CN1052004C - 杂环化合物及其制备和应用 - Google Patents

杂环化合物及其制备和应用 Download PDF

Info

Publication number
CN1052004C
CN1052004C CN94113866A CN94113866A CN1052004C CN 1052004 C CN1052004 C CN 1052004C CN 94113866 A CN94113866 A CN 94113866A CN 94113866 A CN94113866 A CN 94113866A CN 1052004 C CN1052004 C CN 1052004C
Authority
CN
China
Prior art keywords
ring
compound
alkyl
methyl
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94113866A
Other languages
English (en)
Chinese (zh)
Other versions
CN1107476A (zh
Inventor
夏苅英昭
石丸武范
土居孝行
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CN1107476A publication Critical patent/CN1107476A/zh
Application granted granted Critical
Publication of CN1052004C publication Critical patent/CN1052004C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN94113866A 1993-11-10 1994-11-10 杂环化合物及其制备和应用 Expired - Fee Related CN1052004C (zh)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
JP28117893 1993-11-10
JP281178/93 1993-11-10
JP281178/1993 1993-11-10
JP337488/1993 1993-12-28
JP337488/93 1993-12-28
JP33748893 1993-12-28
JP3363794 1994-03-03
JP033637/1994 1994-03-03
JP033637/94 1994-03-03
JP138551/94 1994-06-21
JP138551/1994 1994-06-21
JP13855194 1994-06-21

Publications (2)

Publication Number Publication Date
CN1107476A CN1107476A (zh) 1995-08-30
CN1052004C true CN1052004C (zh) 2000-05-03

Family

ID=27459814

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94113866A Expired - Fee Related CN1052004C (zh) 1993-11-10 1994-11-10 杂环化合物及其制备和应用

Country Status (16)

