CN204766772U - Dual molecular adsorption blood clean system - Google Patents
Dual molecular adsorption blood clean system Download PDFInfo
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- CN204766772U CN204766772U CN201520465580.1U CN201520465580U CN204766772U CN 204766772 U CN204766772 U CN 204766772U CN 201520465580 U CN201520465580 U CN 201520465580U CN 204766772 U CN204766772 U CN 204766772U
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Abstract
The utility model discloses a dual molecular adsorption blood clean system, including blood return circuit arterial line, neutral by macroporous resin adsorption ware, anion adsorption unit and blood return circuit vein pipeline, neutral by macroporous resin adsorption ware and anion adsorption unit are established ties between blood return circuit arterial line and blood return circuit vein pipeline, the anion adsorption unit includes the plasma separator, the resin anion adsorber, separated plasma pipeline and concentrated blood outlet pipe way, concentrated blood outlet pipe way is connected in the concentrated blood export of plasma separator, the separated plasma tube coupling is between the separated plasma export and concentrated blood outlet pipe way of plasma separator, the resin anion adsorber is connected on the separated plasma pipeline. The utility model discloses utilize the whole blood perfusion security of neutral by macroporous resin adsorption ware to carry out the whole blood perfusion to blood, improved the effective absorption nature of neutral macroporous absorbent resin, improved treatment or reached the same treatment through shortening patient's treatment time.
Description
Technical field
This utility model relates to field of blood purification, specifically, relates to a kind of dual Molecular Adsorption blood purification system.
Background technology
Dual blood plasma Molecular Adsorption system (DPMAS) is a kind of associating resin anion (R.A.) adsorber and Microporous resin adsorber, combined therapy pattern specific adsorption combined with broad-spectrum action.This combined therapy pattern is by two kinds of adsorber use in conjunction, and Synergistic, can remove inflammatory mediator while improving jaundice symptom rapidly, improves treatment success rate, improves patient's prognosis.Hepatitis gravis, hepatic encephalopathy, liver failure, the disease such as MOFE/severe sepsis shock with jaundice can be used for.
Setting up blood circuit is the first step using dual blood plasma Molecular Adsorption system to treat patient, is also one of most important step.The blood circuit system of existing dual blood plasma Molecular Adsorption system is made up of blood circuit venous line four part flowing out the blood circuit arterial line of human body, plasma separator, the resin anion (R.A.) adsorber of series connection and Microporous resin adsorber and flow into human body.Its Therapeutic mode first blood is carried out blood plasma separation, and isolated blood plasma is sent into resin anion (R.A.) adsorber and Microporous resin adsorber successively, after adsorbent in resin anion (R.A.) adsorber and Microporous resin adsorber is adsorbed target substance successively, the concentrate blood exported with plasma separator again converges dilution, and then sends human body back to.
But, in order to prevent damaging the fibrous membrane of plasma separator in therapeutic process, the plasma flow rate in plasma separator be generally whole blood flow velocity 20% ~ 25% or lower.In blood, blood plasma accounts for about 55% of whole blood, therefore, in existing DPMAS therapeutic process, plasma separator the not enough total plasma volume of isolated blood plasma 50%, the blood plasma with morbid substance of not separated more than 50% then carries out adsorbing therapy without above-mentioned two kinds of adsorbers, and directly feeds back in patient body together with hemocyte.
Utility model content
Technical problem to be solved in the utility model is to provide a kind of dual Molecular Adsorption blood purification system, to improve therapeutic effect or to reach identical therapeutic effect by shortening the patient treatment time.
For solving the problems of the technologies described above, this utility model have employed following technical scheme: design a kind of dual Molecular Adsorption blood purification system, comprise blood circuit arterial line, Microporous resin adsorber, Anion-adsorption unit and blood circuit venous line, described Microporous resin adsorber and Anion-adsorption unit are connected between described blood circuit arterial line and blood circuit venous line by intermediate duct, wherein said Anion-adsorption unit comprises plasma separator, resin anion (R.A.) adsorber, separated plasma pipeline and concentrate blood export pipeline, described plasma separator has separated plasma outlet and concentrate blood outlet, described concentrate blood export pipeline is connected to the outlet of described concentrate blood, described separated plasma pipeline is connected between the outlet of described separated plasma and described concentrate blood export pipeline, described resin anion (R.A.) adsorber is connected on described separated plasma pipeline.
From such scheme, dual Molecular Adsorption blood purification system of the present utility model by Microporous resin adsorber and Anion-adsorption units in series between blood circuit arterial line and blood circuit venous line, take full advantage of the whole blood perfusion safety of Microporous resin adsorber, whole blood perfusion is carried out to blood, resin anion (R.A.) adsorber then carries out plasma perfusion, improve the active adsorption of neutral macroporous adsorbent resin, thus improve therapeutic effect, or reach identical therapeutic effect by shortening the patient treatment time.
