CN105168461A - Paste for treating primary trigeminal neuralgia - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating primary trigeminal neuralgia. The traditional Chinese medicine preparation is mainly prepared from, by weight, 22%-36% of oysters, 5%-9% of liquorice, 6%-12% of safflower carthamus, 6%-15% of radix ligustici sinensis, 6%-12% of securinega suffruticosa, 2%-6% of asarum, 18%-28% of gypsum, 8%-12% of divaricate saposhnikovia roots, 3%-6% of scorpions, 4%-6% of centipedes, 20%-40% of the root of red-rooted salvia, 3%-6% of concha haliotidis, 12%-22% of red peony roots, 6%-9% of earthworms, 5%-12% of prunella vulgaris, 5%-15% of prepared peach kernels, 6%-12% of incised notopterygium, 4%-12% of chrysanthemum indicum, 6%-16% of radix angelicae, 5%-15% of uncaria rhynchophylla, 12%-22% of fried jujube kernels, 5%-9% of apocynum venetum, 8%-16% of poria cocos, 25%-35% of leonurus, 10%-20% of herba lycopi and 6%-9% of rhodiola rosea. The traditional Chinese medicine composition is scientific in component, a preparation method of various dosage forms is simple, and obtained products are convenient to take.

Description

A kind of unguentum for the treatment of primary trigeminal neuralgia

divisional application, original applying number 2014104439925, applying date 2014.09.03, the Chinese medicine preparation of title treatment primary trigeminal neuralgia and preparation method.

Technical field

The invention discloses a kind of Chinese medicine preparation, especially treat Chinese medicine preparation and the preparation method of primary trigeminal neuralgia.Belong to traditional Chinese medicine field.

Background technology

Primary trigeminal neuralgia refers to and has not showed nervous system signs, and there is no obviously relevant with morbidity organic or functional pathological changes with various inspection.The primary trigeminal neuralgia cause of disease is not yet completely clear, and around theory thinks that pathological changes is positioned at part between semilunar ganglion to pons, is caused by the compressing that causes due to many reasons; Maincenter theory thinks that trigeminal neuralgia is the outbreak of a kind of epilepsia thalamica sample, and paradoxical discharge position may at spinal nucleus of trigeminal nerve or brain stem.Grow up and old people common, within more than 40 years old, patient accounts for 70% ~ 80%, and women is more than male.Trigeminal neuralgia is often confined to nervi trigeminus one or two areal area, common with ramus maxillaris, ramus of mandible.Show as during outbreak with lower jaw on buccal and tongue significantly acutely shock by electricity sample, acupuncture sample, lancinate sample or tear sample pain, last for several seconds or 1 ~ 2 minute, burst is only prominent, and the intermission is completely normal.Patient's bicker, the wing of nose, buccal or tongue are sensitizing range, touch and can bring out, and are called trigger point or trigger point.Because of pain, several cases can occur that facial muscle reflexive is twitched, bicker is led to Ipsilateral and trismus dolorificus.The course of disease is in periodically, and outbreak not can be a few days, several weeks or several months not etc., and the catabasis is as ordinary person.Along with course of disease delay attack times will increase gradually, duration of seizure extends, and the intermission shortens, and is even persistence outbreak, little spontaneous recovery.The general no positive sign of neurologic check, patient's main manifestations dare not wash one's face, brushes teeth, take food because of Fear, Pain, and facial oral hygiene is poor, look wane and sallow, depressed.

Typical primary trigeminal neuralgia, according to panic attacks position, character, facial trigger point and the no positive sign of nervous system, is not difficult to make a definite diagnosis.For Therapeutic Method, choice drug treat, invalid or lost efficacy time select other therapies.Medicine can select carbamazepine, phenytoin Sodium, clonazepam or auxiliary megavitamin B12.The medicine does no good to can try dehydrated alcohol or glycerol closes nervi trigeminus branch or semilunar ganglion, destroys sensory neurone, can reach analgesic effect.Untoward reaction is injection zone facial anaesthesia.Or select radix sensoria nervi trigemini partial amputation, analgesic effect is definite, but can occur the complication such as auditory dysesthesia, aeroembolism and coaster, exhibition, the temporary paralysis of nervus facialis.Publication number CN103301294A(application number 201310280379.1) Chinese patent literature disclose a kind of pharmaceutical composition for the treatment of primary trigeminal neuralgia, it is made up of the material of following weight proportioning: Folium Sauropi, Herba Thlaspis, Radix Et Rhizoma Rhei, Folium Isatidis, Rhizoma Polygoni Cuspidati, RADIX PEUCEDANI, Herba Portulacae, Rhizoma Coptidis, Rhizoma Saururi (Herba Saururi), Myrrha, Fructus Phyllanthi, Herba Menthae, Herba Potentillae Discoloris, Herba pterocephali, Eupolyphaga Seu Steleophaga, Rhizoma Drynariae, Scorpio, Cortex Syingae Amurensis, Medulla Stachyuri (Medulla Helwingiae), Flos Caryophylli, Flos Bombacis Malabarici, Zaocys, Herba Gendarussae, Cortex Phellodendri, Rhizoma Chuanxiong, Rhizoma Cimicifugae, Flos Rhododendri Mollis, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, Rhizoma Dioscoreae Septemlobae, Cortex Dictamni, Fructus Forsythiae, Herba Polygoni cymosi, Semen Trigonellae and Semen Litchi.Publication number CN103585417A(application number 201310586682.4) Chinese patent literature disclose a kind of medicament for the treatment of primary trigeminal neuralgia, it is made up by weight of following bulk drugs: 10 parts, flag, Herba Piperris Tonkinensis 15 parts, Flos koelreuteriae paniculatae 15 parts, Herba Heliotroph 20 parts, Herba Monochoriae Korsakowii 10 parts, Flos Woodfordiae Fruticosae 10 parts, 5 parts, ten liang of leaves, Herba Epilobii Angustifoii 15 parts, HERBA VERONICAE DILATATAE 15 parts, Herba indigoferae bungeanae 10 parts, Herba Tricyrtis Pilosae 15 parts and Herba Zornia Diphyllae 10 parts.Publication number CN101623404A(application number 200910065763.3) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of primary trigeminal neuralgia, the raw material mainly containing following weight portion is made: Rhizoma Chuanxiong 10-30 part, Bombyx Batryticatus 10-30 part, Rhizoma Acori Graminei 10-30 part, Rhizoma Typhonii 6-25 part, Radix Angelicae Dahuricae 6-25 part, Herba Asari 2-15 part.

