CN105147830B - A kind of maca bacteriostatic gel and preparation method thereof - Google Patents
A kind of maca bacteriostatic gel and preparation method thereof Download PDFInfo
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- CN105147830B CN105147830B CN201510543724.5A CN201510543724A CN105147830B CN 105147830 B CN105147830 B CN 105147830B CN 201510543724 A CN201510543724 A CN 201510543724A CN 105147830 B CN105147830 B CN 105147830B
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Abstract
The invention discloses a kind of maca bacteriostatic gels and preparation method thereof, it is by maca extract 0.5-1.0%, cinnamomum cassia extract 1.0-1.5%, cloves extracting solution 0.1-0.15%, pericarpium zanthoxyli extracting solution 0.1-0.15%, cistanche extracts 0.1-0.5%, benzalkonium bromide 0.10-0.15%, carbomer 2.0-2.5 ‰, surplus are water composition.The preparation-obtained bacteriostatic gel of the present invention has the effects that antibacterial, anti-inflammatory anti-itch, antimycotic, it is inhibited to hemolytic streptococcus, streptococcus pneumonia, escherichia coli, proteus vulgaris, Salmonella paratyphi A, shigella dysenteriae, Escherichia coli, staphylococcus aureus, resistance to methoxy staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa etc., its skin-friendliness height, good antimicrobial effect work rapid.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicine bacteriostatic gels and preparation method thereof, and in particular to a kind of maca bacteriostatic gel
And preparation method thereof, belong to sterile products field.
Background technique
The bacteriostatic gel of existing market sale is mostly the production made with single acidic disinfectant by a certain concentration requirement
Product make one the uncomfortable feeling for having dry and astringent, and have one qualitatively to damage skin and mucous membrane, and some can also draw
Hyperblastosis is played, biggish damage is caused to the body and mind of patient after long-time service.As people are to health, health, safety requirements
Increasingly raising, more and more consumers are in the bacteriostatic gel of the compoundings such as medicinal plant and Chinese herbal medicine.
Maca is the plateau plant of Cruciferae, originates in the plateau plant in 4000 meters of South America Peru Andes or more,
It is a kind of plant with a variety of medical values.Protein content in its plant is 15.7%, can be with active balance human body meals
The nutrition intake of food；Starch in maca can be effectively formed glycoprotein in conjunction with protein to be had lubricating joint, protects mucous membrane
Effect；Polysaccharide component rich in maca, polysaccharide component intake can effectively improve human immunologic function, and have and inhibit swollen
The functions such as tumor, antibacterial removing toxic substances；Dextrin ingredient in maca can be effectively improved male erectile time and hardness.The present invention completes
On the basis of maca bacteriostatic gel agent producing process, using the antifatigue of maca, immunity and a variety of functional effects are improved
Chinese medicine is compound, develops bacteriostatic gel strong with bacteriostasis, improving immunity function.
Chinese patent application CN104544074A discloses Maca extract of a kind of high stability and preparation method thereof, system
Agent and application, the Maca extract of the high stability be using maca as raw material, through crushing, extracting and developing, filtering, concentration,
Drying steps are prepared.The extract can be applied in food additives and nutraceutical field, and have certain inhibition
The effect of microorganism growth and breeding, extends the shelf-life of food, but its, and bacteriostasis is limited when exclusive use, it is difficult to be made
There is the preparation of bacteriostasis.
Summary of the invention
In order to overcome skin-friendliness existing for commercially available bacteriostatic gel in the prior art low, the drug of long-time service presses down
The defect of bacterium effect difference, of the invention to provide a kind of maca bacteriostatic gel and preparation method thereof, the present invention is preparation-obtained
Bacteriostatic gel has skin-friendliness height, good antimicrobial effect, and work rapid advantage.