In one embodiment, described Microporous resin adsorber is positioned at the upstream of described Anion-adsorption unit, and described intermediate duct is connected with the vein end of described Microporous resin adsorber and the blood entry port of described plasma separator respectively.Blood first carries out whole blood perfusion through Microporous resin adsorber, give full play to Microporous resin adsorber curative effect, then through plasma separator, isolated blood plasma carries out plasma perfusion through resin anion (R.A.) adsorber after drawing from human body artery.
In another embodiment, described Microporous resin adsorber is positioned at the downstream of described Anion-adsorption unit, be connected with one end of described intermediate duct after described concentrate blood export pipeline and described separated plasma pipeline collect, the other end of described intermediate duct is connected with the arterial end of described Microporous resin adsorber.After blood is drawn from human body artery, first through plasma separator, isolate blood plasma and carry out plasma perfusion by resin anion (R.A.) adsorber, after adsorbed target material, after the concentrate blood that blood plasma and plasma separator export converges dilution, then carry out whole blood perfusion through Microporous resin adsorber.
In a kind of preferred version, described dual Molecular Adsorption blood purification system also comprises and the first blood bypass of described Microporous resin adsorbers parallel or second blood bypass in parallel with described Anion-adsorption unit.
In another kind of preferred version, described dual Molecular Adsorption blood purification system also comprises and the first blood bypass of described Microporous resin adsorbers parallel and second blood bypass in parallel with described Anion-adsorption unit, comprise the first blood bypass on-off system controlling described first blood bypass break-make in addition, control the second blood bypass on-off system of described second blood bypass break-make, second branch road on-off system of the first branch road on-off system controlling the first branch road break-make at described Microporous resin adsorber place and the second branch road break-make controlling described Anion-adsorption unit place.
Further, this system also comprises the 3rd blood bypass, and the 3rd blood bypass walks around described Microporous resin adsorber makes the arterial end of described resin anion (R.A.) adsorber directly be communicated with described blood circuit arterial line with plasma separator.
Further, described 3rd blood bypass is also connected with described intermediate duct, and described 3rd blood bypass comprises the on-off system controlling its break-make.
Further, described first blood bypass is communicated with near Anion-adsorption unit side with described intermediate duct; Described second blood bypass is communicated with near Microporous resin adsorber side with described intermediate duct.
In one embodiment, described first blood bypass on-off system, the second blood bypass on-off system, the first branch road on-off system and the second branch road on-off system are the safety clamp be arranged on corresponding pipeline.
Preferably, described blood circuit arterial line is provided with the first blood pump, and described separated plasma pipeline is provided with the second blood pump.
Above-mentioned preferred version constructs a kind of selecting type blood circuit connected mode; certain part that can realize happening suddenly in dual Molecular Adsorption systematic treating process is abnormal or owing to exempting to tear open adsorber and pipeline when other reason need stop a certain adsorber to treat and realizing the object of continual cure; the misery of patient can be reduced clinically; farthest play curative effect during actual therapeutic; effective risk reducing treatment, and easy to operate, quick.
Accompanying drawing explanation
Fig. 1 is the structural representation of the embodiment one of the dual Molecular Adsorption blood purification system of this utility model.
Fig. 2 is the structural representation of the embodiment two of the dual Molecular Adsorption blood purification system of this utility model.
Fig. 3 is the structural representation of the embodiment three of the dual Molecular Adsorption blood purification system of this utility model.
Fig. 4 is the structural representation of the embodiment four of the dual Molecular Adsorption blood purification system of this utility model.
Fig. 5 is the structural representation of the embodiment five of the dual Molecular Adsorption blood purification system of this utility model.
Detailed description of the invention
To describe various embodiment of the present utility model below in detail, embodiment wherein in conjunction with the accompanying drawings and describe hereinafter.Although this utility model will be described in conjunction with illustrative embodiments, be to be understood that this utility model is not limited to these illustrative embodiments.On the contrary, this utility model not only comprises these embodiments, but also comprises various distortion, improvement.
In field of blood purification, Microporous resin adsorber is widely used in whole blood perfusion, and resin anion (R.A.) adsorber is widely used in plasma perfusion.This utility model provides a kind of dual Molecular Adsorption blood purification system, make full use of the active adsorption of Microporous resin adsorber, carry out whole blood perfusion, improve blood treatment amount, avoid part to enter human body direct time containing the blood of morbid substance without absorption, give full play to Microporous resin adsorber curative effect.
