CN204766771U - Hemoperfusion ware and external blood circulation pipe -line system - Google Patents
Hemoperfusion ware and external blood circulation pipe -line system Download PDFInfo
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- CN204766771U CN204766771U CN201520465565.7U CN201520465565U CN204766771U CN 204766771 U CN204766771 U CN 204766771U CN 201520465565 U CN201520465565 U CN 201520465565U CN 204766771 U CN204766771 U CN 204766771U
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Abstract
The utility model discloses a hemoperfusion ware and external blood circulation pipe -line system, this pipe -line system include artery pipe, vein pipe and connect the perfusion module between artery pipe and vein pipe, and the perfusion module has module entry, module export and is located the module entry and the hemoperfusion ware of module between exporting, and the module entry linkage extremely the artery is managed and module exit linkage to vein pipe, and the hemoperfusion ware is provided with artery end filter screen and vein end filter screen respectively at its artery end and vein end, and it has the adsorbent to hold between artery end filter screen and the vein end filter screen, and the perfusion module still includes the first bypass and the second bypass of connecting in parallel with the hemoperfusion ware. The utility model discloses an external blood circulation pipe -line system can accomplish hemoperfusion and treat with the combination of other treatment modes under the condition of not dismantling the pipeline, can avoid the treatment process to cause the patient to infect because of the pipeline is inside with the external environment contact, and whole process only needs the one man operation moreover, uses manpower sparingly.
Description
Technical field
This utility model relates to field of blood purification, specifically, relates to a kind of blood perfusion device and extracorporeal circulation of blood pipe-line system.
Background technology
In prior art there is the problem of exhaust problem in blood perfusion device, and what make perfusion device rushes complicated operation in advance, and the time of rushing in advance is long.On the other hand, due to the compatibility issue of machine, in use need dismounting and re-assembly treatment circulation line, thus perfusion device is directly exposed in air ambient, increasing the contaminated probability of perfusion device, increasing the potential safety hazard of medical treatment; And complicated operation, high to the requirement of medical personnel, increase the human cost of medical personnel.
Utility model content
A technical problem to be solved in the utility model is to provide a kind of blood perfusion device, adsorbent not only can be effectively stoped to enter circulation bloody path, and can effectively stop the microgranule in blood to enter circulation bloody path, avoid blood contamination, improve therapeutic effect, be conducive to the bubble of discharging perfusion device inside simultaneously, improve safety during patient treatment.
Another technical problem to be solved in the utility model is to provide a kind of extracorporeal circulation of blood pipe-line system, bubble when making to rush in advance in perfusion device is easy to quick emptying, and when rushing in advance and treatment time without the need to dismounting and re-assembly pipeline, simplify the operation, and avoid perfusion device to contact with atmospheric environment over the course for the treatment of and contaminated, thus ensure the safety of therapeutic process.
For solving above-mentioned first technical problem, this utility model provides a kind of blood perfusion device, comprise the perfusion device body with arterial end and vein end, described perfusion device body is respectively arranged with arterial end filter screen and vein end filter screen at its arterial end and vein end, accommodate adsorbent between described arterial end filter screen and vein end filter screen, the aperture of described arterial end filter screen is greater than the aperture of described vein end filter screen; When rushing in advance, described vein end is as fluid input port, and described arterial end is as fluid output port; When treating, described arterial end is as fluid input port, and described vein end is as fluid output port.。
Described blood perfusion device can be any one in Microporous resin adsorber, resin anion (R.A.) adsorber, active carbon adsorber, DNA immunization adsorber, Endotoxin adsorption device; Preferably, the aperture of described arterial end filter screen is 100-300 μm, and the aperture of described vein end filter screen is 20-200 μm.More preferably, the aperture of described arterial end filter screen is 200-300 μm, and the aperture of vein end filter screen is 60-120 μm.
From such scheme, the filter screen at two ends is arranged to the different filter screen in aperture by blood perfusion device of the present utility model, wherein the aperture of arterial end filter screen is greater than the aperture of vein end filter screen, such blood perfusion device can realize oppositely pre-punching and forward treatment, adsorbent not only can be effectively stoped to enter circulation bloody path, and can effectively stop the microgranule in blood to enter circulation bloody path, avoid blood contamination, improve therapeutic effect, be conducive to the bubble of discharging perfusion device inside simultaneously, improve safety during patient treatment.
For solving above-mentioned second technical problem, this utility model provides a kind of extracorporeal circulation of blood pipe-line system, comprise arterial, duct of Arantius and the perfusion module be connected between described arterial and duct of Arantius, described perfusion module has module inlet, module outlet and the blood perfusion device between described module inlet and module outlet, described module inlet is connected to described arterial and described module outlet is connected to described duct of Arantius, described blood perfusion device is respectively arranged with arterial end filter screen and vein end filter screen at its arterial end and vein end, adsorbent is accommodated between described arterial end filter screen and vein end filter screen, described perfusion module also comprises first bypass in parallel with described blood perfusion device and the second bypass, when rushing in advance and treating, in described blood perfusion device, the flow direction of liquid is just in time contrary.
From such scheme, the extracorporeal circulation of blood pipe-line system that this utility model provides can complete the combined therapy of hemoperfusion with other Therapeutic mode when not detaching pipelines, therapeutic process can be avoided to cause patient infection because channel interior contacts with external environment, and whole process only needs one man operation, save manpower.
Further, the aperture of described arterial end filter screen is greater than the aperture of described vein end filter screen.
Preferably, the aperture of described arterial end filter screen is 100-300 μm, and the aperture of described vein end filter screen is 20-200 μm.More preferably, the aperture of described arterial end filter screen is 200-300 μm, and the aperture of vein end filter screen is 60-120 μm.
In one embodiment, described perfusion module also comprises four intervalves and four three way cock, described module inlet is connected with described first bypass and the first intervalve by first three way cock, described first intervalve is connected with the second intervalve and described second bypass by second three way cock, and described second intervalve is connected with the vein end of described blood perfusion device; The arterial end of described blood perfusion device connects the 3rd intervalve, described 3rd intervalve is connected with described first bypass and the 4th intervalve by the 3rd three way cock, and described module outlet is connected with described 4th intervalve and described second bypass by the 4th three way cock; Described four intervalves and described first bypass and the second bypass are equipped with pipe clamp.