Above-mentioned purpose that the invention is realized by the following technical scheme:
A kind of maca bacteriostatic gel, is grouped as by the group of following weight percentage: maca extract 0.5-
1.0%, cinnamomum cassia extract 1.0-1.5%, cloves extracting solution 0.1-0.15%, pericarpium zanthoxyli extracting solution 0.1-0.15%, Herba Cistanches mention
Object 0.1-0.5% is taken, benzalkonium bromide 0.1-0.15%, carbomer 2.0-2.5 ‰, surplus is water；
Wherein the maca extract is prepared by the following method to obtain: taking maca, is ground into 3~8mm's of diameter
Particle is added the water of 10 times of amounts, impregnates 30~60 minutes under room temperature；Then it is decocted 60 minutes at 85~95 DEG C, filters to obtain filter
Liquid adds the water of 10 times of amounts in filter residue, decocts again twice；Merge filtrate three times, as maca extract；
The cloves extracting solution is prepared by the following method to obtain: taking cloves (plant clove of myrtaceae Eugenia
The dry flower of caryophllata Thunb.), 75% ethanol solution of 50 times of amounts is added, is impregnated 72 hours at 30 DEG C, mistake
Filter, gained filtrate is cloves extracting solution；
The pericarpium zanthoxyli extracting solution is prepared by the following method to obtain: taking pericarpium zanthoxyli, 75% ethyl alcohol that 50 times of amounts are added is molten
Liquid impregnates 72 hours at 30 DEG C, and filtering, gained filtrate is pericarpium zanthoxyli extracting solution.
The cinnamomum cassia extract is prepared by water extraction, and the weight percentage of cinnamic acid polyphenol therein exists
Between 10%-40%.It is preferable to use the cinnamomum cassia extracts that the ratio produced by Xi'an Kang Wei Biotechnology Co., Ltd is 10:1.
The cistanche extracts are prepared by water extraction.It is preferable to use the ratios produced by Xi'an Kang Wei Biotechnology Co., Ltd
Example is the cistanche extracts of 10:1.
Cinnamomum cassia extract and cistanche extracts described above can be used following extraction processes and be prepared: raw material warp
It is selected clean up after 65-80 DEG C at a temperature of dry 1-1.5 hour, the particle of diameter 3-8mm is ground into after cooling down, addition
The water of 10 times of medicinal material weight amount volumes, is centrifugated under 85-95 DEG C of state after Dynamic Extraction 1.5 hours, and centrifugate is concentrated dry
It is dry to be crushed to powdered, particle before preparing gelling agent up to extract, the cinnamomum cassia extract and cistanche extracts
Size is 80-120 mesh.
In the present invention in raw material described in maca bacteriostatic gel, maca have the function of it is antifatigue, have a variety of human bodies
Required nutriment.Cortex cinnamomi has the effect of mends fire supporing yang, let the fire back to its origin, eliminating cold to stop pain, blood circulation, middle benefit gas yang-tonifying, medicine
Pharmacological research shows that cortex cinnamomi plays the role of expanding blood vessel；Cloves, the warm kidney of middle benefit gas is supporing yang, for the treatment of sombre impotence, cloves pair
15 kinds of bacteriums such as staphylococcus, tubercle bacillus and various pathogens have antibacterial action.Pericarpium zanthoxyli have certain strengthen immunity and
Antibacterial action, Herba Cistanches are traditional traditional tonic medicine, alkaloid rich in, crystalline neutral substance, amino acid, micro
Element, vitamin etc., can kidney-replenishing, benefiting essence-blood, benzalkonium bromide is surfactant, has a broad antifungal spectrum, to most grams sun
Property and negative bacteria have killing effect.Have the effect of significant antibacterial action and strengthen immunity after all medicines share, and difficult
Can be valuable, sharing rear each drug in antibiosis has significant synergistic effect, and to skin without any stimulation.
Inventor according to the drug activity of the maca bacteriostatic gel in antibiosis and the irritation to skin into
Prescription of having gone is preferred, is that the maca is antibacterial as a kind of embodiment preferred for this invention according to above-mentioned preferred standard
Gelling agent is grouped as by the group of following weight percentage: maca extract 0.5%, cinnamomum cassia extract 1.0%, cloves extracting solution
0.1%, pericarpium zanthoxyli extracting solution 0.1%, cistanche extracts 0.1%, benzalkonium bromide 0.1% and carbomer 2.0 ‰, surplus are water.