In a word, the etiology unknown of primary trigeminal neuralgia, recurrent exerbation, is difficult to cure, although Therapeutic Method is many now, all undesirable, the therapy of also not thoroughly radical cure at present, and the effect of Chinese traditional treatment needs to be improved further.

Summary of the invention

Not enough for prior art, the object of this invention is to provide a kind of Chinese medicine preparation for the treatment of primary trigeminal neuralgia, there is feature simple to operate, evident in efficacy, and it adopts comparatively common Chinese crude drug with low cost, without financial burden.

Technical scheme of the present invention is:

The Chinese medicine preparation for the treatment of primary trigeminal neuralgia, the main raw material(s) taking off row weight proportion is prepared from: Concha Ostreae 22-36; Radix Glycyrrhizae 5-9; Flos Carthami 6-12; Rhizoma Ligustici 6-15; Cacumen Securinegae Suffruticosae 6-12; Herba Asari 2-6; Gypsum Fibrosum 18-28; Radix Saposhnikoviae 8-12; Scorpio 3-6; Scolopendra 4-6; Radix Salviae Miltiorrhizae 20-40; Concha Haliotidis 3-6; Radix Paeoniae Rubra 12-22; Pheretima 6-9; Spica Prunellae 5-12; Semen Persicae 5-15 processed; Rhizoma Et Radix Notopterygii 6-12; Herba Dendranthematis indici 4-12; Radix Angelicae Dahuricae 6-16; Ramulus Uncariae Cum Uncis 5-15; Semen Ziziphi Spinosae (parched) 12-22; Herba Apocyni veneti 5-9; Poria 8-16; Herba Leonuri 25-35; Herba Lycopi 10-20; Radix Rhodiolae 6-9.

Preferred version is: Concha Ostreae 28-30; Radix Glycyrrhizae 6-8; Flos Carthami 8-10; Rhizoma Ligustici 9-12; Cacumen Securinegae Suffruticosae 8-10; Herba Asari 3-5; Gypsum Fibrosum 22-24; Radix Saposhnikoviae 9-11; Scorpio 4-5; Scolopendra 4-6; Radix Salviae Miltiorrhizae 28-32; Concha Haliotidis 4-5; Radix Paeoniae Rubra 15-19; Pheretima 7-8; Spica Prunellae 7-10; Semen Persicae 9-11 processed; Rhizoma Et Radix Notopterygii 8-10; Herba Dendranthematis indici 7-9; Radix Angelicae Dahuricae 10-12; Ramulus Uncariae Cum Uncis 9-11; Semen Ziziphi Spinosae (parched) 15-19; Herba Apocyni veneti 6-8; Poria 11-13; Herba Leonuri 28-32; Herba Lycopi 14-16; Radix Rhodiolae 7-8.

Be more preferably: Concha Ostreae 29, Radix Glycyrrhizae 7, Flos Carthami 9, Rhizoma Ligustici 10.5, Cacumen Securinegae Suffruticosae 9, Herba Asari 23, Gypsum Fibrosum 23, Radix Saposhnikoviae 10, Scorpio 4.5, Scolopendra 5, Radix Salviae Miltiorrhizae 30, Concha Haliotidis 4.5, Radix Paeoniae Rubra 17, Pheretima 7.5, Spica Prunellae 8.5, Semen Persicae 10 processed, Rhizoma Et Radix Notopterygii 9, Herba Dendranthematis indici 8, the Radix Angelicae Dahuricae 11, Ramulus Uncariae Cum Uncis 10, Semen Ziziphi Spinosae (parched) 17, Herba Apocyni veneti 7, Poria 12, Herba Leonuri 30, Herba Lycopi 15, Radix Rhodiolae 7.5.

Present invention also offers and this Chinese medicine preparation is made pharmaceutically acceptable decoction, powder, pill and unguentum.