Preferably, the pipe clamp on described first intervalve and the 4th intervalve has the first color, and the pipe clamp in described first bypass and the second bypass has the second color, and described first color is not identical with described second color.
In another embodiment, described perfusion module also comprises the first intervalve, the second intervalve and first four-way connection, second four-way connection; Described first intervalve is connected with the vein end of described blood perfusion device, and described second intervalve is connected with the arterial end of described blood perfusion device; Described first bypass, the first intervalve and the second bypass are connected with described first four-way connection, and described first bypass, the second intervalve and the second bypass are connected with described second four-way connection; When described first four-way connection is in the first duty, described module inlet and described first bypass and described first intervalve and described second bypass, when described first four-way connection is in the second duty, described module inlet is communicated with described first intervalve; When described second four-way connection is in the first duty, described first bypass is communicated with described second intervalve and described second bypass is communicated with described module outlet, when described second four-way connection is in the second duty, described module outlet is communicated with described second intervalve, when described second four-way connection is in the 3rd duty, described first bypass is communicated with described module outlet and described second bypass is communicated with described second intervalve.
In another embodiment, described perfusion module also comprises the first intervalve, the second intervalve, the 3rd intervalve and controls the pipeline on-off system of described first bypass, the second bypass, the second intervalve and the 3rd intervalve break-make, one in the vein end of described first intervalve and described blood perfusion device and arterial end is connected, and another in the vein end of described second intervalve and described blood perfusion device and arterial end is connected; Described first bypass, the first intervalve and the second bypass are connected with a four-way connection, described first bypass is connected by first three way cock with described second intervalve and the 3rd intervalve, and described module outlet is connected with described second bypass and described 3rd intervalve by second three way cock; When described four-way connection is in the first duty, described module inlet and described first bypass and described first intervalve and described second bypass, when described four-way connection is in the second duty, described module inlet is communicated with described first intervalve.
Further, this pipe-line system also comprises the dialysis module be connected between described arterial and described perfusion module, described dialysis module comprises the dialysis main road be arranged in parallel, dialyse bypass and the dialyser that is connected on described dialysis main road, and described dialysis main road and dialysis bypass are respectively equipped with pipe clamp.
Further, this pipe-line system also comprises plasma separator, wherein said arterial is connected with the blood mouth that enters of described plasma separator, the plasma outlet port of described plasma separator is connected with the module inlet of described perfusion module, and the concentrate blood of described plasma separator is connected with described duct of Arantius after exporting and collecting via pipeline with the module outlet of described perfusion module.
Further, described perfusion module comprises first group of perfusion module and second group of perfusion module of series connection mutually, blood perfusion device in the middle of wherein said first group of perfusion module is bilirubin adsorption perfusion device, and the blood perfusion device in the middle of described second group of perfusion module is Microporous resin absorption perfusion device.
Further, this pipe-line system also comprise be connected on described arterial or duct of Arantius another organize described perfusion module.
Accompanying drawing explanation
Fig. 1 is the structural representation of this utility model embodiment 1.
Fig. 2 A to Fig. 2 C is the structural representation of this utility model embodiment 2.
Fig. 3 is the structural representation of this utility model embodiment 3.
Fig. 4 is the structural representation of this utility model embodiment 4.
Fig. 5 is the structural representation of this utility model embodiment 5.
Fig. 6 is the structural representation of this utility model embodiment 6.
Fig. 7 is the structural representation of this utility model embodiment 7.
Fig. 8 is the structural representation of this utility model embodiment 8.
Detailed description of the invention
To describe various embodiment of the present utility model below in detail, embodiment wherein in conjunction with the accompanying drawings and describe hereinafter.Although this utility model will be described in conjunction with illustrative embodiments, be to be understood that this utility model is not limited to these illustrative embodiments.On the contrary, this utility model not only comprises these embodiments, but also comprises various distortion, improvement.
A kind of blood perfusion device that this utility model provides comprises the perfusion device body with arterial end and vein end, perfusion device body is respectively arranged with arterial end filter screen and vein end filter screen at its arterial end and vein end, adsorbent is accommodated between arterial end filter screen and vein end filter screen, the aperture of described arterial end filter screen is greater than the aperture of described vein end filter screen, wherein the aperture of arterial end filter screen is 100-300 μm, the aperture of vein end filter screen is 20-200 μ, preferably, the aperture of arterial end filter screen is 200-300 μm, be such as 250 μm, the aperture of vein end filter screen is 60-120 μm, be such as 80 μm.The blood perfusion device of said structure can be applicable in the middle of extracorporeal circulation pipeline system of the present utility model, and in addition, extracorporeal circulation pipeline system of the present utility model can also apply the blood perfusion device of any structure and type.
embodiment 1
The perfusion module that extracorporeal circulation pipeline system as shown in Figure 1 comprises arterial 1, duct of Arantius 2 and is connected between arterial 1 and duct of Arantius 2, arterial 1 is connected to the module inlet of perfusion module, and duct of Arantius 2 is connected to the module outlet of perfusion module.Perfusion module comprises blood perfusion device (hereinafter referred to as " perfusion device ") 3, first three way cock 11, second three way cock 12, the 3rd three way cock 13, the 4th three way cock 14, first bypass 21, second bypass 22, first pipe clamp 31, second pipe clamp 32, the 3rd pipe clamp 33, the 4th pipe clamp 34, the 5th pipe clamp 35, the 6th pipe clamp 36, first intervalve 41, second intervalve 42, the 3rd intervalve 43 and the 4th intervalve 44.
Arterial 1 one end connecting puncture needle, the other end is connected with first three way cock 11 one end, first other two ends of three way cock 11 connects the first bypass 21 and the first intervalve 41 respectively, the other end of the first intervalve 41 is connected with second three way cock 12, other two ends of second three way cock 12 are connected with the second intervalve 42 and the second bypass 22 respectively, second intervalve 42 other end connects the vein end of perfusion device 3, the arterial end of perfusion device 3 connects the 3rd intervalve 43, 3rd intervalve 43 other end is connected with the 3rd three way cock 13 one end, 3rd three way cock 13 connects the first bypass 21 and the 4th intervalve 44 one end in two ends in addition respectively, 4th intervalve 44 other end is connected with the 4th three way cock 14 one end, other two ends of 4th three way cock 14 are connected with second bypass 22 one end and duct of Arantius 2 one end respectively, the other end of duct of Arantius 2 is connected with puncture needle.Wherein the first bypass 21 and the second bypass 22 can be one section of pipeline, also can be the pipeline that multistage pipeline is coupled together by multiple-pass joint.
First intervalve 41 is provided with that the first pipe clamp 31, second intervalve 42 is provided with the second pipe clamp 32, the 3rd intervalve 43 is provided with the 3rd pipe clamp 33, the 4th intervalve 44 is provided with the 4th pipe clamp 34, first bypass 21 and is provided with the 5th pipe clamp 35, second bypass 22 and is provided with the 6th pipe clamp 36.Wherein the first pipe clamp 31 is identical with the 4th pipe clamp 34 color, as white; 5th pipe clamp 35 is identical with the 6th pipe clamp 36 color, but different from the color of the first pipe clamp, as green.Arterial 1 comprises pump line (not shown), and pump line part is entrenched in kinetic pump, and tremulous pulse pump is for the liquid in whole circulation line is as blood or rush the power that liquid etc. provides flowing in advance.
After connecting pipe-line system, overturn perfusion device 3 by blood cleaning equipment or manual operation before carrying out pre-punching, make the arterial end of perfusion device 3 upward.When rushing in advance, first closing the second pipe clamp 32 and the 3rd pipe clamp 33, opening other all pipe clamp.Rush liquid in advance and enter pipe-line system from arterial 1, after gas in first bypass 21, second bypass 22, first intervalve 41 and the 4th intervalve 44 is discharged, open the second pipe clamp 32 and the 3rd pipe clamp 33, then close the 5th pipe clamp 35 and the 6th pipe clamp 36, rush liquid in advance and flow through the first intervalve 41, second intervalve 42, perfusion device 3, the 3rd intervalve 43, the 4th intervalve 44 and duct of Arantius 2 successively from arterial 1.Arterial end filter screen due to perfusion device 3 is the larger filter screen in aperture, filter screen is less relative to the surface tension of liquid, so gas is easy to discharge from arterial end filter screen, evacuation time is short, rush easy and simple to handle in advance, and the resin chips caused due to reasons such as transports in perfusion device 3 is also easy to go out.Simultaneously due to perfusion device 3 arterial end upward, so contribute to the gas drained in perfusion device, make not there is gas in pipe-line system, thus avoid the potential safety hazard that causes because gas enters human body by pipe-line system.
After pre-punching terminates, close the first pipe clamp 31 and the 4th pipe clamp 34, open the 5th pipe clamp 35 and the 6th pipe clamp 36, carry out hemoperfusion treatment, blood is flowed back in human body through arterial 1, first bypass 21, the 3rd intervalve 43, perfusion device 3, second intervalve 42, second bypass 22 and duct of Arantius 2 successively by human body.Filter screen due to perfusion device 3 medium-sized vein end is the less filter screen in aperture, effectively can stop the adsorbent in perfusion device, avoid the adsorbent in perfusion device 3 to enter in human body, improve the safety of therapeutic process.
Because the first pipe clamp 31 and the 4th pipe clamp 34 are same color, as white; 5th pipe clamp 35 and the 6th pipe clamp 36 are same color, and they are different from the color of the first pipe clamp 31 and the 4th pipe clamp 34, as green; When carrying out pre-punching operation or perfusion treatment, open or close the pipe clamp of same color, the identity of pipe clamp is high, workable.
Arterial end can be placed according to needing during treatment by perfusion device 3 in this utility model upward, or its vein end is placed perfusion device upset upward, but does not change the connection of pipeline.
Blood perfusion device in this utility model is different with the aperture of filter screen of vein end by arterial end, gas when making to rush in advance in perfusion device is easy to drain fast, and effectively can stop when treating that the adsorbent in perfusion device enters in human body, thus safety when improving operation convenience and the treatment of pre-punching.Simultaneously in pre-punching and therapeutic process, perfusion device is connected in pipeline without the need to taking and re-start the connection between perfusion device and circulation line apart, maintain the blood circulation that perfusion device and pipeline form to be in all the time in the environment of closed, thus avoid perfusion device and circulation line to contact with atmospheric environment, avoid perfusion device and circulation line by secondary pollution, ensure the safety of therapeutic process.
Three way cock in this embodiment outer blood circulation pipeline system also can change in prior art can the special three way cock of control piper flow, if three way cock is the special three way cock that can control perfusion flow, then the pipe clamp on each pipeline also can be cancelled.
Perfusion device in the present embodiment extracorporeal circulation of blood pipe-line system also can be the identical common perfusion device of two ends aperture of filter screen, described extracorporeal circulation of blood pipe-line system can realize when not needing to dismantle and re-assembly pipeline and to complete direction rush in advance with treatment when perfusion device contrary, and compatibility needs oppositely to rush the blood cleaning equipments such as the hsempdiakysing systems that forward treats in advance on the market.
embodiment 2
Extracorporeal circulation pipeline system as shown in Fig. 2 A to Fig. 2 C comprises arterial 101, duct of Arantius 102, perfusion device 103, first four-way connection 111, second four-way connection 112, first bypass 121, second bypass 122, first intervalve 131 and the second intervalve 132.Arterial 101 one end connecting puncture needle, the other end is connected to one end of first four-way connection 111, and other three ports of first four-way connection 111 are by counterclockwise connecting the first bypass 121, first intervalve 131 and the second bypass 122 successively.The other end of the first intervalve 131 is connected with the vein end of perfusion device 103, the arterial end of perfusion device 103 is connected with second intervalve 132 one end, the other end of the second intervalve 132 is connected with one end of second four-way connection 112, and other three ports of second four-way connection 112 are by being counterclockwise connected with the other end of the first bypass 121, duct of Arantius 102 one end, second bypass 122 other end successively.The other end connecting puncture needle of duct of Arantius 102.
After connecting perfusion device 103 and circulation line, make the arterial end of perfusion device 103 before rushing in advance upward.When rushing in advance, regulate first four-way connection 111 and second four-way connection 112, as shown in Figure 2 A, arterial 101 connects rushes liquid in advance, make to rush the gas emptying in circulation line along arterial 101, first bypass 121, second intervalve 132, the bypass 122 of perfusion device 103, first intervalve 131, second, duct of Arantius 102 in advance, then as shown in Figure 2 B, adjust first four-way connection 111 and second four-way connection 112, make to rush liquid in advance and flow through the first intervalve 131, perfusion device 103, second intervalve 132 and duct of Arantius 102 successively from arterial 101.When rushing in advance, rush liquid in advance and enter perfusion device 103 from the vein end of perfusion device 103, flow out from the arterial end of perfusion device 103, because the aperture of the arterial end filter screen of perfusion device 103 is larger, relatively little relative to the surface tension of rushing liquid in advance, thus make the bubble in perfusion device 103 be easy to quick discharge, and the adsorbent fragment in perfusion device 103 is easy to emptying, and simple to operate.
After pre-punching terminates, adjust first four-way connection 111 and second four-way connection 112, as shown in Figure 2 A, blood is made to flow through arterial 101, first bypass 121, second intervalve 132, the bypass 122 of perfusion device 103, first intervalve 131, second, duct of Arantius 102 and the Huis' body successively.Filter screen due to blood perfusion device 103 medium-sized vein end is the less filter screen in aperture, effectively can stop the adsorbent in perfusion device, avoid the adsorbent in perfusion device to enter in human body, improve the safety of therapeutic process.
As perfusion device in use procedure 103 breaks down, then can adjust first four-way connection 111 and second four-way connection 112 as shown in Figure 2 C, arterial 101, first bypass 121 is communicated with duct of Arantius 102, thus makes perfusion device 103 short circuit, be convenient to safeguard perfusion device 103.First intervalve 131 and the second intervalve 132 are equipped with pipe clamp, when needs are changed perfusion device 103, then first close the pipe clamp on the first intervalve 131 and the second intervalve 132, and then change.
The present embodiment extracorporeal circulation pipeline system also can after connecting perfusion device 103 and circulation line, rush in advance after adjusting the pipeline connection mode shown in first four-way connection 111 and second four-way connection 112 to Fig. 2 B, the pipeline connecting method shown in first four-way connection 111 and second four-way connection 112 to Fig. 2 A was again adjusted before pre-punching terminates, make to rush liquid in advance the gas in the first bypass 121 and the second bypass 122 is discharged, and then pipeline carries out perfusion treatment according to Fig. 2 A.
Arterial end can be placed according to needing during treatment by blood perfusion device 103 in this utility model upward, or is overturn by perfusion device, its vein end is placed upward, but does not change the connection of pipeline.
Blood perfusion device in this utility model is different with the aperture of filter screen of vein end by arterial end, gas when making to rush in advance in perfusion device is easy to drain fast, and when treating, effectively can stop that the adsorbent in perfusion device enters in human body, thus safety when improving operation convenience and the treatment of pre-punching, simultaneously in pre-punching and therapeutic process, perfusion device is connected in pipeline without the need to taking and reconnect the connection between perfusion device and circulation apart, maintain the blood circulation that perfusion device and pipeline form to be in all the time in the environment of closed, thus avoid contacting with atmospheric environment in perfusion device and circulation line, avoid perfusion device and circulation line by secondary pollution, ensure the safety of therapeutic process.
embodiment 3
As shown in Figure 3, the blood perfusion device in the present embodiment and dialyser are series at the Therapeutic mode in circulation line jointly, i.e. combined artificial kidney Therapeutic mode of the prior art.
This pipe-line system comprises arterial 201, duct of Arantius 202, dialysis module and perfusion module, dialysis module and perfusion block coupled in series.Module of wherein dialysing comprises dialyser 204, the 3rd bypass 223, the 5th three way cock 215, the 6th three way cock 216, the 6th intervalve 246, the 7th intervalve 247, the 7th pipe clamp 237, the 8th pipe clamp 238.Arterial 201 is connected with the 5th three way cock 215 one end, and other two ends of the 5th three way cock 215 are connected with the 6th intervalve 246 respectively at the 3rd bypass 213, and the other end of the 6th intervalve 246 is connected with the arterial end of dialyser 204; The vein end of dialyser 204 is connected with the 7th intervalve 247; The other end of the 7th intervalve 247 is connected with the 6th three way cock 216 one end, and other two ends of the 6th three way cock 216 are connected with the first bypass 223 and the 5th intervalve 245 respectively.3rd bypass 223 is provided with the 7th pipe clamp the 237, six intervalve 246 and is provided with the 8th pipe clamp the 238, seven intervalve 247 and is provided with the 9th pipe clamp 239.
Perfusion module comprises perfusion device 203, first three way cock 211, second three way cock 212, the 3rd three way cock 213, the 4th three way cock 214, first bypass 221, second bypass 222, first pipe clamp 231, second pipe clamp 232, the 3rd pipe clamp 233, the 4th pipe clamp 234, the 5th pipe clamp 235, the 6th pipe clamp 236, first intervalve 241, second intervalve 242, the 3rd intervalve 243 and the 4th intervalve 244.
5th intervalve 245 other end is connected with first three way cock 211 one end, first other two ends of three way cock 211 connects the first bypass 221 and the first intervalve 241 respectively, the other end of the first intervalve 241 is connected with second three way cock 212, other two ends of second three way cock 212 are connected with the second intervalve 242 and the second bypass 222 respectively, second intervalve 242 other end connects the vein end of perfusion device 203, the arterial end of perfusion device 203 connects the 3rd intervalve 243, 3rd intervalve 243 other end is connected with the 3rd three way cock 213 one end, 3rd three way cock 213 connects the first bypass 221 and the 4th intervalve 244 one end in two ends in addition respectively, 4th intervalve 244 other end is connected with the 4th three way cock 214 one end, other two ends of 4th three way cock 214 are connected with second bypass 222 one end and duct of Arantius 202 one end respectively, the other end of duct of Arantius 202 is connected with puncture needle.Wherein the first bypass 221 and the second bypass 222, the 3rd bypass 223 can be one section of pipeline, also can be the pipeline that multistage pipeline is coupled together by multiple-pass joint.
First intervalve 241 is provided with that the first pipe clamp 231, second intervalve 242 is provided with the second pipe clamp 232, the 3rd intervalve 243 is provided with the 3rd pipe clamp 233, the 4th intervalve 244 is provided with the 4th pipe clamp 234, first bypass 221 and is provided with the 5th pipe clamp 235, second bypass 222 and is provided with the 6th pipe clamp 236.Wherein the first pipe clamp 231 is identical with the 4th pipe clamp 234 color, as white; 5th pipe clamp 235 is identical with the 6th pipe clamp 236 color, but different from the color of the first pipe clamp, as green.Arterial is provided with pump line (not shown), pump line part is entrenched in kinetic pump, tremulous pulse pump is for the liquid in whole circulation line is as blood or rush the power that liquid etc. provides flowing in advance, and wherein arterial is also provided with tremulous pulse kettle, duct of Arantius is provided with venous chambers (not shown).
After connecting pipeline, make the arterial end of perfusion device 3 before rushing in advance upward.When rushing in advance, first closing the second pipe clamp 232, the 3rd pipe clamp 233, the 8th pipe clamp 238 and the 9th pipe clamp 239, opening other all pipe clamp.Rush liquid in advance and enter circulation line from arterial, by the first bypass 221, second bypass 222, 3rd bypass 223, first intervalve 241, after gas in 4th intervalve 244 and the 5th intervalve 245 is discharged, open the second pipe clamp 232, 3rd pipe clamp 233, 8th pipe clamp 238 and the 9th pipe clamp 239, then the 5th pipe clamp 235 is closed, 6th pipe clamp 236 and the 7th pipe clamp 237, rush liquid in advance and flow through the 6th intervalve 246 successively from arterial 201, dialyser 204, 7th intervalve 247, 5th intervalve 245, first intervalve 241, second intervalve 242, perfusion device 203, 3rd intervalve 243, 4th intervalve 244 and duct of Arantius 202.Because the filter screen on perfusion device 203 arterial end is the larger filter screen in aperture, filter screen is less relative to the surface tension of liquid, so gas is easy to discharge from arterial end filter screen, evacuation time is short, rush easy and simple to handle in advance, and the resin chips caused due to reasons such as transports in perfusion device 203 is also easy to go out.Simultaneously due to perfusion device 203 arterial end upward, so contribute to the gas drained in perfusion device, make without gas in circulation line, thus avoid the potential safety hazard that causes because gas enters human body by circulation line.
The extracorporeal circulation pipeline of the present embodiment also can realize the pre-separately punching of dialyser and perfusion device, avoids the liquid that rushes in advance breaking through dialyser in advance again rush perfusion device in advance and pollute perfusion device.When needs rush separately in advance to dialyser and perfusion device, realize by the open and-shut mode of control section pipe clamp.During as rushed dialyser in advance separately, close the first safety clamp 231, the 3rd safety clamp 233, the 6th safety clamp 236 and the 7th safety clamp 237, open the 4th safety clamp 234, the 5th safety clamp 235, the 8th safety clamp and the 9th safety clamp, make to rush liquid in advance along arterial 201, the 6th intervalve 246, dialyser 204, the 7th intervalve 247, the 5th intervalve 245, first bypass 221, the 4th intervalve 234, duct of Arantius 202, realize the pre-separately punching to dialyser 204.Or the pipe clamp in the first intervalve 241, second bypass 222 is opened, and closes the pipe clamp on the first bypass 221, second intervalve 232, the 4th intervalve 234, thus make to rush in advance liquid and along the pipeline of path, dialyser 204 is rushed in advance.
When needs rush perfusion device 203 separately in advance, close the 5th pipe clamp 235, the 6th pipe clamp 236, the 8th pipe clamp 238, the 9th pipe clamp 239, open the first pipe clamp 231, second pipe clamp 232, the 3rd pipe clamp 233, the 4th pipe clamp 234 and the 7th pipe clamp 237, make to rush liquid in advance along arterial 201, the 3rd bypass 223, the 5th intervalve 245, first intervalve 241, second intervalve 242, perfusion device 203, the 3rd intervalve 243, the 4th intervalve 244, duct of Arantius 202, thus realize the pre-separately punching to perfusion 203.
After pre-punching terminates, close the first pipe clamp 231 and the 4th pipe clamp 234, open the 5th pipe clamp 235 and the 6th pipe clamp 236, carry out hemoperfusion treatment, blood is returned in human body through arterial 201, the 6th intervalve 246, dialyser 204, the 7th intervalve 247, the 5th intervalve 245, first bypass 221, the 3rd intervalve 243, perfusion device 203, second intervalve 242, second bypass 222 and duct of Arantius 202 by human body successively.Filter screen due to blood perfusion device 203 medium-sized vein end is the less filter screen in aperture, effectively can stop the adsorbent in perfusion device, avoid the adsorbent in perfusion device to enter in human body, improve the safety of therapeutic process.
In the present embodiment, also on the jointings such as three way cock are between the 3rd intervalve 243 and perfusion device 203, blood back liquid input tube is accessed, blood back liquid input tube is provided with pipe clamp, and it is closed condition when pre-punching and treatment, opens when needs carry out blood back again.Because perfusion module is different from the treatment time of dialysis module, it is generally the treatment time being shorter than treatment time of perfusion module dialysis module, when terminating perfusion module, blood backflow in perfusion module need be entered human body, at the end of avoiding treating the treatment of dialysis module, blood in vitro the holdup time oversize and cause blood coagulation and waste.When perfusion module stops treatment, close the 3rd pipe clamp 233, open the pipe clamp on the 4th pipe clamp 234 and blood back liquid input tube, blood back liquid is injected by blood back liquid input tube, make the blood backflow in the 3rd intervalve 243, the bypass 222 of perfusion device 203, second intervalve 242, second enter duct of Arantius 202, and then can human body be flowed into, when blood is by the 6th pipe clamp 236, close the pipe clamp on blood back liquid input tube and the 6th pipe clamp 236, complete blood backflow operation.
