CN105124167A - Anti-stress traditional Chinese medicine feed additive as well as preparation method and application thereof - Google Patents
Anti-stress traditional Chinese medicine feed additive as well as preparation method and application thereof Download PDFInfo
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- CN105124167A CN105124167A CN201510628786.6A CN201510628786A CN105124167A CN 105124167 A CN105124167 A CN 105124167A CN 201510628786 A CN201510628786 A CN 201510628786A CN 105124167 A CN105124167 A CN 105124167A
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Abstract
The invention discloses an anti-stress traditional Chinese medicine feed additive as well as a preparation method and an application thereof. The anti-stress traditional Chinese medicine feed additive mainly comprises the following medicinal components: codonopsis pilosula, seeds of wild jujube, poria cocos, magnolia officinalis, ash bark, pseudo-ginseng, hawthorn, herba andrographitis, coptis chinensis, radix paeoniae rubra, prepared rehmannia root, rheum officinale and liquorice. The raw materials are dried, crushed, screened and uniformly mixed by adopting a traditional Chinese medicine production device, the prepared traditional Chinese medicinal preparation is added into basic daily ration of 60-day-old health little meishan sow to be uniformly mixed so as to feed the sow, and the freedom foraging and drinking are implemented. The test proves that the anti-stress traditional Chinese medicine feed additive can remarkably improve the total protein and albumin concentration in porcine serum; the content of immune globulin IgG and the content of complement C3 in the porcine serum can be remarkably increased; the antibody level of the immunized swine fever is obviously increased; the pig spleen index is increased. Various weaknesses of various chemical drugs and antibiotic feed additives can be overcome, no toxicity and side effect and no chemical residue exist, and the production of environment-friendly and high-quality animal product is guaranteed while the immunity of the body is improved.
Description
Technical field
The present invention relates to a kind of resisting stress Chinese herbal feed additive and preparation method thereof and application, belong to field of feed additive technology.
Background technology
Body constantly undergo in its life process stress, change from a stable state to another stable state, this is also the necessary process of biological evolution.But what more pay close attention in herding research is the harm that stress bring, mortality of animals stress be caused to raise and production performance decline.Therefore, strive to find prevent stress generation and alleviate the adverse consequences that stress produce, the production of animal and welfare are all had great significance.In order to not threaten the health of consumer, ensure the health of animal, animal product safe and reliable, the desirable anti-stress medicine of the feature such as find efficient, nontoxic, noresidue, have no drug resistance has become the striving direction of Chinese scholars.Chinese herbal medicine is the traditional medicine of China, has the multiple advantages such as aboundresources, cost are low, non-toxic, noresidue, natural sex.It is a kind of trustworthy green food additive.Therefore, the development and application of novel Chinese herbal feed additive more and more comes into one's own.Traditional Chinese medicine has the advantage place of preventing diseases instead for the treatment of diseases, and therefore, the present invention is under the guidance of traditional Chinese medical theory knowledge, and in conjunction with clinical practice, a kind of Chinese herbal feed additive of resisting stress has been invented in research.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese herbal feed additive of resisting stress.
The present invention also needs the technical problem solved to be to provide the preparation method of above-mentioned feed addictive.
The technical problem that the present invention finally will solve is to provide the application of above-mentioned feed addictive.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows:
A kind of resisting stress Chinese herbal feed additive, it is made up of the component of following parts by weight: Radix Codonopsis 15 ~ 20 parts, spina date seed 15 ~ 20 parts, 15 ~ 20 parts, Poria cocos, the bark of official magnolia 10 ~ 15 parts, the bark of ash 15 ~ 20 parts, pseudo-ginseng 15 ~ 20 parts, the membrane of a chicken's gizzard 10 ~ 15 parts, Herba Andrographitis 10 ~ 15 parts, the coptis 10 ~ 15 parts, the radix paeoniae rubrathe 5 ~ 10 parts, prepared rhizome of rehmannia 5 ~ 10 parts, rheum officinale 5 ~ 10 parts, 1 ~ 5 part, Radix Glycyrrhizae.
Wherein, described feed is animal feed is mouse, pig, ox or sheep feed.
Wherein, after the Radix Codonopsis of formula ratio, spina date seed, Poria cocos, the bark of official magnolia, the bark of ash, pseudo-ginseng, the membrane of a chicken's gizzard, Herba Andrographitis, the coptis, the radix paeoniae rubrathe, prepared rhizome of rehmannia, rheum officinale and Radix Glycyrrhizae mixing, decoct 30 minutes, the concentration of liquid medicine after filtration to concentration is 1mg/mL.Wherein, thickening temperature is 40 DEG C.
Above-mentioned resisting stress Chinese herbal feed additive improves the application in the medicine of animal resisting stress in preparation.Wherein, described animal is mouse, pig, ox or sheep feed.
For every 100g feed, the addition of described resisting stress Chinese herbal feed additive is 3.5 ~ 5mL.
Beneficial effect: Chinese herbal feed additive of the present invention, its formula is theoretical according to traditional Chinese veterinary medicine, makes with the Chinese medicine of tranquilizing and allaying excitement, tonifying middle-Jiao and Qi, the regulation of qi and blood, anti-inflammation.23 ages in days stress to be fed the growth performances such as body weight, body weight gains, feed intake and the feed conversion rate that can improve body by mouse.Chinese herbal feed additive of the present invention has that service time is short, effect is high, the feature of safety non-toxic, has the effect obviously promoting mouse resisting stress.
Detailed description of the invention
According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only for illustration of the present invention, and should can not limit the present invention described in detail in claims yet.
Embodiment 1:
Chinese herbal feed additive is made up of the component of following parts by weight:
Radix Codonopsis 15 parts, spina date seed 15 parts, 15 parts, Poria cocos, the bark of official magnolia 10 parts, the bark of ash 15 parts, pseudo-ginseng 15 parts, the membrane of a chicken's gizzard 10 parts, Herba Andrographitis 10 parts, the coptis 10 parts, the radix paeoniae rubrathe 5 parts, prepared rhizome of rehmannia 5 parts, rheum officinale 5 parts, 1 part, Radix Glycyrrhizae.
Preparation method: after the Radix Codonopsis of formula ratio, spina date seed, Poria cocos, the bark of official magnolia, the bark of ash, pseudo-ginseng, the membrane of a chicken's gizzard, Herba Andrographitis, the coptis, the radix paeoniae rubrathe, prepared rhizome of rehmannia, rheum officinale and Radix Glycyrrhizae mixing, decoct 30 minutes, it is 1mg/mL that the liquid after filtration is concentrated into concentration at 40 DEG C.
Embodiment 2:
Chinese herbal feed additive is made up of the component of following parts by weight:
Radix Codonopsis 20 parts, spina date seed 20 parts, 20 parts, Poria cocos, the bark of official magnolia 15 parts, the bark of ash 20 parts, pseudo-ginseng 20 parts, the membrane of a chicken's gizzard 15 parts, Herba Andrographitis 15 parts, the coptis 15 parts, the radix paeoniae rubrathe 10 parts, prepared rhizome of rehmannia 10 parts, rheum officinale 10 parts, 5 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3:
Chinese herbal feed additive is made up of the component of following parts by weight:
Radix Codonopsis 18 parts, spina date seed 18 parts, 18 parts, Poria cocos, the bark of official magnolia 13 parts, the bark of ash 18 parts, pseudo-ginseng 18 parts, the membrane of a chicken's gizzard 13 parts, Herba Andrographitis 13 parts, the coptis 13 parts, the radix paeoniae rubrathe 8 parts, prepared rhizome of rehmannia 8 parts, rheum officinale 8 parts, 3 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 4:
Healthy 23 day-old Mices are divided into 3 groups at random, often organize 10, are respectively control group 1, control group 2 and test group, experimental period 15d, the body weight of each group mouse before weighing record on-test.Control group fed arm's length basis diet and drinking-water, Chinese herbal feed additive (embodiment 2 prepares) is added in basal diet with 5% (ml/g) dosage by test group, uses 10d continuously.Ingesting and health condition of viewing test animal every day.Feed after medicine 10d, control group 2 and test group mouse carry out 10min noise stimulation and 15min hot water motion (30 DEG C) every day respectively, and continued stimulus 5d, control group 1 is left intact.The fugue reaction of observed and recorded mouse and swimming are held time.Duration of test, weighs at interval of 5d and records the body weight and feed intake of often organizing mouse.
A kind of Chinese herbal feed additive of the present invention is fed after mouse, and the escape number of times of mouse reduces gradually, and is all less than control group 2.Swimming time is also longer than control group 2.
1 compound traditional Chinese medicine is on stress the impact of Mouse Weight
The Chinese herbal feed additive of a kind of resisting stress of the present invention is on respectively organizing the impact of Mouse Weight after off-test in table 1.
Table 1 Chinese herbal feed additive is on stress the impact of Mouse Weight
Note: different letter representation group difference is remarkable, P ﹤ 0.05.
Result shows: a kind of Chinese herbal feed additive of the present invention is fed after mouse, and Mouse Weight has rising trend, but difference is remarkable, and this may be relevant with the factor such as the selection of animal model and processing time.
2 compound traditional Chinese medicines are on stress Mice Body weightening finish and the impact of daily gain
The Chinese herbal feed additive of a kind of resisting stress of the present invention on each group stress the impact of Mice Body weightening finish and daily gain in table 2.
Table 2 Chinese herbal feed additive is on stress Mice Body weightening finish and the impact of daily gain
Result shows: a kind of Chinese herbal feed additive of the present invention is fed after mouse, and the body weight gains of mouse all has rising in rear 3 time periods, and is all significantly higher than control group 2 (P ﹤ 0.05) at 5-10d, 10-15d and 0-15d.Test group mouse daily gain all occurred raising 4 time periods, and was significantly higher than control group 1 and control group 2 at 5-10d.
3 compound traditional Chinese medicines are on stress the impact of mouse feed intake
The Chinese herbal feed additive of a kind of resisting stress of the present invention on each group stress the impact of mouse feed intake in table 3.
Table 3 Chinese herbal feed additive is on stress the impact of mouse feed intake
Result shows: a kind of Chinese herbal feed additive of the present invention is fed after mouse, the feed intake of mouse 3 time periods all higher than control group, and during stress test (10-15d) and whole experimental stage, the feed intake of test group mouse is significantly higher than control group 2 (P ﹤ 0.05).This shows that compound traditional Chinese medicine has remarkable anti-stress effect, and can suppress stress on the impact of digestion power.
4 compound traditional Chinese medicines are on stress the impact of mouse feed conversion ratio
The Chinese herbal feed additive of a kind of resisting stress of the present invention on each group stress the impact of mouse feed conversion ratio in table 4.
Table 4 Chinese herbal feed additive is on stress the impact of mouse feed conversion ratio
Result shows: a kind of Chinese herbal feed additive of the present invention is fed after mouse, and the feed conversion rate of mouse is all significantly higher than control group 23 time periods.This shows that compound Chinese medicinal preparation can suppress the stress reaction of mouse, improves the production performance of mouse.