Embodiment one
As shown in Figure 1, the dual Molecular Adsorption blood purification system of the present embodiment comprises blood circuit arterial line 1, blood circuit venous line 2, Microporous resin adsorber 5 and Anion-adsorption unit, Microporous resin adsorber 5 is connected by intermediate duct with Anion-adsorption unit and is connected between blood circuit arterial line 1 and blood circuit venous line 2, Microporous resin adsorber 5 is positioned at the upstream of Anion-adsorption unit, and blood circuit arterial line 1 is provided with the first blood pump 3.
Wherein said Anion-adsorption unit comprises plasma separator 6, resin anion (R.A.) adsorber 7, separated plasma pipeline 16 and concentrate blood export pipeline 17, plasma separator 6 has separated plasma outlet 18 and concentrate blood outlet 19, concentrate blood export pipeline 17 is connected to concentrate blood outlet 19, separated plasma pipeline 16 is connected between separated plasma outlet 18 and concentrate blood export pipeline 17, resin anion (R.A.) adsorber 7 is connected on separated plasma pipeline 16, and separated plasma pipeline 16 is provided with the second blood pump 4.
In addition, in order to certain part that can realize happening suddenly in dual Molecular Adsorption systematic treating process is abnormal or owing to exempting to tear open adsorber and pipeline when other reason need stop a certain adsorber to treat and realizing the object of continual cure, realize realizing rushing in advance respectively of centering macroporous resin adsorption device 5 and Anion-adsorption unit in closed environment simultaneously, the dual Molecular Adsorption blood purification system of said structure also comprises first blood bypass 14 in parallel with Microporous resin adsorber 5 and second blood bypass 15 in parallel with Anion-adsorption unit, first blood bypass 14 is provided with the first blood bypass safety clamp 8 controlling this first blood bypass 14 break-make, second blood bypass 15 is provided with the second blood bypass safety clamp 9 controlling this second blood bypass 15 break-make, first branch road 20 at Microporous resin adsorber 5 place is provided with the first branch road safety clamp 10 controlling this first branch road 20 break-make, 11, second branch road 21 at Anion-adsorption unit place is provided with the second branch road safety clamp 12 controlling this second branch road 21 break-make, 13.
When needs centering macroporous resin adsorption device 5 rushes in advance, close the second branch road safety clamp 12,13 and first blood bypass safety clamp 8, open other safety clamps, rush liquid in advance and enter blood circuit arterial line 1, and flow through Microporous resin adsorber 5 along the first branch road 20, more successively through the second blood bypass 15, blood circuit duct of Arantius 2 and flowing out in circulation line.When needs rush in advance to Anion-adsorption unit, close the first branch road safety clamp 10,11 and second blood bypass safety clamp 9, rush liquid stream in advance through blood circuit arterial line 1, first blood bypass 14, second branch road 21 and plasma separator 6; The liquid that rushes in advance in plasma separator 6 is divided into two bursts of tributaries, and one tributary flows through resin anion (R.A.) adsorber 7 along separated plasma pipeline 16, then converges to concentrate blood export pipeline 17; Another burst of tributary is directly converged through concentrate blood export pipeline 17 and the liquid that rushes in advance flowed out by separated plasma pipeline 16, then flows out circulation line by blood circuit duct of Arantius 2.
Blood from human body artery through blood circuit arterial line 1 draw after, first whole blood perfusion is carried out through Microporous resin adsorber 5, blood after Microporous resin adsorber 5 purifies carries out blood plasma separation through plasma separator 6, isolated blood plasma adsorbs through resin anion (R.A.) adsorber 7, thus blood is purified further, be back to human body again, so constantly circulation, thus reach final therapeutic purposes.
The blood that Microporous resin adsorber 5 pairs of human bodies are drawn carries out whole blood perfusion, avoid more than 50% blood containing morbid substance be not separated in the DPMAS therapeutic process of prior art and directly pass back into human body without adsorption cleaning, within identical treatment time, Microporous resin resin absorption device improves more than 50% to the treating capacity of blood, effective usability of neutral macroporous adsorbent resin is increased, thus the absorption increased target substance, target substance elimination efficiency is improved, and therapeutic effect obviously improves.
Under this Therapeutic mode, Microporous resin adsorber 5 and resin anion (R.A.) adsorber 7 use in conjunction, whole blood perfusion and plasma perfusion Synergistic, improve dual Molecular Adsorption system to the therapeutic effect of disease.
Meanwhile, by increasing by the first blood bypass 14 at Microporous resin adsorber 5 side, increasing by the second blood bypass 15 at Anion-adsorption unit side, optimizing treatment pipeline, thus formation one is exempted to tear type closed type blood circuit form open.
