CN105125436B - A kind of composite whitening composition and preparation method - Google Patents
A kind of composite whitening composition and preparation method Download PDFInfo
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- CN105125436B CN105125436B CN201510506222.5A CN201510506222A CN105125436B CN 105125436 B CN105125436 B CN 105125436B CN 201510506222 A CN201510506222 A CN 201510506222A CN 105125436 B CN105125436 B CN 105125436B
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Abstract
The invention particularly discloses a kind of composite whitening composition and preparation method.The raw material weight number of the composite whitening composition is:Traditional Chinese medicine active site extract 0.1 10, NAP 0.05 5, Semen Pisi sativi extract 0.1 5 and deionized water 80 99.75;The raw material weight number of the traditional Chinese medicine active site extract is:Safflower 10 40, the Radix Astragali 2 30, cactus 5 25, Roselle 5 30.The composite whitening composition of the present invention with the addition of plurality of Chinese active component in whitening active thing, can activate blood circulation and disperse blood clots, and efficiently suppresses activity and the control melanin generation of tyrosinase, scavenging activated oxygen, has potent whitening and skin-protecting effect, and nontoxic.After consumer uses the cosmetics containing the composite whitening composition for a period of time, skin is white touched with red.
Description
Technical field
The present invention relates to a kind of composite whitening composition, and in particular to a kind of composite whitening composition and preparation method thereof.
Background technology
Everybody has a love of beauty, and due to traditional thought attractive in appearance of " one white hide three ugly ", Asia women having deep love for naturally is pale
The skin of health, whitening is set to turn into the focus and trend of beauty.The depth of skin color is regulated and controled by many factors, but is mainly depended on
Content and distribution in melanin, therefore whitening is mainly the generation of modulating melanin, distribution.For melanin generation, distribution
Mechanism, its whitening Regulation Mechanism mainly have:Suppress melanin to be formed, suppress melanin granule transfer, make more containing melanin
Skin exfoliation, ability signal transduction pathway in melanin production process is blocked, reduce the extrinsic factor for forming melanin.
Regulation Mechanism based on melanin, at present the whitening agent of market mainly have following several classes:1. suppress melanin to be formed
Class, mainly there is tyrosinase inhibitor, such as kojic acid and its derivative, quinhydrones and its derivative, oxidation reaction inhibitor, as L- resists
Bad hematic acid and its derivative;2. suppressing melanin granule is transferred to horn cell, such as niacinamide;3. skin exfoliation agent, if
Acid and niacinamide;4. ultra-violet absorber, such as benzophenone, paraaminobenzoic acid esters, cinnamate derivative.These chemistry
Whitening agent is mostly economical but certain excitant, property are unstable, skin absorption is poor, especially skin exfoliation agent is there is having
Directly one kind of human body skin is damaged, caused sometimes a kind of unsound white.So how to reach what is thought in traditional concept
The U.S. of " white touched with red ", it is clearly unpractical to uniquely rely on chemical whitening agent.The present invention uses Chinese prescription, is aided with safe
Whitening agent, reach and activate blood circulation and disperse blood clots, promote the blood circulation of capillary, while suppress melanin generation, to reach " Bai Litou
It is red " healthy whitening effect.
The content of the invention
It is a kind of efficient, safety compound present invention aims at providing in order to solve the problems, such as that existing whitening product is present
Lightening compositions and preparation method thereof.
For achieving the above object, the present invention uses technical scheme as follows:
A kind of composite whitening composition, it is characterised in that be made up of the raw material of following parts by weight:Traditional Chinese medicine active site carries
Take thing 0.1-10, NAP 0.05-5, Semen Pisi sativi extract 0.1-5 and deionized water 80-99.75;The Chinese medicine
The raw material weight number of active site extract is:Safflower 10-40, Radix Astragali 2-30, cactus 5-25, Roselle 5-30.
Preferably, a kind of composite whitening composition, it is characterised in that be made up of the raw material of following parts by weight:Active Chinese drug component
Extractive part 5, NAP 0.8, Semen Pisi sativi extract 2 and deionized water 92.2;The traditional Chinese medicine active site carries
The raw material weight number for taking thing is:Safflower 30, the Radix Astragali 25, cactus 20, Roselle 25.
Preferably, a kind of composite whitening composition, it is characterised in that be made up of the raw material of following parts by weight:Active Chinese drug component
Extractive part 8, NAP 0.5, Semen Pisi sativi extract 2.5 and deionized water 89;The traditional Chinese medicine active site carries
The raw material weight number for taking thing is:Safflower 35, the Radix Astragali 25, cactus 22, Roselle 23.
Preferably, a kind of composite whitening composition, it is characterised in that be made up of the raw material of following parts by weight:Active Chinese drug component
Extractive part 6, NAP 1, Semen Pisi sativi extract 1.5 and deionized water 91.5;The traditional Chinese medicine active site carries
The raw material weight number for taking thing is:Safflower 32, the Radix Astragali 23, cactus 25, Roselle 20.
Preferably, a kind of composite whitening composition, it is characterised in that be made up of the raw material of following parts by weight:Active Chinese drug component
Extractive part 7, NAP 0.9, Semen Pisi sativi extract 2.1 and deionized water 90;The traditional Chinese medicine active site carries
The raw material weight number for taking thing is:Safflower 38, the Radix Astragali 22, cactus 20, Roselle 20.
A kind of preparation method of composite whitening composition, comprises the following steps:
(1)The method for extraction and purification of traditional Chinese medicine active site extract is:
The traditional Chinese medicine active site of safflower, the Radix Astragali, cactus, Roselle is extracted into raw material according to 1:5 to 1:10 medicine
Concentration is soaked in as in 20% ~ 80% ethanol, soak time is 2 hours with solvent ratios, it is then small in 60 DEG C of stirring extraction 1-2
When, extraction 2-3 times is repeated, merges extract solution;Then filter, by filtrate decompression concentration and recovery ethanol to after without alcohol taste, add 2-5 times
Water dilution is measured, then the macroporous resin column washing that upper resin model is D101 or AB-8 is to after colourless, then with 30%-90% ethanol elutions
It is colourless to eluent, and ethanol eluate is collected, then it is 1 that ethanol to decoction and medicinal material weight ratio, which is recovered under reduced pressure,:1~1:5, it is made
Traditional Chinese medicine active site extract;
(2)The traditional Chinese medicine active site extract, NAP, Semen Pisi sativi extract are added to deionized water
In, fed during charging while stirring, and 10-20 minutes are stirred for after charging terminates;It is small to stand 24-48
When, filtering, produce.
Preferably, in the preparation method of the composite whitening composition:The step(1)In be used for soak active Chinese drug component
The concentration of alcohol of extractive part raw material is 60%, and the traditional Chinese medicine active site extraction raw material and proportion of ethanol are 1:8.
Preferably, in the preparation method of the composite whitening composition:The step(1)In be used for elute concentration of alcohol
For 75%.
The second object of the present invention is that above-mentioned whitening composite whitening composition is used in skin-lightening cosmetic, and it is steady to make property
Skin-lightening cosmetic that is fixed, working well.
In order to realize this purpose, the present invention uses technical scheme as follows:Containing a kind of compound described in claim 1
The cosmetics of lightening compositions, it is characterised in that containing a kind of composite whitening composition described in claim 1 in cosmetics, its
Dosage is 1-99% by weight percentage.
The theory of the composite whitening composition application combination of Chinese tradiational and Western medicine of the present invention, is plurality of Chinese component and whitening active group
The combination divided.Traditional Chinese medicinal components using monarch theory of traditional Chinese medical science carry out prescription, safflower is monarch, have very strong promoting blood circulation latus rectum,
Blood stasis removing analgesic, the effect of stimulating circulation;The Radix Astragali is minister, has the effect of invigorating qi for consolidating superficies, inducing diuresis for removing edema, detoxification, myogenic, has very
Nourishes rough skin and anti-aging effects well;Roselle is assistant, has the activity of extremely strong suppression tyrosinase and removes free radical
Function, can effectively suppress the generation of melanin, desalinate the melanin formed;Cactus has clearing heat and detoxicating, scattered to make
Detumescence effect of becoming silted up and moisturizing, antiallergic effect, can coordinating the drug actions of a prescription;NAP has stronger suppression tyrosinase activity
Function, be the whitening agent that security is higher in modern cosmetics;《Compendium of Materia Medica》In record, pea have " dispels face it is black
Spot, order face is glossy " the effect of, and have in Semen Pisi sativi extract also containing compositions such as abundant pea peptides and amino acid
The effect of rich often good moisturizing and lifting skin elasticity.
