall of arteries and veins end end cap 12 is provided with outwardly arterial end blood mouth 14, and the first adsorbent 121 is filled in arterial end end cap 12.It is dynamic
The position that arteries and veins end end cap 12 is connected with arterial end blood mouth 14 is equipped with strainer, first inhaling in artery end cap 12 during for preventing pre- rush
It is gone out from arterial end blood mouth for attached dose 121, arterial end end cap 12 is equipped with strainer close to 112 one end of the first adhesive layer, so as to prevent controlling
Adsorbent gets lodged in the entrance of dialysis membrane hollow fiber conduit under the impact force action of gravity and blood during treatment, so that blood cannot
Smoothly enter dialysis membrane hollow fiber conduit.First adsorbent 121 is filled inwardly from the bottom wall of arterial end end cap 12, artery
The lid of end cap 12 is held to close on shell 11 on one end equipped with the first adhesive layer 112.
Vein end end cap 13 is set in bottomed tube, and the cavity hatch of vein end end cap 13 is set towards 111 ground of dialysis membrane,
The bottom wall of vein end end cap 13 is provided with outwardly vein end blood mouth 15, and the second adsorbent 131 is filled in vein end end cap 13.
The position that vein end end cap 13 is connected with vein end blood mouth 15 is equipped with strainer, during for preventing pre- rush in vein end cap 13 second
Adsorbent 131 is gone out from vein end blood mouth, while when preventing blood purification treatment, the adsorbent in vein end end cap 13 passes through quiet
Arteries and veins end blood mouth 15 eventually enters into human body into extracorporeal circulation pipeline causes security risk, improves the security of product.Specifically,
Two adsorbents 131 are filled inwardly from the bottom wall of vein end end cap 13, and the lid of vein end end cap 13 is closed outside the second adhesive layer 113
And be fixedly connected with shell 11, the second adsorbent 131 is abutted with the second adhesive layer 113, the mode being fixedly connected of above-mentioned end cap
Either welding or threaded connection.It is equipped with when end cap is coupled with outer casing screw, between step and casing ends close
Packing, and close pressing.
The internal diameter of the internal diameter of shell 11, the internal diameter of arterial end end cap 12 and vein end end cap 13 is substantially equally set.
First adsorbent and the second adsorbent can be resin sorbent, acticarbon, native cellulose adsorbent etc..
First adsorbent 121 and the second adsorbent 131 can be identical adsorbent, also can be different adsorbents.Preferably, the present embodiment
Middle dialysis membrane is the hollow fiber dialysis membrane of polyether sulfone materials, and the first adsorbent 121 and the second adsorbent 131 are using neutral big
Hole resin sorbent.
Input port 17 and delivery outlet 16 are arranged on the periphery wall of the opposite shell 11 of dialysis membrane 111, and input port 17 is used for
Dialyzate or pre- fliud flushing are inputted, delivery outlet 16 is used to export dialyzate.Preferably, in the present embodiment, input port 17 is located at and leans on
On the one side of nearly vein end end cap 13, delivery outlet 16 is located on the one side of arterial end end cap 12, and input port 17 and output
Mouth 16 is located on radial direction the same side.Dialyzate entrance is input port 17, and dialyzate outlet is delivery outlet 16.It it is, of course, also possible to will
Input port and delivery outlet are arranged on one side diametrically.
In the present embodiment, housing is cylindrical setting, and the cross section of certain housing is also with rectangular or elliptically
It sets, as long as so that the cross section of dialysis membrane, adhesive layer and adsorbent is roughly the same to can be realized the purpose of the present invention.And
Outside the present embodiment, housing can also be exported close to arterial end end cap one side equipped with dialyzate, housing is close to vein end end cap one
Side is equipped with dialyzate entrance, and dialyzate outlet is input port, and dialyzate entrance is delivery outlet.
Blood purification system first embodiment：
With reference to Fig. 2, Fig. 2 is the structure diagram of blood purification system first embodiment, and blood purification system includes blood purification
Device 1 and pipeline assembly, blood purification 1 use the scheme of above-mentioned blood purification embodiment 1.
Pipeline assembly includes pre- fliud flushing input pipe, dialyzate input pipe 27, dialyzate efferent duct 24, dialyzate connecting tube
22nd, arterial 25 and duct of Arantius 26.22 one end of dialyzate connecting tube in the middle part of pre- fliud flushing input pipe with connecting, the other end and dialyzate
Input pipe 27 connects, and 27 other end of dialyzate input pipe is connected with dialyzate storage device.Pre- fliud flushing input pipe includes pipeline
21 and pipeline 23, wherein 21 one end of pipeline be connected with input port 17.Pipeline 21, pipeline 23 and dialyzate connecting tube 22 pass through threeway
Structure connects.24 one end of dialyzate efferent duct is connected with delivery outlet 16；The other end is connected with dialyzate storage device.Arterial 25
It is connected with arterial end blood mouth, duct of Arantius 26 is connected with vein end blood mouth.Sealing is respectively equipped in dialyzate connecting tube 22, pipeline 23
221 and 231 are pressed from both sides, is also there are clips in arterial and duct of Arantius（It is not shown）.