In the therapeutic process of dual Molecular Adsorption blood purification system, article two, the first blood bypass safety clamp 8 on blood bypass 14,15 and the second blood bypass safety clamp 9 are folder and close state, and the first branch road safety clamp 10,11 and second branch road safety clamp 12,13 is all opened.As the Microporous resin adsorber 5 that happens suddenly in therapeutic process, plasma separator 6, resin anion (R.A.) adsorber 7, certain is a part of abnormal; or need the instant treatment time regulating wherein a certain adsorber over the course for the treatment of; or due to other reason need stop a certain part treat time, without the need to shutting down and taking adsorber and pipeline apart.According to practical situation, treat as Microporous resin adsorber 5 need be stopped, then close the first branch road safety clamp 10,11, open the first blood bypass safety clamp 8, thus only carry out the treatment of Anion-adsorption unit; As the treatment of Anion-adsorption unit need be stopped, then close the second branch road safety clamp 12,13 and second blood pump 4, open the second blood bypass safety clamp 9, thus only carry out the treatment of Microporous resin adsorber 5.
Such scheme constructs a kind of selecting type blood circuit connected mode, can reduce the misery of patient clinically, farthest plays curative effect during actual therapeutic, effectively reduces the risk for the treatment of, and easy to operate, quick.
Embodiment two
Fig. 2 shows another kind of embodiment of the present utility model, and in the present embodiment, Microporous resin adsorber 5 is positioned at the downstream of Anion-adsorption unit.Blood from human body artery through blood circuit arterial line 1 draw after, first through plasma separator 6, isolated blood plasma carries out plasma perfusion through resin anion (R.A.) adsorber 7, after adsorbed target material, after the concentrate blood that blood plasma and plasma separator 6 export converges dilution, then carry out whole blood perfusion through Microporous resin adsorber 5.In addition, other structures of the present embodiment are all identical with embodiment one, just repeat no more herein.
Embodiment three
Fig. 3 shows another kind of embodiment of the present utility model, and in the present embodiment, Microporous resin adsorber 5 is positioned at the upstream of Anion-adsorption unit.Microporous resin adsorber 5 is connected by intermediate duct with Anion-adsorption unit and is connected between blood circuit arterial line 1 and blood circuit venous line 2.Blood circuit arterial line 1 is connected with first threeway 101 one end, and the other two ends of first threeway 101 are connected with Microporous resin adsorber arterial 111, first intervalve 121 respectively.Microporous resin adsorber arterial 111 is connected with the arterial end of Microporous resin adsorber 5, and the vein end of Microporous resin adsorber 5 is connected with Microporous resin adsorber duct of Arantius 112 one end.The other end of the first intervalve 121 is connected with second threeway 102, and the other two ends of second threeway 102 are connected with plasma separator arterial 131, the 3rd bypass 122 one end respectively.Plasma separator arterial 131 other end is connected with the arterial end of blood separator 6, and the concentrate blood outlet 19 of plasma separator 6 is connected with concentrate blood outlet 132, and the separated plasma outlet 18 of plasma separator 6 is connected with separated plasma pipeline 133.The other end of the 3rd bypass 122, separated plasma pipeline 133 one end and resin anion (R.A.) adsorber arterial 134 are connected by the 3rd threeway 103.Resin anion (R.A.) adsorber arterial 134 other end is connected with the arterial end of resin anion (R.A.) adsorber 7, the vein end of Anion-adsorption device 7 is connected with Anion-adsorption device duct of Arantius 135, and the other end of Anion-adsorption device duct of Arantius 135 is connected on concentrate blood outlet 132.Microporous resin adsorber duct of Arantius 112 and plasma separator arterial 131 realize by the 3rd intervalve 123 being interconnected, preferably, Microporous resin adsorber duct of Arantius 112 and plasma separator arterial 131 are respectively equipped with three-port structure, macroporous resin adsorption device duct of Arantius 112 and plasma separator arterial 131 are connected with two joints in the three-port structure that it is arranged respectively, and another joint is connected with the two ends of the 3rd intervalve 123 respectively.Microporous resin adsorber duct of Arantius 112, to connect respectively by the 4th threeway 104 between concentrate blood outlet 132 and blood circuit venous line 2.
Microporous resin adsorber arterial 111 is provided with that the first safety clamp 141, first intervalve 121 is provided with the second safety clamp 142, the 3rd bypass 122 is provided with the 3rd safety clamp 143, the 3rd intervalve 123 is provided with the 4th safety clamp 144, plasma separator arterial 131 is provided with the 5th safety clamp 145, Microporous resin adsorber duct of Arantius 112 is provided with the 6th safety clamp 146, concentrate blood outlet 132 is provided with the 7th safety clamp 147 and the 8th safety clamp 148, separated plasma pipeline 133 are provided with the 9th safety clamp 149.Wherein, on concentrate blood outlet 132, and the downstream being positioned at Anion-adsorption device duct of Arantius 135 and concentrate blood outlet 132 meet is provided with the 7th safety clamp 147, and the upstream side of meet is provided with the 8th safety clamp 148.
