CN105126003A - Traditional Chinese medicine composition for preventing and curing madness and preparation method - Google Patents
Traditional Chinese medicine composition for preventing and curing madness and preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and curing madness. The traditional Chinese medicine composition is prepared from the following main materials in parts by weight: 9 to 12 parts of radix ophiopogonis, 11 to 14 parts of sorghum root, 8 to 16 parts of wisteria root, 10 to 14 parts of rosa davurica pall, 8 to 15 parts of exocarpium, 6 to 9 parts of coriaria sinica root, 7 to 12 parts of Alpiniajaponica (Thunb.) Miq., 9 to 13 parts of wintersweet root or stem, 8 to 14 parts of Oreas, 6 to 15 parts of zhulan tree, 7 to 13 parts of lepironia articulata, 9 to 15 parts of vernonia cinerea, 8 to 14 parts of crocus sativus, 3 to 6 parts of rhizoma acori graminei and 7 to 14 parts of Indian epimeredi herb. The traditional Chinese medicine composition is prepared by selecting and refining common Chinese herbal medicines, has the effects of clearing away the heart-fire and calming, tonifying qi and the spleen, tranquilizing mind by nourishing the heart, and regulating the flow of vital energy, removing obstruction toit and dispelling melancholy, effectively regulates neuropeptide in brain nerve cells, activates the regeneration of the neuropeptide, enhances the self-immunity of the nerve cells, and has a remarkable curative effect in curing madness.
Description
Technical field
The invention belongs to traditional Chinese medicine field, especially relate to and a kind ofly prevent and treat demented Chinese medicine composition and preparation method.
Background technology
Demented is a kind of Mental Subnormality disease, is by internal injury caused by excess of seven emotions, intemperance of taking food, and innate deficiency, cause mental disorder pent-up, or phlegm-fire is cruelly high, and make visceral-qi uneven, imbalance of YIN and YANG, inaccessible thinking, refreshing machine is disorderly inverse.Depressive psychosis and mania syndrome all belong to non compos mentis illness.Its pathological changes is at liver, gallbladder, the heart, spleen.Because the two can not be well-separated in symptom, can mutually transform again, thus demented and claim, common person between twenty and fifty.Demented Etiological is depressive QI causing phlegm-fire, imbalance of YIN and YANG.Depressive psychosis clinical manifestation is being reticent and dementia, soliloquy, spirit depressing, apathetic expression, being reticent and dementia, speaking incoherently, calm with joy.And mania syndrome clinical to show as noise and excitement peaceful, dryly absurdly to curse, spirit is excited, and scolding is scolded and ruined thing, dynamic and many anger.
Demented generation is mainly due to imbalance of YIN and YANG, and internal injury caused by excess of seven emotions, phlegm and stagnant QI attacking upwards, caused by coagulation of QI-blood.Depressive psychosis can be converted into mania syndrome, and mania syndrome with the passing of time often again more transfers depressive psychosis to., manic state excessively surging and low with emotion and depressive state alternately appear as basic characteristics.Manic state shows as in high spirits, and rapidly, action increases, even excited restless, hits the person and ruins thing etc. in association; Depressive state shows as depressed, and it is blunt to associate, and action reduces, sleep disorder, even has for suicide etc.Clinical manifestation is mainly manifested in patient's thinking, emotion, behavior three aspect are not normal.The common symptom having the Four types such as manic, depressed, hallucination, vain hope.The common depressive symptom of general depressive psychosis, is dullly fond of tranquility; The common manic symptoms of mania syndrome, many anger is active.As for hallucination and vain hope symptom, be both found in depressive psychosis, also showed in mania syndrome.
In the method that existing Chinese traditional treatment is demented, publication number CN103919989A(application number 201310010990.2) the one that patent discloses treat schizoid oral Chinese medicine Chinese medicine composition of demented property and preparation method thereof, comprise Poria cum Radix Pini 1300g-1500g in mass ratio, 1200g-1400g Radix Polygalae, 800g-1100g winter wheat, 1300g-1500g Radix Sophorae Flavescentis, 1200g-1400g Semen Platycladi, 1200g-1400g Radix Salviae Miltiorrhizae, 1900g-2100g Fructus Schisandrae Chinensis, 800g-1000g Radix Glycyrrhizae, 1200g-1400g Fructus Aurantii, 1200g-1400g Pericarpium Citri Reticulatae Viride.Publication number CN102716212A(application number 201210206028.1) patent discloses and a kind ofly treat demented medicine, raw material composition and the parts by weight of making described Chinese medicine Chinese medicine composition effective ingredient are: Folium Artemisiae Argyi 60-84 part, Radix Clerodenri Cyrtophylli 59-83 part, Cortex Melaleucae leucadendrae skin 59-83 part, Bulbus Lilii 55-79 part, Herba Cynanchi Thesioidis 54-78 part, Borneolum Syntheticum 53-77 part, Fructus Piperis Longi 53-77 part, Radix Aconiti Kusnezoffii 49-73 part, river cypress 45-69 part, Herba Xanthii 40-64 part, Caulis Clematidis Armandii 37-61 part, gristle wind 35-59 part, Mel Alhagi 35-59 part, Rhizoma Acori Graminei 34-58 part, Spica Cannabis Tener 30-54 part, Flos Phaseoli 15-39 part.Publication number CN102793894A(application number 201210324874.3) patent discloses and a kind ofly treat demented Chinese medicine, be made up of the raw material of following parts by weight: Radix Musae 9-15 part, Radix Et Rhizoma Rhei 3-9 part, Fructus Gardeniae 4-10 part, Massa Medicata Fermentata 6-12 part, Radix Sophorae Flavescentis 3-9 part, Herba Menthae 2-6 part, trichosanthes seed 9-15 part, Fructus Crataegi 3-9 part, Radix Curcumae 3-9 part, Rhizoma Anemarrhenae 6-12 part, Bulbus Lilii 6-12 part, Radix Rehmanniae 9-15 part, Poria 9-15 part, Os Draconis 9-15 part, Folium Bambusae 6-12 part, Terra Flava Usta 10-20 part.
At present, for demented treatment also unusual imperfection, it is less to treat demented specific drug, is generally main mainly with calm, hypnosis.Western medicine can only be control, and can not effect a radical cure, and side effect is large, very easily produces dependency and Drug resistance, easily recurs, and treats difficulty more greatly, have very large infringement to darling renal function after recurrence.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind ofly prevents and treats demented Chinese medicine composition, select Common Chinese Herbs to refine to form, there is the calmness that clears away heart-fire, replenishing QI to invigorate the spleen, tranquilizing by nourishing the heart, to regulate the flow of vital energy effect of resolving depression, effectively regulate the neuropeptide in cranial nerve cell, activate neuropeptide regeneration, strengthen neurocyte autoimmunity, treat demented evident in efficacy.Another object of the present invention is to provide above-mentioned a kind of preparation method of preventing and treating demented Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Prevent and treat a demented Chinese medicine composition, take off the primary raw material stating weight proportion and be prepared from: Radix Ophiopogonis 9-12 part; Radix Sorghum vulgare Pers. 11-14 part; Radix wisteriae sinensis 8-16 part; Flos Rosae Davuricae 10-14 part; Exocarpium Citri Grandis 8-15 part; Radix Coriariae Sinicae 6-9 part; Build Fructus Amomi 7-12 part; Radix Chimonanthi praecocis 9-13 part; Oreas martiana (Hopp. Et Hornsch.) Brid. 8-14 part; Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 6-15 part; Medulla Junci 7-13 part; Herba Vernoniae Cinereae 9-15 part; Stigma Croci 8-14 part; Rhizoma Acori Graminei 3-6 part; To fail clothing 7-14 part.
Prevent and treat a demented Chinese medicine composition, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Ophiopogonis 10-11 part; Radix Sorghum vulgare Pers. 12-13 part; Radix wisteriae sinensis 11-13 part; Flos Rosae Davuricae 11-13 part; Exocarpium Citri Grandis 11-13 part; Radix Coriariae Sinicae 7-8 part; Build Fructus Amomi 9-11 part; Radix Chimonanthi praecocis 10-12 part; Oreas martiana (Hopp. Et Hornsch.) Brid. 10-12 part; Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 10-12 part; Medulla Junci 9-11 part; Herba Vernoniae Cinereae 11-13 part; Stigma Croci 10-12 part; Rhizoma Acori Graminei 4-5 part; To fail clothing 10-12 part.
Prevent and treat a demented Chinese medicine composition, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Radix Ophiopogonis 10.5 parts; Radix Sorghum vulgare Pers. 12.5 parts; Radix wisteriae sinensis 12 parts; Flos Rosae Davuricae 12 parts; Exocarpium Citri Grandis 12 parts; Radix Coriariae Sinicae 7.5 parts; Build Fructus Amomi 10 parts; Radix Chimonanthi praecocis 11 parts; Oreas martiana (Hopp. Et Hornsch.) Brid. 11 parts; Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 11 parts; Medulla Junci 10 parts; Herba Vernoniae Cinereae 12 parts; Stigma Croci 11 parts; Rhizoma Acori Graminei 4.5 parts; To fail 11 parts, clothing.
Present invention also offers and a kind ofly prevent and treat the preparation method that demented Chinese medicine composition makes pharmaceutically acceptable decoction, granule, concentrated pill, Tablet and Capsula by above-mentioned.