When rushing in advance, pre- fliud flushing input pipe is used to input pre- fliud flushing；Arterial 25 and duct of Arantius 26 are used to discharge pre- fliud flushing,
So that in pre- fliud flushing input pipe, pre- fliud flushing chamber, hollow-fibre membrane, arterial end end cap is interior, arterial forms a pre- fliud flushing and leads to
Road；Make pre- fliud flushing input pipe, pre- fliud flushing chamber, in hollow-fibre membrane, in vein end end cap, duct of Arantius forms another pre- fliud flushing and lead to
Road.
During treatment, pre- fliud flushing input pipe blocks, and dialyzate input pipe 27 is used to provide to the dialysate chamber of blood purification
Dialyzate, dialyzate efferent duct 24 is for the dialyzate in dialysate chamber to be expelled in dialyzate storage device, so that thoroughly
It is formed between analysis liquid memory, dialyzate input pipe 27, dialyzate connecting tube, pipeline 21, dialysate chamber, dialyzate efferent duct 24
Dialysis fluid circuit.And arterial 25 is for the blood of patient's body to be led in blood purification, duct of Arantius 26 is for will be through
1 purified blood recovery of blood purification enters patient's body, so that the artery in patient, arterial 25, blood purification
It holds in end cap, hollow-fibre membrane is interior, vein end end cap is interior and duct of Arantius 26 forms blood circuit.During treatment, blood circuit with thoroughly
Analysis liquid circuit is two mutually independent circuits, and the harmful substance in blood is by way of permeating, spreading and in dialysate chamber
Dialyzate swap, so as to fulfill the purpose for the treatment of.Simultaneously as blood first passes through the first adsorbent, make from blood mouth into
It is the defects of blood entered stops through the first adsorbent or shunts and avoid axis stream, uniform in all directions so as to be effectively formed speed
Blood a fluid stream, and then make blood uniformly enter it is each dialysis membrane tube in, avoid prior art dialyzer because blood is trapped in
Blood coagulation caused by space between adhesive linkage and end cap, and increase effective contact area of blood and adsorbent and dialysis membrane,
So as to increase filtration effect of the adsorbent to the adsorption rate of target substance and improvement dialysis membrane.
The pre- punching method first embodiment of blood purification system：
With reference to Fig. 2 and with reference to Fig. 1, applied to the pre- punching method of blood purification system first embodiment, pre- punching method includes：
First break-make step, clips 231 are opened, and clips 221 are closed, by pipeline 21,23,25 turn on, by pipeline 22,
24th, 26 block；
First rushes step in advance, and pre- fliud flushing is inputted from pipeline 23, and is inputted by pipeline 21 and input port 17, and pre- fliud flushing is rushed into pre-
Sap cavity and the hollow tube that dialysis membrane 111 is infiltrated through under the action of membrane pressure difference, then through arterial end end cap 12, to arterial end end
The first adsorbent 121 in lid 12 is rushed in advance, after exported from arterial end blood mouth 14, arterial 25；
Second break-make step blocks pipeline 22,24,25, and pipeline 21,23,26 is turned on；
Second rushes step in advance, and pre- fliud flushing is inputted from pipeline 23, and is inputted by pipeline 21 and input port 17, and pre- fliud flushing is rushed into pre-
Sap cavity simultaneously enters the hollow tube of dialysis membrane 111, again through vein end end cap 13 under the action of membrane pressure difference, to vein end end cap
The second adsorbent 131 in 13 is rushed in advance, after exported from vein end blood mouth 15, duct of Arantius 26.
Preferably, when inputting pre- fliud flushing from pipeline 23, pipeline 23 is placed in blood pump, the driving force by blood pump is pre-
Fliud flushing provides driving force.
3rd break-make step closes clips 231, and clips 221 are opened, by pre- fliud flushing input pipe 27, pipeline 22,
21st, 25 and 26 conducting, dialyzate efferent duct 24 are closed.
3rd rushes step in advance, and blood purification is horizontal positioned, and dialyzate is connected from dialyzate input pipe 27 through dialyzate
Pipe 22, pipeline 21 enter pre- fliud flushing chamber/dialysate chamber, pass through the pre- fliud flushing of residual in the pre- fliud flushing chamber/dialysate chamber of membrane pressure official post
It infiltrates through in hollow-fibre membrane, and then is discharged from arterial 25 and duct of Arantius 26, so as to complete to rush in advance.
Then complete it is above-mentioned it is pre- rush step, blood purification process can be continued.
Blood purification system second embodiment：
With reference to Fig. 3, the present embodiment is based on blood purification first embodiment, unlike blood purification first embodiment：
Dialyzate connecting tube 22 is cancelled, pre- fliud flushing is inputted by pipeline 31, i.e., in pre- rush, pipeline 31 inputs pre- fliud flushing, treats first
Adsorbent and the second adsorbent are when punching reaches target in advance, after pipeline 31 is dismantled, input port 17 and delivery outlet 16 respectively with dialysis
Liquid input pipe 27 and dialyzate efferent duct 26 connect, and the pre- fliud flushing of the residual in dialysate chamber is then made to penetrate into hollow-fibre membrane
It is interior, then discharged from arterial 25 and duct of Arantius 26, and then complete pre- punching.
The pre- punching method second embodiment of blood purification system：
The present embodiment is based on the step of blood purification system pre- punching method first embodiment and real based on blood purification system second
Apply example.
The present embodiment the difference is that cancel the first and second break-make steps, and by pipeline 31,25,26 turn on, make
After pre- fliud flushing is from pre- fliud flushing input pipe 31 into pre- fliud flushing chamber, logical membrane pressure is penetrated into inside hollow fiber conduit, and simultaneously
It is rushed in advance into arterial end end cap 12 and vein end end cap 13, while to the first adsorbent and the second adsorbent.
When punching reaches target in advance for the first adsorbent and the second adsorbent, after pipeline 31 is dismantled, input port 17 and output
Mouth 16 is connected and connects with dialyzate input pipe 27 and dialyzate efferent duct 26 respectively, further according to the pre- punching method first of blood purification system
The pre- step of rushing of the 3rd break-make step and the 3rd in embodiment carries out, and then completes pre- punching.
The present embodiment can efficiently shorten it is pre- rush the time, optimal rescue time is provided for patient.
Blood purification second embodiment：
With reference to Fig. 4, the present embodiment is based on the net device first embodiment of blood, the difference is that blood purification 18 uses input port
181st, input port 182 and delivery outlet 183, input port 182 is arranged on the position between input port 181 and delivery outlet 183, defeated
Entrance 181, delivery outlet 183 are arranged on radial direction the same side, and input port 182 and input port 181 are arranged on diametrically one side.
Input port 181 is dialyzate entrance in the present embodiment, and delivery outlet 183 exports for dialyzate, and input port 182 is used to input pre- punching
Liquid.
Blood purification system 3rd embodiment：
With reference to Fig. 5, the blood purification of the blood purification system based on second embodiment of the present embodiment, pre- fliud flushing pipe 31 and input
Mouth 182 connects, and dialyzate input pipe 27 is connected with input port 181, and dialyzate efferent duct 24 is connected with delivery outlet 183, arterial end
Blood mouth 184 is connected with arterial 25, and vein end blood mouth 185 is connected with duct of Arantius 26.
The pre- punching method 3rd embodiment of blood purification system：
The present embodiment is based on blood purification system 3rd embodiment, and pre- punching method includes：
First break-make step, pipeline 31 is turned on, and pipeline 24,27 is blocked；
First rushes step in advance, and blood purification 18 is horizontal positioned, and pre- fliud flushing is inputted from pipeline 31, liquid into pre- fliud flushing chamber and
The hollow tube of dialysis membrane 111 is infiltrated through under the action of membrane pressure difference；The pre- fliud flushing of a portion is through arterial end end cap, to artery
End end cap in the first adsorbent rushed in advance, after exported from arterial end blood mouth, arterial 25；The pre- fliud flushing of another part is into meditation
Arteries and veins end end cap rushes the second adsorbent in vein end end cap in advance, after exported from vein end blood mouth, duct of Arantius 26.
Second break-make step blocks pre- fliud flushing input pipe 31, dialyzate input pipe 27 and dialyzate efferent duct 24, artery
Pipe 25 and duct of Arantius 26 turn on.
Second rushes step in advance, and blood purification is horizontal positioned, and dialyzate enters dialysate chamber from dialyzate input pipe 27,
It is infiltrated through by the pre- fliud flushing of residual in membrane pressure official post dialysate chamber in hollow-fibre membrane, and then from arterial 25 and duct of Arantius 26
Discharge, so as to complete to rush in advance.
Then complete it is above-mentioned it is pre- rush step, blood purification process can be continued.
The present embodiment can efficiently shorten it is pre- rush the time, optimal rescue time is provided for patient.
Blood purification system fourth embodiment：
Fig. 2 is simultaneously combined with reference to Fig. 6, based on blood purification system first embodiment, embodiment adds pre- fliud flushing efferent duct 29,
In particular, pipeline assembly further includes pre- fliud flushing pipeline 29, clips 251, clips 261 and clips 291, pre- fliud flushing output
The first end of pipe 29 is connected with arterial 25, and second end is connected with duct of Arantius 26；Clips 251 are arranged in arterial 25；It is close
Binder 291 is arranged on pre- fliud flushing efferent duct 29, and the first end of pipeline 29 is located between clips 251 and arterial end blood mouth 14；
Clips 261 are arranged on duct of Arantius 26, and clips 261 are located at the second end of pre- fliud flushing efferent duct 29 and vein end blood mouth 15
Between.