In the present embodiment, along liquid flow direction, be connected with Microporous resin adsorber 5, and the pipe between the first intervalve 121 and the 3rd intervalve 123 forms the first branch road; Be connected with plasma separator 6, and the pipeline between the 3rd intervalve 123 and Microporous resin adsorber duct of Arantius 112 forms the second branch road.The first intervalve 121 between Microporous resin adsorber arterial 111 and the 3rd intervalve 123 and plasma separator arterial 131 form the first blood bypass; Microporous resin adsorber duct of Arantius 112 between the 3rd intervalve 123 and blood circuit venous line 2 forms the second bypass.
One of advantage in the present embodiment is for can centering macroporous resin adsorption device 5, plasma separator 6 and resin anion (R.A.) adsorber 7 rush in advance respectively, avoid any one liquid that rushes in advance in Microporous resin adsorber 5, plasma separator 6 and resin anion (R.A.) adsorber 7 to enter other two cylinder consumptive materials again, and cause and rush the cylinder consumptive material that liquid pollutes other in advance.
When rushing in advance, close the 4th safety clamp 144, rush liquid in advance from blood circuit arterial line 1 respectively along Microporous resin adsorber arterial 111, enter Microporous resin adsorber 5, through neutral macroporous adsorbent resin duct of Arantius 112, thus centering macroporous resin adsorption device 5 rushes in advance; Part through blood circuit arterial line 1 rushes liquid in advance again through the first intervalve 121, plasma separator arterial 131, plasma separator 6, concentrate blood outlet 132, thus plasma separator 6 is rushed in advance, what flow through plasma separator 6 rushes liquid part in advance through separated plasma outlet and separated plasma pipeline, thus separated plasma pipeline is rushed in advance, after separated plasma pipeline rushes in advance and terminates, close the 9th safety clamp 149; The part flowing through the first intervalve 121 is rushed liquid in advance and is shunted a part again to the 3rd bypass 122, resin anion (R.A.) adsorber arterial 134, resin anion (R.A.) adsorber duct of Arantius 135, thus rushes in advance resin anion (R.A.) adsorber 7.
In the present embodiment, the pre-punching of dual Molecular Adsorption blood purification system also can centering macroporous resin adsorption device 5, plasma separator 6 and resin anion (R.A.) adsorber 7 be rushed respectively in order in advance, when rushing Microporous resin adsorber 5 in advance, close the second safety clamp 142, the 4th safety clamp 144, the 7th safety clamp 147; When rushing plasma separator 6 in advance, close the first safety clamp 141, the 3rd safety clamp 143, the 4th safety clamp 144; When rushing resin anion (R.A.) adsorber 7 in advance, close the first safety clamp 141, the 5th safety clamp 145, the 6th safety clamp 146, the 8th safety clamp 148.
When treating, close the second safety clamp 142, the 3rd safety clamp 143, the 5th safety clamp 145 and the 6th safety clamp 146, open other safety clamps, blood flows through blood circuit arterial line 1 by human body and flows through Microporous resin adsorber tremulous pulse 111, Microporous resin adsorber 5, neutral macroporous absorption device duct of Arantius 112 part, the 3rd intervalve 123, plasma separator arterial 131 part, plasma separator 6 successively; Through the isolated blood plasma of plasma separator 6 along separated plasma pipeline 133, flow through resin anion (R.A.) adsorber arterial 134, resin anion (R.A.) adsorber 7, resin anion (R.A.) adsorber duct of Arantius 135 successively, enter concentrate blood outlet 132 and export 19 concentrate bloods of discharging by plasma separator 6 concentrate blood and converge, and then enter human body 2 times by blood circuit venous line.
In therapeutic process, when neutral macroporous resin adsorption device 5 or Anion-adsorption unit must stop treatment for a certain reason or change, can operate without the need to shutting down.When needing for a certain reason as needed when neutral macroporous resin adsorption device 5 stop treatment or change, open the second safety clamp 142, close the first safety clamp 141, the 4th safety clamp 144, the 6th safety clamp 146, blood just enters plasma separator arterial 131 by blood circuit arterial line 1, Anion-adsorption unit is made to proceed treatment, Microporous resin adsorber 5 then carries out necessary operation, as stopped treatment or changing.When Anion-adsorption unit needs stop treatment or change for a certain reason, stop the second blood pump 4, close the 4th safety clamp 144 and the 7th safety clamp 147, blood just enters Microporous resin adsorber arterial 111, Microporous resin adsorber 5, Microporous resin adsorber duct of Arantius 112 by blood circuit arterial line 1, enters human body 2 times through blood circuit venous line.Anion-adsorption unit then can operate accordingly, as changed or stopping treatment.
Threeway in the present embodiment also can be in prior art can the special three-port structure of control piper break-make.
Also can being respectively equipped with blood back mouth in Microporous resin adsorber arterial 111 He in plasma separator arterial 131 in the present embodiment, stopping the pipeline portions for the treatment of or replacing to carry out blood back for needing.In addition, in treatment or break through in advance in journey, turning operation is carried out by blood cleaning equipment or artificial centering macroporous resin adsorption device 5, plasma separator 6, resin anion (R.A.) adsorber 7 as required.
Embodiment four
Fig. 4 shows another kind of embodiment of the present utility model, and in the present embodiment, Microporous resin adsorber 5 is positioned at the upstream of Anion-adsorption unit.Along liquid flow direction, blood circuit arterial line 1 downstream separates Liang Ge branch, and one is Microporous resin adsorber arterial 211, is the first intervalve 221.Microporous resin adsorber arterial 211 is connected with the arterial end of Microporous resin adsorber 5, the vein end of Microporous resin adsorber 5 is connected with Microporous resin adsorber duct of Arantius 212, and the other end of Microporous resin adsorber duct of Arantius 212, first intervalve 221 one end, plasma separator arterial 231, the 3rd bypass 222 are interconnected by four-way 201.The concentrate blood outlet 19 of plasma separator 6 connects concentrate blood outlet 232, the separated plasma outlet 18 of plasma separator 6 is connected with separated plasma pipeline 233,3rd bypass 222 other end is communicated with separated plasma pipeline 233, separated plasma pipeline 233 other end connects the arterial end of resin anion (R.A.) adsorber 7, and resin anion (R.A.) adsorber duct of Arantius 234 is communicated with concentrate blood outlet 232.Concentrate blood outlet 232 is communicated with blood circuit venous line 2.The 3rd intervalve 223 is communicated with between Microporous resin adsorber duct of Arantius 212 and blood circuit venous line 2.
Microporous resin adsorber arterial 211, Microporous resin adsorber duct of Arantius 212, first intervalve 221, the 3rd bypass 222, the 3rd intervalve 223, plasma separator arterial 231, concentrate blood outlet 232, separated plasma pipeline 233 are respectively equipped with safety clamp.Safety clamp wherein on Microporous resin adsorber duct of Arantius 212 is arranged between the 3rd intervalve 223 and four-way; Safety clamp on concentrate blood outlet 232 is arranged between the concentrate blood outlet 19 of plasma separator 7 and resin anion (R.A.) adsorber duct of Arantius 234; Safety clamp in blood circuit venous line 2 is arranged on the pipeline between resin anion (R.A.) adsorber duct of Arantius 234 and the 3rd intervalve 223.
Microporous resin adsorber arterial 211 in the present embodiment, the Microporous resin adsorber duct of Arantius 212 between Microporous resin adsorber 5 and the 3rd intervalve 223 form the first branch road; Plasma separator arterial 231 and concentrate blood outlet 232 form the second branch road.It is the intermediate duct being connected Microporous resin adsorber 5 and Anion-adsorption unit at the 3rd intermediate duct 223 and the Microporous resin adsorber duct of Arantius 212 between plasma separator arterial 231.First intervalve 221 is the first blood bypass; 3rd intervalve 223 is the second bypass.
Dual Molecular Adsorption blood purification system in the present embodiment according to the needs in pre-punching or therapeutic process by opening or pressing from both sides and close and realize centering macroporous resin adsorption device 5 and Anion-adsorption unit individually operates safety clamp, can meet in the closed environment of whole system the operation rushed and treat or carry out due to special circumstances selective therapy in advance, change consumptive material.During owing to rushing in advance and treatment time operation and embodiment three similar, so place repeats no more.
Embodiment five
Fig. 5 shows another kind of embodiment of the present utility model, and in the present embodiment, Microporous resin adsorber 5 is positioned at the downstream of Anion-adsorption unit.Along liquid flow direction, blood circuit arterial line 1 downstream separates Liang Ge branch, and one is plasma separator arterial 331, and another is the first intervalve 321.The concentrate blood outlet of plasma separator 6 is connected with concentrate blood outlet 332; The separated plasma outlet of plasma separator 6 is connected with separated plasma outlet 333; Separated plasma outlet 333 other end is connected with the arterial end of resin anion (R.A.) adsorber 7, resin anion (R.A.) adsorber duct of Arantius 334 is communicated with concentrate blood outlet 332 or blood circuit venous line 2, and in the present embodiment, preferred anionic resin absorption device duct of Arantius 334 is communicated with concentrate blood outlet 332.Microporous resin adsorber arterial 311 one end is communicated with the first intervalve 321, and the other end is connected with the arterial end of Microporous resin adsorber 5; The vein end of Microporous resin adsorber 5 is connected with Microporous resin adsorber duct of Arantius 312 one end, and the other end of Microporous resin adsorber duct of Arantius 312 is communicated with blood circuit venous line 2.On the pipeline that first intervalve 321 and Microporous resin adsorber arterial 311 are communicated with and be provided with between blood circuit venous line 2 between second intervalve 322, second intervalve 322 and separated plasma outlet 333 and be interconnected by the 3rd intervalve 323.
Plasma separator arterial 331 is provided with the first safety clamp 341, first intervalve 321 is provided with the second safety clamp 342, separated plasma outlet 333 is provided with the 3rd safety clamp 343, second intervalve 322 is provided with the 4th safety clamp 344, 3rd intervalve 323 is provided with the 5th safety clamp 345, Microporous resin adsorber duct of Arantius 312 is provided with the 6th safety clamp 346, pipeline between Microporous resin adsorber duct of Arantius 312 and the second intervalve 322 is provided with the 7th safety clamp 347, resin anion (R.A.) adsorber duct of Arantius 334 is provided with the 8th safety clamp 348, concentrate blood outlet 332 is provided with the 9th safety clamp 349, pipeline between Microporous resin adsorber 5 arterial end and the second intervalve 322 is provided with the tenth safety clamp 340.
In the present embodiment, Microporous resin adsorber arterial 311 and Microporous resin adsorber duct of Arantius 312 form the first branch road; Plasma separator arterial 331 and concentrate blood outlet 332 form the second branch road.First intervalve 321 is the second bypass; Pipeline between the second intervalve 322 and Microporous resin adsorber duct of Arantius 312 is the first blood bypass.
When rushing in advance, optionally can carry out pre-punching separately according to demand, during as rushed in advance plasma separator 6, open the first safety clamp 341, the 7th safety clamp 347, close the second safety clamp 342, the 3rd safety clamp 343, the 8th safety clamp 348, rush liquid in advance and along pipeline, plasma separator 6 is rushed in advance.When needs rush separately in advance to resin anion (R.A.) adsorber 7, open the second safety clamp 342, the 5th safety clamp 345 and the 7th safety clamp 347, close the first safety clamp 341, the 3rd safety clamp 343, the 4th safety clamp 344, the 6th safety clamp 346, the 9th safety clamp 349, the tenth safety clamp 340, rush liquid in advance and along pipeline, resin anion (R.A.) adsorber 7 is rushed in advance.When needs centering macroporous resin adsorption device 5 rushes separately in advance, open the second safety clamp 342, the tenth safety clamp 340, the 6th safety clamp 346, close the first safety clamp 341, the 4th safety clamp 344, the 5th safety clamp 345, the 7th safety clamp 347, rush liquid in advance and carry out pre-punching separately along pipeline centering punching resin absorption device 5.Dual Molecular Adsorption blood purification system in certain the present embodiment, also can according to demand by safety clamp open and folder closes and controls and realize centering macroporous resin adsorption device 5 and Anion-adsorption unit and to connect pre-punching.
When treating, open the first safety clamp 341, 3rd safety clamp 343, 4th safety clamp 344, tenth safety clamp 340, 6th safety clamp 346, close the second safety clamp 342, 5th safety clamp 345, 7th safety clamp 347, blood enters blood circuit arterial line 1 from human body, plasma separator 6 is entered through plasma separator arterial 331, isolated blood plasma enters resin anion (R.A.) adsorber 7 through separated plasma outlet 333, resin anion (R.A.) adsorber duct of Arantius 334 is had to converge with the concentrate blood in concentrate blood outlet 332, and successively through the second intervalve 322, Microporous resin adsorber arterial 311, Microporous resin adsorber 5, Microporous resin adsorber duct of Arantius 312, blood circuit venous line 2 and the Huis' human body.
In therapeutic process as a certain reason and the treatment of Microporous resin adsorber 5 or Anion-adsorption unit need be stopped or changeing time, by safety clamp open and folder closes and realizes.If when need stop or changing Microporous resin adsorber 5, open the 7th safety clamp 347, close the 4th safety clamp 344, by the blood after the treatment of Anion-adsorption unit along blood circuit venous line 2 the Huis human body, thus can operate accordingly by centering macroporous resin adsorption device 5, as stopped treatment or changing.When need stop or Anion-adsorption unit time, open the second safety clamp 342, close the first safety clamp 341 and the 4th safety clamp 344, blood along the first intervalve 321, Microporous resin adsorber arterial 311, Microporous resin adsorber 5, Microporous resin adsorber duct of Arantius 312, blood circuit venous line 25 and return enter human body, and then according to demand Anion-adsorption unit is operated, when adjusting the safety clamp in blood circulator circuit after having operated again according to demand, then treat.
As seen from the above-described embodiment, dual Molecular Adsorption blood purification system of the present utility model by Microporous resin adsorber and Anion-adsorption units in series between blood circuit arterial line and blood circuit venous line, take full advantage of the whole blood perfusion safety of Microporous resin adsorber, whole blood perfusion is carried out to blood, resin anion (R.A.) adsorber then carries out plasma perfusion, improve the active adsorption of neutral macroporous adsorbent resin, thus improve therapeutic effect, or reach identical therapeutic effect by shortening the patient treatment time.
Above-described is only preferred implementation of the present utility model; it should be pointed out that for the person of ordinary skill of the art, under the prerequisite not departing from inventive concept of the present utility model; can also make some distortion and improvement, these all belong to protection domain of the present utility model.
Claims (10)
1. dual Molecular Adsorption blood purification system, comprise blood circuit arterial line, Microporous resin adsorber, Anion-adsorption unit and blood circuit venous line, it is characterized in that: described Microporous resin adsorber and Anion-adsorption unit are connected between described blood circuit arterial line and blood circuit venous line by intermediate duct, wherein said Anion-adsorption unit comprises plasma separator, resin anion (R.A.) adsorber, separated plasma pipeline and concentrate blood export pipeline, described plasma separator has separated plasma outlet and concentrate blood outlet, described concentrate blood export pipeline is connected to the outlet of described concentrate blood, described separated plasma pipeline is connected between the outlet of described separated plasma and described concentrate blood export pipeline, described resin anion (R.A.) adsorber is connected on described separated plasma pipeline.
2. dual Molecular Adsorption blood purification system according to claim 1, it is characterized in that: described Microporous resin adsorber is positioned at the upstream of described Anion-adsorption unit, described intermediate duct is connected with the vein end of described Microporous resin adsorber and the blood entry port of described plasma separator respectively.
3. dual Molecular Adsorption blood purification system according to claim 1, it is characterized in that: described Microporous resin adsorber is positioned at the downstream of described Anion-adsorption unit, be connected with one end of described intermediate duct after described concentrate blood export pipeline and described separated plasma pipeline collect, the other end of described intermediate duct is connected with the arterial end of described Microporous resin adsorber.
4. the dual Molecular Adsorption blood purification system according to any one of claims 1 to 3, is characterized in that: this system also comprises and the first blood bypass of described Microporous resin adsorbers parallel or second blood bypass in parallel with described Anion-adsorption unit.
5. the dual Molecular Adsorption blood purification system according to any one of claims 1 to 3, it is characterized in that: this system also comprises and the first blood bypass of described Microporous resin adsorbers parallel and second blood bypass in parallel with described Anion-adsorption unit, comprise the first blood bypass on-off system controlling described first blood bypass break-make in addition, control the second blood bypass on-off system of described second blood bypass break-make, second branch road on-off system of the first branch road on-off system controlling the first branch road break-make at described Microporous resin adsorber place and the second branch road break-make controlling described Anion-adsorption unit place.
6. dual Molecular Adsorption blood purification system according to claim 5, it is characterized in that: also comprise the 3rd blood bypass, the 3rd blood bypass walks around described Microporous resin adsorber makes the arterial end of described resin anion (R.A.) adsorber directly be communicated with described blood circuit arterial line with plasma separator.
7. dual Molecular Adsorption blood purification system according to claim 6, is characterized in that: described 3rd blood bypass is also connected with described intermediate duct, and described 3rd blood bypass comprises the on-off system controlling its break-make.
8. dual Molecular Adsorption blood purification system according to claim 5, is characterized in that: described first blood bypass is communicated with near Anion-adsorption unit side with described intermediate duct; Described second blood bypass is communicated with near Microporous resin adsorber side with described intermediate duct.
9. dual Molecular Adsorption blood purification system according to claim 5, is characterized in that: described first blood bypass on-off system, the second blood bypass on-off system, the first branch road on-off system and the second branch road on-off system are the safety clamp be arranged on corresponding pipeline.
10. the dual Molecular Adsorption blood purification system according to any one of claims 1 to 3, is characterized in that: described blood circuit arterial line is provided with the first blood pump, and described separated plasma pipeline is provided with the second blood pump.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114404703A (en) * | 2021-12-21 | 2022-04-29 | 健帆生物科技集团股份有限公司 | Combined artificial kidney and its pre-flushing method and working method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114404703A (en) * | 2021-12-21 | 2022-04-29 | 健帆生物科技集团股份有限公司 | Combined artificial kidney and its pre-flushing method and working method |
| CN114404703B (en) * | 2021-12-21 | 2024-03-26 | 健帆生物科技集团股份有限公司 | Combined artificial kidney, pre-flushing method and working method thereof |
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Address after: 519080 Zhuhai hi tech Zone No. six road, Guangdong Province, 98 Patentee after: Jianfan Biotechnology Group Co., Ltd. Address before: 519080 Zhuhai hi tech Zone No. six road, Guangdong Province, 98 Patentee before: Jafron Biomedical Co., Ltd. |