CN105189769A - 从腐霉属物种生产ω-3脂肪酸 - Google Patents
从腐霉属物种生产ω-3脂肪酸 Download PDFInfo
- Publication number
- CN105189769A CN105189769A CN201480026068.5A CN201480026068A CN105189769A CN 105189769 A CN105189769 A CN 105189769A CN 201480026068 A CN201480026068 A CN 201480026068A CN 105189769 A CN105189769 A CN 105189769A
- Authority
- CN
- China
- Prior art keywords
- biomass
- mould
- epa
- fatty acids
- corruption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000233639 Pythium Species 0.000 title claims abstract description 18
- 238000004519 manufacturing process Methods 0.000 title abstract description 12
- 235000020660 omega-3 fatty acid Nutrition 0.000 title 1
- 229940012843 omega-3 fatty acid Drugs 0.000 title 1
- 239000006014 omega-3 oil Substances 0.000 title 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims abstract description 63
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims abstract description 43
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims abstract description 42
- 239000000194 fatty acid Substances 0.000 claims abstract description 35
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 32
- 229930195729 fatty acid Natural products 0.000 claims abstract description 32
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 32
- 229940114079 arachidonic acid Drugs 0.000 claims abstract description 21
- 235000021342 arachidonic acid Nutrition 0.000 claims abstract description 21
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims abstract description 19
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 19
- 239000002028 Biomass Substances 0.000 claims description 54
- HXWJFEZDFPRLBG-UHFFFAOYSA-N Timnodonic acid Natural products CCCC=CC=CCC=CCC=CCC=CCCCC(O)=O HXWJFEZDFPRLBG-UHFFFAOYSA-N 0.000 claims description 15
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 12
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 8
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 8
- 239000008103 glucose Substances 0.000 claims description 7
- 229940041514 candida albicans extract Drugs 0.000 claims description 6
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 4
- 239000004641 Diallyl-phthalate Substances 0.000 claims description 4
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- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- SRBFZHDQGSBBOR-LECHCGJUSA-N alpha-D-xylose Chemical compound O[C@@H]1CO[C@H](O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-LECHCGJUSA-N 0.000 claims description 4
- 239000004202 carbamide Substances 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 229960003487 xylose Drugs 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 6
- 150000002632 lipids Chemical class 0.000 abstract description 33
- 241000195493 Cryptophyta Species 0.000 abstract description 15
- 241000894007 species Species 0.000 abstract description 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 abstract 4
- 241001505297 Pythium irregulare Species 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 27
- 235000019198 oils Nutrition 0.000 description 27
- 239000002253 acid Substances 0.000 description 23
- 210000004027 cell Anatomy 0.000 description 22
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 13
- 241000233866 Fungi Species 0.000 description 8
- 230000002159 abnormal effect Effects 0.000 description 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 241000251468 Actinopterygii Species 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 4
- 239000008272 agar Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
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- 241001465754 Metazoa Species 0.000 description 3
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- 238000012258 culturing Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 235000019387 fatty acid methyl ester Nutrition 0.000 description 3
- 238000010353 genetic engineering Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000002054 inoculum Substances 0.000 description 3
- 235000008935 nutritious Nutrition 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241000233654 Oomycetes Species 0.000 description 2
- 241000599030 Pythium debaryanum Species 0.000 description 2
- 241000918584 Pythium ultimum Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 235000012041 food component Nutrition 0.000 description 2
- 239000005417 food ingredient Substances 0.000 description 2
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- 239000011491 glass wool Substances 0.000 description 2
- 238000004442 gravimetric analysis Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
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- 239000004677 Nylon Substances 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000233612 Pythiaceae Species 0.000 description 1
- 241001622909 Pythium intermedium Species 0.000 description 1
- 241001325478 Pythium megalacanthum Species 0.000 description 1
- 241001622895 Pythium paroecandrum Species 0.000 description 1
- 241001622887 Pythium sylvaticum Species 0.000 description 1