The pre- punching method fourth embodiment of blood purification system：
With reference to Fig. 6 and with reference to Fig. 2, applied to the pre- punching method of blood purification system fourth embodiment, pre- punching method includes：
First break-make step turns on pipeline 21,23, and dialyzate connecting tube 22, dialyzate input pipe 24 and dialyzate are exported
Pipe 27 blocks, and clips 251 and clips 261 are closed, and turns on pre- fliud flushing efferent duct 29 opening of clips 291；
First rushes step in advance, and pre- fliud flushing is inputted from pipeline 23, is inputted by pipeline 21 and input port 17, into pre- fliud flushing chamber, leads to
Membrane pressure acts on the hollow tube for penetrating into dialysis membrane 111, enters back into arterial end end cap 12 in arterial end end cap 12
The first adsorbent 121 rushed in advance, then from arterial end blood mouth 14, by part of arteries pipe pipe 25, pre- fliud flushing efferent duct 29
It is exported with section of vein end pipe 26 to vein end；
Second break-make step, clips 261 are opened, and dialyzate connecting tube 22, dialyzate input pipe 27 and dialyzate are exported
Pipe 24 blocks, and pipeline 21,23,26 is turned on, clips 251, clips 291 are closed, then hinder pre- fliud flushing efferent duct 29
It is disconnected；
Second rushes step in advance, and pre- fliud flushing is inputted from pipeline 23, and is inputted by pipeline 21 and input port 17, into pre- fliud flushing chamber,
Logical membrane pressure effect penetrates into the hollow tube of dialysis membrane 111, enters back into vein end end cap 13 to vein end end cap 13
In the second adsorbent 131 rushed in advance, after exported from arterial end blood mouth 15, pipeline 26；
3rd break-make step blocks pipeline 23, and pipeline 21,22,24,26,27 is turned on, and the closing of clips 251 is made artery
Pipe 25 blocks.
3rd rushes step in advance, and blood purification is horizontal positioned, and dialyzate is connected from dialyzate input pipe 27 through dialyzate
Pipe 22, pipeline 21 enter dialysate chamber, are infiltrated through by the pre- fliud flushing of residual in membrane pressure official post dialysate chamber in hollow-fibre membrane,
And then discharged from part of arteries pipe 25, pre- fliud flushing efferent duct 29 and section of vein pipe 26, so as to complete to rush in advance.
Then complete it is above-mentioned it is pre- rush step, blood purification process can be continued.
Apparatus for purifying blood first embodiment：
With reference to Fig. 7, the apparatus for purifying blood of the present embodiment includes blood purification 4 and pipeline assembly, and blood purification 4 uses blood
The scheme of liquid purifier first embodiment.
Pipeline assembly include artery connecting tube 47, Connect of Vein pipe 48, dialyzate connecting tube 49, pre- fliud flushing input pipe 45,
Pre- fliud flushing efferent duct 46；Wherein 47 one end of artery connecting tube is connected 43 with arterial end blood mouth, and the other end is by the first cap sealed；It is quiet
48 one end of arteries and veins connecting tube is connected with vein end blood mouth 44, and the other end is by the second cap sealed；49 one end of dialyzate connecting tube with it is defeated
Entrance 41 or delivery outlet 42 connect, and the other end is by the 3rd cap sealed；Pre- 45 one end of fliud flushing input pipe is connected by threeway and artery
47 connection of take over, the other end are connected by threeway with dialyzate connecting tube 49；Pre- 46 one end of fliud flushing efferent duct is by threeway with moving
Arteries and veins connecting tube 47 connects, and the other end is connected by threeway with Connect of Vein pipe 48.Wherein artery connecting tube 47, Connect of Vein pipe
48th, pre- fliud flushing input pipe 45, pre- fliud flushing efferent duct 46, be equipped with liquid on-off control device in dialyzate connecting tube 49.
Pre- fliud flushing input pipe 45 is the 3rd pipeline in the present embodiment；Pre- fliud flushing efferent duct 46 is the 4th pipeline.Artery connects
Pipe 47 includes the first pipeline 471, pre- fliud flushing input pipe 45 and the pre- fliud flushing efferent duct 46 between pre- fliud flushing input pipe 45 and block
Between the 9th pipeline 473, the second pipeline 472 between arterial end blood mouth 43 and pre- fliud flushing efferent duct 46.Connect of Vein pipe 48
Including between vein end blood mouth 44 and pre- fliud flushing efferent duct 46 the 5th pipeline 481, between pre- fliud flushing efferent duct 46 and block
6th pipeline 482.Pre- fliud flushing connecting tube 49 includes the 7th pipeline 491 between pre- fliud flushing input pipe 45 and input port 41, pre- punching
The 8th pipeline 492 between liquid input pipe 45 and block.
Three-port structure is common threeway, wherein the 9th pipeline 473, the 5th pipeline 481, the 8th pipeline 492, the 3rd pipeline 45
Clips are equipped with on the 4th pipeline 46.