The blood perfusion device of the present embodiment is different with the aperture of filter screen of vein end by arterial end, gas when making to rush in advance in perfusion device is easy to drain fast, and when treating, effectively can stop that the adsorbent in perfusion device enters in human body, thus safety when improving operation convenience and the treatment of pre-punching, simultaneously in pre-punching and therapeutic process, perfusion device is connected in pipeline without the need to taking and reconnect the connection between perfusion device and circulation apart, maintain the blood circulation that perfusion device and pipeline form to be in all the time in the environment of closed, thus avoid contacting with atmospheric environment in perfusion device and circulation line, avoid perfusion device and circulation line by secondary pollution, ensure the safety of therapeutic process.
embodiment 4
As shown in Figure 4, the present embodiment is the Therapeutic mode that blood perfusion device and dialyser are series in circulation line jointly, circulation line, comprise arterial 301, duct of Arantius 302, perfusion module 303, dialysis module 304 and intervalve 305, module 304 of wherein dialysing is identical with the dialysis module in embodiment 3, perfusion module 303 is identical with embodiment 2, and perfusion module 303 is together in series by intervalve 305 with dialysis module 304, and the puncture needle being connected to arterial is cancelled.No longer burden introduction is carried out to dialysis module and perfusion module herein.
embodiment 5
Extracorporeal circulation pipeline system as shown in Figure 5 comprises arterial 401, duct of Arantius 402, perfusion device 403, four-way connection 411, first three way cock 412, second three way cock 413, first bypass 421, second bypass 422, first pipe clamp 431, second pipe clamp 432, the 3rd pipe clamp 433, the 4th pipe clamp 434, first intervalve 441, second intervalve 442, the 3rd intervalve 443.Wherein arterial 401 connects four-way connection 411 one end, and other three port of four-way connection 411 is by being counterclockwise connected with the first bypass 421, first intervalve 441, second bypass 422 successively; First intervalve 441 other end is connected with perfusion device vein end; Perfusion device arterial end is connected with second intervalve 442 one end; Second intervalve 442 other end is connected with first three way cock 412 one end, and other two ends of first three way cock 412 are connected with first bypass 421 other end and the 3rd intervalve 443 one end respectively; The other end of the 3rd intervalve 443 is connected with second three way cock 413 one end, and other two ports of second three way cock 413 are connected with duct of Arantius 402 respectively at the second bypass 422.Arterial 401 is provided with puncture needle away from four-way connection 411 one end, and arterial 401 is provided with pump line (not shown), and pump line is embedded on the blood pump on blood cleaning equipment, thus by blood pump, provides the power of liquid flow on circulation line.
After connecting pipeline, close the first pipe clamp 431, open the second pipe clamp 432, 3rd pipe clamp 433 and the 4th pipe clamp 434, adjustment four-way connection 411, make to rush liquid in advance and flow through the first bypass 421 successively from arterial 401, , second intervalve 442, perfusion device 403, first intervalve 441, second bypass 422, duct of Arantius 402, thus the bubble in pipeline is discharged, then four-way connection 411 is adjusted, close the 3rd pipe clamp 433 and the 4th pipe clamp 434, open the first pipe clamp 431 to make to rush liquid in advance successively along arterial 401, first intervalve 441, perfusion device 403, second intervalve 442, 3rd intervalve 443 and duct of Arantius 402, thus the pre-punching realized perfusion device.Because the aperture of the arterial end filter screen of perfusion device 403 is larger, screen surface tension force is relatively little, when rushing in advance, rush liquid in advance and enter perfusion device 403 from vein end, then flow out from arterial end, the bubble in perfusion device 403 just can be discharged from arterial end filter screen fast under less External Force Acting, thus make to rush time shorten in advance, easy and simple to handle, simplify the operation easier of medical personnel, improve the ease of use of perfusion device.
After pre-punching terminates, adjustment four-way connection 411, close the first pipe clamp 431, open the 3rd pipe clamp 433 and the 4th pipe clamp 434, arterial 401 1 termination human body artery, makes blood flow through arterial 401, first bypass 421, second intervalve 442, the bypass 422 of perfusion device 403, first intervalve 441, second, duct of Arantius 402 and flow back to people's human body successively.Because blood enters perfusion device 403 from the arterial end of perfusion device 403, flow out from the vein end of perfusion device 403, and the aperture of filter screen of vein end is less, thus effectively stops the absorbent particles in perfusion device, thus ensure the safety of therapeutic process.
In the above-described embodiments, can also by the vein end of perfusion device 403 and the second intervalve 442, arterial end is then connected with the first intervalve 441.When rushing in advance perfusion device 403, making to rush liquid in advance and flowing through arterial 401, first bypass 421, second intervalve 442, perfusion device 403, first intervalve 441, second bypass 422 and duct of Arantius 402 successively; When utilizing perfusion device 403 to treat, blood is made to flow through arterial 401, first intervalve 441, perfusion device 403, second intervalve 442, the 3rd intervalve 443 and duct of Arantius 402 successively.
Perfusion module in the present embodiment can be used as an integral module and perfusion module in alternative embodiment 4, when rushing in advance and treatment time in perfusion module the flow direction of liquid same as described above, therefore no longer burden describes.The present embodiment extracorporeal circulation of blood pipe-line system by the control to pipe clamp and four-way connection, and realizes the pre-separately punching to perfusion device and dialyser, avoids the dialysis solution breaking through dialyser in advance again rush perfusion device in advance and pollute perfusion device.When rushing in advance separately, utilize bypass to the short circuit effect of dialyser or perfusion device, and make to rush liquid in advance and avoid dialyser or perfusion device, thus realize the pre-separately punching to dialyser and perfusion device.
When perfusion module in the present embodiment is used as a module, and it is different from the treatment time of other module, when needing first to stop treatment, blood back liquid input tube can be increased by the mode such as three way cock and intervalve between the second intervalve 442 and perfusion device 403 arterial end, open the first pipe clamp 431, close the second pipe clamp 432, thus make the blood in pipeline and perfusion device 403 along the bypass 422 of perfusion device 403, first intervalve 441, second, duct of Arantius 402 and pass back into human body.
embodiment 6
As shown in Figure 6, the present embodiment is the Therapeutic mode that blood perfusion device and plasma separator are connected in circulation line jointly, perfusion module 603 is the perfusion module in embodiment 3, arterial 601 is connected with the blood mouth that enters of plasma separator 602, the plasma outlet port of plasma separator 602 is connected with the module inlet of perfusion module 603, the concentrate blood outlet of plasma separator 602 is connected with concentrate blood pipeline 604, the module outlet of perfusion module 603 is collected at venous chambers 605 by pipeline and concentrate blood pipeline 604, thus the blood plasma after perfusion treatment and concentrated blood plasma are converged, again by the defeated the Huis' body of duct of Arantius 606.
In the present embodiment, between the plasma outlet port of plasma separator 602 and the module inlet of perfusion module 603, blood back liquid input tube 607 can be provided with, thus realize passing back into human body to the blood plasma of perfusion module.
In the present embodiment also can pipeline between plasma outlet port and perfusion module with between arterial 601, pipeline is set and is communicated with, thus realize the pre-separately punching of plasma separator 602 and perfusion device, avoid the liquid that rushes in advance breaking through plasma separator in advance again rush perfusion device in advance and pollute perfusion device.Carry out plasma separator 601 and perfusion device when rushing in advance separately, realize by controlling the opening and closing of pipe clamp, concrete mode of rushing in advance is similar with embodiment 3 to embodiment 1 with therapeutic modality, so place's no longer burden introduction.
embodiment 7
As shown in Figure 7, Therapeutic mode in the present embodiment is identical with dual Molecular Adsorption blood purification system (DPMAS) pattern of the prior art, compared with above-described embodiment 6, perfusion module comprises first group of perfusion module 701 and second group of perfusion module 702 of series connection mutually, blood perfusion device 703 wherein in the middle of first group of perfusion module 701 is bilirubin adsorption perfusion device, and the blood perfusion device 704 in the middle of described second group of perfusion module 702 is Microporous resin absorption perfusion device.
First group of perfusion module 701 and second group of perfusion module 702 all adopt the perfusion modular structure in embodiment 3, thus it is fast to realize perfusion device aerofluxus, processing ease, and all do not need dismounting and re-assembly pipeline in pre-punching and therapeutic process, simplify the operating process of medical personnel, guarantee that extracorporeal circulation of blood pipe-line system is in closed environment in pre-punching and therapeutic process simultaneously, avoid perfusion device and pipeline to be in atmospheric environment and be subject to air environmental pollution, ensure that the safety for the treatment of.
Dual Molecular Adsorption blood purification system pipeline in the present embodiment also can the pipeline between plasma outlet port and perfusion module with between arterial, pipeline is set and is communicated with, thus realize the pre-separately punching of plasma separator and perfusion device, avoid the liquid that rushes in advance broken through in advance again rush the perfusion device in downstream in advance and pollute perfusion device.Carry out plasma separator and perfusion device when rushing in advance separately, realize by controlling the opening and closing of pipe clamp, concrete mode of rushing in advance is similar with embodiment 3 to embodiment 1 with therapeutic modality, so place's no longer burden introduction.
embodiment 8
As shown in Figure 8, Therapeutic mode in the present embodiment is substantially the same manner as Example 6, distinctive points is come together in venous chambers 803 after first group of perfusion module 802 of the isolated blood plasma of plasma separator 801 through comprising bilirubin adsorption perfusion device is adsorbed, then carries out adsorbing therapy through the second group of perfusion module 804 containing neutral macroporous adsorbent resin perfusion device.In addition, also comprise first blood bypass 805 and second blood bypass 806 in parallel with plasma separator 801, described first blood bypass 805 and the second blood bypass 806 are respectively equipped with pipe clamp.
First group of perfusion module 802 in the present embodiment and second group of perfusion module 804 all adopt the perfusion modular structure in embodiment 3, and no longer burden is introduced herein.
As seen from the above-described embodiment, the blood perfusion device that this utility model provides is different with the aperture of filter screen of vein end by arterial end, gas when making to rush in advance in perfusion device is easy to drain fast, and when treating, effectively can stop that the adsorbent in perfusion device enters in human body, thus safety when improving operation convenience and the treatment of pre-punching, simultaneously in pre-punching and therapeutic process and perfusion device be connected in pipeline without the need to taking and re-start the connection between perfusion device and circulation line apart, thus make extracorporeal circulation of blood pipe-line system be in closed environment in pre-punching and therapeutic process, avoid contacting with atmospheric environment in perfusion device and circulation line, avoid perfusion device and circulation line by secondary pollution, ensure the safety of therapeutic process.On the other hand, if the extracorporeal circulation of blood pipe-line system in above-mentioned example has multiple module, then can rush in advance modules respectively, that avoids breaking through in advance up-stream module rushes the module that liquid rushes downstream again in advance in advance, thus cause downstream module to be polluted, ensure the function of each module, optimize therapeutic effect.
In this utility model, embodiment 1, embodiment 2 are similar with the functions of modules of embodiment 5, if perfusion device is identical, then pipeline can be replaced mutually.
Above-described is only preferred implementation of the present utility model; it should be pointed out that for the person of ordinary skill of the art, under the prerequisite not departing from inventive concept of the present utility model; can also make some distortion and improvement, these all belong to protection domain of the present utility model.
Claims (15)
1. a blood perfusion device, comprise the perfusion device body with arterial end and vein end, described perfusion device body is respectively arranged with arterial end filter screen and vein end filter screen at its arterial end and vein end, accommodate adsorbent between described arterial end filter screen and vein end filter screen, it is characterized in that: the aperture of described arterial end filter screen is greater than the aperture of described vein end filter screen; When rushing in advance, described vein end is as fluid input port, and described arterial end is as fluid output port; When treating, described arterial end is as fluid input port, and described vein end is as fluid output port.
2. blood perfusion device according to claim 1, is characterized in that: described blood perfusion device is any one in Microporous resin adsorber, resin anion (R.A.) adsorber, active carbon adsorber, DNA immunization adsorber, Endotoxin adsorption device; The aperture of described arterial end filter screen is 100-300 μm, and the aperture of described vein end filter screen is 20-200 μm.
3. blood perfusion device according to claim 2, is characterized in that: the aperture of described arterial end filter screen is 200-300 μm, and the aperture of vein end filter screen is 60-120 μm.
4. an extracorporeal circulation of blood pipe-line system, comprise arterial, duct of Arantius and the perfusion module be connected between described arterial and duct of Arantius, described perfusion module has module inlet, module outlet and the blood perfusion device between described module inlet and module outlet, described module inlet is connected to described arterial and described module outlet is connected to described duct of Arantius, described blood perfusion device is respectively arranged with arterial end filter screen and vein end filter screen at its arterial end and vein end, adsorbent is accommodated between described arterial end filter screen and vein end filter screen, it is characterized in that: described perfusion module also comprises first bypass in parallel with described blood perfusion device and the second bypass, when rushing in advance and treating, in described blood perfusion device, the flow direction of liquid is just in time contrary.
5. extracorporeal circulation of blood pipe-line system according to claim 4, is characterized in that: the aperture of described arterial end filter screen is greater than the aperture of described vein end filter screen.
6. extracorporeal circulation of blood pipe-line system according to claim 5, is characterized in that: the aperture of described arterial end filter screen is 100-300 μm, and the aperture of described vein end filter screen is 20-200 μm.
7. extracorporeal circulation of blood pipe-line system according to claim 6, is characterized in that: the aperture of described arterial end filter screen is 200-300 μm, and the aperture of vein end filter screen is 60-120 μm.
8. extracorporeal circulation of blood pipe-line system according to claim 4, it is characterized in that: described perfusion module also comprises four intervalves and four three way cock, described module inlet is connected with described first bypass and the first intervalve by first three way cock, described first intervalve is connected with the second intervalve and described second bypass by second three way cock, and described second intervalve is connected with the vein end of described blood perfusion device; The arterial end of described blood perfusion device connects the 3rd intervalve, described 3rd intervalve is connected with described first bypass and the 4th intervalve by the 3rd three way cock, and described module outlet is connected with described 4th intervalve and described second bypass by the 4th three way cock; Described four intervalves and described first bypass and the second bypass are equipped with pipe clamp.
9. extracorporeal circulation of blood pipe-line system according to claim 8, it is characterized in that: the pipe clamp on described first intervalve and the 4th intervalve has the first color, pipe clamp in described first bypass and the second bypass has the second color, and described first color is not identical with described second color.
10. extracorporeal circulation of blood pipe-line system according to claim 4, is characterized in that: described perfusion module also comprises the first intervalve, the second intervalve and first four-way connection, second four-way connection; Described first intervalve is connected with the vein end of described blood perfusion device, and described second intervalve is connected with the arterial end of described blood perfusion device; Described first bypass, the first intervalve and the second bypass are connected with described first four-way connection, and described first bypass, the second intervalve and the second bypass are connected with described second four-way connection; When described first four-way connection is in the first duty, described module inlet and described first bypass and described first intervalve and described second bypass, when described first four-way connection is in the second duty, described module inlet is communicated with described first intervalve; When described second four-way connection is in the first duty, described first bypass is communicated with described second intervalve and described second bypass is communicated with described module outlet, when described second four-way connection is in the second duty, described module outlet is communicated with described second intervalve, when described second four-way connection is in the 3rd duty, described first bypass is communicated with described module outlet and described second bypass is communicated with described second intervalve.
11. extracorporeal circulation of blood pipe-line systems according to claim 4, it is characterized in that: described perfusion module also comprises the first intervalve, the second intervalve, the 3rd intervalve and controls the pipeline on-off system of described first bypass, the second bypass, the second intervalve and the 3rd intervalve break-make, one in the vein end of described first intervalve and described blood perfusion device and arterial end is connected, and another in the vein end of described second intervalve and described blood perfusion device and arterial end is connected; Described first bypass, the first intervalve and the second bypass are connected with a four-way connection, described first bypass is connected by first three way cock with described second intervalve and the 3rd intervalve, and described module outlet is connected with described second bypass and described 3rd intervalve by second three way cock; When described four-way connection is in the first duty, described module inlet and described first bypass and described first intervalve and described second bypass, when described four-way connection is in the second duty, described module inlet is communicated with described first intervalve.
Extracorporeal circulation of blood pipe-line system described in 12. any one of according to Claim 8 to 11, it is characterized in that: this pipe-line system also comprises the dialysis module be connected between described arterial and described perfusion module, described dialysis module comprises the dialysis main road be arranged in parallel, dialyse bypass and the dialyser that is connected on described dialysis main road, and described dialysis main road and dialysis bypass are respectively equipped with pipe clamp.
Extracorporeal circulation of blood pipe-line system described in 13. any one of according to Claim 8 to 11, it is characterized in that: this pipe-line system also comprises plasma separator, wherein said arterial is connected with the blood mouth that enters of described plasma separator, the plasma outlet port of described plasma separator is connected with the module inlet of described perfusion module, and the concentrate blood of described plasma separator is connected with described duct of Arantius after exporting and collecting via pipeline with the module outlet of described perfusion module.
14. extracorporeal circulation of blood pipe-line systems according to claim 13, it is characterized in that: described perfusion module comprises first group of perfusion module and second group of perfusion module of series connection mutually, blood perfusion device in the middle of wherein said first group of perfusion module is bilirubin adsorption perfusion device, and the blood perfusion device in the middle of described second group of perfusion module is Microporous resin absorption perfusion device.
15. extracorporeal circulation of blood pipe-line systems according to claim 13, is characterized in that: this pipe-line system also comprise be connected on described arterial or duct of Arantius another organize described perfusion module.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520465565.7U CN204766771U (en) | 2015-06-30 | 2015-06-30 | Hemoperfusion ware and external blood circulation pipe -line system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201520465565.7U CN204766771U (en) | 2015-06-30 | 2015-06-30 | Hemoperfusion ware and external blood circulation pipe -line system |
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| CN204766771U true CN204766771U (en) | 2015-11-18 |
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| CN201520465565.7U Withdrawn - After Issue CN204766771U (en) | 2015-06-30 | 2015-06-30 | Hemoperfusion ware and external blood circulation pipe -line system |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906648A (en) * | 2015-06-30 | 2015-09-16 | 珠海健帆生物科技股份有限公司 | Blood perfusion device and external blood circulation pipeline system |
| CN110585503A (en) * | 2018-06-12 | 2019-12-20 | 上海立马医疗器械有限公司 | Hose and extracorporeal circulation pipeline adopting same |
| CN114404703A (en) * | 2021-12-21 | 2022-04-29 | 健帆生物科技集团股份有限公司 | Combined artificial kidney and its pre-flushing method and working method |
-
2015
- 2015-06-30 CN CN201520465565.7U patent/CN204766771U/en not_active Withdrawn - After Issue
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906648A (en) * | 2015-06-30 | 2015-09-16 | 珠海健帆生物科技股份有限公司 | Blood perfusion device and external blood circulation pipeline system |
| CN110585503A (en) * | 2018-06-12 | 2019-12-20 | 上海立马医疗器械有限公司 | Hose and extracorporeal circulation pipeline adopting same |
| CN114404703A (en) * | 2021-12-21 | 2022-04-29 | 健帆生物科技集团股份有限公司 | Combined artificial kidney and its pre-flushing method and working method |
| CN114404703B (en) * | 2021-12-21 | 2024-03-26 | 健帆生物科技集团股份有限公司 | Combined artificial kidney, pre-flushing method and working method thereof |
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Granted publication date: 20151118 Effective date of abandoning: 20180216 |