Country Link
US (1) US5585385A (cg-RX-API-DMAC7.html)
EP (1) EP0652218B1 (cg-RX-API-DMAC7.html)
KR (1) KR950014108A (cg-RX-API-DMAC7.html)
CN (1) CN1052004C (cg-RX-API-DMAC7.html)
AT (1) ATE203024T1 (cg-RX-API-DMAC7.html)
AU (1) AU678295B2 (cg-RX-API-DMAC7.html)
BR (1) BR9404403A (cg-RX-API-DMAC7.html)
CA (1) CA2135440A1 (cg-RX-API-DMAC7.html)
DE (1) DE69427675T2 (cg-RX-API-DMAC7.html)
FI (1) FI945281A7 (cg-RX-API-DMAC7.html)
HU (1) HUT68810A (cg-RX-API-DMAC7.html)
IL (1) IL111590A0 (cg-RX-API-DMAC7.html)
NO (1) NO301764B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ264887A (cg-RX-API-DMAC7.html)
RU (1) RU2135471C1 (cg-RX-API-DMAC7.html)
TW (1) TW263498B (cg-RX-API-DMAC7.html)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0733632B1 (en) * 1995-03-24 2003-06-04 Takeda Chemical Industries, Ltd. Cyclic compounds, their production and use as tachykinin receptor antagonists
US5770590A (en) * 1995-03-24 1998-06-23 Takeda Chemical Industries, Ltd. Cyclic compounds, their prudiction and use
FR2732221B1 (fr) * 1995-03-28 1997-04-25 Oreal Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue
GB9524104D0 (en) 1995-11-24 1996-01-24 Smithkline Beecham Spa Novel compounds
US6087373A (en) * 1997-09-23 2000-07-11 Merck & Co., Inc. Thrombin inhibitors
JP2001517623A (ja) * 1997-09-23 2001-10-09 メルク エンド カムパニー インコーポレーテッド トロンビン阻害薬
US5939432A (en) * 1997-10-29 1999-08-17 Medco Research, Inc. Thiophenes useful for modulating the adenosine receptor
US6727258B2 (en) 1997-10-29 2004-04-27 King Pharmaceutical Research & Development, Inc. Allosteric adenosine receptor modulators
US6323214B1 (en) 1997-10-29 2001-11-27 Medco Research, Inc Allosteric adenosine receptor modulators
WO2000012503A1 (en) * 1998-08-26 2000-03-09 Tanabe Seiyaku Co., Ltd. Naphthyridine derivatives and process for the preparation thereof
AU6228499A (en) * 1998-10-22 2000-05-08 Akzo Nobel N.V. Tetrahydropyridopyridine derivatives and intermediates for producing the same
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
JP2003501389A (ja) 1999-06-04 2003-01-14 メルク エンド カムパニー インコーポレーテッド トロンビン阻害物質
US20040152727A1 (en) * 2001-05-18 2004-08-05 Hay Douglas William Pierre Novel use
EP1457493A4 (en) 2001-12-10 2005-11-30 Kyorin Seiyaku Kk CONDENSED, BICYCLIC PYRIDINE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS
WO2003062245A1 (en) 2002-01-18 2003-07-31 Kyorin Pharmaceutical Co., Ltd. Fused bicyclic pyrimidine derivatives
AU2003211931A1 (en) * 2002-02-13 2003-09-04 Takeda Chemical Industries, Ltd. Jnk inhibitor
EP1496836B1 (en) 2002-03-15 2008-09-24 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
WO2003080626A1 (en) * 2002-03-26 2003-10-02 Kyorin Pharmaceutical Co., Ltd. Fused bicyclic pyridine derivative as tachykinin receptor antagonist
CA2509233A1 (en) * 2002-12-13 2004-07-01 Neurogen Corporation 2-substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators
RU2229475C1 (ru) * 2003-03-06 2004-05-27 ООО "Исследовательский институт химического разнообразия 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека
CA2539541C (en) * 2003-09-23 2010-06-29 Merck & Co., Inc. Isoquinolinone potassium channel inhibitors
WO2005030792A2 (en) * 2003-09-23 2005-04-07 Merck & Co., Inc. Quinoline potassium channel inhibitors
EP1705176A4 (en) * 2004-01-14 2009-06-03 Takeda Pharmaceutical CARBOXYLAMIDE DERIVATIVE AND ITS USE
KR100781704B1 (ko) * 2005-04-20 2007-12-03 에스케이케미칼주식회사 피리딘 유도체와 이의 제조방법, 및 이를 포함하는약제조성물
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR056048A1 (es) * 2005-09-01 2007-09-12 Tanabe Seiyaku Co Compuesto tiomorfolina y procedimiento para preparar el mismo
RU2359962C1 (ru) * 2007-12-13 2009-06-27 Общество с ограниченной ответственностью "Консорциум-ПИК" (ООО "Консорциум-ПИК") Нейротропное средство и способ его получения
RU2429230C1 (ru) * 2010-05-27 2011-09-20 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения n-метил-4-бензилкарбамидопиридиния йодида
EP2681200A4 (en) * 2011-03-03 2015-05-27 Zalicus Pharmaceuticals Ltd INHIBITORS OF BENZIMIDAZOLE TYPE OF SODIUM CHANNEL
CN102358730A (zh) * 2011-08-24 2012-02-22 济南赛文医药技术有限公司 一种小分子mek蛋白激酶抑制剂
WO2013097052A1 (en) * 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
EP2920183B1 (en) * 2012-11-14 2017-03-08 Glaxosmithkline LLC Thieno[3,2-c]pyridin-4(5h)-ones as bet inhibitors
RU2016102647A (ru) 2013-06-28 2017-08-01 Эббви Инк. Ингибиторы бромодомена
DK3265087T3 (da) 2015-03-04 2020-10-19 Vanda Pharmaceuticals Inc Fremgangsmåde til behandling med tradipitant
EP3133065A1 (en) 2015-08-21 2017-02-22 Merck Patent GmbH Compounds for optically active devices
BR112018071216A2 (pt) 2016-04-15 2019-02-05 Abbvie Inc inibidores de bromodomínios
EP3363786A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Compounds for optically active devices
EP3363793A1 (en) 2017-02-15 2018-08-22 Merck Patent GmbH Hydrophobic compounds for optically active devices
CA3073998A1 (en) 2017-09-13 2019-03-21 Vanda Pharmaceuticals Inc. Improved treatment of atopic dermatitis with tradipitant
WO2021233800A1 (en) 2020-05-20 2021-11-25 Merck Patent Gmbh Azacoumarin and azathiocoumarin derivatives for use in optically active devices
US11753413B2 (en) 2020-06-19 2023-09-12 Incyte Corporation Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
AU2021300429A1 (en) 2020-07-02 2023-02-16 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
WO2022046989A1 (en) 2020-08-27 2022-03-03 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
TW202302589A (zh) 2021-02-25 2023-01-16 美商英塞特公司 作為ｊａｋ２ ｖ６１７ｆ抑制劑之螺環內醯胺
CN119173514A (zh) 2022-03-17 2024-12-20 因赛特公司 作为jak2 v617f抑制剂的三环脲化合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0472116A1 (en) * 1990-08-17 1992-02-26 Takeda Chemical Industries, Ltd. Thienopyridine Derivatives, their production and use
EP0481383A1 (en) * 1990-10-16 1992-04-22 Takeda Chemical Industries, Ltd. Heterocyclic amine derivatives, their production and use
EP0566069A1 (en) * 1992-04-15 1993-10-20 Takeda Chemical Industries, Ltd. Tachykinin receptor antagonists, isoquinolones and their production