Apparatus for purifying blood second embodiment：
With reference to Fig. 8, the present embodiment is based on apparatus for purifying blood first embodiment, and difference is that three-port structure uses cock-type three
Logical, i.e., pre- 55 one end of fliud flushing input pipe is connected to by cock-type threeway in artery connecting tube 57, and the other end passes through cock-type three
Lead to and be connected in dialyzate connecting tube 59；Pre- 56 one end of fliud flushing efferent duct is connected to artery connecting tube 57 by cock-type threeway
On, the other end is connected to by cock-type threeway on Connect of Vein pipe 58；Cancel pre- fliud flushing input pipe 55, pre- fliud flushing efferent duct
56th, the clips in artery connecting tube 57, Connect of Vein pipe 58 and dialyzate connecting tube 59.
Apparatus for purifying blood 3rd embodiment：
With reference to Fig. 9, the present embodiment is based on apparatus for purifying blood first embodiment, and difference is, cancels the 9th pipeline, pre- fliud flushing
Input pipe 65 and pre- 66 one end of fliud flushing efferent duct are connected to by cock-type four-way in artery connecting tube 69 simultaneously, pre- fliud flushing input
65 other end of pipe is connected to by cock-type threeway in dialyzate connecting tube；Pre- 66 other end of fliud flushing efferent duct passes through cock threeway
It is connected on Connect of Vein pipe 68.Cancel pre- fliud flushing input pipe 55, pre- fliud flushing efferent duct 56, artery connecting tube 57, Connect of Vein
Clips on pipe 58 and dialyzate connecting tube 59.
The 5th embodiment of blood purification system：
With reference to Figure 10, the present embodiment blood purification system includes apparatus for purifying blood and pipeline, and apparatus for purifying blood is using above-mentioned
The scheme of apparatus for purifying blood first embodiment.
Arterial 25 is connected with the free end of the first pipeline 471, and duct of Arantius 26 is connected with the free end of the 6th pipeline 482,
27 one end of dialyzate input pipe is connected with dialyzate connecting tube 492, and 24 one end of dialyzate efferent duct is connected with delivery outlet 42, dialysis
The other end of liquid input pipe 27 and dialyzate efferent duct 24 is connected respectively with dialyzate storage device 19.Arterial 25 and duct of Arantius
Liquid communication control device is equipped on 26.
The 5th embodiment of pre- punching method of blood purification system：
The pre- punching method of blood purification system of the present embodiment is applied to the 5th embodiment of blood purification system, the pre- punching of the present embodiment
Method includes：
By the sealing clip closure on the 5th pipeline 481, the 8th pipeline 492, the 9th pipeline 473, the 3rd is managed for first break-make step
Clips on road 45, the 6th pipeline 46 are opened, then so that arterial 25, the first pipeline 471, the 3rd pipeline 45 and the 7th pipe
Road 491 connects, and the second pipeline 472, the 4th pipeline 46, the 6th pipeline 482, duct of Arantius 26 connect, the first pipeline 471 and the second pipe
It is blocked between road 472, the 5th pipeline 481 and the 6th pipeline 482 block；
First rushes step in advance, and pre- fliud flushing is inputted from arterial, into the first pipeline 471, is managed successively by the 3rd pipeline the 45, the 7th
Road 491 enters in the hollow tube of dialysis membrane into pre- fliud flushing chamber, logical membrane pressure effect, and enters artery along hollow fiber conduit
Hold end cap, the first adsorbent 121 in arterial end end cap is rushed in advance, then along the second pipeline 472, the 4th pipeline 46,
6th pipeline 482 is exported from duct of Arantius 26；
By the sealing clip closure on the 4th pipeline 46, the 9th pipeline 473, the 8th pipeline 492, the 5th is managed for second break-make step
Clips on road 481 are opened so that and arterial 25, the first pipeline 471, the 3rd pipeline 45 are connected with the 7th pipeline 491, and the 5th
Pipeline 481, the 6th pipeline 482 are connected with duct of Arantius 26；Second pipeline 472 is blocked with the 4th pipeline 46 and the 9th pipeline 473；
Second rushes step in advance, and pre- fliud flushing is inputted from arterial 25, into the first pipeline 471, successively by the 3rd pipeline the 45, the 7th
Pipeline 491 is into pre- fliud flushing chamber, the effect of logical membrane pressure into the hollow tube of dialysis membrane, and along hollow fiber conduit into meditation
Arteries and veins end end cap rushes the second adsorbent 131 in vein end end cap, in advance then along the 5th pipeline 481, the 6th pipeline
482nd, exported from duct of Arantius 26；
3rd break-make step opens the clips on the 4th pipeline 46, the 5th pipeline 481, the 9th pipeline 473, by the 8th pipe
Sealing clip closure on road 482 so that arterial 25, the first pipeline 471, the 3rd pipeline 45 are connected with the 7th pipeline 491；Second
Pipeline 472, the 4th pipeline 46, the 6th pipeline 482, duct of Arantius 26 connect；5th pipeline 481, the 6th pipeline 482 and duct of Arantius 26
Connection；
3rd rushes step in advance, and blood purification 4 is horizontal positioned, and dialyzate is from dialyzate input pipe 27, through dialyzate connecting tube
49 enter dialysate chamber, and logical membrane pressure effect makes the pre- fliud flushing of the residual in dialysate chamber infiltrate through in hollow-fibre membrane, one
Point enter arterial end end cap along hollow fiber conduit, and then from the second pipeline 472, pre- fliud flushing efferent duct 46, the 6th pipeline 482,
It is discharged from duct of Arantius 26；Another part enters vein end end cap along hollow fiber conduit, and then from vein end connecting tube 48, vein
Pipe 26 is discharged, so as to complete to rush in advance.
Apparatus for purifying blood fourth embodiment：
With reference to Figure 11, based on apparatus for purifying blood first embodiment, the present embodiment makes change to the connection mode between pipeline,
Specifically, dialyzate connecting tube 79 is connected with delivery outlet 72.
Blood purification system sixth embodiment：
With reference to Figure 11, based on apparatus for purifying blood fourth embodiment, the present embodiment blood purification system and the 5th blood purification system
The distinctive points of system embodiment are that dialyzate connecting tube 79 is connected with dialyzate delivery outlet 72, and dialyzate efferent duct 24 with it is saturating
Analysis liquid connecting tube 79 connects, and dialyzate input pipe 27 is connected with dialyzate input port.
Therefore by the blood purification, apparatus for purifying blood and system of this case, pre- fliud flushing enter dialysate chamber/
Pre- fliud flushing chamber, the effect of logical membrane pressure are infiltrated through in hollow fiber conduit, and enter arterial end end cap along in hollow fiber conduit
And/or rushed in advance in vein end end cap and to the first adsorbent therein and/or the second adsorbent, then it is then exhausted from.It solves
Pre- fliud flushing first passes through adsorbent and adsorbent is rushed in advance in the prior art, and breaks through the pre- with granule foreign of adsorbent in advance
Fliud flushing enters back into the problem of dialysis membrane, enters dialysis membrane so as to which pre- fliud flushing be avoided to carry particle；It need not remove or connect during treatment
Enter pipeline so that blood is few needed for extracorporal circulatory system, improves the comfort level of patient, especially for the smaller total blood volume of build compared with
Few patient.When on the other hand treating, without adjusting the break-make of pipeline or changing the flow direction of blood, make medical staff's
It operates more convenient, avoids the risk caused by operation error, improve the security stability of blood purification system.
It should be noted that this case uses the on off operating mode for referring to realizing in each break-make step in pre- punching method, such as
The upper break-make step of fruit then can keep corresponding break-make shape as the state of next break-make step without being operated again
State.In addition, the use of plug valve and the use of clips are mutually to mix in the same embodiment in above-described embodiment
It closes and uses, can specifically be adjusted according to cost needs, application demand and performance requirement, during using pre- punching method, as long as realizing pipe
Priority break-make between road can achieve the object of the present invention, and this field skill can be used in the mode of break-make and the flow direction switching of fluid
The means of art personnel routine make choice.These above-mentioned modes changed are in protection scope of the present invention.
Claims (9)
1. apparatus for purifying blood, including blood purification and pipeline assembly, it is characterised in that：
Blood purification includes housing, and the housing forms hollow chamber, dialysis membrane, the dialysis membrane are filled in the chamber
Both ends are fixed in the cavity respectively by the first adhesive layer and the second adhesive layer, the opposite housing of the dialysis membrane
Outer wall on be provided with input port and delivery outlet, the housing both ends are respectively arranged with the first adsorbent filled chamber and the second absorption
Agent filled chamber, arterial end blood mouth is provided on the first adsorbent filled chamber, and the second adsorbent filled chamber is equipped with quiet
Arteries and veins end blood mouth, the dialysis membrane are hollow fiber conduit, the housing, first adhesive layer, second adhesive layer and described
Pre- fliud flushing chamber is surrounded between hollow fiber conduit outside, the input port and the delivery outlet are connected with the pre- fliud flushing chamber, institute
It is described for exporting for inputting pre- fliud flushing, the arterial end blood mouth and the vein end blood mouth to state input port or the delivery outlet
Pre- fliud flushing；
It is defeated that the pipeline assembly includes artery connecting tube, Connect of Vein pipe, dialyzate connecting tube, pre- fliud flushing input pipe, pre- fliud flushing
Outlet pipe, the first end of the artery connecting tube are connected with the arterial end blood mouth, the first end of the Connect of Vein pipe with it is described
Vein end blood mouth connects, and the first end of the dialyzate connecting tube is connected with the input port or the delivery outlet, the pre- punching
The first end of liquid input pipe is connected with the artery connecting tube, and the second end of the pre- fliud flushing input pipe is connected with the dialyzate
Pipe connects, and the first end of the pre- fliud flushing efferent duct is connected with the artery connecting tube, the second end of the pre- fliud flushing efferent duct
It is connected with the Connect of Vein pipe.
