CN105125436A - Compound whitening composition and preparation method - Google Patents
Compound whitening composition and preparation method Download PDFInfo
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Abstract
The invention particularly discloses a compound whitening composition and a preparation method. The compound whitening composition comprises the following raw materials in parts by weight: 0.1-10 parts of traditional Chinese medicine active part extractives, 0.05-5 parts of sodium ascorbyl phosphate, 0.1-5 parts of peat extractive and 80-99.75 parts of water; the traditional Chinese medicine active part extractives comprise the following raw materials in parts by weight: 10-40 parts of carthamus tinctorius, 2-30 parts of astragalus membranaceus, 5-25 parts of cactus and 5-30 parts of roselle calyx. Multiple traditional Chinese medicine active ingredients are added into the compound whitening composition disclosed by the invention, so that the compound whitening composition has the effects of activating blood circulation to dissipate stasis, efficiently inhibiting activity of tyrosinase and controlling melanogenesis, removing oxygen free radicals and efficiently whitening and protecting skin, and is non-toxic and harmless. After a consumer using a cosmetic containing the compound whitening composition for a period of time, the skin of the consumer is white red.
Description
Technical field
The present invention relates to a kind of composite whitening compositions, be specifically related to a kind of composite whitening composition and method of making the same.
Background technology
Everybody has a love of beauty, and due to the tradition thought attractive in appearance of " hide in vain three ugly ", the skin of pale health that what Asia women was natural have deep love for, makes whitening become focus and the trend of beauty treatment.The depth of skin color regulates and controls by many factors, but depends primarily on melanic content and distribution, the therefore whitening mainly generation of modulating melanin, distribution.For melanin generation, distribution mechanism, its whitening Regulation Mechanism mainly contains: check melanin is formed, check melanin transfer of granules, makes containing the more skin exfoliation of melanin, block ability signal transduction pathway in melanin production process, reduce the extrinsic factor that melanin is formed.
Based on melanic Regulation Mechanism, the whitening agent of current market mainly contains following a few class: 1. check melanin forms class, mainly contains tyrosinase inhibitor, as kojic acid and derivant, hydroquinone and derivant thereof, oxidation reaction inhibitor, as L-AA and derivant thereof; 2. check melanin transfer of granules is to horn cell, as nicotiamide; 3. skin exfoliation agent, as fruit acid and nicotiamide; 4. UV absorbent, as benzophenone, paraaminobenzoic acid esters, cinnamate derivative.These chemical whitening agents are mostly economical but there is certain zest, character is unstable, skin absorption is poor, especially skin exfoliation agent be directly the one of human body skin is damaged, sometimes cause one in vain unsound.So, how to reach the U.S. of " white touched with red " thought in traditional view, just rely on chemical whitening agent to be obviously unpractical.The present invention adopts Chinese prescription, is aided with safe whitening agent, reaches activating blood circulation to dissipate blood stasis, promotes the blood circulation of blood capillary, and check melanin generates simultaneously, reaches the healthy whitening effect of " white touched with red ".
Summary of the invention
In order to solve existing whitening product Problems existing, the object of the invention is to provide a kind of efficient, safe composite whitening composition and method of making the same.
For achieving the above object, technical scheme that the present invention adopts is as follows:
A kind of composite whitening compositions, is characterized in that being made up of the raw material of following parts by weight: traditional Chinese medicine active site extract 0.1-10, NAP 0.05-5, Semen Pisi sativi extract 0.1-5 and deionized water 80-99.75; The raw material weight number of described traditional Chinese medicine active site extract is: Flos Carthami 10-40, Radix Astragali 2-30, Radix et Caulis Opuntiae Dillenii 5-25, Hibiscus Sabdariffa Linn 5-30.
Preferably, a kind of composite whitening compositions, is characterized in that being made up of the raw material of following parts by weight: traditional Chinese medicine active site extract 5, NAP 0.8, Semen Pisi sativi extract 2 and deionized water 92.2; The raw material weight number of described traditional Chinese medicine active site extract is: Flos Carthami 30, the Radix Astragali 25, Radix et Caulis Opuntiae Dillenii 20, Hibiscus Sabdariffa Linn 25.