The effect that the composite whitening composition of the present invention is mutually cooperateed with by active ingredient of Chinese herbs with other whitening active things,
It can activate blood circulation and disperse blood clots, the effective activity for suppressing tyrosinase, efficient scavenging activated oxygen, prevent the generation of melanin, decompose light
Change the melanin formed, while the internal system of human body can be adjusted, repair because the chemical compositions such as hormone are to skin
Caused by damage, so as to reach the quick, effect treated both principal and secondary aspect of disease comprehensively.The composite whitening composition of the present invention is free of to be had to human body
Malicious harmful substance, it is a kind of safely and effectively product.
Embodiment
The present invention is described in detail below in conjunction with specific implementation method, is used in the exemplary embodiment and description of the present invention
The present invention is explained, but it is not as a limitation of the invention.
A kind of composite whitening composition of embodiment 1(Ⅰ)And preparation method
Present embodiment discloses a kind of composite whitening composition, the raw material number in its composition of raw materials is:Active Chinese drug component portion
Position extract 5, NAP 0.8, Semen Pisi sativi extract 2 and deionized water 92.2;The traditional Chinese medicine active site extraction
The raw material weight number of thing is:Safflower 30, the Radix Astragali 25, cactus 20, Roselle 25.
What the composite whitening preparation method of composition of the present embodiment was realized in:
(1)The method for extraction and purification of traditional Chinese medicine active site extract is:By safflower, the Radix Astragali, cactus, Roselle Chinese medicine
Active site extracts raw material according to 1:8 medicine and solvent ratios is soaked in concentration as in 60% ethanol, soak time is 2 small
When, then extracted 1.5 hours in 60 DEG C of stirrings, repeat extraction 2 times, merge extract solution;Then filter, filtrate decompression is concentrated back
Ethanol is received to after without alcohol taste, adding 3 times of amount water dilutions, then the macroporous resin column washing that upper resin model is AB-8 is to after colourless, then
It is colourless to eluent with 70% ethanol elution, and ethanol eluate is collected, then ethanol to decoction and medicinal material weight ratio is recovered under reduced pressure and is
1:2, traditional Chinese medicine active site extract is made;
(2)The traditional Chinese medicine active site extract, NAP, Semen Pisi sativi extract are added to deionized water
In, fed during charging while stirring, and be stirred for 15 minutes after charging terminates;36 hours are stood, filtering,
Produce.
A kind of composite whitening composition of embodiment 2(Ⅱ)And preparation method
Present embodiment discloses a kind of composite whitening composition, the raw material number in its composition of raw materials is:Active Chinese drug component portion
Position extract 8, NAP 0.5, Semen Pisi sativi extract 2.5 and deionized water 89;The traditional Chinese medicine active site extraction
The raw material weight number of thing is:Safflower 35, the Radix Astragali 25, cactus 22, Roselle 23.
What the composite whitening preparation method of composition of the present embodiment was realized in:
(1)The method for extraction and purification of traditional Chinese medicine active site extract is:By safflower, the Radix Astragali, cactus, Roselle Chinese medicine
Active site extracts raw material according to 1:6 medicine and solvent ratios is soaked in concentration as in 70% ethanol, soak time is 2 small
When, then extracted 2 hours in 60 DEG C of stirrings, repeat extraction 3 times, merge extract solution;Then filter, by filtrate decompression concentration and recovery
Ethanol is to after without alcohol taste, adding 3 times of amount water dilutions, then the macroporous resin column washing that upper resin model is AB-8 is to after colourless, then uses
75% ethanol elution is colourless to eluent, and collects ethanol eluate, then it is 1 that ethanol to decoction and medicinal material weight ratio, which is recovered under reduced pressure,:
2, traditional Chinese medicine active site extract is made;
(2)The traditional Chinese medicine active site extract, NAP, Semen Pisi sativi extract are added to deionized water
In, fed during charging while stirring, and be stirred for 15 minutes after charging terminates;36 hours are stood, filtering,
Produce.
A kind of composite whitening composition of embodiment 3(Ⅲ)And preparation method
Present embodiment discloses a kind of composite whitening composition, the raw material number in its composition of raw materials is:Active Chinese drug component portion
Position extract 6, NAP 1, Semen Pisi sativi extract 1.5 and deionized water 91.5;The traditional Chinese medicine active site extraction
The raw material weight number of thing is:Safflower 32, the Radix Astragali 23, cactus 25, Roselle 20.
What the composite whitening preparation method of composition of the present embodiment was realized in:
(1)The method for extraction and purification of traditional Chinese medicine active site extract is:By safflower, the Radix Astragali, cactus, Roselle Chinese medicine
Active site extracts raw material according to 1:8 medicine and solvent ratios is soaked in concentration as in 60% ethanol, soak time is 2 small
When, then extracted 1 hour in 60 DEG C of stirrings, repeat extraction 3 times, merge extract solution;Then filter, by filtrate decompression concentration and recovery
Ethanol is to after without alcohol taste, adding 3 times of amount water dilutions, then the macroporous resin column washing that upper resin model is AB-8 is to after colourless, then uses
75% ethanol elution is colourless to eluent, and collects ethanol eluate, then it is 1 that ethanol to decoction and medicinal material weight ratio, which is recovered under reduced pressure,:
2, traditional Chinese medicine active site extract is made;
(2)The traditional Chinese medicine active site extract, NAP, Semen Pisi sativi extract are added to deionized water
In, fed during charging while stirring, and be stirred for 15 minutes after charging terminates;36 hours are stood, filtering,
Produce.
A kind of composite whitening composition of embodiment 4(Ⅳ)And preparation method
Present embodiment discloses a kind of composite whitening composition, the raw material number in its composition of raw materials is:Active Chinese drug component portion
Position extract 7, NAP 0.9, Semen Pisi sativi extract 2.1 and deionized water 90;The traditional Chinese medicine active site extraction
The raw material weight number of thing is:Safflower 38, the Radix Astragali 22, cactus 20, Roselle 20.
What the composite whitening preparation method of composition of the present embodiment was realized in:
(1)The method for extraction and purification of traditional Chinese medicine active site extract is:By safflower, the Radix Astragali, cactus, Roselle Chinese medicine
Active site extracts raw material according to 1:9 medicine and solvent ratios is soaked in concentration as in 50% ethanol, soak time is 2 small
When, then extracted 1.5 hours in 60 DEG C of stirrings, repeat extraction 2 times, merge extract solution;Then filter, filtrate decompression is concentrated back
Ethanol is received to after without alcohol taste, adding 3 times of amount water dilutions, then the macroporous resin column washing that upper resin model is AB-8 is to after colourless, then
It is colourless to eluent with 75% ethanol elution, and ethanol eluate is collected, then ethanol to decoction and medicinal material weight ratio is recovered under reduced pressure and is
1:2, traditional Chinese medicine active site extract is made;
(2)The traditional Chinese medicine active site extract, NAP, Semen Pisi sativi extract are added to deionized water
In, fed during charging while stirring, and be stirred for 15 minutes after charging terminates;36 hours are stood, filtering,
Produce.
The whitening skin-protection cream of the composition containing composite whitening of embodiment 5 and its preparation
Table 1 provides the whitening skin-protection cream formula of the composite whitening composition containing the present invention, the dosage quality of each material
Score graph:
Table 1
Preparation method:The 80 DEG C of dissolvings of A phases are well mixed, and the 80 DEG C of dissolvings of B phases are well mixed, cyclomethicone emulsification
Preceding addition B phases, B is added to A phases and homogeneous 5 minutes during emulsification, and C phase and homogeneous 2 minutes, ageing 24h are added when being cooled to 50 DEG C
After pack, you can.
