CN105142641A - 用于治疗癌症的化合物 - Google Patents
用于治疗癌症的化合物 Download PDFInfo
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- CN105142641A CN105142641A CN201480013734.1A CN201480013734A CN105142641A CN 105142641 A CN105142641 A CN 105142641A CN 201480013734 A CN201480013734 A CN 201480013734A CN 105142641 A CN105142641 A CN 105142641A
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- Prior art keywords
- methylpyridin
- amine
- methyl
- pyridin
- quinazolin
- Prior art date
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- IFNYMKADXAEQAV-UHFFFAOYSA-N 6-(2-chloropyridin-4-yl)-n-[[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]methyl]-2,7-naphthyridin-1-amine Chemical compound C1=NC(C)=CC(C=2C(=CC(CNC=3C4=CN=C(C=C4C=CN=3)C=3C=C(Cl)N=CC=3)=CN=2)C)=C1 IFNYMKADXAEQAV-UHFFFAOYSA-N 0.000 claims description 4
- DUDNBOSZCOIFNJ-UHFFFAOYSA-N 6-(2-methylmorpholin-4-yl)-n-[[4-(2-methylpyridin-4-yl)phenyl]methyl]-2,7-naphthyridin-1-amine Chemical compound C1COC(C)CN1C1=CC2=CC=NC(NCC=3C=CC(=CC=3)C=3C=C(C)N=CC=3)=C2C=N1 DUDNBOSZCOIFNJ-UHFFFAOYSA-N 0.000 claims description 4
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Landscapes
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PCT/US2014/024885 WO2014165232A1 (fr) | 2013-03-12 | 2014-03-12 | Composés pour le traitement du cancer |
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EP (1) | EP2968348A4 (fr) |
JP (1) | JP2016518328A (fr) |
KR (1) | KR20150125665A (fr) |
CN (1) | CN105142641A (fr) |
AU (1) | AU2014248568B2 (fr) |
CA (1) | CA2905830C (fr) |
WO (1) | WO2014165232A1 (fr) |
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WO2017167150A1 (fr) * | 2016-03-31 | 2017-10-05 | 苏州云轩医药科技有限公司 | Composé hétérocyclique 3-fluoropyridine et son application |
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AU2010258800B2 (en) * | 2009-06-09 | 2013-10-10 | Nantbio, Inc. | Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling |
CN102558173B (zh) | 2010-12-31 | 2015-05-20 | 广州源生医药科技有限公司 | 抑制wnt信号传导的化合物、组合物及其应用 |
WO2013130364A1 (fr) | 2012-02-28 | 2013-09-06 | Novartis Ag | Sélection de patient atteints d'un cancer pour administrer des inhibiteurs de signalisation de la voie wnt au moyen de l'état de mutation rnf43 |
SG11201408237YA (en) | 2012-06-15 | 2015-01-29 | Curegenix Inc | Compound as wnt signaling inhibitor, composition, and use thereof |
CA2905830C (fr) | 2013-03-12 | 2022-01-18 | Curegenix Inc. | Derives de quinazoline et de naphtyridine utiles dans le traitement du cancer |
CN107708699A (zh) | 2015-05-26 | 2018-02-16 | 源生公司 | 肿瘤生物标志物及其应用 |
-
2014
- 2014-03-12 CA CA2905830A patent/CA2905830C/fr active Active
- 2014-03-12 AU AU2014248568A patent/AU2014248568B2/en not_active Ceased
- 2014-03-12 JP JP2016501667A patent/JP2016518328A/ja active Pending
- 2014-03-12 US US14/772,337 patent/US9713612B2/en active Active
- 2014-03-12 WO PCT/US2014/024885 patent/WO2014165232A1/fr active Application Filing
- 2014-03-12 CN CN201480013734.1A patent/CN105142641A/zh active Pending
- 2014-03-12 KR KR1020157024496A patent/KR20150125665A/ko not_active Application Discontinuation
- 2014-03-12 EP EP14778108.2A patent/EP2968348A4/fr not_active Withdrawn
-
2017
- 2017-06-08 US US15/617,988 patent/US10238652B2/en active Active
-
2019
- 2019-01-29 US US16/261,353 patent/US10660889B2/en active Active
Cited By (10)
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CN105348298A (zh) * | 2014-07-04 | 2016-02-24 | 沈阳中化农药化工研发有限公司 | 取代芳基吡啶类化合物及其用途 |
CN105348298B (zh) * | 2014-07-04 | 2019-03-19 | 沈阳中化农药化工研发有限公司 | 取代芳基吡啶类化合物及其用途 |
WO2017167150A1 (fr) * | 2016-03-31 | 2017-10-05 | 苏州云轩医药科技有限公司 | Composé hétérocyclique 3-fluoropyridine et son application |
CN110506129A (zh) * | 2016-12-21 | 2019-11-26 | 新加坡科技研究局 | 用于鉴定恶性肿瘤的试剂盒及其用途 |
CN110506129B (zh) * | 2016-12-21 | 2023-06-30 | 新加坡科技研究局 | 用于鉴定恶性肿瘤的试剂盒及其用途 |
CN110678466A (zh) * | 2017-03-30 | 2020-01-10 | 豪夫迈·罗氏有限公司 | 作为hpk1抑制剂的二氮杂萘类 |
CN110678466B (zh) * | 2017-03-30 | 2023-01-31 | 豪夫迈·罗氏有限公司 | 作为hpk1抑制剂的二氮杂萘类 |
CN108685923A (zh) * | 2018-06-07 | 2018-10-23 | 广州源生医药科技有限公司 | Wnt信号通路抑制剂在治疗LGR5阳性癌症中的应用 |
CN114072408A (zh) * | 2019-07-08 | 2022-02-18 | 南京明德新药研发有限公司 | 作为porcupine抑制剂的化合物及其应用 |
CN114072408B (zh) * | 2019-07-08 | 2023-05-12 | 南京明德新药研发有限公司 | 作为porcupine抑制剂的化合物及其应用 |
Also Published As
Publication number | Publication date |
---|---|
KR20150125665A (ko) | 2015-11-09 |
JP2016518328A (ja) | 2016-06-23 |
US10660889B2 (en) | 2020-05-26 |
US9713612B2 (en) | 2017-07-25 |
EP2968348A4 (fr) | 2016-11-09 |
CA2905830A1 (fr) | 2014-10-09 |
US20170304302A1 (en) | 2017-10-26 |
WO2014165232A1 (fr) | 2014-10-09 |
CA2905830C (fr) | 2022-01-18 |
AU2014248568A1 (en) | 2015-09-17 |
EP2968348A1 (fr) | 2016-01-20 |
US20160000780A1 (en) | 2016-01-07 |
US10238652B2 (en) | 2019-03-26 |
AU2014248568B2 (en) | 2017-07-13 |
US20190142827A1 (en) | 2019-05-16 |
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