The preparation method of described decoction is as follows:

1. Concha Ostreae, Gypsum Fibrosum, Concha Haliotidis are smashed, put into saline and soak 50-70 minute (preferably 60 minutes), water consumption is 3-4 times (preferably 3.5 times) of medical material weight;

2. be heated to boiling, turn slow fire boiling 40-50 minute (preferably 45 minutes), leach medicinal liquid, recrement adds water and continues to decoct 30-40 minute (preferably 35 minutes), crosses and filters recrement, mix twice gained medicinal liquid;

3. Radix Glycyrrhizae, Flos Carthami, Rhizoma Ligustici, Cacumen Securinegae Suffruticosae, Herba Asari, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Pheretima, Spica Prunellae, Semen Persicae processed, Rhizoma Et Radix Notopterygii, Herba Dendranthematis indici, the Radix Angelicae Dahuricae, Ramulus Uncariae Cum Uncis, Semen Ziziphi Spinosae (parched), Herba Apocyni veneti, Poria, Herba Leonuri, Herba Lycopi, Radix Rhodiolae are pulverized, cross 110-130 mesh sieve (preferably 120 orders), obtain fine powder;

4. by step 3. in fine powder mix homogeneously, be placed in bag filter, soak 30-50 minute (preferably 40 minutes) with clear water, water consumption be the 2-4 of fine powder weight doubly (preferably 3 times), intense fire is fried open fire of larding speech with literary allusions and boils 30-40 minute (preferably 35 minutes), obtains medicinal liquid;

5. Scorpio, Scolopendra are pulverized, cross 80-100 order (preferably 90 orders) sieve, obtain even medicated powder;

6. mix the whole medicinal liquid of above-mentioned gained, then add step 5. in medicated powder, obtain Chinese medicine decoction.

The preparation method of described powder is:

1. first Concha Ostreae, Herba Asari, Gypsum Fibrosum, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Ziziphi Spinosae (parched), Herba Leonuri, Herba Lycopi are put into mortar, gently grind mixing, then add surplus stock medicine gradually, until all pulverize;

2. by step 1. in medicated powder, sieving obtains that granular size is identical, the Chinese powder medicine of mix homogeneously.

The preparation method of described powder, step 2. in the order number of sieve be 70-90 order (preferably 80 orders).

The preparation process of described pill is as follows:

1. Scorpio, Scolopendra, Cacumen Securinegae Suffruticosae are put into marmite, slow fire fries ten minutes, and taking-up is smashed to pieces;

2. will remain the drip washing of medical material clear water, crushed after being dried becomes powder;

3. gained medicated powder is crossed 90 mesh sieves, add water and generally make ball;

4. 8mm medicine sieve crossed by the pill made, and selects pill of the same size, encapsulates after dry sterilization.

The preparation method of described unguentum:

1. first Concha Ostreae, Herba Asari, Gypsum Fibrosum, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Ziziphi Spinosae (parched), Herba Leonuri, Herba Lycopi are put into mortar, gently grind mixing, then add surplus stock medicine gradually, until all pulverize;

2. by step 1. in gains, cross 70-90 order (preferably 80 orders) sieve and obtain the medicated powder of mix homogeneously;

3. in medicated powder, add Mel, modulation is shaped, and spreads upon in the circular framed back material of diameter 3cm, makes Chinese medicinal ointment.

Present invention also offers the application of described Chinese medicine preparation when preparing the medicine for the treatment of primary trigeminal neuralgia.

The pharmacological effect of each crude drug is respectively:

Concha Ostreae: nature and flavor with return through: salty, be slightly cold.Return liver, gallbladder, kidney channel.There is tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, effect of hard masses softening and resolving.For insomnia of palpitating with fear, dizzy ear toot, scrofula sucutaneous nodule, abdominal mass abdominal mass mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating, relieving gastric hyperacidity to alleviate stomachache.For spontaneous sweating, emission and spermatorrhea, bleeding not during menses, stomachache acid regurgitation.

Radix Glycyrrhizae: sweet in the mouth, property is put down.There is QI invigorating invigorating middle warmer, relieving spasm to stop pain, effect of eliminating fire and detoxication, for the disease of laryngopharynx swelling and pain.

Flos Carthami: base is former: Compositae, Flos Carthami platymiscium, dry tubular flower, orange red.Chemical composition: containing carthamone, neocarthamin, saffloside, Carthamus yellow and flavochrome.Another containing safflower oil, oil comprises Palmic acid, myristic acid, lauric acid, stearic acid, arachidic acid, oleic acid etc.Pharmacological action: the effect having slight excited heart, reduce coronary resistance, increase coronary flow and cardiac muscle nutritional blood flow; Protect and improve myocardial ischemia, reducing myocardial infarct size; Reddish yellow pigment separator can to arrhythmia; Decoct, Aqueous extracts, Carthamus yellow etc. can be expanded peripheral vessels, reduce blood pressure.Energy anticoagulant, fortifying fibre protein dissolution, reduces whole blood viscosity.Injection, ethanol extract, saffloside can significantly improve hypoxia-bearing capability, have protective effect to the weary oxygen encephalopathy of ischemia.Nature and flavor with return through: pungent, temperature.GUIXIN, Liver Channel.There is effect of promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.For controlling amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.

Rhizoma Ligustici: nature and flavor with return through: pungent, temperature.Return urinary bladder channel.Dispel the wind, cold expelling, dehumidifying, effect of pain relieving.For anemofrigid cold, top, mountain peak pain, rheumatic arthralgia.

Cacumen Securinegae Suffruticosae: base is former: be browse or the root of Euphorbiaceae Suffrutescent Securinega Twig platymiscium Suffrutescent Securinega Twig.Composition: Herb contains alkaloid: Securinine, Suffrutescent Securinega Twig alkali.Containing dihydrosecurinine in leaf, securinol A, B, securinol C picrate, Bie Securinine, Securinine; Also containing phenolic constituent: Herba Euphorbiae Helioscopiae tannin B and the nor-Bergeninum of 11-O-galloyl.Containing gallic acid etc. in stem.The property of medicine: pungent, bitter, tepor, slightly poisonous.Function cures mainly: expelling wind and activating blood circulation, the strong muscle of kidney tonifying.Cure mainly lumbago due to pathogenic wind-dampness, sexual impotence, dizzy, tinnitus, deaf, facial paralysis, poliomyelitis sequela.