The whitening and skin-protecting emulsion of the composition containing composite whitening of embodiment 6 and its preparation
Table 2 provides the whitening and skin-protecting emulsion formulations of the composite whitening composition containing the present invention, the dosage matter of each material
Measure fraction representation:
Table 2
Preparation method:The 80 DEG C of dissolvings of A phases are well mixed, and the 80 DEG C of dissolvings of B phases are well mixed, and C is added into B phases, breast before emulsification
A is added to B phases simultaneously homogeneous 5 minutes during change, and D simultaneously homogeneous 2 minutes are added when being cooled to 50 DEG C, are packed after being aged 24h, you can.
The whitening and skin-protecting facial mask liquid of the composition containing composite whitening of embodiment 7 and its preparation
Table 3 provides the whitening and skin-protecting facial mask formula of liquid of the composite whitening composition containing the present invention, and the dosage of each material is used
Mass fraction represents:
Table 3
Material title | Mass fraction/% |
Water | Surplus |
EDETATE SODIUM | 0.02 |
Sodium Hyaluronate | 0.08 |
Glycerine | 2.00 |
1,3 butylene glycol | 4.00 |
Composite whitening composition(Ⅲ) | 20.0 |
Methyl hydroxybenzoate | 0.10 |
Nipasol | 0.05 |
Phenoxyethanol | 0.30 |
Preparation method:75 DEG C are heated water to, methyl hydroxybenzoate, Nipasol, EDETATE SODIUM is added, after dissolving, is cooled to
50 DEG C, Sodium Hyaluronate, glycerine, the mixture and Phenoxyethanol of 1,3-BDO are added, after stirring and dissolving, adds composite whitening
Composition, stirring and dissolving is uniform, is packed after being aged 24h, you can.
The whitening and skin-protecting Essence of the composition containing composite whitening of embodiment 8 and its preparation
Table 4 provides the whitening and skin-protecting elite formula of liquid of the composite whitening composition containing the present invention, and the dosage of each material is used
Mass fraction represents:
Table 4
Material title | Mass fraction/% |
Water | Surplus |
EDETATE SODIUM | 0.02 |
Sodium Hyaluronate | 0.10 |
Glycerine | 3.00 |
1,3 butylene glycol | 4.00 |
Composite whitening composition(Ⅳ) | 60.0 |
Methyl hydroxybenzoate | 0.10 |
Nipasol | 0.05 |
Phenoxyethanol | 0.30 |
Preparation method:75 DEG C are heated water to, methyl hydroxybenzoate, Nipasol, EDETATE SODIUM is added, after dissolving, is cooled to
50 DEG C, Sodium Hyaluronate, glycerine, the mixture and Phenoxyethanol of 1,3-BDO are added, after stirring and dissolving, adds composite whitening
Composition, stirring and dissolving is uniform, is packed after being aged 24h, you can.
Experimental example 1 suppresses Tyrosinase Assay in vitro
1st, experiment material
TYR solution (0.5mg/mL), tyrosinase (100U/ml), composite whitening composition.
2nd, instrument:
10ml test tubes, water-bath, oscillator, ultraviolet spectrometry degree meter.
3rd, test method:
Deionized water is added to be diluted to 0.05% the gained composite whitening composition of embodiment 1,0.10%, 0.15%, 0.20%
Solution, the suppression tyrosinase activity of dilution is determined by literature method.The document is:It is Ren Qing, gorgeous etc. at 2008 03 in knowing
Phase《Fragrance flavor and cosmetic》In deliver《Enzyme microb whitening anti-aging efficacy study》;
4th, experimental result
Composite whitening composition suppresses tyrosinase measurement result and is shown in Table 5.
Table 5
Composite whitening composition concentration/% | To inhibiting rate/% of tyrosinase |
0.05% | 91.80% |
0.10% | 96.64% |
0.15% | 97.34% |
0.20% | 98.86% |
From table 5, there is the composite whitening composition that the present invention makes very strong suppression tyrosinase to act on.