According to above-mentioned preferred standard, as another embodiment preferred for this invention are as follows: the maca is antibacterial solidifying
Jelly is grouped as by the group of following weight percentage: maca extract 1.0%, cinnamomum cassia extract 1.5%, cloves extracting solution
0.15%, pericarpium zanthoxyli extracting solution 0.15%, cistanche extracts 0.5%, benzalkonium bromide 0.15% and carbomer 2.5 ‰, surplus are
Water.
Of the invention also provides a kind of preparation method of maca bacteriostatic gel described above, specifically includes following step
It is rapid:
1) prepared by raw material: preparing or buy according to the method described above maca extract, cinnamomum cassia extract, cloves extracting solution, river
Green pepper extracting solution, cistanche extracts；
2) prepared by drug stoste: ratio accurately weighs cinnamomum cassia extract, cistanche extracts and benzalkonium bromide simultaneously by weight
Pill tank mixing is added under stirring conditions after completely dissolution with appropriate purified water respectively, after mixing evenly thereto at addition
Maca extract, cloves extracting solution and the pericarpium zanthoxyli extracting solution allotment feed liquid just measured are stirred 30-40 minutes using purified water constant volume
It stands 30 minutes afterwards and obtains drug stoste；
3) prepared by gelling agent: drug stoste is used to 50 μm of secondary filter under the pressure condition of 0.1MPa-0.2MPa
Filtrate is obtained by filtration in device；It is stirred evenly after 2.0 ‰ -2.5 ‰ carbomer is added into filtrate, standing is filling to can be obtained maca
Bacteriostatic gel.
In the preparation method of maca bacteriostatic gel described above, the filling environment of the maca bacteriostatic gel is net
Change the gnotobasis that grade is 300,000 grades.
Above-mentioned maca bacteriostatic gel is also claimed in the application of preparation antibacterium or fungal infection preparation in the present invention.This
Inventive embodiments 6 show that maca bacteriostatic gel of the present invention all has good fungistatic effect to most of pathogenic bacteria, above-mentioned
The infection that experimental result prompts maca bacteriostatic gel of the present invention that may cause for bacterium or fungi has inhibits effect well
Fruit, these bacteriums or fungi include but is not limited to hemolytic streptococcus, streptococcus pneumonia, escherichia coli, common variation bar
Bacterium, Salmonella paratyphi A, shigella dysenteriae, staphylococcus aureus, resistance to methoxy staphylococcus aureus, white are read
One of pearl bacterium and Pseudomonas aeruginosa are a variety of.From fungistatic effect, maca corresponding to embodiment 1 and embodiment 2
Bacteriostatic gel is more preferable to the fungistatic effect of most of pathogenic bacteria, is optimal two embodiments of the invention.
Maca bacteriostatic gel of the present invention is developed using plant, Chinese medicine are compound, and having to be substantially better than single has
The anti-bacteriostatic agent of composition is imitated, each drug component must act synergistically in antibiosis with significant, wide sterilization spectrum, to a variety of bacillus
Very strong bactericidal effect is all had with fungi, and wetability is strong, readily penetrates through deep skin and kill pathogenic bacteria.It is preparation-obtained
Maca bacteriostatic gel is provided with that antimicrobial spectrum is wide, and booster action is strong compared with other bacteriostatic gels, using comfortable, non-stimulated
Sense, long-time service do not damage skin and mucous membrane, with 100% fungistatic effect.
Specific embodiment
It elaborates by the following examples to implementation of the invention, but those skilled in the art should be able to know
Dawn, the embodiment do not limit the scope of protection of the present invention in any way.
Maca bacteriostatic gel of the present invention of embodiment 1 and preparation method thereof
The maca bacteriostatic gel is grouped as by the group of following weight percentage: maca extract 0.5%, cortex cinnamomi
Extract 1.0%, cloves extracting solution 0.1%, pericarpium zanthoxyli extracting solution 0.1%, cistanche extracts 0.1%, 0.1% and of benzalkonium bromide
Carbomer 2.0 ‰.
The preparation method of the maca bacteriostatic gel specifically comprises the following steps:
Raw material preparation: prepare or buy according to the method described above maca extract, cinnamomum cassia extract, cloves extracting solution, pericarpium zanthoxyli
Extracting solution, cistanche extracts；
The preparation of drug stoste: ratio accurately weighs cinnamomum cassia extract, cistanche extracts and benzalkonium bromide and divides by weight
Pill tank mixing is not added under stirring conditions after completely dissolution with appropriate purified water, prescription is added thereto after mixing evenly
Maca extract, cloves extracting solution and the pericarpium zanthoxyli extracting solution of amount deploy feed liquid, using purified water constant volume, after stirring 30-40 minutes
It stands 30 minutes and obtains drug stoste；
Gelling agent preparation: drug stoste is used to 50 μm of accurate filter under the pressure condition of 0.1MPa-0.2MPa
Filtrate is obtained by filtration；It is stirred evenly after 2.0 ‰ -2.5 ‰ carbomer is added into filtrate, stands the filling maca that can be obtained and press down
Bacterium gelling agent.
Maca bacteriostatic gel of the present invention of embodiment 2 and preparation method thereof
The maca bacteriostatic gel is grouped as by the group of following weight percentage: maca extract 1.0%, cortex cinnamomi
Extract 1.5%, cloves extracting solution 0.15%, pericarpium zanthoxyli extracting solution 0.15%, cistanche extracts 0.5%, benzalkonium bromide
0.15% and carbomer 2.5 ‰.
The preparation method is the same as that of Example 1 for the maca bacteriostatic gel.
Maca bacteriostatic gel of the present invention of embodiment 3 and preparation method thereof
The maca bacteriostatic gel is grouped as by the group of following weight percentage: maca extract 0.8%, cortex cinnamomi
Extract 1.3%, cloves extracting solution 0.13%, pericarpium zanthoxyli extracting solution 0.13%, cistanche extracts 0.3%, benzalkonium bromide
0.13% and carbomer 2.3 ‰.
The preparation method is the same as that of Example 1 for the maca bacteriostatic gel.
Maca bacteriostatic gel of the present invention of embodiment 4 and preparation method thereof
The maca bacteriostatic gel is grouped as by the group of following weight percentage: maca extract 0.5%, cortex cinnamomi
Extract 1.5%, cloves extracting solution 0.1%, pericarpium zanthoxyli extracting solution 0.15%, cistanche extracts 0.1%, benzalkonium bromide 0.15%
With carbomer 2.2 ‰.
The preparation method is the same as that of Example 1 for the maca bacteriostatic gel.
Maca bacteriostatic gel of the present invention of embodiment 5 and preparation method thereof
The maca bacteriostatic gel is grouped as by the group of following weight percentage: maca extract 1.0%, cortex cinnamomi
Extract 1.0%, cloves extracting solution 0.15%, pericarpium zanthoxyli extracting solution 0.1%, cistanche extracts 0.5%, benzalkonium bromide 0.13%
With carbomer 2.0 ‰.
The preparation method is the same as that of Example 1 for the maca bacteriostatic gel.
Antibacterial experiment in vitro of the maca bacteriostatic gel of the present invention of embodiment 6 to common causative bacterium
1, experimental material and method
Strain and culture medium used in this experiment be respectively hemolytic streptococcus, streptococcus pneumonia, escherichia coli,
Proteus vulgaris, Salmonella paratyphi A, shigella dysenteriae, staphylococcus aureus, resistance to methoxy golden yellow grape
Coccus, Candida albicans and Pseudomonas aeruginosa, nutrient agar (Nat'l Pharmaceutical & Biological Products Control Institute)；Opacity tube (in
State's bacterial turbidity standard, Nat'l Pharmaceutical & Biological Products Control Institute).
Antibacterial experiment in vitro: drug containing agar plate is 1. prepared.Tested material is prepared into different pharmaceutical concentration by doubling dilution
Culture medium, heating, pH value needed for modulating respectively, 121 DEG C of sterilizing 30min are cooled to 45 DEG C.Pour into aseptic flat board (plate d=
65mm, 10ml/ plate), finally making the extension rate of stoste containing tested material in culture medium (2g/ml) is respectively l:2,1:4 to 1:
1024.Respective blank control culture medium is done simultaneously.2. being inoculated with.The young age bacterium for reaching the third generation is taken, respectively with 0.9% sodium chloride
The bacterium solution to be checked that solution is 108cfu/ml by standard opacity tube corrected concentrations, is inoculated in each self-contained of different doubling dilutions respectively
Medicine agar surface, while 3 points of parallel point are inoculated with, make contain 2 one bacterium solutions at every.The liquid-drop diameter of each vaccination is 5-8mm.It is waiting
After kind point is dry, overturning plate observes result (while doing blank control) in 36 DEG C of constant incubator culture 20h.3. determining mark
It is quasi-.To there is not the minimum dilution tested material concentration on the agar plate of bacterium colony for its minimum inhibitory concentration (MIC).In this experiment
Tested material stoste be that the drug solution before gelling agent carbomer is not added.Maca bacteriostatic gel of the present invention is to each in this experiment
The minimal inhibitory concentration of pathogenic strain is as shown in table 1.
2, experimental result and analysis
Minimal inhibitory concentration measurement result of the 1 maca bacteriostatic gel of table to common causative bacterial strain
The results show that maca bacteriostatic gel of the present invention all has good fungistatic effect to most of pathogenic bacteria, on
Stating the infection that experimental result prompts maca bacteriostatic gel of the present invention that may cause for bacterium or fungi has inhibition well
Effect, these bacteriums or fungi include but is not limited to hemolytic streptococcus, streptococcus pneumonia, escherichia coli, common variation
Bacillus, Salmonella paratyphi A, shigella dysenteriae, staphylococcus aureus, resistance to methoxy staphylococcus aureus, white
Candida albicans and Pseudomonas aeruginosa.From fungistatic effect, maca bacteriostatic gel pair corresponding to embodiment 1 and embodiment 2
The fungistatic effect of most of pathogenic bacteria is more preferable, is optimal two embodiments of the invention.
Claims (9)
1. a kind of maca bacteriostatic gel, is grouped as by the group of following weight percentage: maca extract 0.5-1.0%,
Cinnamomum cassia extract 1.0-1.5%, cloves extracting solution 0.1-0.15%, pericarpium zanthoxyli extracting solution 0.1-0.15%, cistanche extracts
0.1-0.5%, benzalkonium bromide 0.10-0.15%, carbomer 2.0-2.5 ‰, surplus are water；
Wherein the maca extract is prepared by the following method to obtain: maca is taken, the particle of 3~8mm of diameter is ground into,
The water of 10 times of amounts is added, is impregnated 30~60 minutes under room temperature；Then it decocts 60 minutes, filters to get filtrate at 85~95 DEG C, filter
The water that 10 times of amounts are added in slag, decocts twice again；Merge filtrate three times, as maca extract；
The cinnamomum cassia extract and cistanche extracts is all made of following extraction processes and is prepared: the featured cleaning of raw material is dry
After net 65-80 DEG C at a temperature of dry 1-1.5 hour, the particle of diameter 3-8mm, addition medicinal material weight 10 are ground into after cooling down
The water of volume is measured again, is centrifugated after Dynamic Extraction 1.5 hours under 85-95 DEG C of state, centrifugate is concentrated to be drying to obtain extraction
Object；
The cloves extracting solution is prepared by the following method to obtain: cloves taken, 75% ethanol solution of 50 times of amounts is added,
It impregnates 72 hours, filters, gained filtrate is cloves extracting solution at 30 DEG C；
The pericarpium zanthoxyli extracting solution is prepared by the following method to obtain: pericarpium zanthoxyli taken, 75% ethanol solution of 50 times of amounts is added,
It impregnates 72 hours, filters, gained filtrate is pericarpium zanthoxyli extracting solution at 30 DEG C.
2. maca bacteriostatic gel as described in claim 1, which is characterized in that the cinnamomum cassia extract and Herba Cistanches are extracted
Object must be crushed to before preparing gelling agent it is powdered, granular size be 80-120 mesh.
3. maca bacteriostatic gel as described in claim 1, which is characterized in that the cinnamomum cassia extract and Herba Cistanches are extracted
Object is produced by Xi'an Kang Wei Biotechnology Co., Ltd.
4. maca bacteriostatic gel as described in claim 1, which is characterized in that the maca bacteriostatic gel by weighing as follows
The group of amount percentage composition is grouped as: maca extract 0.5%, cinnamomum cassia extract 1.0%, cloves extracting solution 0.1%, pericarpium zanthoxyli are extracted
Liquid 0.1%, cistanche extracts 0.1%, benzalkonium bromide 0.1% and carbomer 2.0 ‰, surplus are water.
5. maca bacteriostatic gel as described in claim 1, which is characterized in that the maca bacteriostatic gel by weighing as follows
The group of amount percentage composition is grouped as: maca extract 1.0%, cinnamomum cassia extract 1.5%, cloves extracting solution 0.15%, pericarpium zanthoxyli mention
Liquid 0.15%, cistanche extracts 0.5%, benzalkonium bromide 0.15% and carbomer 2.5 ‰ are taken, surplus is water.
6. a kind of preparation method of maca bacteriostatic gel described in claim 1-3 any one, specifically includes following step
It is rapid:
1) prepared by raw material: preparing or buys according to the method described above maca extract, cinnamomum cassia extract, cloves extracting solution, pericarpium zanthoxyli and mention
Take liquid, cistanche extracts；
2) prepared by stoste: ratio accurately weighs cinnamomum cassia extract, cistanche extracts and benzalkonium bromide and respectively with suitable by weight
It measures purified water and pill tank mixing is added under stirring conditions after completely dissolution, the Ma of recipe quantity is added thereto after mixing evenly
Coffee extracting solution, cloves extracting solution and pericarpium zanthoxyli extracting solution deploy feed liquid, and using purified water constant volume, stirring stood 30 after 30-40 minutes
Minute obtains drug stoste；
3) prepared by gelling agent: drug stoste is used to 50 μm of accurate filter mistake under the pressure condition of 0.1MPa-0.2MPa
Filter obtains filtrate；It is stirred evenly after 2.0 ‰ -2.5 ‰ carbomer is added into filtrate, stands that filling that maca can be obtained is antibacterial
Gelling agent.
7. preparation method as claimed in claim 6, which is characterized in that the filling environment of the maca bacteriostatic gel is purification
The gnotobasis that grade is 300,000 grades.
8. application of any maca bacteriostatic gel of claim 1-5 in preparation antibacterium or fungal infection preparation.
9. application as claimed in claim 8, which is characterized in that the bacterium or fungi is hemolytic streptococcus, pneumonia chain
Coccus, escherichia coli, proteus vulgaris, Salmonella paratyphi A, shigella dysenteriae, Staphylococcus aureus
One of bacterium, resistance to methoxy staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa are a variety of.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455724A (en) * | 2007-12-14 | 2009-06-17 | 北京琥珀光华医药科技开发有限公司 | Medicine composition for treating skin pruritus, eczema, gynecology inflammation |
| CN101584751A (en) * | 2008-05-21 | 2009-11-25 | 上海医药科技发展有限公司 | Antifungal pharmaceutical composition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090191288A1 (en) * | 1996-02-12 | 2009-07-30 | Squires Meryl J | Composition to Treat Herpes, Pseudomonas, Staph, Hepatitis and Other Infectious Diseases |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455724A (en) * | 2007-12-14 | 2009-06-17 | 北京琥珀光华医药科技开发有限公司 | Medicine composition for treating skin pruritus, eczema, gynecology inflammation |
| CN101584751A (en) * | 2008-05-21 | 2009-11-25 | 上海医药科技发展有限公司 | Antifungal pharmaceutical composition |
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