Herba Asari: nature and flavor with return through: pungent, temperature.GUIXIN, lung, kidney channel.There is expelling wind and cold, wind-expelling pain-stopping, sensible, effect of warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.

Gypsum Fibrosum: Gypsum Fibrosum is monoclinic system mineral, main chemical compositions is calcium sulfate (CaSO ₄) hydrate.Gypsum Fibrosum is natural dihydrate gypsum (CaSO both ₄2H ₂o).Nature and flavor: pungent, sweet, are slightly cold.Attach to the lung and stomach meridians.Have clearing away heat-fire, relieving restlessness is quenched the thirst, effect of convergence granulation promoting.Cure mainly: apoplexy cold and heat, heart subinverse gas is frightened to be breathed heavily, and xerostomia scorching tongue, can not cease, hardness and fullness in the abdomen pain, evil removing ghost, puerperium incised wound.Except seasonal epidemic pathogens headache fever of the body, three burnt large heat, skin heat, stagnation of QI in the intestines and stomach, expelling pathogenic factors from muscles by diaphoresis, restlessness accompanied by ascending of QI of only quenching one's thirst, the sudden and violent gas of abdominal distention, pharynx heat of panting, also can do bath soup.Cure the wound cold headache as split.Simmer tea with Herba Alii fistulosi, pain of decaptitating.Control sky capable fanatic, wind syndrome of head revolves, stimulating milk secretion, wipes tooth benefit tooth.Except gastric heat lung-heat, loose YIN pathogen, slow spleen QI invigorating.Only Yangming Channel headache, fever with chills, day feeds hectic fever, and drinking a large amount of water due to extreme thirst, heatstroke hectic fever, has a toothache.

Radix Saposhnikoviae: nature and flavor: pungent, sweet, tepor.Gui Jing: return bladder, lung, spleen, Liver Channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain.Cure mainly: for affection of exogenous wind-cold, headache general pain, rheumatic arthralgia.

Scorpio: nature and flavor with return through: pungent, flat; Poisonous.Return Liver Channel.There is endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, effect of dispersing pathogen accumulation.For liver-wind stirring up internally, spasm twitch, infantile convulsion, middle air port fish sticking its mouth out of the water, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.

Scolopendra: nature and flavor with return through: pungent, temperature; Poisonous.Return Liver Channel.There is endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, effect of dispersing pathogen accumulation.For liver-wind stirring up internally, spasm twitch, infantile convulsion, middle air port fish sticking its mouth out of the water, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula, snake bite and insect sting.

Radix Salviae Miltiorrhizae: nature and flavor are bitter, cold nature.Energy blood circulation promoting and blood stasis dispelling, removing heat from blood, calms the nerves.Enter the heart, spleen two warp.According to " book on Chinese herbal medicine is looked for the truth ": Radix Salviae Miltiorrhizae has the effect into percardium removing blood stasis with potent drugs.Modern medicine study confirms, its energy coronary artery dilator, increases coronary flow, improve myocardial ischemia, infraction and cardiac function, regulate the rhythm of the heart, and can expand peripheral blood vessel, improve microcirculation; Body's hypoxia tolerance can be improved; There is anticoagulation, promote fibrinolytic, suppress platelet aggregation, the effect of inhibition thrombosis; Can blood fat be reduced, suppress coronary atherosclerosis to be formed; The convalescent period of erythrocyte and hematochrome can be shortened, Reticulocyte is increased, the reparation organized can be promoted, accelerate the healing of fracture; Nervus centralis is had to have inhibitory action; There is antitumor action; Energy enhancing human body immunity function; Blood glucose can be reduced; Inhibitory action is had to various bacteria such as tubercule bacillus.

Concha Haliotidis: have another name called Carnis Haliotidis first, Herba Senecionis Scandentis, abalone shells, for Bao Kebao belongs to the shell of animal Haliotis diversicolor, haliotis discus hannai Ino, sheep Bao, haliotis ruber, ear Bao, white Bao etc.The property of medicine: salty in the mouth, cold in nature.Composition: main component is calcium carbonate, also has conchiolin and Choline.Find according to modern pharmacological research, this medical instrument have protecting the liver, expand trachea, in and gastric acid, improving eyesight removing nebula effect, dizzy for having a headache, blurring of vision, optic atrohic blindness nyctalopia.

Radix Paeoniae Rubra: sour in the mouth, hardship, cool in nature.There is eliminating stasis to stop pain, effect of removing heat from blood detumescence, for stomachache, hypochondriac pain, discharging fresh blood stool, conjunctival congestion, carbuncle

Pheretima: nature and flavor with return through: salty, cold.Return liver, spleen, urinary bladder channel.There is heat clearing away to calm the frightened, dredging collateral, relieving asthma, effect of diuresis.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, edema oliguria.

Spica Prunellae: nature and flavor with return through: pungent, bitter, cold.Return liver, gallbladder meridian.There is purging liver-fire, improving eyesight, effect of mass dissipating and swelling eliminating.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, acute mastitis, nodules of the breast, distending pain of the breast.

Semen Persicae: bitter in the mouth, sweet, property is put down, GUIXIN, liver, large intestine channel.There is effect of blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, for amenorrhea. dysmenorrhea. mass in the abdomen mass in the abdomen, injury from falling down, dryness of the intestine constipation.Concocting method is Dan Semen Persicae, gets clean Semen Persicae, and according to the peeling of Dan method, the used time smashs to pieces.

Rhizoma Et Radix Notopterygii: warm in nature, acrid in the mouth, hardship.Have that cold expelling dispels the wind, the function of removing damp and stopping pain.For anemofrigid cold, headache body pain.The pungent temperature of this product, gas is male and fall apart, delivers power strong, the heresy of main fall apart Taiyang channel ailment said due to cold or exposure and cold-damp, has cold expelling to dispel the wind, the merit of removing dampness to relieve pain.

Herba Dendranthematis indici: base is former: be root or the herb of Compositae Dendranthema Herba Dendranthematis indici or lavandulaleaf dendranthema herb.The property of medicine: bitter, acrid, cold.Return liver, heart channel.Function cures mainly: heat-clearing and toxic substances removing, improving eyesight.Cure mainly flu, dysentery, carbuncle, furuncle, conjunctival congestion and swelling pain, dizzy, scrofula, eczema.

The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature.For inducing sweat, dispel-wind drug.There is expelling wind and removing dampness, understand things pain-stopping, effect of detumescence and apocenosis, for headache of catching a cold, nasal obstruction, nasal sinusitis.

Ramulus Uncariae Cum Uncis: nature and flavor with return through: sweet, cool.Return liver, pericardium channel.There is dispelling wind and relieving convulsion, effect of heat clearing away suppressing the hyperactive liver.For liver-wind stirring up internally, infantile convulsion is twitched, and hyperpyrexia convulsion, dysphoric cold, children's's night crying due to fright in infant, pre-eclampsia, has a headache dizzy.

Semen Ziziphi Spinosae: another name: Semen Ziziphi Spinosae, nature and flavor with return through: sweet, sour, flat.Return liver, gallbladder, heart channel.Nourish heart tonifying liver, mind tranquilizing and the heart calming, arresting sweating, the effect of promoting the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.Semen Ziziphi Spinosae (parched): get clean Semen Ziziphi Spinosae, fry to heaving according to frying method, color is micro-to be deepened.Used time smashs to pieces.

Poria: nature and flavor with return through: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, effect of mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Herba Apocyni veneti: base is former: be the leaf of Apocynaceae Apocynum plant Herba Apocyni veneti.Composition: leaf contains Quercetin, isoquercitrin, hyperin, Trifolin, cloud English glycosides, rutin, cianidanol, anthraquinone, and the several amino acids such as glutamic acid, alanine.The property of medicine: sweet, micro-hardship, cool.Function cures mainly: heat clearing away, and suppressing the hyperactive liver is calmed the nerves, diuretic.Cure mainly hypertension, dizzy, headache, cardiopalmus, insomnia, edema oliguria.

Herba Leonuri (Herba Leonuri): nature and flavor with return through: bitter, pungent, be slightly cold.Return liver, pericardium, urinary bladder channel.There is promoting blood flow to regulate menstruation, inducing diuresis to remove edema, effect of heat-clearing and toxic substances removing.For menoxenia, dysmenorrhea amenorrhea, lochiorrhea, edema oliguria, sore swollen toxin.

Herba Lycopi: nature and flavor with return through: bitter, pungent, tepor.Return liver, spleen channel.There is promoting blood flow to regulate menstruation, blood stasis dispelling eliminating carbuncle, effect of inducing diuresis to remove edema.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, sore and toxic, edema ascites.

Radix Rhodiolae: another name: Rhizoma Rhodiolae kirilowii, base is former: be the root and rhizome of Crassulaceae Rhodida plant Rhodiola kirilowii (Regel) Maxim..Composition: herb is containing butyl alcohol, and daucosterol, rhodioside, hundred arteries and veins are with glycosides.The property of medicine: bitter, puckery, temperature.Return lung, the heart, liver, large intestine channel.Function cures mainly: tranquilizing by nourishing the heart, blood stasis dispelling, hemostasis.Cure mainly deficiency of vital energy and physically weak, weak palpitation and insomnia of losing heart, dizzy dizzy, pain uncomfortable in chest, traumatic injury, menoxenia, metrorrhagia, spits blood, dysentery, diarrhoea.Compatibility and incompatibility of drugs: " Shaanxi Chinese herbal medicine ": " anemia of pregnant woman prohibits clothes, excessive also removing blood stasis.”

Chinese medicine composition scientific formula provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, and in addition, excellent results of the present invention also shows:

1, get Concha Ostreae, Radix Salviae Miltiorrhizae, Herba Leonuri in side for monarch, described Concha Ostreae and Radix Salviae Miltiorrhizae cooperatively interact, for primary trigeminal neuralgia, by coronary artery dilator, increase coronary flow, improve microcirculation to improve neuralgia, add promoting blood flow to regulate menstruation effect of Herba Leonuri, be applicable to affected nerves of patients with trigeminal neuralgia.

2, with Herba Asari, Gypsum Fibrosum for minister, Herba Asari can sensible, dispel the wind, pain relieving, enter cardiopulmonary kidney channel, Gypsum Fibrosum energy clearing away heat-fire, relieving restlessness quenched the thirst, slow spleen QI invigorating, contribute to the immunity of enhancing body, improve the mental status.

3, in side, adjuvant drug is fewer but better, Flos Carthami promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing, the strong muscle of Cacumen Securinegae Suffruticosae expelling wind and activating blood circulation, kidney tonifying, full scorpion obstruction removing pain relieving, dispersing pathogen accumulation.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1

The Chinese medicine preparation for the treatment of primary trigeminal neuralgia, is prepared from by following bulk drugs: Concha Ostreae 22g, Radix Glycyrrhizae 5g, Flos Carthami 6g, Rhizoma Ligustici 6g Cacumen Securinegae Suffruticosae 6g, Herba Asari 2g, Gypsum Fibrosum 18g, Radix Saposhnikoviae 8g, Scorpio 3g, Scolopendra 4g, Radix Salviae Miltiorrhizae 20g, Concha Haliotidis 3g, Radix Paeoniae Rubra 12g, Pheretima 6g, Spica Prunellae 5g, Semen Persicae 5g processed, Rhizoma Et Radix Notopterygii 6g, Herba Dendranthematis indici 4g, Radix Angelicae Dahuricae 6g, Ramulus Uncariae Cum Uncis 5g, Semen Ziziphi Spinosae (parched) 12g, Herba Apocyni veneti 5g, Poria 8g, Herba Leonuri 25g, Herba Lycopi 10g, Radix Rhodiolae 6g.The preparation method of the Chinese medicine decoction of above-mentioned treatment primary trigeminal neuralgia:

1. Concha Ostreae, Gypsum Fibrosum, Concha Haliotidis are smashed, put into saline and soak 50 minutes, water consumption is 3 times of medical material weight;

2. be heated to boiling, turn slow fire boiling 40 minutes, leach medicinal liquid, recrement adds water and continues decoction 30 minutes, crosses and filters recrement, mix twice gained medicinal liquid;

3. Radix Glycyrrhizae, Flos Carthami, Rhizoma Ligustici, Cacumen Securinegae Suffruticosae, Herba Asari, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Pheretima, Spica Prunellae, Semen Persicae processed, Rhizoma Et Radix Notopterygii, Herba Dendranthematis indici, the Radix Angelicae Dahuricae, Ramulus Uncariae Cum Uncis, Semen Ziziphi Spinosae (parched), Herba Apocyni veneti, Poria, Herba Leonuri, Herba Lycopi, Radix Rhodiolae are pulverized, cross 110 mesh sieves, obtain fine powder;

4. by step 3. in fine powder mix homogeneously, be placed in bag filter, soak 30 minutes with clear water, water consumption is 2 times of fine powder weight, and intense fire is fried open fire of larding speech with literary allusions and boils 30 minutes, obtains medicinal liquid;

5. Scorpio, Scolopendra are pulverized, cross 80 mesh sieves, obtain even medicated powder;

6. mix the whole medicinal liquid of above-mentioned gained, then add step 5. in medicated powder, obtain Chinese medicine decoction.

The instructions of taking of decoction of the present invention: take every day twice (warm), each 300m1,7 days courses for the treatment of.

embodiment 2

The Chinese medicine preparation for the treatment of primary trigeminal neuralgia, is prepared from by following bulk drugs: Concha Ostreae 36g, Radix Glycyrrhizae 9g, Flos Carthami 12g, Rhizoma Ligustici 15g Cacumen Securinegae Suffruticosae 12g, Herba Asari 6g, Gypsum Fibrosum 28g, Radix Saposhnikoviae 12g, Scorpio 6g, Scolopendra 6g, Radix Salviae Miltiorrhizae 40g, Concha Haliotidis 6g, Radix Paeoniae Rubra 22g, Pheretima 9g, Spica Prunellae 12g, Semen Persicae 15g processed, Rhizoma Et Radix Notopterygii 12g, Herba Dendranthematis indici 12g, Radix Angelicae Dahuricae 16g, Ramulus Uncariae Cum Uncis 15g, Semen Ziziphi Spinosae (parched) 22g, Herba Apocyni veneti 9g, Poria 16g, Herba Leonuri 35g, Herba Lycopi 20g, Radix Rhodiolae 9g.The preparation method of the Chinese powder medicine of above-mentioned treatment primary trigeminal neuralgia:

1. first Concha Ostreae, Herba Asari, Gypsum Fibrosum, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Ziziphi Spinosae (parched), Herba Leonuri, Herba Lycopi are put into mortar, gently grind mixing, then add surplus stock medicine gradually, until all pulverize;

2. by step 1. in medicated powder, cross 70 mesh sieves and obtain that granular size is identical, the Chinese powder medicine of mix homogeneously.

Powder is made 4g/ bag.Instructions of taking: every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.

Model case: xxx, the age: 52 years old; Sex: man, peasant, buccal paroxysmal pain on the right side of readme, show effect more than 20 time within one day, the persistent period is 10-30 second, suffers from cold and show effect whenever flu, and overcast and rainy pain number of times increases, and takes poor effect after Western medicine.Check: bilateral isocoria to exist luminous reflectance, ocular movement is normal, and physiological reflex exists, and case reflection is not drawn, and blood pressure and examination of ocular fundus are all normal.Clinical diagnosis is: primary trigeminal neuralgia.

Take the Chinese powder medicine of this example gained, every day three times, once a bag, warm boiled water seven days is a course for the treatment of.Taken 14 days, face ache alleviates, and number of incidences obviously reduces, and continues to take two courses for the treatment of, does not substantially recur, and patient's self-induction is fully recovered.

embodiment 3

The Chinese medicine preparation for the treatment of primary trigeminal neuralgia, is prepared from by following bulk drugs: Concha Ostreae 28g, Radix Glycyrrhizae 6g, Flos Carthami 8g, Rhizoma Ligustici 9g Cacumen Securinegae Suffruticosae 8g, Herba Asari 3g, Gypsum Fibrosum 22g, Radix Saposhnikoviae 9g, Scorpio 4g, Scolopendra 4g, Radix Salviae Miltiorrhizae 28g, Concha Haliotidis 4g, Radix Paeoniae Rubra 15g, Pheretima 7g, Spica Prunellae 7g, Semen Persicae 9g processed, Rhizoma Et Radix Notopterygii 8g, Herba Dendranthematis indici 7g, Radix Angelicae Dahuricae 10g, Ramulus Uncariae Cum Uncis 9g, Semen Ziziphi Spinosae (parched) 15g, Herba Apocyni veneti 6g, Poria 11g, Herba Leonuri 28g, Herba Lycopi 14g, Radix Rhodiolae 7g.