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom
IL75987A (en) * 1984-08-25 1991-07-18 Goedecke Ag Tri-and tetrasubstituted-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
TW205037B (cg-RX-API-DMAC7.html) * 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
WO1991009844A1 (en) * 1990-01-04 1991-07-11 Pfizer Inc. Substance p antagonists
WO1991012249A1 (en) * 1990-02-10 1991-08-22 Takeda Chemical Industries, Ltd. Chromene derivatives, their production and use
DE4215588A1 (de) * 1992-05-12 1993-11-18 Bayer Ag Biphenylmethyl-substituierte Pyridone
DE4215587A1 (de) * 1992-05-12 1993-11-18 Bayer Ag Sulfonylbenzyl-substituierte Benzo- und Pyridopyridone
EP0585913B1 (en) * 1992-09-04 1997-12-29 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
JPH06298757A (ja) * 1993-04-15 1994-10-25 Kissei Pharmaceut Co Ltd ピペリジノ−３，４−ジヒドロカルボスチリル誘導体

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0472116A1 (en) * 1990-08-17 1992-02-26 Takeda Chemical Industries, Ltd. Thienopyridine Derivatives, their production and use
EP0481383A1 (en) * 1990-10-16 1992-04-22 Takeda Chemical Industries, Ltd. Heterocyclic amine derivatives, their production and use
EP0566069A1 (en) * 1992-04-15 1993-10-20 Takeda Chemical Industries, Ltd. Tachykinin receptor antagonists, isoquinolones and their production

Also Published As

Publication number Publication date
RU2135471C1 (ru) 1999-08-27
TW263498B (cg-RX-API-DMAC7.html) 1995-11-21
IL111590A0 (en) 1995-01-24
CN1107476A (zh) 1995-08-30
FI945281L (fi) 1995-05-11
NO301764B1 (no) 1997-12-08
NO944252D0 (no) 1994-11-08
FI945281A7 (fi) 1995-05-11
FI945281A0 (fi) 1994-11-09
DE69427675T2 (de) 2002-05-16
BR9404403A (pt) 1995-07-18
NO944252L (no) 1995-05-11
EP0652218A1 (en) 1995-05-10
AU678295B2 (en) 1997-05-22
KR950014108A (ko) 1995-06-15
HUT68810A (en) 1995-05-19
RU94040174A (ru) 1996-10-10
ATE203024T1 (de) 2001-07-15
HU9403230D0 (en) 1995-01-30
NZ264887A (en) 1996-12-20
EP0652218B1 (en) 2001-07-11
AU7773894A (en) 1995-05-18
DE69427675D1 (de) 2001-08-16
US5585385A (en) 1996-12-17
CA2135440A1 (en) 1995-05-11

Similar Documents

Publication Publication Date Title
CN1052004C (zh) 杂环化合物及其制备和应用
CN1031570C (zh) 吡唑并吡啶化合物的制备方法
CN1189467C (zh) 药学活性磺酰胺衍生物
CN1254474C (zh) 作为多巴胺D<sub>3</sub>受体调节剂(精神抑制药)的四氢苯并氮杂䓬衍生物
CN1038511C (zh) 咪唑并吡啶及其制备方法和制药的应用
CN1040755C (zh) 杂环化合物的制备方法
CN1044237C (zh) 4,1－苯并氧氮杂䓬衍生物和其用途
CN1642915A (zh) 用作组蛋白脱乙酰基酶抑制剂的苯甲酰胺衍生物
CN1070404A (zh) 新的杂环衍生物
CN1633416A (zh) 用作p38抑制剂的烟酰胺衍生物
CN1325390A (zh) 2－脲基噻唑衍生物及其制备方法和作为抗肿瘤剂的应用
CN1073174A (zh) 杂环衍生物
CN101048412A (zh) 哌啶基氨基－噻吩并[2,3－d]嘧啶化合物
CN1113236A (zh) 非肽基速激肽受体拮抗剂
CN1140172A (zh) 环状化合物，它们的制备方法和用途
CN1950371A (zh) 用作组胺h3受体配体的四氢萘啶衍生物
CN1250776A (zh) 杂双环衍生物
CN1761671A (zh) 用作PDE7抑制剂的4－氨基噻吩并[2,3－d]嘧啶－6－甲腈衍生物
CN1585749A (zh) 类大麻苷受体配体
CN1379777A (zh) 氨基－三唑并吡啶衍生物
CN1017242B (zh) 新的喹唑啉衍生物的制备方法
CN1070173C (zh) 用作药物的苯甲酰基胍衍生物
CN1610671A (zh) 具有5－ht－拮抗特性的治疗用的喹啉化合物
CN1441801A (zh) 用作磷酸二酯酶抑制剂的取代的吡咯并吡啶酮衍生物
CN1777612A (zh) 新的哌啶基氨基－噻吩并[2,3－d]嘧啶化合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee