CN105147683B - 用于肾脏细胞癌的治疗的3,3＇,4，4＇-四羟基-2,2＇-联吡啶-n,n＇-二氧化物 - Google Patents

用于肾脏细胞癌的治疗的3,3＇,4，4＇-四羟基-2,2＇-联吡啶-n,n＇-二氧化物 Download PDF

Info

Publication number
CN105147683B
CN105147683B CN201510353115.3A CN201510353115A CN105147683B CN 105147683 B CN105147683 B CN 105147683B CN 201510353115 A CN201510353115 A CN 201510353115A CN 105147683 B CN105147683 B CN 105147683B
Authority
CN
China
Prior art keywords
compound
cell
orellanine
kidney
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201510353115.3A
Other languages
English (en)
Chinese (zh)
Other versions
CN105147683A (zh
Inventor
燕妮·尼斯特伦
莉萨·布瓦尔
乌尔夫·尼尔松
伯耶·哈拉尔德松
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncorena AB
Original Assignee
Oncorena AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncorena AB filed Critical Oncorena AB
Publication of CN105147683A publication Critical patent/CN105147683A/zh
Application granted granted Critical
Publication of CN105147683B publication Critical patent/CN105147683B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201510353115.3A 2008-10-06 2009-10-06 用于肾脏细胞癌的治疗的3,3＇,4，4＇-四羟基-2,2＇-联吡啶-n,n＇-二氧化物 Active CN105147683B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19531208P 2008-10-06 2008-10-06
US61/195,312 2008-10-06
US12/586,849 US8053430B2 (en) 2008-10-06 2009-09-29 Treatment of renal cell carcinoma
US12/586,849 2009-09-29
CN200980139366.4A CN102170881B (zh) 2008-10-06 2009-10-06 用于肾脏细胞癌的治疗的3,3’,4,4’-四羟基-2,2’-联吡啶-n,n’-二氧化物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200980139366.4A Division CN102170881B (zh) 2008-10-06 2009-10-06 用于肾脏细胞癌的治疗的3,3’,4,4’-四羟基-2,2’-联吡啶-n,n’-二氧化物

Publications (2)

Publication Number Publication Date
CN105147683A CN105147683A (zh) 2015-12-16
CN105147683B true CN105147683B (zh) 2019-01-22

Family

ID=41395600

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200980139366.4A Active CN102170881B (zh) 2008-10-06 2009-10-06 用于肾脏细胞癌的治疗的3,3’,4,4’-四羟基-2,2’-联吡啶-n,n’-二氧化物
CN201510353115.3A Active CN105147683B (zh) 2008-10-06 2009-10-06 用于肾脏细胞癌的治疗的3,3＇,4，4＇-四羟基-2,2＇-联吡啶-n,n＇-二氧化物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN200980139366.4A Active CN102170881B (zh) 2008-10-06 2009-10-06 用于肾脏细胞癌的治疗的3,3’,4,4’-四羟基-2,2’-联吡啶-n,n’-二氧化物

Country Status (11)

Country Link
US (2) US8053430B2 (OSRAM)
EP (1) EP2349268B1 (OSRAM)
JP (1) JP5340393B2 (OSRAM)
KR (1) KR101678702B1 (OSRAM)
CN (2) CN102170881B (OSRAM)
CA (1) CA2736322C (OSRAM)
DK (1) DK2349268T3 (OSRAM)
ES (1) ES2401671T3 (OSRAM)
PL (1) PL2349268T3 (OSRAM)
PT (1) PT2349268E (OSRAM)
WO (1) WO2010040750A1 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2891564T3 (es) 2010-04-01 2022-01-28 Oncorena Ab Tratamiento mejorado del carcinoma de células renales
GB201103578D0 (en) * 2011-03-02 2011-04-13 Sabrepharm Ltd Dipyridinium derivatives
CN105450495B (zh) * 2014-09-18 2018-09-21 中国电信股份有限公司 用于重新建立安全通信通道的方法、装置和系统
WO2024002909A1 (en) 2022-07-01 2024-01-04 Oncorena Ab Orellanine formulation
AU2024265564A1 (en) 2023-05-03 2025-11-13 Oncorena Ab Synthesis of orellanine
KR20250083338A (ko) 2023-11-30 2025-06-10 가톨릭대학교 산학협력단 신장암 어셈블로이드 및 이의 제조 방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713352A (en) 1981-08-31 1987-12-15 Sloan-Kettering Institute For Cancer Reseach Monoclonal antibody panel for early diagnosis and therapy of renal carcinoma
US6403373B1 (en) * 1997-10-10 2002-06-11 Ludwig Institute For Cancer Research Isolated nucleic acid molecules associated with colon, renal, and stomach cancer and methods of using these
US6440663B1 (en) * 1998-10-05 2002-08-27 Ludwig Institute For Cancer Research Renal cancer associated antigens and uses therefor
ATE296638T1 (de) 1999-04-08 2005-06-15 Schering Corp Behandlung von nierenzellen-karzinom
CN1359941A (zh) 2000-12-20 2002-07-24 上海博德基因开发有限公司 一种新的多肽——人肾癌rage4抗原11.44和编码这种多肽的多核苷酸
RU2188026C1 (ru) 2001-01-12 2002-08-27 Ростовский научно-исследовательский онкологический институт Способ лечения рака почки
SI1427420T1 (sl) 2001-09-12 2006-12-31 Novartis Ag Uporaba kombinacije, ki vsebuje 4-piridilmetilftalazine za zdravljenje raka
EP1524995B1 (en) * 2002-07-01 2011-12-21 Wilex AG Co-administration of cg250 and il-2 or ifn-alpha for treating cancer such as renal cell carcinomas
DE10307928A1 (de) 2003-02-25 2004-09-16 Faustus Forschungs Cie. Translational Cancer Research Gmbh Verwendung von 1-(2-Chlorethyl)-1-nitroso-3-(2-hydroxyethyl)-urea zur Behandlung von Pankreaskarzinomen, Weichteilsarkomen, Hodentumoren, Lymphomen, Thymomen, Wilms Tumoren, Nierenkarzinomen, Melanomen, Lungentumoren, intracerebralen Metastasen, Tumoren im Kopf- und Halsbereich, und Mamma-Karzinomen
US20060134708A1 (en) * 2004-10-14 2006-06-22 Northwestern University Detection and treatment of renal cancer
CA2625741C (en) 2005-10-14 2013-08-06 Government Of The United States Of America, As Represented By The Secret Ary, Department Of Health And Human Services Treating renal cancer using 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-2-methyl-benzaldehyde
EP1957115B8 (en) 2005-11-10 2014-03-05 Celldex Therapeutics, Inc. Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Efficiency of Hemoperfusion materia1s at removing the funga1 toxin ore11anine from human plasma";FULDE K ET AL;《DIE PHARMAZIE》;19980101;第53卷(第1期);58-59
"Investigations on the";HEUFLER，C．ET AL;《Agents and Actions》;19871231;第21卷(第1/2期);203-208
"The fungal nephrotoxin ";NILSSON ET AL;《FREE RADICAL BIOLOGY AND MEDICINE》;20080131;第44卷(第8期);1562-1569
"THE TOXIC ACTION OF ORELLANINE AND OTHER DIPYRIDYLS ON DIFFERENT EPITHELIAL CELL CULTURES LLC-PK-1 CACO-2 AND OK";RUEDL C ET AL;《MYCOLOGIA HELVETICA》;19901231;第4卷(第1期);99-109

Also Published As

Publication number Publication date
JP5340393B2 (ja) 2013-11-13
EP2349268B1 (en) 2013-01-16
PT2349268E (pt) 2013-04-02
JP2012504584A (ja) 2012-02-23
EP2349268A1 (en) 2011-08-03
KR20110073486A (ko) 2011-06-29
US20120077846A1 (en) 2012-03-29
WO2010040750A1 (en) 2010-04-15
ES2401671T3 (es) 2013-04-23
HK1161116A1 (zh) 2012-08-24
CN102170881A (zh) 2011-08-31
PL2349268T3 (pl) 2013-06-28
KR101678702B1 (ko) 2016-11-22
CA2736322C (en) 2017-01-10
CA2736322A1 (en) 2010-04-15
US8053430B2 (en) 2011-11-08
US8349823B2 (en) 2013-01-08
US20100152243A1 (en) 2010-06-17
DK2349268T3 (da) 2013-04-15
CN102170881B (zh) 2015-07-22
HK1218857A1 (zh) 2017-03-17
CN105147683A (zh) 2015-12-16

Similar Documents

Publication Publication Date Title
CN105147683B (zh) 用于肾脏细胞癌的治疗的3,3＇,4，4＇-四羟基-2,2＇-联吡啶-n,n＇-二氧化物
ES2713699T3 (es) 17alfa,21-Diésteres de cortexolona para el uso en el tratamiento de tumores
PL231418B1 (pl) 40-O-( 2-hydroksyetylo)- rapamycyna do zastosowania w leczeniu guzów litych płuc, innych niż nowotwór tkanki limfatycznej
JP7530116B2 (ja) エムトール信号伝達抑制剤を有効成分として含む癌の予防又は治療用薬剤学的組成物
JP7673993B2 (ja) 癌の転移抑制および治療用組成物
JP2021169534A (ja) 化学療法の改善
CN110290787B (zh) 用于抑制癌的转移及治疗癌的组合物
KR101901001B1 (ko) PPAR-β 길항제를 포함하는 항암 효과 증진용 약학적 조성물
KR102509715B1 (ko) 암의 전이 억제 및 치료용 조성물
TWI222868B (en) Use of an anthracycline derivative for the treatment of a liver tumor
KR102694803B1 (ko) A-노르-5α안드로스테인 화합물계 약물 및 항암제의 병용
HK1161116B (en) 3, 3' 4, 4' -tetrahydroxy-2,2'-bipyridine-n, n'-dioxides for the treatment of renal cell carcinoma
US20160106792A1 (en) Treatment of cancer
HK1138797A (zh) 肝癌治疗剂
HK1178458A (en) Therapeutic agent for liver cancer

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1218857

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant