CN109758633A - A kind of filiform adsorbent perfusion device - Google Patents
A kind of filiform adsorbent perfusion device Download PDFInfo
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- CN109758633A CN109758633A CN201910077074.8A CN201910077074A CN109758633A CN 109758633 A CN109758633 A CN 109758633A CN 201910077074 A CN201910077074 A CN 201910077074A CN 109758633 A CN109758633 A CN 109758633A
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- adsorbent
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Abstract
The invention patent discloses a kind of Filamentous adsorbent perfusion device, belongs to the field of medical instrument technology.A kind of filiform adsorbent perfusion device is by shell, end cap, separation net, and Filamentous adsorbent is constituted.End cap is installed on shell both ends, and two filter screens are installed on interior of shell, and Filamentous adsorbent is placed between two filter screens.Filamentous adsorbent uses polyether sulfone, and polysulfones, polypropylene is fine or PEPA material.The invention patent using when be installed in dialysis machine, blood samples of patients is introduced into perfusion device, when flowing through Filamentous adsorbent, harmful waste in blood is adsorbed in adsorption filament hole by hydrogen bond, Van der Waals force, covalent bond, zwitterion effect etc., reaches therapeutic purposes.
Description
Technical field
The present invention relates to a kind of Filamentous adsorbent perfusion devices, and the perfusion device is in clinical treatment kidney trouble and acute and chronic poisoning
When can belong to the field of medical instrument technology with the objectionable impurities in Adsorption blood samples of patients.
Background technique
Blood perfusion is mainly used for treating the illnesss such as chronic renal failure, acute renal failure and drug poisoning, in clinic
On be widely applied.Blood samples of patients is introduced perfusion device by hemoperfusion treatment, and blood flows through the adsorbent in perfusion device
When, noxious material in blood is by chemisorption, and mechanism is trapped in adsorbent the effects of physical absorption, affine absorption, with
Blood separation reaches therapeutic purposes.
Blood perfusion device needs to contact with the blood samples of patients progress long period in use, and the treatment to chronic sufferer
It is periodic long-term treatment, cumulative contact time is longer, so the safety of adsorbent and biocompatibility are in perfusion device
It is extremely important.
In the prior art, the common active charcoal of blood perfusion device adsorbent material, the materials such as absorption resin, is made ball
Shape is particles filled in perfusion device.
Wherein the aperture of active carbon particle is limited to big middle molecule toxins Scavenging activity based on micropore (d < 2nm), simultaneously
The problem of active carbon particle easily causes small carbon granules to fall off, and causes blood embolization and white blood cell, and blood platelet declines.Although at present
Existing film-coating technique can solve the problems, such as that its blood compatibility is poor and carbon granules falls off to a certain extent, but coating also can shadow simultaneously
Its porosity and pore size are rung, and original problem can not avoid completely.In addition, in acticarbon preparation process,
It needs to remove grey matter purification through techniques such as overpicklings, pollutes more serious, preparation flow complexity.
Resin adsorption material mainly has polystyrene, acrylic resin, and polyvinyl alcohol etc. is generally made up of suspension polymerisation
Bead, preparation process residual and transportational process increase particle risk newly.Meanwhile blood compatibility is poor, needs by surface
Modification still has blood coagulation risk in treatment on this basis, needs test tube of hepari before the treatment, in pre- punching, therapeutic process
The anti-coagulants such as heparin are repeatedly added, making patients' angiocarpy burden increases treatment cost.
In addition, spherical adsorbent is deposited in perfusion device, hydrodynamic drag is big, in order to drain the gas in perfusion device
Bubble, thousands of milliliters etc. need to be prepared by rushing physiological saline in advance, be operated time-consuming and laborious.It is insufficient to will cause blood back again in blood back, it is residual
Blood is more.
Summary of the invention
The purpose of the present invention is to provide a kind of Filamentous adsorbent perfusion devices, aim to solve the problem that existing blood perfusion technique
In, because of particle risk caused by adsorbent material and shape, blood compatibility risk, anti-coagulants and pre- fliud flushing dosage are more, return
The problems such as blood is insufficient.
In order to solve the above-mentioned technical problem, the present invention adopts the following technical scheme:
A kind of filiform adsorbent perfusion device, which is characterized in that be equipped with shell, end cap, separation net, Filamentous adsorbent.
The end cap is fixed on shell both ends, and end cap is equipped with standard luer fittings.
The separation net is two panels, is individually fixed in interior of shell upper and lower ends, for fixed Filamentous adsorbent to be isolated.
The filiform adsorbent is placed between the separation net, material can for polyether sulfone, polysulfones, polypropylene be fine or PEPA
It is 1nm~40nm Deng, surface micropore diameter, specific surface area is 300~1500m2/ g, volume are 50mL~500mL.
The invention patent using when be installed in haemodialysis control unit, blood samples of patients introduces perfusion device by pipeline when being treated
Cavity, when blood flows through adsorbent, the toxin in blood plasma can pass through hydrogen bond, Van der Waals force, covalent bond, the machines such as zwitterion effect
System is adsorbed in the micropore of adsorption filament, and the haemocyte in blood plasma, high molecular weight protein etc. flow back to patient because cannot be introduced into micropore
In vivo, reach therapeutic purposes.
Compared to existing blood perfusion solution, the present invention has the following advantages:
The polyether sulfone that the present invention uses, polysulfones, it is haemodialyser common material that polypropylene is fine or the absorption material such as PEPA, warp
It crosses verifying and clinical use, blood compatibility for many years to have gained public acceptance, the anti-coagulants usage amount such as heparin can be effectively reduced, mitigated
Patient's angiocarpy and immune system burden；
Adsorbent of the invention uses filament, is made via solution-polymerized SBR, compared to traditional granular adsorbent, without micro-
Grain residual and particle generate risk, while during the spinning process compared to suspension polymerisation, spinneret speed and of uniform size, are easy to control
Drilling condition, tow surface pore is uniform, and selective adsorption capacity is stronger；
Tow of the present invention is uniformly distributed in perfusion device blood room, and liquid flow forces resistance is smaller, facilitates exclusion bubble when rushing in advance,
Pre- fliud flushing consumption is reduced, reduction rushes operating quantity in advance, also facilitates blood backflow in blood back, reduce residual blood；
The present invention, which adsorbs tow fabrication processes, can realize continuous production, and the continuous controllability of production technology is preferable, reduce pollution and material
Material waste；The high molecular material scalability that the present invention uses is preferable, can be made it have more by grafting, the methods of blending and modifying
Good biocompatibility or specific adsorption ability.
Detailed description of the invention
The present invention will be further described with reference to the accompanying drawings, but the content in attached drawing does not constitute any limitation of the invention.
Fig. 1 is a kind of structural schematic diagram of the invention；
Appended drawing reference are as follows:
101 shells；
201,202 end caps；
301,302 separation nets；
401 Filamentous adsorbents.
Specific embodiment
Below in conjunction with the drawings and the specific embodiments, the invention will be further described.
Embodiment 1
A kind of filiform adsorbent perfusion device, as shown in Figure 1, being equipped with shell 101, end cap 201,202, separation net 301,302 is Filamentous
Adsorbent 401.
The end cap 201,202 is fixed on 101 both ends of shell with ultrasonic Welding, and end cap is equipped with standard luer fittings,
Shell and end cap material can be PC or PP.
The separation net 301,302 is two panels, is individually fixed in 101 inside upper and lower ends of shell, for fixation to be isolated
Nylon can be selected in Filamentous adsorbent 401, separation net material.
The filiform adsorbent 401 is placed between the separation net 301,302, and material can be polyether sulfone, polysulfones, poly- third
Alkene is fine or PEPA etc., and surface micropore diameter is 1nm~40nm, and specific surface area is 300~1500m2/ g, volume be 50mL~
500mL。
In order to increase contact area and the time of contact of adsorbent 401 and blood, the noxious material in blood is allowed to adsorb more
Sufficiently, it can be pressed tow moulding by idler wheel at wavy when weaving tow.
The invention patent using when be installed in haemodialysis control unit, blood samples of patients introduces perfusion device by pipeline when being treated
Cavity, when blood flows through adsorbent, the toxin in blood plasma can pass through hydrogen bond, Van der Waals force, covalent bond, the machines such as zwitterion effect
System is adsorbed in the micropore of adsorption filament, and the haemocyte in blood plasma, high molecular weight protein etc. flow back to patient because cannot be introduced into micropore
In vivo, reach therapeutic purposes.
Embodiment 2
In embodiment 1, end cap 201 and 202 can be connect with the connection type of shell 101 for screw threads for fastening, and junction needs at this time
Sealing ring is installed additional to guarantee leakproofness.
Embodiment 3
In embodiment 1, adsorbent 401 can stack in cavity and place, further increase blood and absorption by weaving networking
The contact area of agent and time of contact promote therapeutic efficiency.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should be managed
Solution, can with modification or equivalent replacement of the technical solution of the present invention are made, without departing from technical solution of the present invention essence and
Range.
Claims (7)
1. a kind of filiform adsorbent perfusion device, is equipped with shell, end cap, separation net, Filamentous adsorbent；It is characterized by: using tree
The adsorption filament of rouge material is as adsorbent.
2. a kind of Filamentous adsorbent perfusion device according to claim 1, it is characterised in that: the end cap passes through ultrasonic bond shell
There are standard luer fittings at both ends on end cap.
3. a kind of Filamentous adsorbent perfusion device according to claim 1, it is characterised in that: the end cap is threadedly secured in
Shell both ends, centre, which is subject to sealing ring, to prevent from leaking.
4. a kind of Filamentous adsorbent perfusion device according to claim 1, it is characterised in that: the separation net is two panels, respectively
It is fixed in interior of shell upper and lower ends.
5. a kind of Filamentous adsorbent perfusion device according to claim 1, it is characterised in that: the filiform adsorbent material is poly-
Ether sulfone, polysulfones, polypropylene is fine or PEPA, surface micropore diameter are 1nm~40nm, and specific surface area is 300~1500m2/ g, volume
For 50mL~500mL.
6. a kind of Filamentous adsorbent perfusion device according to claim 1, Filamentous adsorbent form be it is wavy, be uniformly distributed
Between the separation net.
7. a kind of Filamentous adsorbent perfusion device according to claim 1, Filamentous adsorbent is woven to netted, is laminated in described
Between separation net.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910077074.8A CN109758633A (en) | 2019-01-28 | 2019-01-28 | A kind of filiform adsorbent perfusion device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910077074.8A CN109758633A (en) | 2019-01-28 | 2019-01-28 | A kind of filiform adsorbent perfusion device |
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| CN109758633A true CN109758633A (en) | 2019-05-17 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104902941A (en) * | 2013-02-12 | 2015-09-09 | 东丽株式会社 | Blood purification column |
| JP2016193178A (en) * | 2015-03-31 | 2016-11-17 | 東レ株式会社 | Purification column |
| JP2017185221A (en) * | 2016-03-30 | 2017-10-12 | 東レ株式会社 | Adsorption column |
| CN108114333A (en) * | 2016-11-28 | 2018-06-05 | 珠海健帆生物科技股份有限公司 | Apparatus for purifying blood, blood purification system and its pre- punching method |
-
2019
- 2019-01-28 CN CN201910077074.8A patent/CN109758633A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104902941A (en) * | 2013-02-12 | 2015-09-09 | 东丽株式会社 | Blood purification column |
| JP2016193178A (en) * | 2015-03-31 | 2016-11-17 | 東レ株式会社 | Purification column |
| JP2017185221A (en) * | 2016-03-30 | 2017-10-12 | 東レ株式会社 | Adsorption column |
| CN108114333A (en) * | 2016-11-28 | 2018-06-05 | 珠海健帆生物科技股份有限公司 | Apparatus for purifying blood, blood purification system and its pre- punching method |
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