Claims (7)
1. a resisting stress Chinese herbal feed additive, it is characterized in that, it is made up of the component of following parts by weight: Radix Codonopsis 15 ~ 20 parts, spina date seed 15 ~ 20 parts, 15 ~ 20 parts, Poria cocos, the bark of official magnolia 10 ~ 15 parts, the bark of ash 15 ~ 20 parts, pseudo-ginseng 15 ~ 20 parts, the membrane of a chicken's gizzard 10 ~ 15 parts, Herba Andrographitis 10 ~ 15 parts, the coptis 10 ~ 15 parts, the radix paeoniae rubrathe 5 ~ 10 parts, prepared rhizome of rehmannia 5 ~ 10 parts, rheum officinale 5 ~ 10 parts, 1 ~ 5 part, Radix Glycyrrhizae.
2. resisting stress Chinese herbal feed additive according to claim 1, is characterized in that, described feed is animal feed, and described animal is mouse, pig, ox or sheep feed.
3. the preparation method of resisting stress Chinese herbal feed additive according to claim 1, it is characterized in that, after the Radix Codonopsis of formula ratio, spina date seed, Poria cocos, the bark of official magnolia, the bark of ash, pseudo-ginseng, the membrane of a chicken's gizzard, Herba Andrographitis, the coptis, the radix paeoniae rubrathe, prepared rhizome of rehmannia, rheum officinale and Radix Glycyrrhizae mixing, decoct 30 minutes, the concentration of liquid medicine after filtration to concentration is 1mg/mL.
4. the preparation method of resisting stress Chinese herbal feed additive according to claim 3, is characterized in that, thickening temperature is 40 DEG C.
5. resisting stress Chinese herbal feed additive according to claim 1 improves the application in the medicine of animal resisting stress in preparation.
6. application according to claim 5, is characterized in that, described animal is mouse, pig, ox or sheep feed.
7. application according to claim 5, is characterized in that, for every 100g feed, the addition of described resisting stress Chinese herbal feed additive is 3.5 ~ 5mL.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111296639A (en) * | 2020-03-30 | 2020-06-19 | 河南科技学院 | High-temperature stress resistant Chinese herbal medicine feed additive for pigs, preparation method thereof and high-temperature stress resistant pig feed |
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| CN102805271A (en) * | 2012-08-28 | 2012-12-05 | 安徽农业大学 | Anti-stress anti-diarrhea growth-promotion Chinese herbal medicine feed additive for weaned pig and preparation |
| CN103271242A (en) * | 2013-04-28 | 2013-09-04 | 中国科学院东北地理与农业生态研究所 | Anti heat stress fodder additive for min pig |
| CN104435319A (en) * | 2014-12-09 | 2015-03-25 | 郑州后羿制药有限公司 | Traditional Chinese veterinary medicine for preventing piglet stress reaction |
| CN104886356A (en) * | 2014-03-05 | 2015-09-09 | 甘肃康源生物科技有限公司 | Animal stress-resistant Chinese herbal medicine additive and preparation method thereof |
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Patent Citations (4)
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|---|---|---|---|---|
| CN102805271A (en) * | 2012-08-28 | 2012-12-05 | 安徽农业大学 | Anti-stress anti-diarrhea growth-promotion Chinese herbal medicine feed additive for weaned pig and preparation |
| CN103271242A (en) * | 2013-04-28 | 2013-09-04 | 中国科学院东北地理与农业生态研究所 | Anti heat stress fodder additive for min pig |
| CN104886356A (en) * | 2014-03-05 | 2015-09-09 | 甘肃康源生物科技有限公司 | Animal stress-resistant Chinese herbal medicine additive and preparation method thereof |
| CN104435319A (en) * | 2014-12-09 | 2015-03-25 | 郑州后羿制药有限公司 | Traditional Chinese veterinary medicine for preventing piglet stress reaction |
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| 葛长荣等: "作为饲料添加剂的猪用天然植物中草药组方研究", 《云南农业大学学报》 * |
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| CN111296639A (en) * | 2020-03-30 | 2020-06-19 | 河南科技学院 | High-temperature stress resistant Chinese herbal medicine feed additive for pigs, preparation method thereof and high-temperature stress resistant pig feed |
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