The medicine pill preparation method for the treatment of primary trigeminal neuralgia is:

1. Scorpio, Scolopendra, Cacumen Securinegae Suffruticosae are put into marmite, slow fire fries ten minutes, and taking-up is smashed to pieces;

2. will remain the drip washing of medical material clear water, crushed after being dried becomes powder;

3. gained medicated powder is crossed 90 mesh sieves, add water and generally make ball;

4. 8mm medicine sieve crossed by the pill made, and selects pill of the same size, encapsulates after dry sterilization.

Instructions of taking: each ball, every day three times, warm boiled water seven days is a course for the treatment of.

Model case: xxx, the age: 52 years old; Sex: female; Main suit: left side face paroxysmal pain 10 years, medical history: angry rear left side surface part paroxysmal pain before 10 years, increases the weight of year by year, Facial tic on the left of during outbreak in nearly 2 years, left side nose, cheek, lower jaw are lightning sample severe pain, and outbreak more than ten is secondary, each continue half a minute, show effect during excited, overstrain.Check: pale complexion, chronic face dolorosa, cranial nerve no abnormality seen, facial perception is accessible, causes electric shock sample severe pain when touching left side buccal.Diagnosis: trigeminal neuralgia.

Taking this example gained medicine pill, each ball, three times on the one, warm boiled water, seven days is a course for the treatment of.Take 21 days, paroxysmal pain number of times is obviously less, and pain degree also alleviates greatly, continues to take two courses for the treatment of, and pain no longer occurs substantially, knocks buccal reaction normally.Follow up a case by regular visits to more than a year, pain seldom occurs.

embodiment 4

The Chinese medicine preparation for the treatment of primary trigeminal neuralgia, is prepared from by following bulk drugs: Concha Ostreae 30g, Radix Glycyrrhizae 8g, Flos Carthami 10g, Rhizoma Ligustici 12g Cacumen Securinegae Suffruticosae 10g, Herba Asari 5g, Gypsum Fibrosum 24g, Radix Saposhnikoviae 11g, Scorpio 5g, Scolopendra 6g, Radix Salviae Miltiorrhizae 32g, Concha Haliotidis 5g, Radix Paeoniae Rubra 19g, Pheretima 8g, Spica Prunellae 10g, Semen Persicae 11g processed, Rhizoma Et Radix Notopterygii 10g, Herba Dendranthematis indici 9g, Radix Angelicae Dahuricae 12g, Ramulus Uncariae Cum Uncis 11g, Semen Ziziphi Spinosae (parched) 19g, Herba Apocyni veneti 8g, Poria 13g, Herba Leonuri 32g, Herba Lycopi 16g, Radix Rhodiolae 8g.The preparation method of the Chinese medicinal ointment for the treatment of primary trigeminal neuralgia:

1. first Concha Ostreae, Herba Asari, Gypsum Fibrosum, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Ziziphi Spinosae (parched), Herba Leonuri, Herba Lycopi are put into mortar, gently grind mixing, then add surplus stock medicine gradually, until all pulverize;

2. by step 1. in gains, cross 80 mesh sieves and obtain the medicated powder of mix homogeneously;

3. in medicated powder, add Mel, modulation is shaped, and spreads upon in the circular framed back material of diameter 3cm, makes Chinese medicinal ointment.

Using method: be affixed on head acupoint outward, twice daily, once continuing 4 hours, seven days is a course for the treatment of.

Model case: xxx, the age: 35 years old; Sex: female.Main suit: acutely, similar electric shock, after western medicine a period of time, has no effective for left side buccal and cephalic pain, more so, sharp ache also causes vomiting in outbreak in nearly month.Through examination in hospital, be diagnosed as primary trigeminal neuralgia.

Use this example gained Chinese medicinal ointment, be affixed on head acupoint outward, each lasting 4 hours twice daily, seven days is a course for the treatment of.Use after 7 days, attack times reduces, and symptom alleviates, and without vomiting phenomenon, after continuing two courses for the treatment of of medication, Be very effective, pain disappears, and spirit increases substantially more habitually in the past, follows up a case by regular visits in half a year, and patient is recurrence no.

embodiment 5

The Chinese medicine preparation for the treatment of primary trigeminal neuralgia, is prepared from by following bulk drugs: Concha Ostreae 29g, Radix Glycyrrhizae 7g, Flos Carthami 9g, Rhizoma Ligustici 10.5g Cacumen Securinegae Suffruticosae 9g, Herba Asari 23g, Gypsum Fibrosum 23g, Radix Saposhnikoviae 10g, Scorpio 4.5g, Scolopendra 5g, Radix Salviae Miltiorrhizae 30g, Concha Haliotidis 4.5g, Radix Paeoniae Rubra 17g, Pheretima 7.5g, Spica Prunellae 8.5g, Semen Persicae 10g processed, Rhizoma Et Radix Notopterygii 9g, Herba Dendranthematis indici 8g, Radix Angelicae Dahuricae 11g, Ramulus Uncariae Cum Uncis 10g, Semen Ziziphi Spinosae (parched) 17g, Herba Apocyni veneti 7g, Poria 12g, Herba Leonuri 30g, Herba Lycopi 15g, Radix Rhodiolae 7.5g.

The preparation method of the Chinese medicine decoction of above-mentioned treatment primary trigeminal neuralgia:

1. Concha Ostreae, Gypsum Fibrosum, Concha Haliotidis are smashed, put into saline and soak 60 minutes, water consumption is 3.5 times of medical material weight;

2. be heated to boiling, turn slow fire boiling 45 minutes, leach medicinal liquid, recrement adds water and continues decoction 35 minutes, crosses and filters recrement, mix twice gained medicinal liquid;

3. Radix Glycyrrhizae, Flos Carthami, Rhizoma Ligustici, Cacumen Securinegae Suffruticosae, Herba Asari, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Pheretima, Spica Prunellae, Semen Persicae processed, Rhizoma Et Radix Notopterygii, Herba Dendranthematis indici, the Radix Angelicae Dahuricae, Ramulus Uncariae Cum Uncis, Semen Ziziphi Spinosae (parched), Herba Apocyni veneti, Poria, Herba Leonuri, Herba Lycopi, Radix Rhodiolae are pulverized, cross 120 mesh sieves, obtain fine powder;

4. by step 3. in fine powder mix homogeneously, be placed in bag filter, soak 40 minutes with clear water, water consumption is 3 times of fine powder weight, and intense fire is fried open fire of larding speech with literary allusions and boils 35 minutes, obtains medicinal liquid;

5. Scorpio, Scolopendra are pulverized, cross 90 mesh sieves, obtain even medicated powder;

6. mix the whole medicinal liquid of above-mentioned gained, then add step 5. in medicated powder, obtain Chinese medicine decoction.

The instructions of taking of decoction of the present invention: take every day twice (warm), each 300m1,7 days courses for the treatment of.

test example 1the clinical practice of the Chinese medicine decoction of embodiment 5 gained treatment primary trigeminal neuralgia: choose in April ,-2014 in January, 2013 is diagnosed as primary trigeminal neuralgia patient 355 people in hospital, the range of age is 34-64, male 150 people, women 205, random assortment is two groups, experimental group and matched group.Experimental group takes gained decoction in example five, and matched group takes other conventional medicines (carbamazepine, ZHENGTIAN WAN, Pu Run Bahrain etc.).

Inclusion criteria: be 1. diagnosed as affected nerves of patients with trigeminal neuralgia; 2. do not accept treatment or stopped the patient for the treatment of after one week; 3. the indices of two groups of objects of observation does not have significant difference.

Diagnostic criteria: 1. epidemic disease more: patient pain's symptom all disappears and removes loose, and face does not exist any difference, follows up a case by regular visits to never recur in healing after three months; 2. effective: after pain symptom diffusion, within three months, to occur recurrence, the number of times of outbreak reduces more than 50% compared with before treatment; 3. invalid: morbidity does not obtain any change or aggravation;

Table 1: take embodiment 5 product 34-64 year primary trigeminal neuralgia patient treatment outcome

Two groups of patients all have good therapeutic effect after treatment, and experimental group total effective rate reaches 95.6%, and matched group also has 91.5%.

Pain degree analysis before and after two groups of treatments:

Pain index=(before treatment-treatment is rear) the front pain degree of/treatment

Table 2: patient pain's degree analyzing

Chinese medicine preparation of the present invention safety compared with other medicine for the treatment of primary trigeminal neuralgia is high, and therapeutic effect is good.Use medicine can removing obstruction in the collateral to relieve pain, promoting blood circulation by removing wind in side, more having slow spleen QI invigorating concurrently, take care of health the effect of calming the nerves, be best selection for patient.Through clinical trial certificate, take Chinese medicine preparation of the present invention, the prosopalgic incidence probability of patient reduces greatly, the pain degree comparatively conventional medicine also Be very effective before and after treatment, can short-term and safety healing primary trigeminal neuralgia patient, always have effective percentage to reach 95.6%.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, within the spirit and principles in the present invention all, any amendment, replacement, improvement etc. done, all should be included within protection scope of the present invention.

Claims (2)

1. treat the Chinese medicine preparation of primary trigeminal neuralgia, it is characterized in that, the main raw material(s) taking off row weight proportion is prepared from: Concha Ostreae 30; Radix Glycyrrhizae 8; Flos Carthami 10; Rhizoma Ligustici 12; Cacumen Securinegae Suffruticosae 10; Herba Asari 5; Gypsum Fibrosum 24; Radix Saposhnikoviae 11; Scorpio 5; Scolopendra 6; Radix Salviae Miltiorrhizae 32; Concha Haliotidis 5; Radix Paeoniae Rubra 19; Pheretima 8; Spica Prunellae 10; Semen Persicae 11 processed; Rhizoma Et Radix Notopterygii 10; Herba Dendranthematis indici 9; The Radix Angelicae Dahuricae 12; Ramulus Uncariae Cum Uncis 11; Semen Ziziphi Spinosae (parched) 19; Herba Apocyni veneti 8; Poria 13; Herba Leonuri 32; Herba Lycopi 16; Radix Rhodiolae 8.

2. the preparation method of Chinese medicine preparation unguentum as claimed in claim 1, it is characterized in that, step is as follows:

1. first Concha Ostreae, Herba Asari, Gypsum Fibrosum, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Ziziphi Spinosae (parched), Herba Leonuri, Herba Lycopi are put into mortar, gently grind mixing, then add surplus stock medicine gradually, until all pulverize;

2. by step 1. in gains, cross 70-90 order (preferably 80 orders) sieve and obtain the medicated powder of mix homogeneously;

3. in medicated powder, add Mel, modulation is shaped, and spreads upon in the circular framed back material of diameter 3cm, makes Chinese medicinal ointment.