CN105168999A - Clam powder phlegm-reducing digestion-promoting effervescent tablet for bath and preparation method thereof - Google Patents

Abstract

The invention provides a clam powder phlegm-reducing digestion-promoting effervescent tablet for bath and a preparation method thereof. The effervescent tablet is prepared from the following raw materials by weight: 20 to 35% of a traditional Chinese medicine extract, 10 to 20% of an acid agent, 10 to 20% of an alkali agent, 30 to 50% of a filler, 1 to 10% of an adhesive, 1 to 10% of a lubricant and 0.1 to 1% of an aromatic. The traditional Chinese medicine extract comprises the following raw materials by weight: 50 to 70 parts of clam powder, 15 to 20 parts of Flemingia philippinensis, 15 to 20 parts of shepherd's purse, 8 to 12 parts of Palhinhaea cernua, 8 to 12 parts of Iresine herbstii Hook.f., 5 to 8 parts of pomelo flavedo, 5 to 8 parts of all grass of Hydrocotyle sibthorpioides Lam., 5 to 8 parts of Chinese banana root, 5 to 8 parts of goosegrass herb and 5 to 8parts of dried fruit of Vaccinium bracteatum Thunb. The preparation method comprises the following main steps: step 1, preparation of a traditional Chinese medicine extract: cleaning, impurity removal, mixing and extraction; and step 2, mixing: preparation of an acidic particle, preparation of an alkaline particle, mixing and tableting. After long-term usage, the clam powder phlegm-reducing digestion-promoting effervescent tablet is capable of reducing phlegm, removing food retention, clearing heat, drying dampness, resolving stagnation and clearing away toxic matters.

Description

A kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets and preparation method thereof

Technical field

the present invention relates to a kind of health body-wash articles for use, particularly a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets and preparation method thereof.

Background technology

in the traditional Chinese medical science, dipping method is one of external treatment, and namely by medicinal liquid or a kind of method containing medicinal liquid water washing bath whole body or local, its form is varied: have full bath and claim " liquid medicine bath "; The title having again " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. of local bathing, especially scalds the most conventional.

china's dipping, have existed since ancient times.The dipping side controlling baby's epilepsy is just had in China hospital < 52 Bingfang > the earliest.Say in " Book of Rites " " head has skin ulcer then to wash one's hair, and body has infections then to bathe ", have the record of " it is by exopathogen person, bathing the body with hot decoction to induce diaphoresis " in Huangdi's Internal Classics, can say, the history of dipping is of long standing and well established, is laid a foundation in the Qin Dynasty, develops in Chinese Tang, enriches in Song Ming, ripe in the Qing Dynasty.

the common dipping kind in current market is mainly divided three classes, comprise: full bath, demibain, foot bath, using method also very simple, only needs the liquid medicine dissolved in the bidet entering to mix up water temperature and the water yield or bath bucket, then health is steeped in water; Client progressively can experience the change that health occurs in the process of bathing.

the dipping mechanism of action in general, be drug effect in whole body flesh table, locally, affected part, and through absorb, follow network blood vessels of passing through, inside reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordination internal organs, current QI and blood, moisten the health maintenance effect such as foster whole body.Modern pharmacology also confirms, can improve the content of some immunoglobulin in blood after dipping, strengthens elasticity and the vigor of skin.

the medicine that on market, dipping is used mostly is medicinal liquid or medicated powder, medicinal liquid or medicated powder are not portable, and composition easily runs off, and the medicinal liquid that most of Chinese herbal medicine processes or medicated powder fully effectively cannot play the effective ingredient of Chinese crude drug, loss or the waste of drug effect can be caused, be prepared into effervescent tablet to be then convenient to preserve and carry, dissolution velocity is fast, bioavailability is high, can improve clinical efficacy.

at present, on market transforming phlegm and dispersing accumulations medicine or health product have a lot, but the effect of most drug is not fine, and the side effect of most drug is more, can damage health, therefore, market is badly in need of a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets and preparation method thereof.

Summary of the invention

the object of this invention is to provide a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets and preparation method thereof, life-time service has the effect of transforming phlegm and dispersing accumulations, heat clearing and damp drying, repercussive removing toxic substances.

object of the present invention is achieved through the following technical solutions:

a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets and preparation method thereof, be made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%; Described Chinese medicine extract Raw by weight, Pulvis concha Anodonta seu Cristaria 50-70 part, Radix Flemingiae Philippinensis 15-20 part, Herba Capsellae 15-20 part, Rhizoma et radix panici repentis 8-12 part, Herba Iresines Herbstii 8-12 part, Exocarpium Citri Grandis 5-8 part, Herba Hydrocotylis 5-8 part, Radix Musae 5-8 part, Herba Eleusines Indicae 5-8 part, Fructus Vaccinii Bracteati 5-8 part.

described Chinese medicine extract Raw presses optimum weight number, Pulvis concha Anodonta seu Cristaria 60 parts, Radix Flemingiae Philippinensis 18 parts, 17 parts, Herba Capsellae, Rhizoma et radix panici repentis 12 parts, Herba Iresines Herbstii 10 parts, Exocarpium Citri Grandis 8 parts, Herba Hydrocotylis 7 parts, Radix Musae 6 parts, Herba Eleusines Indicae 5 parts, Fructus Vaccinii Bracteati 5 parts.

described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.

described alkaline agent is sodium carbonate or sodium bicarbonate.

described filler is the mixing of microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more.

described binding agent is starch slurry or microcrystalline Cellulose.

described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate.

described a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets and preparation method thereof, the key step of its preparation method is:

step 1, prepare Chinese medicine extract:

a, by weight, choose the Pulvis concha Anodonta seu Cristaria of high-quality, Radix Flemingiae Philippinensis, Herba Capsellae, Rhizoma et radix panici repentis, Herba Iresines Herbstii, Exocarpium Citri Grandis, Herba Hydrocotylis, Radix Musae, Herba Eleusines Indicae, Fructus Vaccinii Bracteati, clean and remove impurity, mix homogeneously after remove impurity, decoct with water three times, first time adds the little fire of 12-15 water doubly and decocts 90-120 minute, filters, extracts filtrate, second time adds 10-12 water moderate heat doubly and decocts 60-90 minute, filter, extract filtrate, third time adds 6-8 water big fire doubly and decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract;

b, mixed extract to be concentrated, use spray dryer dry after concentrated, obtain solids mixing extract, pulverized 60-80 mesh sieve, and obtained solid particle;

step 2, mixing:

a, divide uniformly two parts by the solid particle obtained in step 1, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves;

b, first part of solid particle add the sour agent after pulverizing, filler, binding agent, then trough type mixing machine is put into, open trough type mixing machine and mix 30 minutes, in trough type mixing machine, add the PVPK30 alcoholic solution that concentration is 1%, soft material processed, add to soft material moderate after, soft material is put into oscillating granulator, makes granule, 60 eye mesh screens on oscillating granulator, dry, obtain acid particles;

c, second part of solid particle add alkaline agent, filler, binding agent after pulverizing, then trough type mixing machine is put into, open trough type mixing machine and mix 30 minutes, in trough type mixing machine, add the PVPK30 alcoholic solution that concentration is 1%, soft material processed, add to soft material moderate after, soft material is put into oscillating granulator, makes granule, 60 eye mesh screens on oscillating granulator, dry, obtain alkali grain;

d, by acid particles, alkali grain, lubricant, aromatic mixing, fully put into automatic tableting press tabletting after mixing, aluminum-plastic packaged, obtain a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets.

in medicine: Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations, heat clearing and damp drying, controls cough due to fluid-retention, stomachache, vomiting, leucorrhea, carbuncle, eczema; Radix Flemingiae Philippinensis expelling wind and removing dampness, repercussive detoxifies; Dispelling the wind and dampness pathogens arthralgia pain, chronic nephritis, traumatic injury, carbuncle, throat moth; Herba Capsellae and spleen, diuretic, hemostasis, improving eyesight; Control dysentery, edema, gonorrhea, chyluria, spit blood, have blood in stool, metrorrhagia, menorrhagia, conjunctival congestion and pain of eye; Rhizoma et radix panici repentis wind-damp dispelling, relaxing muscles and tendons network, invigorates blood circulation, hemostasis; It is numb that dispelling the wind and dampness pathogens arrests pain, hepatitis, dysentery, rubella, Akamu, and spit blood, epistaxis, has blood in stool, traumatic injury, soup, burning hot wound; Herba Iresines Herbstii removing heat from blood, hemostasis; Control haematemesis, epistaxis, hemoptysis, wound hemorrhage, dysentery, dysmenorrhea; Exocarpium Citri Grandis reduces phlegm, and regulates the flow of vital energy, and stomach invigorating helps digestion; Control expectorant in the heart stagnant, cough and asthma, vomiting singultus, eating accumulation; Herba Hydrocotylis controls sand Stranguria, jaundice, hepatitis, nephritis, and liver-fire is had a headache, acute catarrhal conjunctivitis; Radix Musae heat-clearing and toxic substances removing; Quench the thirst; Diuresis; Main calentura; Unhappiness is quenched one's thirst; Carbuncle furunculosis; Erysipelas; Metrorrhagia; Stranguria with turbid discharge; Edema; Foot gas; Herba Eleusines Indicae heat clearing away, dampness removing; The summer-heat that cures the wound generates heat, acute infantile convulsion, jaundice, dysentery, gonorrhea, dysuria; And can encephalitis b be prevented and treated; Fructus Vaccinii Bracteati supplementing the kidney to control the nocturnal, strong muscle improving eyesight; Control chronic diarrhea nocturnal emission, chronic dysentery chronic diarrhea, leucorrhea with red and white discharge.

beneficial effect of the present invention: a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets of the present invention, to cough due to fluid-retention, the main diseases such as stomachache, serving the effect of transforming phlegm and dispersing accumulations, heat clearing and damp drying, repercussive removing toxic substances in varying degrees, have the advantages such as health care, instant effect, pure natural, no side effects.

the present invention is through two groups of clinical verifications, and wherein one group is that treatment group uses the present invention, uses the present invention every day once, within 7 days, is a course for the treatment of, another group matched group takes clearing heat in the lung phlegm-reducing soup, once a day, within 7 days, is a course for the treatment of, every group selection outpatient 110 example, wherein man 55 example, female 55 example, max age 75 years old, minimal ages 29 years old, clinical manifestation is cough due to fluid-retention, stomachache, vomiting, leucorrhea, carbuncle, eczema, table one is for taking the contrasting data after the course for the treatment of:

table 1 is taken front and back and is compared (unit: people) two groups of courses for the treatment of

there were significant differences for treatment group and matched group, thus can find out that the present invention's application clinically has significant curative effect.

Detailed description of the invention

embodiment 1

a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets and preparation method thereof, be made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%; Described Chinese medicine extract Raw by weight, Pulvis concha Anodonta seu Cristaria 50-70 part, Radix Flemingiae Philippinensis 15-20 part, Herba Capsellae 15-20 part, Rhizoma et radix panici repentis 8-12 part, Herba Iresines Herbstii 8-12 part, Exocarpium Citri Grandis 5-8 part, Herba Hydrocotylis 5-8 part, Radix Musae 5-8 part, Herba Eleusines Indicae 5-8 part, Fructus Vaccinii Bracteati 5-8 part.

described Chinese medicine extract Raw presses optimum weight number, Pulvis concha Anodonta seu Cristaria 60 parts, Radix Flemingiae Philippinensis 18 parts, 17 parts, Herba Capsellae, Rhizoma et radix panici repentis 12 parts, Herba Iresines Herbstii 10 parts, Exocarpium Citri Grandis 8 parts, Herba Hydrocotylis 7 parts, Radix Musae 6 parts, Herba Eleusines Indicae 5 parts, Fructus Vaccinii Bracteati 5 parts.

described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.

described alkaline agent is sodium carbonate or sodium bicarbonate.

described filler is the mixing of microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more.

described binding agent is starch slurry or microcrystalline Cellulose.

described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate.

described a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets and preparation method thereof, the key step of its preparation method is:

step 1, prepare Chinese medicine extract:

a, by weight, choose the Pulvis concha Anodonta seu Cristaria of high-quality, Radix Flemingiae Philippinensis, Herba Capsellae, Rhizoma et radix panici repentis, Herba Iresines Herbstii, Exocarpium Citri Grandis, Herba Hydrocotylis, Radix Musae, Herba Eleusines Indicae, Fructus Vaccinii Bracteati, clean and remove impurity, mix homogeneously after remove impurity, decoct with water three times, first time adds the little fire of 12-15 water doubly and decocts 90-120 minute, filters, extracts filtrate, second time adds 10-12 water moderate heat doubly and decocts 60-90 minute, filter, extract filtrate, third time adds 6-8 water big fire doubly and decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract;

b, mixed extract to be concentrated, use spray dryer dry after concentrated, obtain solids mixing extract, pulverized 60-80 mesh sieve, and obtained solid particle;

step 2, mixing:

a, divide uniformly two parts by the solid particle obtained in step 1, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves;

b, first part of solid particle add the sour agent after pulverizing, filler, binding agent, then trough type mixing machine is put into, open trough type mixing machine and mix 30 minutes, in trough type mixing machine, add the PVPK30 alcoholic solution that concentration is 1%, soft material processed, add to soft material moderate after, soft material is put into oscillating granulator, makes granule, 60 eye mesh screens on oscillating granulator, dry, obtain acid particles;

c, second part of solid particle add alkaline agent, filler, binding agent after pulverizing, then trough type mixing machine is put into, open trough type mixing machine and mix 30 minutes, in trough type mixing machine, add the PVPK30 alcoholic solution that concentration is 1%, soft material processed, add to soft material moderate after, soft material is put into oscillating granulator, makes granule, 60 eye mesh screens on oscillating granulator, dry, obtain alkali grain;

d, by acid particles, alkali grain, lubricant, aromatic mixing, fully put into automatic tableting press tabletting after mixing, aluminum-plastic packaged, obtain a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets.

Claims (8)

1. a Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets, it is characterized in that: be made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%; Described Chinese medicine extract Raw by weight, Pulvis concha Anodonta seu Cristaria 50-70 part, Radix Flemingiae Philippinensis 15-20 part, Herba Capsellae 15-20 part, Rhizoma et radix panici repentis 8-12 part, Herba Iresines Herbstii 8-12 part, Exocarpium Citri Grandis 5-8 part, Herba Hydrocotylis 5-8 part, Radix Musae 5-8 part, Herba Eleusines Indicae 5-8 part, Fructus Vaccinii Bracteati 5-8 part.

2. a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets according to claim 1, it is characterized in that: described Chinese medicine extract Raw by optimum weight number, Pulvis concha Anodonta seu Cristaria 60 parts, Radix Flemingiae Philippinensis 18 parts, 17 parts, Herba Capsellae, Rhizoma et radix panici repentis 12 parts, Herba Iresines Herbstii 10 parts, Exocarpium Citri Grandis 8 parts, Herba Hydrocotylis 7 parts, Radix Musae 6 parts, Herba Eleusines Indicae 5 parts, Fructus Vaccinii Bracteati 5 parts.

3. a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets according to claim 1, is characterized in that: described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.

4. a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets according to claim 1, is characterized in that: described alkaline agent is sodium carbonate or sodium bicarbonate.

5. a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets according to claim 1, is characterized in that: described filler is the mixing of microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more.

6. a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets according to claim 1, is characterized in that: described binding agent is starch slurry or microcrystalline Cellulose.

7. a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets according to claim 1, is characterized in that: described lubricant is one or both the mixing in magnesium stearate, sodium lauryl sulphate.

8. a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets according to claim 1-7 and preparation method thereof, is characterized in that: the key step of its preparation method is:

Step 1, prepare Chinese medicine extract:

A, by weight, choose the Pulvis concha Anodonta seu Cristaria of high-quality, Radix Flemingiae Philippinensis, Herba Capsellae, Rhizoma et radix panici repentis, Herba Iresines Herbstii, Exocarpium Citri Grandis, Herba Hydrocotylis, Radix Musae, Herba Eleusines Indicae, Fructus Vaccinii Bracteati, clean and remove impurity, mix homogeneously after remove impurity, decoct with water three times, first time adds the little fire of 12-15 water doubly and decocts 90-120 minute, filters, extracts filtrate, second time adds 10-12 water moderate heat doubly and decocts 60-90 minute, filter, extract filtrate, third time adds 6-8 water big fire doubly and decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract;

B, mixed extract to be concentrated, use spray dryer dry after concentrated, obtain solids mixing extract, pulverized 60-80 mesh sieve, and obtained solid particle;

Step 2, mixing:

A, divide uniformly two parts by the solid particle obtained in step 1, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves;

B, first part of solid particle add the sour agent after pulverizing, filler, binding agent, then trough type mixing machine is put into, open trough type mixing machine and mix 30 minutes, in trough type mixing machine, add the PVPK30 alcoholic solution that concentration is 1%, soft material processed, add to soft material moderate after, soft material is put into oscillating granulator, makes granule, 60 eye mesh screens on oscillating granulator, dry, obtain acid particles;

C, second part of solid particle add alkaline agent, filler, binding agent after pulverizing, then trough type mixing machine is put into, open trough type mixing machine and mix 30 minutes, in trough type mixing machine, add the PVPK30 alcoholic solution that concentration is 1%, soft material processed, add to soft material moderate after, soft material is put into oscillating granulator, makes granule, 60 eye mesh screens on oscillating granulator, dry, obtain alkali grain;

D, by acid particles, alkali grain, lubricant, aromatic mixing, fully put into automatic tableting press tabletting after mixing, aluminum-plastic packaged, obtain a kind of Pulvis concha Anodonta seu Cristaria transforming phlegm and dispersing accumulations bath effervescent tablets.