- CWHJIJJSDGEHNS-MYLFLSLOSA-N Senegenin Chemical compound C1[C@H](O)[C@H](O)[C@@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)C(CC[C@]4(CCC(C[C@H]44)(C)C)C(O)=O)=C4[C@@H](CCl)C[C@@H]3[C@]21C CWHJIJJSDGEHNS-MYLFLSLOSA-N 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
- 239000012346 acetyl chloride Substances 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 238000011021 bench scale process Methods 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000010779 crude oil Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
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- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
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- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
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- 239000000284 extract Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 210000003495 flagella Anatomy 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 239000002035 hexane extract Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000006372 lipid accumulation Effects 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6463—Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fats And Perfumes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/788,372 | 2013-03-07 | ||
| US13/788,372 US9074160B2 (en) | 2013-03-07 | 2013-03-07 | Production of omega-3 fatty acids from pythium species |
| PCT/US2014/019882 WO2014137894A2 (en) | 2013-03-07 | 2014-03-03 | Production of omega-3 fatty acids from pythium species |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105189769A true CN105189769A (zh) | 2015-12-23 |
Family
ID=51488599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480026068.5A Pending CN105189769A (zh) | 2013-03-07 | 2014-03-03 | 从腐霉属物种生产ω-3脂肪酸 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9074160B2 (enExample) |
| EP (1) | EP2964772A4 (enExample) |
| JP (2) | JP2016513452A (enExample) |
| CN (1) | CN105189769A (enExample) |
| CA (1) | CA2904038C (enExample) |
| MX (1) | MX362260B (enExample) |
| TW (1) | TWI512108B (enExample) |
| WO (1) | WO2014137894A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105506008A (zh) * | 2015-12-03 | 2016-04-20 | 福建师范大学 | 一种富含ω-3脂肪酸单甘脂的制备方法 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3085962B1 (fr) | 2018-09-14 | 2021-06-18 | Fermentalg | Procede d'extracton d'une huile riche en pufa |
| FR3111912B1 (fr) | 2020-06-24 | 2025-10-03 | Fermentalg | Procédé de culture de microorganismes pour l’accumulation de lipides |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5246842A (en) * | 1991-10-30 | 1993-09-21 | The United States Of America As Represented By The Secretary Of Agriculture | Production of eicosapentaenoic acid from filamentous fungi utilizing lactose as a primary carbon source |
| US6255505B1 (en) | 1996-03-28 | 2001-07-03 | Gist-Brocades, B.V. | Microbial polyunsaturated fatty acid containing oil from pasteurised biomass |
| US8202713B2 (en) * | 2008-05-19 | 2012-06-19 | Zhiyou Wen | Producing eicosapentaenoic acid (EPA) from biodiesel-derived crude glycerol |
| CN101434908B (zh) * | 2008-12-10 | 2010-12-01 | 华中科技大学 | 产二十碳五烯酸油脂的腐霉及该油脂的发酵制备方法 |
| PE20130491A1 (es) * | 2009-12-30 | 2013-05-02 | Basf Pharma Callanish Ltd | Proceso simulado de separacion cromatografica de lecho movil para la purificacion de acidos grasos poliinsaturados |
| US8703473B2 (en) * | 2010-08-26 | 2014-04-22 | E I Du Pont De Nemours And Company | Recombinant microbial host cells for high eicosapentaenoic acid production |
| JP2014510166A (ja) | 2011-02-11 | 2014-04-24 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 短行程蒸留を使用する微生物源からのトリグリセリド油の精製 |
-
2013
- 2013-03-07 US US13/788,372 patent/US9074160B2/en active Active
-
2014
- 2014-03-03 CA CA2904038A patent/CA2904038C/en active Active
- 2014-03-03 WO PCT/US2014/019882 patent/WO2014137894A2/en not_active Ceased
- 2014-03-03 MX MX2015011508A patent/MX362260B/es active IP Right Grant
- 2014-03-03 JP JP2015561499A patent/JP2016513452A/ja active Pending
- 2014-03-03 EP EP14760704.8A patent/EP2964772A4/en active Pending
- 2014-03-03 CN CN201480026068.5A patent/CN105189769A/zh active Pending
- 2014-03-04 TW TW103107268A patent/TWI512108B/zh active
-
2019
- 2019-01-24 JP JP2019010411A patent/JP6888035B2/ja active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105506008A (zh) * | 2015-12-03 | 2016-04-20 | 福建师范大学 | 一种富含ω-3脂肪酸单甘脂的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016513452A (ja) | 2016-05-16 |
| EP2964772A4 (en) | 2016-10-05 |
| WO2014137894A2 (en) | 2014-09-12 |
| MX2015011508A (es) | 2016-04-07 |
| TWI512108B (zh) | 2015-12-11 |
| JP6888035B2 (ja) | 2021-06-16 |
| MX362260B (es) | 2019-01-09 |
| US20140256973A1 (en) | 2014-09-11 |
| JP2019090042A (ja) | 2019-06-13 |
| CA2904038A1 (en) | 2014-09-12 |
| TW201441371A (zh) | 2014-11-01 |
| CA2904038C (en) | 2020-04-14 |
| US9074160B2 (en) | 2015-07-07 |
| EP2964772A2 (en) | 2016-01-13 |
| WO2014137894A3 (en) | 2014-10-30 |
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