Described a kind of preparation method of preventing and treating demented Chinese medicine composition decoction, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, add yellow wine, moistening 8-10 hour, take out, evenly stand is in food steamer, and moderate heat steams 50-60 minute (preferred moderate heat steams 53-57 minute, is more preferably moderate heat and steams 55 minutes);
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 40-50 minute, adds step (1)-(2) gains, continues heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stir, hold over night, filter, sterile packaged.
According to preparation method recited above, the consumption of the preferred yellow wine of step (2) is the 30%-40% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass, and the consumption being more preferably yellow wine is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass.
Instructions of taking: each 100-150ml, every day 2 times, 12 days courses for the treatment of.
Described a kind of preparation method of preventing and treating demented Chinese medicinal composition granules, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 8-10 hour, takes out, and evenly stand is in food steamer, moderate heat steams 50-60 minute (preferred moderate heat steams 53-57 minute, is more preferably moderate heat and steams 55 minutes);
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 40-50 minute, adds step (1)-(2) gains, continues heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stir, hold over night, filter, be concentrated into relative density 1.10-1.20(25 DEG C) thick paste, make uniform fine particle, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
According to preparation method recited above, step (5) is preferably concentrated into the thick paste of relative density 1.13-1.17, is more preferably the thick paste being concentrated into relative density 1.15.
Instructions of taking: each 1 bag, takes after melting, every day 2 times, 12 days courses for the treatment of by warm water.
Described a kind of preparation method of preventing and treating demented Chinese medicine composition concentrated pill, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 8-10 hour, takes out, and evenly stand is in food steamer, moderate heat steams 50-60 minute (preferred moderate heat steams 53-57 minute, is more preferably moderate heat and steams 55 minutes);
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 40-50 minute, adds step (1)-(2) gains, continues heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stir, hold over night, filter, be concentrated into relative density 1.10-1.20(25 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), (preferred diameter is 3-5mm to make concentrated pill, being more preferably diameter is 4mm), sterile packaged.
Using method: each 6-10 ball, with warm water delivery service, every day 2 times, 12 days courses for the treatment of.
Described a kind of preparation method of preventing and treating demented Chinese medicine composition tablet, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 8-10 hour, takes out, and evenly stand is in food steamer, moderate heat steams 50-60 minute (preferred moderate heat steams 53-57 minute, is more preferably moderate heat and steams 55 minutes);
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 40-50 minute, adds step (1)-(2) gains, continues heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stir, hold over night, filter, be concentrated into relative density 1.10-1.20(25 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), make tablet.
Instructions of taking: each 2-3 sheet, every day 2 times, 12 days courses for the treatment of.
Described a kind of preparation method of preventing and treating demented Chinese medicinal composition capsules, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 8-10 hour, takes out, and evenly stand is in food steamer, moderate heat steams 50-60 minute (preferred moderate heat steams 53-57 minute, is more preferably moderate heat and steams 55 minutes);
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 40-50 minute, adds step (1)-(2) gains, continues heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stir, hold over night, filter, be concentrated into relative density 1.20-1.30(25 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.23-1.27, be more preferably the thick paste being concentrated into relative density 1.25), dry, pulverize, cross 180-200 mesh sieve, make capsule (preferred 0.4-0.6g/ grain, is more preferably 0.5g/ grain).
Instructions of taking: each 2-3 grain, every day 2 times, 12 days courses for the treatment of.
The pharmacological effect of each crude drug is respectively:
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature.GUIXIN, lung, stomach warp.Another name Radix Ophiopogonis is the dried root of liliaceous plant Radix Ophiopogonis.There is YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.
Radix Sorghum vulgare Pers.: sweet in the mouth, property is put down.For the root of grass Sorghum vulgare Pers..Have and relieving asthma, diuretic, hemostasis, effect of dredging collateral.For dyspnea with fullness of the chest of coughing, dysuria, postpartum hemorrhage, metrorrhagia, sufficient knee joint pain.
Radix wisteriae sinensis: sweet in the mouth, warm in nature.Return liver, kidney, heart channel.For the root of leguminous plant Caulis wisteriae sinensis.There is expelling wind and removing dampness, effect of relaxing muscles and tendons and activating QI and blood in the collateral.For gout, arthromyodynia.
Flos Rosae Davuricae: sour in the mouth, sweet, property is put down.Return liver, spleen channel.For the flower of rosaceous plant Rosa bella.There is regulating qi-flowing for harmonizing stomach, effect of cough-relieving.For menoxenia, dysmenorrhea, metrorrhagia, spits blood, intercostal neuralgia, pulmonary tuberculosis cough.
Exocarpium Citri Grandis: bitter in the mouth, pungent, warm in nature.Return spleen, lung meridian.For immaturity or the maturescent outside rind of rutaceae Citrus grandis or Fructus Citri grandis.There is drying dampness to eliminate phlegm, regulate the flow of vital energy, the effect helped digestion.For wind and cold cough with asthma abundant expectoration, vomiting singultus, accumulation of food in the stomach and intes tine due to indigestion, abdominal distention.
Radix Coriariae Sinicae: bitter in the mouth, acid, cool in nature.Poisonous.GUIXIN, Liver Channel.For the root of Coriariaceae plant Coriaria sinica.There is expelling wind and removing dampness, effect of heat reliving and toxin-eliminating.For rheumatic numbness, carbuncle pyogenic infections from tumour or sore, acute toothache, mass in the abdomen, scrofula, acute conjunctivitis, burn, traumatic injury.
Build Fructus Amomi: acrid in the mouth, warm in nature.For the fruit of zingiberaceous plant Alpinia japonica (Thunb.) Miq..Containing radix zedoariae keto-alcohol, Alpinia japonica (Thunb.) Miq. ketone, Palmic acid, cineole, Camphora, rhamnocitrin, kumatakenin.There is warming spleen and stomach for dispelling cold, the effect in circulation of qi promoting tune.For abdominal distention, vomiting is had loose bowels, inappetence.
Radix Chimonanthi praecocis: acrid in the mouth, warm in nature.Return liver, lung meridian.For the root of Calycanthaceae wax prunus mume (sieb.) sieb.et zucc..Containing cardiotonic glycoside hellebrigenin glucorhamnoside. and bufotalidin, Helleborus poison glycoside and helleborin.There is wind-expelling pain-stopping, vital energy regualting and blood circulation-promoting, effect of relieving cough and asthma.For rheumatic arthralgia, anemofrigid cold, traumatic injury, epigastric pain, asthma, epersalgia cough, furuncle swelling toxin.
Oreas martiana (Hopp. Et Hornsch.) Brid.: sweet in the mouth, light, property is put down.GUIXIN, lung meridian.For root and the herb of Malvaceae Herba urenae procumbentis platymiscium Urena lobata Linn.There is expelling wind and removing dampness, effect of heat-clearing and toxic substances removing.For cold, fever, rheumatic arthralgia, dysentery, edema, leucorrhea, spits blood, carbuncle, traumatic hemorrhage, venom, acute infantile convulsion, tetanus, asthma, stomachache puerperal exposure to wind.
Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.): acrid in the mouth, temperature, property is sweet.Return Liver Channel.For Herb or root, the leaf of Chloranthaceae plant chu lan tree.Having dispels the wind determines, promoting blood circulation and stopping pain, effect of parasite killing.For rheumatic arthralgia, traumatic injury, migraine, stubborn dermatitis.
Medulla Junci: bitter in the mouth, cool in nature.GUIXIN, small intestine meridian.For the herb of the wild Medulla Junci of rush family plant.There is relieving stranguria by diuresis, expel the heat-evil, calm the nerves, effect of cooling blood for hemostasis.For pyretic stranguria, oedema due to nephritis, heat in the heart is irritated, palpitation and insomnia, aphtha of the mouth and tongue, pharyngalgia, toothache, conjunctival congestion and swelling pain, epistaxis, spitting of blood, hematuria.
Herba Vernoniae Cinereae: bitter in the mouth, pungent, cool in nature.For herb or the root of feverfew Herba Vernoniae Cinereae.Containing diosmetin, luteolin-7-O-glucuronide, luteolin, luteolin-7-O-glycoside etc.There is wind and heat dispersing, dehumidifying, effect of removing toxic substances.For feeling heating, cough, acute icterohepatitis, damp-heat diarrhea, stagnant in vain, close pyogenic infections from tumour or sore, mastitis, rhinitis, venom.
Stigma Croci: sweet in the mouth, property is put down.GUIXIN, Liver Channel.For top and the stigma of irides Stigma Croci style.Containing Stigma Croci glycoside, crocetin, campesterol, stigmasterol, cupreol, ursolic acid, oleanolic acid, Palmic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid.There is blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, effect of removing pathogenic heat from blood and toxic substance from the body.For dysmenorrhea, amenorrhea, menoxenia, post partum longtime lochia, enclosed mass pain in abdomen, injury from falling down, melancholy painful abdominal mass is vexed, and palpitation with fear, epidemic febrile disease sends out speckle, measles.
Rhizoma Acori Graminei: another name Rhizoma Acori Graminei, prosperous grass, spring snow, water Rhizoma Acori Graminei etc.Acrid in the mouth, hardship, warm in nature.GUIXIN, stomach warp.For the dry rhizome of acorus gramineus araceae plant.There is removing dampness appetizing, eliminating phlegm of having one's ideas straightened out, effect of refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, the insane disease of coma, forgetful deafness.
To fail clothing: acrid in the mouth, hardship, property is put down.For the herb of the wide Radix Saposhnikoviae of labiate.Containing volatile oil and alkaloid.There is wind-damp dispelling, the effect of the sore that disappears.For cold, fever, rheumatic arthralgia, strengthening bone and muscle.
Technical advantage of the present invention is mainly reflected in:
1, Chinese medicine composition of the present invention meets Chinese medicine and pharmacy and modern medicine theory, selects Common Chinese Herbs to refine and forms, have the calmness that clears away heart-fire, replenishing QI to invigorate the spleen, tranquilizing by nourishing the heart, the effect of resolving depression of regulating the flow of vital energy, treat demented evident in efficacy.
2, Chinese medicine composition of the present invention is based on the understanding to demented etiology and pathogenesis, reinforcement and elimination in combination, and remove focus while regulating function, reach the object for the treatment of both the principal and secondary aspects of a disease, not easily recur more, clinic is applied.
3, the effective ingredient of Chinese medicine composition of the present invention acts on the neuropeptide in cranial nerve cell, strengthens neurocyte autoimmunity, effectively alleviates demented all symptoms.
4, Chinese medicine composition selected materials majority of the present invention is Chinese medicine material, and medical material is easy to get, and operation is simple, and cost is low, has no side effect, safe and reliable, alleviates the injury to liver.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1prevent and treat a demented Chinese medicine composition, take off and state primary raw material and be prepared from (getting 60g for every part): Radix Ophiopogonis 9 parts; Radix Sorghum vulgare Pers. 11 parts; Radix wisteriae sinensis 8 parts; Flos Rosae Davuricae 10 parts; Exocarpium Citri Grandis 8 parts; Radix Coriariae Sinicae 6 parts; Build Fructus Amomi 7 parts; Radix Chimonanthi praecocis 9 parts; Oreas martiana (Hopp. Et Hornsch.) Brid. 8 parts; Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 6 parts; Medulla Junci 7 parts; Herba Vernoniae Cinereae 9 parts; Stigma Croci 8 parts; Rhizoma Acori Graminei 3 parts; To fail 7 parts, clothing.
Above-mentioned a kind of preparation method of preventing and treating demented Chinese medicine composition decoction, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, add yellow wine (consumption is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 9 hours, take out, evenly stand is in food steamer, and moderate heat steams 55 minutes;
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, crosses 160 mesh sieves;
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 45 minutes, adds step (1)-(2) gains, continues heating extraction twice, each 35 minutes, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stir, hold over night, filter, sterile packaged.
Instructions of taking: each 100-150ml, every day 2 times, 12 days courses for the treatment of.
embodiment 2prevent and treat a demented Chinese medicine composition, take off and state primary raw material and be prepared from (getting 30g for every part): Radix Ophiopogonis 12 parts; Radix Sorghum vulgare Pers. 14 parts; Radix wisteriae sinensis 16 parts; Flos Rosae Davuricae 14 parts; Exocarpium Citri Grandis 15 parts; Radix Coriariae Sinicae 9 parts; Build Fructus Amomi 12 parts; Radix Chimonanthi praecocis 13 parts; Oreas martiana (Hopp. Et Hornsch.) Brid. 14 parts; Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 15 parts; Medulla Junci 13 parts; Herba Vernoniae Cinereae 15 parts; Stigma Croci 14 parts; Rhizoma Acori Graminei 6 parts; To fail 14 parts, clothing.
Above-mentioned a kind of preparation method of preventing and treating demented Chinese medicinal composition granules, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, add yellow wine (consumption is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 9 hours, take out, evenly stand is in food steamer, and moderate heat steams 55 minutes;
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, crosses 160 mesh sieves;
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 45 minutes, adds step (1)-(2) gains, continues heating extraction twice, each 35 minutes, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stir, hold over night, filter, be concentrated into relative density 1.15(25 DEG C) thick paste, make uniform fine particle, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
Instructions of taking: each 1 bag, takes after melting, every day 2 times, 12 days courses for the treatment of by warm water.
model case onehusky XX, female, 20 years old, people from Liaocheng of Shandong Province.Mrs Sha is a high school student, and certain crys after going home baffledly, ceaselessly says some indescribable language, and language is mixed and disorderly, cataphasia, emotional lability, being irritable and getting angry easily, opposes study, detests school.So father and mother are with it to examination in hospital, final diagnosis is demented, and corresponding treatment recovers normal after one month, but often have an attack of one's old illness subsequently, took multiple Western medicine, also attempted multiple folk prescription, but be all that after treatment, symptom is alleviated, but soon just recur again, Relapse rate shows effect.
After taking that the present invention is a kind of and preventing and treating 2 courses for the treatment of of demented Chinese medicine composition (embodiment 2), situation changes a lot than originally, talk about less, better, the mental status is normal in sleep.After continuing to take 2 courses for the treatment of, basic recovery is normal, and walking step state, tongue, memory etc. recover normal, talk more smooth.Follow up a case by regular visits to and within 2 years, learn normally, do not recur so far.
embodiment 3prevent and treat a demented Chinese medicine composition, take off and state primary raw material and be prepared from (getting 50g for every part): Radix Ophiopogonis 10 parts; Radix Sorghum vulgare Pers. 12 parts; Radix wisteriae sinensis 11 parts; Flos Rosae Davuricae 11 parts; Exocarpium Citri Grandis 11 parts; Radix Coriariae Sinicae 7 parts; Build Fructus Amomi 9 parts; Radix Chimonanthi praecocis 10 parts; Oreas martiana (Hopp. Et Hornsch.) Brid. 10 parts; Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 10 parts; Medulla Junci 9 parts; Herba Vernoniae Cinereae 11 parts; Stigma Croci 10 parts; Rhizoma Acori Graminei 4 parts; To fail 10 parts, clothing.
Above-mentioned a kind of preparation method of preventing and treating demented Chinese medicine composition concentrated pill, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, add yellow wine (consumption is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 9 hours, take out, evenly stand is in food steamer, and moderate heat steams 55 minutes;
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, crosses 160 mesh sieves;
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 45 minutes, adds step (1)-(2) gains, continues heating extraction twice, each 35 minutes, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stirs, hold over night, filter, be concentrated into relative density 1.15(25 DEG C) thick paste, make the concentrated pill that diameter is 4mm, sterile packaged.
Using method: each 8 balls, with warm water delivery service, every day 2 times, 12 days courses for the treatment of.
embodiment 4prevent and treat a demented Chinese medicine composition, take off and state primary raw material and be prepared from (getting 20g for every part): Radix Ophiopogonis 11 parts; Radix Sorghum vulgare Pers. 13 parts; Radix wisteriae sinensis 13 parts; Flos Rosae Davuricae 13 parts; Exocarpium Citri Grandis 13 parts; Radix Coriariae Sinicae 8 parts; Build Fructus Amomi 11 parts; Radix Chimonanthi praecocis 12 parts; Oreas martiana (Hopp. Et Hornsch.) Brid. 12 parts; Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 12 parts; Medulla Junci 11 parts; Herba Vernoniae Cinereae 13 parts; Stigma Croci 12 parts; Rhizoma Acori Graminei 5 parts; To fail 12 parts, clothing.
Above-mentioned a kind of preparation method of preventing and treating demented Chinese medicine composition tablet, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, add yellow wine (consumption is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 9 hours, take out, evenly stand is in food steamer, and moderate heat steams 55 minutes;
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, crosses 160 mesh sieves;
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 45 minutes, adds step (1)-(2) gains, continues heating extraction twice, each 35 minutes, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stirs, hold over night, filter, be concentrated into relative density 1.15(25 DEG C) thick paste, make tablet.
Using method: each 2-3 sheet, every day 2 times, 12 days courses for the treatment of.
model case twostream XX, female, 46 years old, people from Dezhou City Shandong Province.Before 5 or six years, occur speaking incoherently, being happy and angry uncertainly, anorexia without under obvious inducement, flushing conjunctival congestion, two orders are glared at, and hit the person and ruin thing, do not keep away close and distant irregularities of Denging, usually have an attack of one's old illness afterwards, and sick hurried.So remove examination in hospital, last diagnostic is demented, treats rear remission, substantially recovers normal condition.But occur above-mentioned symptom again less than the time of half a year, and more serious.
After taking that the present invention is a kind of and preventing and treating 2 courses for the treatment of of demented Chinese medicine composition (embodiment 4), look takes a turn for the better, and irregularities such as ruining thing of hitting the person obviously reduce, and night can fall asleep, and can carry out normal communication exchange during peace and quiet.After continuing to take 2 courses for the treatment of, substantially recover normal condition.Follow up a case by regular visits in the time so far more than 1 year and do not occur recurrence.
embodiment 5prevent and treat a demented Chinese medicine composition, take off and state primary raw material and be prepared from (getting 40g for every part): Radix Ophiopogonis 10.5 parts; Radix Sorghum vulgare Pers. 12.5 parts; Radix wisteriae sinensis 12 parts; Flos Rosae Davuricae 12 parts; Exocarpium Citri Grandis 12 parts; Radix Coriariae Sinicae 7.5 parts; Build Fructus Amomi 10 parts; Radix Chimonanthi praecocis 11 parts; Oreas martiana (Hopp. Et Hornsch.) Brid. 11 parts; Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 11 parts; Medulla Junci 10 parts; Herba Vernoniae Cinereae 12 parts; Stigma Croci 11 parts; Rhizoma Acori Graminei 4.5 parts; To fail 11 parts, clothing.
Above-mentioned a kind of preparation method of preventing and treating demented Chinese medicinal composition capsules, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, add yellow wine (consumption is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 9 hours, take out, evenly stand is in food steamer, and moderate heat steams 55 minutes;
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, crosses 160 mesh sieves;
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 45 minutes, adds step (1)-(2) gains, continues heating extraction twice, each 35 minutes, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stirs, hold over night, filter, be concentrated into relative density 1.25(25 DEG C) thick paste, dry, pulverize, cross 190 mesh sieves, make capsule (0.5g/ grain).
Instructions of taking: each 2-3 grain, every day 2 times, 12 days courses for the treatment of.
test example:in order to verify a kind of curative effect of preventing and treating demented Chinese medicine composition (embodiment 5) of the present invention, do contrast test in March ,-2013 in August, 2010:
General data: screening 270 routine demented patient, wherein minimal ages 18 years old, max age 65 years old, 43.7 years old mean age.Be divided into experimental group and matched group two groups (wherein experimental group 170 people, matched group 100 people) at random, two groups are compared there was no significant difference, have comparability in sex, age, the course of disease, state of an illness scoring etc.
Diagnostic criteria: 1. with spirit depressing, apathetic expression, quiet and few dynamic, being reticent and dementia, or soliloquy, speaking incoherently; Or bolt suddenly, stir up a disturbance not peaceful, wail shouts of cursing, do not keep away close and distant.2. get rid of caused by the reasons such as medicine, poisoning, calentura.
Usage and dosage: experimental group takes that the present invention is a kind of prevents and treats demented Chinese medicine composition, each serving with 2, every day 2 times, 12 days courses for the treatment of; Matched group takes other medicine (example hydrochloric acid chlorpromazine tablet, proxetine hydrochloride tablets etc.), wherein, and chlorpromazine HCL tablet: oral, from low dose, a 25-50mg, 2-3 time on the one, a 25-50mg is slowly incremented to gradually, therapeutic dose 400-600mg on the one every 2-3 day.Proxetine hydrochloride tablets: general dosage is 20mg every day, take according to sick person's development after 2-3 week, some client need dosage, increase progressively with 10mg amount weekly, every daily maximum can reach 50mg, should follow the doctor's advice.
Criterion of therapeutical effect: cure: all irregularities disappear, sleep is normal, and animation recovers normal, and at least two years do not recur; Effective: all irregularities alleviate or partial disappearance, animation recovers normal substantially; Invalid: increasing the weight of appears in the unchanged even state of an illness of all uncomfortable behaviors.
Adopt the matched group of other drug and take a kind of Comparison of therapeutic of preventing and treating the experimental group of demented Chinese medicine composition of the present invention, result is as shown in table 1:
Table 1
efficacy analysis:as can be seen from Table 1, take a kind of inefficiency of preventing and treating demented Chinese medicine composition of the present invention and be only 3.53%, cure rate is up to 68.82%, effective percentage is up to 96.47%, and take the inefficiency had up to 23% of the demented medicine of other treatment, cure rate only reaches 36%, and effective percentage is also only 77%.Experiment shows that the present invention is a kind of and prevents and treats demented Chinese medicine composition compared with other drug, and cure rate is high, and inefficiency is low, and curative effect is more remarkable.Traditional Chinese medicine composition for treating of the present invention is demented evident in efficacy, takes stopgap measures and effects a permanent cure, and reach the object for the treatment of both the principal and secondary aspects of a disease, not easily recur more, clinic is applied, and is to treat demented ideal medicament simply.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. the demented Chinese medicine composition of control, is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Radix Ophiopogonis 9-12 part; Radix Sorghum vulgare Pers. 11-14 part; Radix wisteriae sinensis 8-16 part; Flos Rosae Davuricae 10-14 part; Exocarpium Citri Grandis 8-15 part; Radix Coriariae Sinicae 6-9 part; Build Fructus Amomi 7-12 part; Radix Chimonanthi praecocis 9-13 part; Oreas martiana (Hopp. Et Hornsch.) Brid. 8-14 part; Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 6-15 part; Medulla Junci 7-13 part; Herba Vernoniae Cinereae 9-15 part; Stigma Croci 8-14 part; Rhizoma Acori Graminei 3-6 part; To fail clothing 7-14 part.
2. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Radix Ophiopogonis 10-11 part; Radix Sorghum vulgare Pers. 12-13 part; Radix wisteriae sinensis 11-13 part; Flos Rosae Davuricae 11-13 part; Exocarpium Citri Grandis 11-13 part; Radix Coriariae Sinicae 7-8 part; Build Fructus Amomi 9-11 part; Radix Chimonanthi praecocis 10-12 part; Oreas martiana (Hopp. Et Hornsch.) Brid. 10-12 part; Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 10-12 part; Medulla Junci 9-11 part; Herba Vernoniae Cinereae 11-13 part; Stigma Croci 10-12 part; Rhizoma Acori Graminei 4-5 part; To fail clothing 10-12 part.
3. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Radix Ophiopogonis 10.5 parts; Radix Sorghum vulgare Pers. 12.5 parts; Radix wisteriae sinensis 12 parts; Flos Rosae Davuricae 12 parts; Exocarpium Citri Grandis 12 parts; Radix Coriariae Sinicae 7.5 parts; Build Fructus Amomi 10 parts; Radix Chimonanthi praecocis 11 parts; Oreas martiana (Hopp. Et Hornsch.) Brid. 11 parts; Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 11 parts; Medulla Junci 10 parts; Herba Vernoniae Cinereae 12 parts; Stigma Croci 11 parts; Rhizoma Acori Graminei 4.5 parts; To fail 11 parts, clothing.
4., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that: the preparation method of described decoction, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, add yellow wine, moistening 8-10 hour, take out, evenly stand is in food steamer, and moderate heat steams 50-60 minute (preferred moderate heat steams 53-57 minute, is more preferably moderate heat and steams 55 minutes);
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 40-50 minute, adds step (1)-(2) gains, continues heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stir, hold over night, filter, sterile packaged.
5. the preparation method of Chinese medicine composition according to claim 4, it is characterized in that: the consumption of the preferred yellow wine of step (2) is the 30%-40% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass, and the consumption being more preferably yellow wine is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass.
6., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that: the preparation method of described granule, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 8-10 hour, takes out, and evenly stand is in food steamer, moderate heat steams 50-60 minute (preferred moderate heat steams 53-57 minute, is more preferably moderate heat and steams 55 minutes);
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 40-50 minute, adds step (1)-(2) gains, continues heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stir, hold over night, filter, be concentrated into the thick paste of relative density 1.10-1.20, make uniform fine particle, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
7. the preparation method of Chinese medicine composition according to claim 6, is characterized in that: step (5) is preferably concentrated into the thick paste of relative density 1.13-1.17, is more preferably the thick paste being concentrated into relative density 1.15.
8., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that: the preparation method of described concentrated pill, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 8-10 hour, takes out, and evenly stand is in food steamer, moderate heat steams 50-60 minute (preferred moderate heat steams 53-57 minute, is more preferably moderate heat and steams 55 minutes);
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 40-50 minute, adds step (1)-(2) gains, continues heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stir, hold over night, filter, be concentrated into the thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15) of relative density 1.10-1.20, (preferred diameter is 3-5mm to make concentrated pill, being more preferably diameter is 4mm), sterile packaged.
9., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that: the preparation method of described tablet, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 8-10 hour, takes out, and evenly stand is in food steamer, moderate heat steams 50-60 minute (preferred moderate heat steams 53-57 minute, is more preferably moderate heat and steams 55 minutes);
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 40-50 minute, adds step (1)-(2) gains, continues heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stir, hold over night, filter, the thick paste being concentrated into relative density 1.10-1.20 (is preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), make tablet.
10., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that: the preparation method of described capsule, step is as follows:
(1) Medulla Junci and Stigma Croci are smashed, load in gauze medicated bag, tighten bag mouth;
(2) Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei are smashed, be placed in container, (consumption of preferred yellow wine is the 30%-40% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass to add yellow wine, the consumption being more preferably yellow wine is 35% of Radix Sorghum vulgare Pers., Oreas martiana (Hopp. Et Hornsch.) Brid. and Rhizoma Acori Graminei gross mass), moistening 8-10 hour, takes out, and evenly stand is in food steamer, moderate heat steams 50-60 minute (preferred moderate heat steams 53-57 minute, is more preferably moderate heat and steams 55 minutes);
(3) by Radix wisteriae sinensis and Radix Chimonanthi praecocis section, be placed in pot, slow fire is fried to surperficial micro-yellow, takes out, cools, grind into powder, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) by Radix Ophiopogonis, Flos Rosae Davuricae, Exocarpium Citri Grandis, Radix Coriariae Sinicae, build Fructus Amomi, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), Herba Vernoniae Cinereae and clothing of failing is cleaned, be placed in marmite, add water, heating extraction 40-50 minute, adds step (1)-(2) gains, continues heating extraction twice, each 30-40 minute, merge extractive liquid, filters, is condensed into 1/2 of original volume;
(5) step (3) gained medicated powder is joined in step (4) gained filtrate, stir, hold over night, filter, the thick paste being concentrated into relative density 1.20-1.30 (is preferably concentrated into the thick paste of relative density 1.23-1.27, be more preferably the thick paste being concentrated into relative density 1.25), dry, pulverize, cross 180-200 mesh sieve, make capsule (preferred 0.4-0.6g/ grain, is more preferably 0.5g/ grain).
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| CN112675207A (en) * | 2021-01-13 | 2021-04-20 | 上海和黄药业有限公司 | Medicine suitable for protecting nerve cells and preparation and application thereof |
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