CN105120839B - 可注射长效局麻药半固体制剂及其组成成分 - Google Patents

可注射长效局麻药半固体制剂及其组成成分 Download PDF

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Publication number
CN105120839B
CN105120839B CN201480011256.0A CN201480011256A CN105120839B CN 105120839 B CN105120839 B CN 105120839B CN 201480011256 A CN201480011256 A CN 201480011256A CN 105120839 B CN105120839 B CN 105120839B
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semi
pharmaceutical composition
solid
semisolid
bupivacaine
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CN201480011256.0A
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Chinese (zh)
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CN105120839A (zh
Inventor
沈惠荣
甘娜
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Huzhou Huizhong Jishi Biotechnology Co ltd
Mira Pharma Corp
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Huzhou Huizhong Jishi Biotechnology Co ltd
Mira Pharma Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pain & Pain Management (AREA)
CN201480011256.0A 2013-02-28 2014-02-28 可注射长效局麻药半固体制剂及其组成成分 Active CN105120839B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361771011P 2013-02-28 2013-02-28
US61/771,011 2013-02-28
PCT/US2014/019704 WO2014134586A2 (en) 2013-02-28 2014-02-28 Injectable long-acting local anesthetic semi-solid formulations and its compostions

Publications (2)

Publication Number Publication Date
CN105120839A CN105120839A (zh) 2015-12-02
CN105120839B true CN105120839B (zh) 2020-07-28

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CN201480011256.0A Active CN105120839B (zh) 2013-02-28 2014-02-28 可注射长效局麻药半固体制剂及其组成成分

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Country Link
US (1) US10500281B2 (enExample)
EP (1) EP2961380B1 (enExample)
JP (1) JP6363115B2 (enExample)
KR (1) KR101768843B1 (enExample)
CN (1) CN105120839B (enExample)
AU (1) AU2014223993B2 (enExample)
CA (1) CA2903020C (enExample)
WO (1) WO2014134586A2 (enExample)

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KR101768843B1 (ko) 2013-02-28 2017-08-17 미라 파마 코포레이션 주사가능 장기-작용 국소 마취제 반고체 제형 및 이의 조성물
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
US9849180B2 (en) * 2014-09-15 2017-12-26 Hui Rong Shen Long-acting semi-solid lipid formulations
US20170296484A1 (en) * 2015-11-23 2017-10-19 Grace Therapeutics Llc Topical Film-Forming Spray
WO2017192347A1 (en) * 2016-05-02 2017-11-09 The General Hospital Corporation Implant surfaces for pain control
CA3048485C (en) * 2016-12-26 2022-07-19 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
JP7046396B2 (ja) * 2017-12-06 2022-04-04 湖州惠中濟世生物科技有限公司 注射可能な長時間作用性局所麻酔薬半固形製剤
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
KR102928295B1 (ko) 2018-09-07 2026-02-13 알.피.쉐러 테크놀러지즈 엘엘씨 경화 및 낮은 hlb 계면 활성제(들)의 첨가를 통한 고체 또는 반고체 지질 기반 제형 안정화
CN113262302B (zh) * 2020-02-17 2022-12-09 湖州惠中济世生物科技有限公司 可注射长效半固体凝胶制剂
JP2024505227A (ja) * 2021-01-29 2024-02-05 インシツ バイオロジクス、インク． 疼痛の持続的治療のための組成物および方法
EP4294367A4 (en) * 2021-02-18 2025-02-12 Navin Saxena Research and Technology Private Limited Non-aqueous injectable composition for sustained release of buprenorphine and use thereof
JP7802471B2 (ja) * 2021-08-17 2026-01-20 株式会社カネカ 貼付剤、貼付剤の製造方法、加水分解抑制剤、及び加水分解抑制方法
CA3249951A1 (en) * 2022-01-28 2023-08-03 Rebel Medicine Inc Injectable pharmaceutical compositions for treating pain
CN121909022A (zh) * 2024-08-20 2026-04-21 南光化学制药股份有限公司 医药组成物及其粒剂与针剂

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WO2007066148A1 (en) * 2005-12-07 2007-06-14 Pharmakodex Ltd Transdermal administration of active agents , in particular diclofenac
CN102458388A (zh) * 2009-06-11 2012-05-16 光治疗Asa公司 半固体组合物及药物制品
CN102858374A (zh) * 2010-04-01 2013-01-02 帕玛内斯特公司 热胶凝麻醉剂组合物
CN102869344A (zh) * 2010-04-01 2013-01-09 帕玛内斯特公司 局部麻醉剂的生物黏附性组合物
CN102892408A (zh) * 2010-04-01 2013-01-23 帕玛内斯特公司 适于局部麻醉剂的无水药物组合物

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SE9200952D0 (sv) * 1992-03-27 1992-03-27 Kabi Pharmacia Ab Pharmaceutical carrier system containing defined lipids
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
JPH08143449A (ja) * 1994-11-17 1996-06-04 Lederle Japan Ltd 徐放性局所麻酔用注射剤
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US5942241A (en) 1995-06-09 1999-08-24 Euro-Celtique, S.A. Formulations and methods for providing prolonged local anesthesia
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AU781682B2 (en) * 2000-03-20 2005-06-09 Zoetis Services Llc Sustained-release compositions for parenteral administration
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GB0015617D0 (en) 2000-06-26 2000-08-16 Vectura Ltd Improved preparations for dermal delivery of active substances
DE10033059A1 (de) * 2000-07-07 2002-01-31 Wacker Chemie Gmbh Komplexe aus gamma-Cyclodextrin und Benzocain, Verfahren zu ihrer Herstellung und ihre Verwendung
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007066148A1 (en) * 2005-12-07 2007-06-14 Pharmakodex Ltd Transdermal administration of active agents , in particular diclofenac
CN102458388A (zh) * 2009-06-11 2012-05-16 光治疗Asa公司 半固体组合物及药物制品
CN102858374A (zh) * 2010-04-01 2013-01-02 帕玛内斯特公司 热胶凝麻醉剂组合物
CN102869344A (zh) * 2010-04-01 2013-01-09 帕玛内斯特公司 局部麻醉剂的生物黏附性组合物
CN102892408A (zh) * 2010-04-01 2013-01-23 帕玛内斯特公司 适于局部麻醉剂的无水药物组合物

Also Published As

Publication number Publication date
WO2014134586A2 (en) 2014-09-04
EP2961380B1 (en) 2020-04-08
US10500281B2 (en) 2019-12-10
WO2014134586A3 (en) 2014-11-06
JP2016510041A (ja) 2016-04-04
AU2014223993B2 (en) 2016-09-08
CA2903020C (en) 2019-06-18
CN105120839A (zh) 2015-12-02
EP2961380A2 (en) 2016-01-06
US20150366967A1 (en) 2015-12-24
JP6363115B2 (ja) 2018-07-25
AU2014223993A1 (en) 2015-10-15
KR20150126375A (ko) 2015-11-11
CA2903020A1 (en) 2014-09-04
KR101768843B1 (ko) 2017-08-17

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Address after: No.1366, Hongfeng Road, Huzhou City, Zhejiang Province

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Applicant before: MIRA PHARMA Corp.

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