The normal individual trial evaluation experimental of experimental example 2
(One)Experimental method
Cream emulsion prepared by embodiment 5 and embodiment 6 carries out normal individual trial evaluation respectively.It is deeper to choose 60 colours of skin
Volunteer, men and women half and half.3 groups are randomly divided into, every group of 10 males, 10 women.3 groups use commercially available skin-lightening cosmetic respectively,
The whitening skin-protection cream of embodiment 5, the whitening and skin-protecting Essence of embodiment 8.Application method is uses after daily face cleaning, once a day, real
The phase is tested as one month, evaluation table on probation is filled according to sensory evaluation(Scoring mechanism is evaluated using volunteer, wherein highest is divided into 3 points
Represent effective, 2 points represent effective, and 1 point of expression is not imitated).Respectively counted once using the 15th day, the 30th day.
(Two)Experimental result
Normal individual trial evaluation result statistics is shown in Table 6.
Table 6
From the result of table 6, the skin-lightening cosmetic white-skinned face function containing composite whitening composition of the present invention is obvious, and than commercially available
Skin-lightening cosmetic effect is notable.This example skin-lightening cosmetic is comfortable using skin sense, and without excitant, not only white-skinned face function is notable, and
And skin is white touched with red, the healthy colour of skin.
The technical scheme provided above the embodiment of the present invention is described in detail, specific case used herein
The principle and embodiment of the embodiment of the present invention are set forth, the explanation of above example is only applicable to help and understands this
The principle of inventive embodiments;Meanwhile for those of ordinary skill in the art, according to the embodiment of the present invention, in specific embodiment party
There will be changes in formula and application, in summary, this specification content should not be construed as limiting the invention.
Claims (2)
1. a kind of composite whitening composition, it is characterised in that be made up of the raw material of following parts by weight:Traditional Chinese medicine active site is extracted
Thing 0.1-10, NAP 0.05-5, Semen Pisi sativi extract 0.1-5 and deionized water 80-99.75;The Chinese medicine is lived
The raw material weight number of property extractive part is:Safflower 10-40, Radix Astragali 2-30, cactus 5-25, Roselle 5-30;Compound U.S.
The preparation of white composition is prepared according to the following steps:(1)The method for extraction and purification of traditional Chinese medicine active site extract is:By safflower, Huang
Stilbene, cactus, the traditional Chinese medicine active site extraction raw material of Roselle are soaked in dense according to the ﹕ 10 of 1 ﹕ 5 to 1 medicine and solvent ratios
Spend in 20%-80% ethanol, soak time is 2 hours, then extract 2-3 times, close in 60 DEG C of stirring extraction 1-2 hours, repetition
And extract solution;Then filter, by filtrate decompression concentration and recovery ethanol to after without alcohol taste, add 2-5 times to measure water dilution, then upper resin type
Number for D101 or AB-8 macroporous resin column washing to after colourless, it is then colourless to eluent with 30%-90% ethanol elutions, and collect
Ethanol eluate, then it is 1 that ethanol to decoction and medicinal material weight ratio, which is recovered under reduced pressure,:1-1:5, traditional Chinese medicine active site extract is made;
(2)The traditional Chinese medicine active site extract, NAP, Semen Pisi sativi extract are added in deionized water, added
Fed during material while stirring, and 10-20 minutes are stirred for after charging terminates;24-48 hours are stood, filtering,
Produce.
2. the cosmetics containing a kind of composite whitening composition described in claim 1, it is characterised in that contain in cosmetics and have the right
Profit requires a kind of composite whitening composition described in 1, and its dosage is 1-99% by weight percentage.
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CN102247446A (en) * | 2011-08-15 | 2011-11-23 | 广州环亚化妆品科技有限公司 | Composite whitening and spot correcting lotion and manufacturing method thereof |
CN103536468A (en) * | 2013-10-12 | 2014-01-29 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with whitening effect and application of traditional Chinese medicine composition in cosmetics |
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CN102247446A (en) * | 2011-08-15 | 2011-11-23 | 广州环亚化妆品科技有限公司 | Composite whitening and spot correcting lotion and manufacturing method thereof |
CN103536468A (en) * | 2013-10-12 | 2014-01-29 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with whitening effect and application of traditional Chinese medicine composition in cosmetics |
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