Preferably, a kind of composite whitening compositions, is characterized in that being made up of the raw material of following parts by weight: traditional Chinese medicine active site extract 8, NAP 0.5, Semen Pisi sativi extract 2.5 and deionized water 89; The raw material weight number of described traditional Chinese medicine active site extract is: Flos Carthami 35, the Radix Astragali 25, Radix et Caulis Opuntiae Dillenii 22, Hibiscus Sabdariffa Linn 23.
Preferably, a kind of composite whitening compositions, is characterized in that being made up of the raw material of following parts by weight: traditional Chinese medicine active site extract 6, NAP 1, Semen Pisi sativi extract 1.5 and deionized water 91.5; The raw material weight number of described traditional Chinese medicine active site extract is: Flos Carthami 32, the Radix Astragali 23, Radix et Caulis Opuntiae Dillenii 25, Hibiscus Sabdariffa Linn 20.
Preferably, a kind of composite whitening compositions, is characterized in that being made up of the raw material of following parts by weight: traditional Chinese medicine active site extract 7, NAP 0.9, Semen Pisi sativi extract 2.1 and deionized water 90; The raw material weight number of described traditional Chinese medicine active site extract is: Flos Carthami 38, the Radix Astragali 22, Radix et Caulis Opuntiae Dillenii 20, Hibiscus Sabdariffa Linn 20.
A preparation method for composite whitening compositions, comprises the following steps:
(1) method for extraction and purification of traditional Chinese medicine active site extract is:
It is in 20% ~ 80% ethanol that the traditional Chinese medicine active site extract raw material of Flos Carthami, the Radix Astragali, Radix et Caulis Opuntiae Dillenii, Hibiscus Sabdariffa Linn is soaked in concentration according to the medicine of 1:5 to 1:10 and solvent ratios, soak time is 2 hours, then stir at 60 DEG C and extract 1-2 hour, repeat to extract 2-3 time, merge extractive liquid; Then filter, filtrate reduced in volume is reclaimed ethanol extremely without after alcohol taste, add 2-5 times of water gaging dilution, go up again macroporous resin column that resin type number is D101 or AB-8 wash colourless after, colourless to eluent with 30%-90% ethanol elution again, and collect ethanol elution, then decompression recycling ethanol is 1:1 ~ 1:5 to medicinal liquid and medical material weight ratio, obtained traditional Chinese medicine active site extract;
(2) described traditional Chinese medicine active site extract, NAP, Semen Pisi sativi extract are joined in deionized water, feed in raw material in reinforced process and stir, and stir 10-20 minute again after reinforced end; Leave standstill 24-48 hour, filter, to obtain final product.
Preferably, in the preparation method of described composite whitening compositions: in described step (1) is 60% for soaking the concentration of alcohol of traditional Chinese medicine active site extract raw material, and described traditional Chinese medicine active site extract raw material and proportion of ethanol are 1:8.
Preferably, in the preparation method of described composite whitening compositions: be 75% for the concentration of alcohol of eluting in described step (1).
The second object of the present invention is used in skin-lightening cosmetic by above-mentioned whitening composite whitening compositions, makes stable in properties, respond well skin-lightening cosmetic.
In order to realize this purpose, the present invention adopt technical scheme as follows: the cosmetics containing a kind of composite whitening compositions according to claim 1, it is characterized in that its consumption is 1-99% by weight percentage containing a kind of composite whitening compositions according to claim 1 in cosmetics.
The theory of the composite whitening compositions application combination of Chinese and Western medicine of the present invention is the combination of plurality of Chinese component and whitening active component.Chinese medicinal components adopts the theory of Chinese medical science of monarch to carry out prescription, and Flos Carthami is monarch, has effect of very strong latus rectum of invigorating blood circulation, eliminating stasis to stop pain, blood circulation promoting; The Radix Astragali is minister, has effect of benefiting QI for strengthening the superficies, inducing diuresis to remove edema, detoxification, granulation promoting, has nourishes rough skin and anti-aging effects well; Hibiscus Sabdariffa Linn is assistant, has the activity of extremely strong restraint of tyrosinase and the function of scavenging free radicals, can the generation of effective check melanin, the melanin that desalination has been formed; Radix et Caulis Opuntiae Dillenii for making, there is heat-clearing and toxic substances removing, scattered silt subsides a swelling effect and moisturizing, antiallergic effect, can coordinating the actions of various ingredients in a prescription; NAP has the function of stronger restraint of tyrosinase activity, is the whitening agent that in modern cosmetics, safety is higher; Record in Compendium of Material Medica, effect that Semen Pisi sativi has " dispel facial black speck, order face is glossy ", and also containing compositions such as abundant Semen Pisi sativi peptide and aminoacid in Semen Pisi sativi extract, there is the moisturizing of Feng Changhao and promote effect of skin elasticity.
The effect that composite whitening compositions of the present invention is worked in coordination with mutually by active ingredient of Chinese herbs and other whitening active thing, energy activating blood circulation to dissipate blood stasis, the activity of effective restraint of tyrosinase, efficient scavenging activated oxygen, prevent melanic generation, decompose the melanin of desalinating and having been formed, the hormonal system of human body can be regulated simultaneously, repair damage skin caused due to chemical compositions such as hormones, thus reach comprehensively fast, the effect for the treatment of both the principal and secondary aspects of a disease.Composite whitening compositions of the present invention containing to human body poisonous and harmful substance, is not one product safely and effectively.
Detailed description of the invention
Describe the present invention in detail below in conjunction with specific implementation method, be used for explaining the present invention in exemplary embodiment and description of the present invention, but not as a limitation of the invention.
Embodiment 1 one kinds of composite whitening compositionss (I) and preparation method
Present embodiment discloses a kind of composite whitening compositions, the raw material number in its composition of raw materials is: traditional Chinese medicine active site extract 5, NAP 0.8, Semen Pisi sativi extract 2 and deionized water 92.2; The raw material weight number of described traditional Chinese medicine active site extract is: Flos Carthami 30, the Radix Astragali 25, Radix et Caulis Opuntiae Dillenii 20, Hibiscus Sabdariffa Linn 25.
The composite whitening preparation method of composition of the present embodiment is achieved in that
(1) method for extraction and purification of traditional Chinese medicine active site extract is: it is in 60% ethanol that the traditional Chinese medicine active site extract raw material of Flos Carthami, the Radix Astragali, Radix et Caulis Opuntiae Dillenii, Hibiscus Sabdariffa Linn is soaked in concentration according to the medicine of 1:8 and solvent ratios, soak time is 2 hours, then extraction 1.5 hours is stirred at 60 DEG C, repeat extraction 2 times, merge extractive liquid; Then filter, filtrate reduced in volume is reclaimed ethanol extremely without after alcohol taste, add 3 times of water gaging dilutions, go up again macroporous resin column that resin type number is AB-8 wash colourless after, colourless to eluent with 70% ethanol elution again, and collect ethanol elution, then decompression recycling ethanol is 1:2 to medicinal liquid and medical material weight ratio, obtained traditional Chinese medicine active site extract;
(2) described traditional Chinese medicine active site extract, NAP, Semen Pisi sativi extract are joined in deionized water, feed in raw material in reinforced process and stir, and stir 15 minutes again after reinforced end; Leave standstill 36 hours, filter, to obtain final product.
Embodiment 2 one kinds of composite whitening compositionss (II) and preparation method
Present embodiment discloses a kind of composite whitening compositions, the raw material number in its composition of raw materials is: traditional Chinese medicine active site extract 8, NAP 0.5, Semen Pisi sativi extract 2.5 and deionized water 89; The raw material weight number of described traditional Chinese medicine active site extract is: Flos Carthami 35, the Radix Astragali 25, Radix et Caulis Opuntiae Dillenii 22, Hibiscus Sabdariffa Linn 23.
The composite whitening preparation method of composition of the present embodiment is achieved in that
(1) method for extraction and purification of traditional Chinese medicine active site extract is: it is in 70% ethanol that the traditional Chinese medicine active site extract raw material of Flos Carthami, the Radix Astragali, Radix et Caulis Opuntiae Dillenii, Hibiscus Sabdariffa Linn is soaked in concentration according to the medicine of 1:6 and solvent ratios, soak time is 2 hours, then extraction 2 hours is stirred at 60 DEG C, repeat extraction 3 times, merge extractive liquid; Then filter, filtrate reduced in volume is reclaimed ethanol extremely without after alcohol taste, add 3 times of water gaging dilutions, go up again macroporous resin column that resin type number is AB-8 wash colourless after, colourless to eluent with 75% ethanol elution again, and collect ethanol elution, then decompression recycling ethanol is 1:2 to medicinal liquid and medical material weight ratio, obtained traditional Chinese medicine active site extract;
(2) described traditional Chinese medicine active site extract, NAP, Semen Pisi sativi extract are joined in deionized water, feed in raw material in reinforced process and stir, and stir 15 minutes again after reinforced end; Leave standstill 36 hours, filter, to obtain final product.
Embodiment 3 one kinds of composite whitening compositionss (III) and preparation method
Present embodiment discloses a kind of composite whitening compositions, the raw material number in its composition of raw materials is: traditional Chinese medicine active site extract 6, NAP 1, Semen Pisi sativi extract 1.5 and deionized water 91.5; The raw material weight number of described traditional Chinese medicine active site extract is: Flos Carthami 32, the Radix Astragali 23, Radix et Caulis Opuntiae Dillenii 25, Hibiscus Sabdariffa Linn 20.
The composite whitening preparation method of composition of the present embodiment is achieved in that
(1) method for extraction and purification of traditional Chinese medicine active site extract is: it is in 60% ethanol that the traditional Chinese medicine active site extract raw material of Flos Carthami, the Radix Astragali, Radix et Caulis Opuntiae Dillenii, Hibiscus Sabdariffa Linn is soaked in concentration according to the medicine of 1:8 and solvent ratios, soak time is 2 hours, then extraction 1 hour is stirred at 60 DEG C, repeat extraction 3 times, merge extractive liquid; Then filter, filtrate reduced in volume is reclaimed ethanol extremely without after alcohol taste, add 3 times of water gaging dilutions, go up again macroporous resin column that resin type number is AB-8 wash colourless after, colourless to eluent with 75% ethanol elution again, and collect ethanol elution, then decompression recycling ethanol is 1:2 to medicinal liquid and medical material weight ratio, obtained traditional Chinese medicine active site extract;
(2) described traditional Chinese medicine active site extract, NAP, Semen Pisi sativi extract are joined in deionized water, feed in raw material in reinforced process and stir, and stir 15 minutes again after reinforced end; Leave standstill 36 hours, filter, to obtain final product.
Embodiment 4 one kinds of composite whitening compositionss (IV) and preparation method
Present embodiment discloses a kind of composite whitening compositions, the raw material number in its composition of raw materials is: traditional Chinese medicine active site extract 7, NAP 0.9, Semen Pisi sativi extract 2.1 and deionized water 90; The raw material weight number of described traditional Chinese medicine active site extract is: Flos Carthami 38, the Radix Astragali 22, Radix et Caulis Opuntiae Dillenii 20, Hibiscus Sabdariffa Linn 20.
The composite whitening preparation method of composition of the present embodiment is achieved in that
(1) method for extraction and purification of traditional Chinese medicine active site extract is: it is in 50% ethanol that the traditional Chinese medicine active site extract raw material of Flos Carthami, the Radix Astragali, Radix et Caulis Opuntiae Dillenii, Hibiscus Sabdariffa Linn is soaked in concentration according to the medicine of 1:9 and solvent ratios, soak time is 2 hours, then extraction 1.5 hours is stirred at 60 DEG C, repeat extraction 2 times, merge extractive liquid; Then filter, filtrate reduced in volume is reclaimed ethanol extremely without after alcohol taste, add 3 times of water gaging dilutions, go up again macroporous resin column that resin type number is AB-8 wash colourless after, colourless to eluent with 75% ethanol elution again, and collect ethanol elution, then decompression recycling ethanol is 1:2 to medicinal liquid and medical material weight ratio, obtained traditional Chinese medicine active site extract;
(2) described traditional Chinese medicine active site extract, NAP, Semen Pisi sativi extract are joined in deionized water, feed in raw material in reinforced process and stir, and stir 15 minutes again after reinforced end; Leave standstill 36 hours, filter, to obtain final product.
Embodiment 5 contains whitening skin-protection cream and the preparation thereof of composite whitening compositions
Table 1 provides the whitening skin-protection cream formula containing composite whitening compositions of the present invention, the consumption mass fraction table of each material:
Table 1
Preparation method: A phase 80 DEG C dissolves mix homogeneously, B phase 80 DEG C dissolves mix homogeneously, adds B phase before Cyclomethicone emulsifying, and during emulsifying, B is added to A phase also homogenizing 5 minutes, adds C phase also homogenizing 2 minutes, pack after ageing 24h when being cooled to 50 DEG C.
Embodiment 6 contains whitening and skin-protecting emulsion and the preparation thereof of composite whitening compositions
Table 2 provides the whitening and skin-protecting emulsion formulations containing composite whitening compositions of the present invention, and the consumption of each material represents with mass fraction:
Table 2
Preparation method: A phase 80 DEG C dissolves mix homogeneously, B phase 80 DEG C dissolves mix homogeneously, C is added B phase before emulsifying, and during emulsifying, A is added to B phase also homogenizing 5 minutes, adds D and homogenizing 2 minutes, pack after ageing 24h when being cooled to 50 DEG C.
Embodiment 7 contains whitening and skin-protecting facial mask liquid and the preparation thereof of composite whitening compositions
Table 3 provides the whitening and skin-protecting facial mask liquid formula containing composite whitening compositions of the present invention, and the consumption of each material represents with mass fraction:
Table 3
| Material title | Mass fraction/% |
| Water | Surplus |
| EDETATE SODIUM | 0.02 |
| Hyaluronate sodium | 0.08 |
| Glycerol | 2.00 |
| 1,3 butylene glycol | 4.00 |
| Composite whitening compositions (III) | 20.0 |
| Methyl hydroxybenzoate | 0.10 |
| Propyl hydroxybenzoate | 0.05 |
| Phenoxyethanol | 0.30 |
Preparation method: heat water to 75 DEG C, add methyl hydroxybenzoate, propyl hydroxybenzoate, EDETATE SODIUM, after dissolving, be cooled to 50 DEG C, add hyaluronate sodium, glycerol, 1, the mixture of 3-butanediol and phenoxyethanol, after stirring and dissolving, add composite whitening compositions, stirring and dissolving is even, pack after ageing 24h.
Embodiment 8 contains whitening and skin-protecting essence and the preparation thereof of composite whitening compositions
Table 4 provides the whitening and skin-protecting essence formula containing composite whitening compositions of the present invention, and the consumption of each material represents with mass fraction:
Table 4
| Material title | Mass fraction/% |
| Water | Surplus |
| EDETATE SODIUM | 0.02 |
| Hyaluronate sodium | 0.10 |
| Glycerol | 3.00 |
| 1,3 butylene glycol | 4.00 |
| Composite whitening compositions (IV) | 60.0 |
| Methyl hydroxybenzoate | 0.10 |
| Propyl hydroxybenzoate | 0.05 |
| Phenoxyethanol | 0.30 |
Preparation method: heat water to 75 DEG C, add methyl hydroxybenzoate, propyl hydroxybenzoate, EDETATE SODIUM, after dissolving, be cooled to 50 DEG C, add hyaluronate sodium, glycerol, 1, the mixture of 3-butanediol and phenoxyethanol, after stirring and dissolving, add composite whitening compositions, stirring and dissolving is even, pack after ageing 24h.
Experimental example 1 vitro inhibition Tyrosinase Assay
1, experiment material
TYR solution (0.5mg/mL), tryrosinase (100U/ml), composite whitening compositions.
2, instrument:
10ml test tube, water-bath, agitator, ultraviolet spectrometry degree meter.
3, test method:
Embodiment 1 gained composite whitening compositions is added deionized water and is diluted to 0.05%, 0.10%, 0.15%, the solution of 0.20%, the restraint of tyrosinase measuring diluent by literature method is active.The document is: " enzyme microb whitening anti-aging efficacy study " that Ren Qing, Yu Xiaoyan etc. deliver in 03 phase in 2008 " fragrance flavor and cosmetic ";
4, experimental result
Composite whitening compositions restraint of tyrosinase measurement result is shown in Table 5.
Table 5
| Composite whitening composition concentration/% | To the suppression ratio/% of tryrosinase |
| 0.05% | 91.80% |
| 0.10% | 96.64% |
| 0.15% | 97.34% |
| 0.20% | 98.86% |
From table 5, the composite whitening compositions that the present invention makes has very strong restraint of tyrosinase effect.
Experimental example 2 normal individual trial evaluation experimental
(1) experimental technique
Cream frost emulsion prepared by embodiment 5 and embodiment 6 carries out normal individual trial evaluation respectively.Choose the volunteer that 60 colours of skin are darker, men and women half and half.Be divided into 3 groups at random, often organize 10 male, 10 women.3 groups use commercially available skin-lightening cosmetic respectively, embodiment 5 whitening skin-protection cream, embodiment 8 whitening and skin-protecting essence.Using method is use after clean of every day, and once a day, experiment periods is one month, fills in evaluation table on probation (adopt volunteer to evaluate scoring mechanism, wherein best result is that 3 points of expressions are effective, and 2 submeters are shown with effect, and 1 point represents no effect) according to sensory evaluation.Use the 15th day, within the 30th day, respectively add up once.
(2) experimental result
Normal individual trial evaluation result statistics is in table 6.
Table 6
From table 6 result, the skin-lightening cosmetic white-skinned face function containing composite whitening compositions of the present invention is obvious, and more remarkable than commercially available skin-lightening cosmetic effect.This routine skin-lightening cosmetic uses skinfeel comfortable, does not have zest, and not only white-skinned face function is remarkable, and skin is white touched with red, the healthy colour of skin.
Above the technical scheme that the embodiment of the present invention provides is described in detail, apply specific case herein to set forth the principle of the embodiment of the present invention and embodiment, the explanation of above embodiment is only applicable to the principle helping to understand the embodiment of the present invention; Meanwhile, for one of ordinary skill in the art, according to the embodiment of the present invention, detailed description of the invention and range of application all will change, and in sum, this description should not be construed as limitation of the present invention.
Claims (3)
1. a composite whitening compositions, is characterized in that being made up of the raw material of following parts by weight: traditional Chinese medicine active site extract 0.1-10, NAP 0.05-5, Semen Pisi sativi extract 0.1-5 and deionized water 80-99.75; The raw material weight number of described traditional Chinese medicine active site extract is: Flos Carthami 10-40, Radix Astragali 2-30, Radix et Caulis Opuntiae Dillenii 5-25, Hibiscus Sabdariffa Linn 5-30.
2. the preparation method of a kind of composite whitening compositions according to claim 1, is characterized in that comprising the following steps:
(1) method for extraction and purification of traditional Chinese medicine active site extract is: it is in 20% ~ 80% ethanol that the traditional Chinese medicine active site extract raw material of Flos Carthami, the Radix Astragali, Radix et Caulis Opuntiae Dillenii, Hibiscus Sabdariffa Linn is soaked in concentration according to the medicine of 1:5 to 1:10 and solvent ratios, soak time is 2 hours, then stir at 60 DEG C and extract 1-2 hour, repeat to extract 2-3 time, merge extractive liquid; Then filter, filtrate reduced in volume is reclaimed ethanol extremely without after alcohol taste, add 2-5 times of water gaging dilution, go up again macroporous resin column that resin type number is D101 or AB-8 wash colourless after, colourless to eluent with 30%-90% ethanol elution again, and collect ethanol elution, then decompression recycling ethanol is 1:1 ~ 1:5 to medicinal liquid and medical material weight ratio, obtained traditional Chinese medicine active site extract;
(2) described traditional Chinese medicine active site extract, NAP, Semen Pisi sativi extract are joined in deionized water, feed in raw material in reinforced process and stir, and stir 10-20 minute again after reinforced end; Leave standstill 24-48 hour, filter, to obtain final product.
3. the cosmetics containing a kind of composite whitening compositions according to claim 1, is characterized in that its consumption is 1-99% by weight percentage containing a kind of composite whitening compositions according to claim 1 in cosmetics.
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| CN105434288A (en) * | 2016-01-06 | 2016-03-30 | 朱昭辉 | Plant essence with skin whitening effect and preparation method and application thereof |
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| CN103536468A (en) * | 2013-10-12 | 2014-01-29 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with whitening effect and application of traditional Chinese medicine composition in cosmetics |
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| CN102247446A (en) * | 2011-08-15 | 2011-11-23 | 广州环亚化妆品科技有限公司 | Composite whitening and spot correcting lotion and manufacturing method thereof |
| CN103536468A (en) * | 2013-10-12 | 2014-01-29 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with whitening effect and application of traditional Chinese medicine composition in cosmetics |
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| CN105434288A (en) * | 2016-01-06 | 2016-03-30 | 朱昭辉 | Plant essence with skin whitening effect and preparation method and application thereof |
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