2. apparatus for purifying blood according to claim 1, it is characterised in that：
The both ends of the pre- fliud flushing input pipe are connected respectively by threeway with the artery connecting tube, the dialyzate connecting tube,
The both ends of the pre- fliud flushing efferent duct are connected respectively by threeway with the artery connecting tube, the Connect of Vein pipe, described pre-
The first end of fliud flushing efferent duct is located between first end and the arterial end blood mouth of the pre- fliud flushing input pipe；
The artery connecting tube the first end positioned at the pre- fliud flushing efferent duct and the first end of the pre- fliud flushing input pipe it
Between position on be provided with pipe clamp；
The Connect of Vein pipe is provided with pipe on the position between the pre- fliud flushing efferent duct and the vein end blood mouth
Folder；
Pipe clamp is respectively equipped on the pre- fliud flushing input pipe and the pre- fliud flushing efferent duct.
3. apparatus for purifying blood according to claim 1, it is characterised in that：
The both ends of the pre- fliud flushing input pipe pass through cock-type threeway and the artery connecting tube, the dialyzate connecting tube respectively
Connection, the both ends of the pre- fliud flushing efferent duct pass through cock-type threeway and the artery connecting tube, the Connect of Vein pipe respectively
Connection, the first end of the pre- fliud flushing efferent duct be located at the pre- fliud flushing input pipe first end and the arterial end blood mouth it
Between.
4. apparatus for purifying blood according to claim 1, it is characterised in that：
The first end of the pre- fliud flushing input pipe, the pre- fliud flushing efferent duct first end and the artery connecting tube pass through cock-type
Four-way connects, and the pre- fliud flushing input pipe second end is connected by cock-type threeway with the pre- fliud flushing connecting tube, the pre- punching
Liquid efferent duct second end is connected by cock-type threeway with the Connect of Vein pipe.
5. the apparatus for purifying blood according to Claims 2 or 3, it is characterised in that：
The second end of the artery connecting tube is equipped with the first block, and the second end of the Connect of Vein pipe is equipped with the second block, institute
The second end for stating dialyzate connecting tube is equipped with the 3rd block；
The artery connecting tube includes the first pipe between the first end of the pre- fliud flushing input pipe and first block
Road, between the first end of the pre- fliud flushing efferent duct and arterial end blood mouth the second pipeline, positioned at the pre- fliud flushing input pipe
First end and the pre- fliud flushing efferent duct first end between the 9th pipeline；
The Connect of Vein pipe includes the 5th between the vein end blood mouth and the second end of the pre- fliud flushing efferent duct
Pipeline, the 6th pipeline between the pre- fliud flushing efferent duct second end and second block；
The dialyzate connecting tube includes the 7th between the pre- fliud flushing input pipe and the input port/delivery outlet
The 8th pipeline between pipeline, the second end positioned at the pre- fliud flushing input pipe and the 3rd block；
The pre- fliud flushing input pipe is the 3rd pipeline；
The pre- fliud flushing efferent duct is the 4th pipeline.
6. apparatus for purifying blood according to claim 4, it is characterised in that：
The second end of the artery connecting tube is equipped with the first block, and the second end of the Connect of Vein pipe is equipped with the second block, institute
The second end for stating dialyzate connecting tube is equipped with the 3rd block；
The artery connecting tube includes the first pipeline between the cock-type four-way and the first block, positioned at the cock
The second pipeline between formula four-way and the arterial end blood mouth；
The vein end connecting tube includes the between the vein end blood mouth and the second end of the pre- fliud flushing efferent duct
The 6th pipeline between five pipelines, the second end positioned at the pre- fliud flushing efferent duct and the second block；
The dialyzate connecting tube include positioned at the pre- fliud flushing input pipe second end and the input port/delivery outlet it
Between the 7th pipeline, the 8th pipeline between the second end positioned at the pre- fliud flushing input pipe and the 3rd block；
The pre- fliud flushing input pipe is the 3rd pipeline；
The pre- fliud flushing efferent duct is the 4th pipeline.
7. blood purification system, it is characterised in that：
Including any apparatus for purifying blood of the claims 1-6；
The artery connecting tube is connected with arterial, and the Connect of Vein pipe is connected with duct of Arantius, the dialyzate connecting tube with
The dialyzate input pipe or dialyzate efferent duct connection, the delivery outlet is connected with the dialyzate efferent duct, described
Input port is connected with dialyzate input pipe, and the dialyzate input pipe and the dialyzate efferent duct store with dialyzate fill respectively
Put connection.
8. the pre- punching method of blood purification system, it is characterised in that：
The blood purification system uses the blood purification system of any one of the claims 7；
The pre- punching method includes：
First break-make step, by the arterial and first pipeline connection, first pipeline and the 3rd pipeline connect
It is logical, the 3rd pipeline and the 7th pipeline connection；By second pipeline and the 4th pipeline connection, by first pipeline and institute
State the second pipeline, the 4th pipeline block, will the 4th pipeline and the 6th pipeline connection, by the 5th pipeline with
6th pipeline blocks；
First rushes step in advance, and pre- fliud flushing is inputted from the arterial, and the pre- fliud flushing is successively by first pipeline, described the
Three pipelines, the 7th pipeline into pre- fliud flushing chamber and are infiltrated into the dialysis membrane, then are inhaled through first in the arterial end end cap
It exports to duct of Arantius from the 6th pipeline after attached dose, second pipeline and the 4th pipeline, is finally discharged from duct of Arantius,
Complete the pre- punching to the first adsorbent；
Second break-make step, by arterial and first pipeline connection, first pipeline and the 3rd pipeline connection, institute
State the 3rd pipeline and the 7th pipeline connection；First pipeline blocks respectively with second pipeline, the 4th pipeline, by institute
It states the 4th pipeline and the 6th pipeline blocks, by the 5th pipeline and the 6th pipeline connection；
Second rushes step in advance, inputs the pre- fliud flushing from the arterial, the pre- fliud flushing is successively by first pipeline, institute
The 3rd pipeline, the 7th pipeline are stated, into pre- fliud flushing chamber and is infiltrated into the dialysis membrane, through in the vein end end cap
It is exported after two adsorbents, the 5th pipeline from the 6th pipeline to duct of Arantius, finally discharges, completed to second from duct of Arantius
The pre- punching of adsorbent；
3rd break-make step blocks first pipeline and second pipeline, the 4th pipeline；3rd pipeline and the described 7th
Pipeline and the 8th pipeline block；By second pipeline and the 4th pipeline connection, the 4th pipeline and the 6th pipeline connection, institute
State the 5th pipeline and the 6th pipeline connection, the 7th pipeline and the 8th pipeline connection；
3rd rushes step in advance, and dialyzate enters from the 8th pipeline, will be in pre- fliud flushing chamber by the 7th pipeline into pre- fliud flushing chamber
A pre- fliud flushing part is remained out of dialysis membrane through the first adsorbent, arterial end blood mouth, the second pipeline, the 4th pipe in artery end cap
Road exports to duct of Arantius from the 6th pipeline, is finally discharged from duct of Arantius；Another part is out of dialysis membrane through in vein end cap second
Adsorbent is exported to duct of Arantius through the 5th pipeline, the 6th pipeline, finally discharged from duct of Arantius.
9. the pre- punching method of blood purification system, it is characterised in that：
The blood purification system uses the blood purification system of the claims 8；
The pre- punching method includes：
First break-make step, by the arterial and first pipeline connection, first pipeline and the 3rd pipeline connect
It is logical, the 3rd pipeline and the 7th pipeline connection；By second pipeline and the 4th pipeline connection, by first pipeline and institute
The second pipeline, the 4th pipeline blocking are stated, by the 4th pipeline and the 6th pipeline connection；By the 5th pipeline and
6th pipeline connection；
First rushes step in advance, inputs pre- fliud flushing from the arterial, the pre- fliud flushing is by first pipeline, the 3rd pipe
Road, the 7th pipeline, into pre- fliud flushing chamber, infiltrate into the dialysis membrane；The pre- fliud flushing of a portion is from by the arterial end
It is exported after the first adsorbent, second pipeline and the 4th pipeline in end cap from the 6th pipeline to duct of Arantius, most
It is discharged eventually from duct of Arantius, completes the pre- punching to the first adsorbent；The pre- fliud flushing of another part is out of dialysis membrane through in vein end cap
Two adsorbents export to duct of Arantius through the 5th pipeline, the 6th pipeline, finally discharge, completed to the second adsorbent from duct of Arantius
Pre- punching；
Second break-make step blocks first pipeline and second pipeline, the 4th pipeline；3rd pipeline and the described 7th
Pipeline and the 8th pipeline block；By second pipeline and the 4th pipeline connection, the 4th pipeline and the 6th pipeline connection, institute
State the 5th pipeline and the 6th pipeline connection, the 7th pipeline and the 8th pipeline connection；
Second rushes step in advance, and dialyzate enters from the 8th pipeline, will be in pre- fliud flushing chamber by the 7th pipeline into pre- fliud flushing chamber
A pre- fliud flushing part is remained out of dialysis membrane through the first adsorbent, arterial end blood mouth, the second pipeline, the 4th pipe in artery end cap
Road exports to duct of Arantius from the 6th pipeline, is finally discharged from duct of Arantius；Another part is out of dialysis membrane through in vein end cap second
Adsorbent is exported to duct of Arantius through the 5th pipeline, the 6th pipeline, finally discharged from duct of Arantius.
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| CN108114333B (en) | 2023-09-05 |
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