CA2903020C - Injectable long-acting local anesthetic semi-solid formulations and its compostions - Google Patents
Injectable long-acting local anesthetic semi-solid formulations and its compostions Download PDFInfo
- Publication number
- CA2903020C CA2903020C CA2903020A CA2903020A CA2903020C CA 2903020 C CA2903020 C CA 2903020C CA 2903020 A CA2903020 A CA 2903020A CA 2903020 A CA2903020 A CA 2903020A CA 2903020 C CA2903020 C CA 2903020C
- Authority
- CA
- Canada
- Prior art keywords
- semi
- solid
- pharmaceutical composition
- bupivacaine
- local anesthetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (3)
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| US201361771011P | 2013-02-28 | 2013-02-28 | |
| US61/771,011 | 2013-02-28 | ||
| PCT/US2014/019704 WO2014134586A2 (en) | 2013-02-28 | 2014-02-28 | Injectable long-acting local anesthetic semi-solid formulations and its compostions |
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| CA2903020A1 CA2903020A1 (en) | 2014-09-04 |
| CA2903020C true CA2903020C (en) | 2019-06-18 |
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| EP (1) | EP2961380B1 (enExample) |
| JP (1) | JP6363115B2 (enExample) |
| KR (1) | KR101768843B1 (enExample) |
| CN (1) | CN105120839B (enExample) |
| AU (1) | AU2014223993B2 (enExample) |
| CA (1) | CA2903020C (enExample) |
| WO (1) | WO2014134586A2 (enExample) |
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| KR101768843B1 (ko) | 2013-02-28 | 2017-08-17 | 미라 파마 코포레이션 | 주사가능 장기-작용 국소 마취제 반고체 제형 및 이의 조성물 |
| US10220093B2 (en) | 2013-02-28 | 2019-03-05 | Mira Pharma Corporation | Long-acting semi-solid lipid formulations |
| US9849180B2 (en) * | 2014-09-15 | 2017-12-26 | Hui Rong Shen | Long-acting semi-solid lipid formulations |
| US20170296484A1 (en) * | 2015-11-23 | 2017-10-19 | Grace Therapeutics Llc | Topical Film-Forming Spray |
| WO2017192347A1 (en) * | 2016-05-02 | 2017-11-09 | The General Hospital Corporation | Implant surfaces for pain control |
| CA3048485C (en) * | 2016-12-26 | 2022-07-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of chronic pain |
| US10561606B2 (en) | 2017-12-06 | 2020-02-18 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid gel formulations |
| JP7046396B2 (ja) * | 2017-12-06 | 2022-04-04 | 湖州惠中濟世生物科技有限公司 | 注射可能な長時間作用性局所麻酔薬半固形製剤 |
| US11426418B2 (en) | 2017-12-06 | 2022-08-30 | Mira Pharma Corporation | Injectable long-acting semi-solid gel formulations |
| KR102928295B1 (ko) | 2018-09-07 | 2026-02-13 | 알.피.쉐러 테크놀러지즈 엘엘씨 | 경화 및 낮은 hlb 계면 활성제(들)의 첨가를 통한 고체 또는 반고체 지질 기반 제형 안정화 |
| CN113262302B (zh) * | 2020-02-17 | 2022-12-09 | 湖州惠中济世生物科技有限公司 | 可注射长效半固体凝胶制剂 |
| JP2024505227A (ja) * | 2021-01-29 | 2024-02-05 | インシツ バイオロジクス、インク． | 疼痛の持続的治療のための組成物および方法 |
| EP4294367A4 (en) * | 2021-02-18 | 2025-02-12 | Navin Saxena Research and Technology Private Limited | Non-aqueous injectable composition for sustained release of buprenorphine and use thereof |
| JP7802471B2 (ja) * | 2021-08-17 | 2026-01-20 | 株式会社カネカ | 貼付剤、貼付剤の製造方法、加水分解抑制剤、及び加水分解抑制方法 |
| CA3249951A1 (en) * | 2022-01-28 | 2023-08-03 | Rebel Medicine Inc | Injectable pharmaceutical compositions for treating pain |
| CN121909022A (zh) * | 2024-08-20 | 2026-04-21 | 南光化学制药股份有限公司 | 医药组成物及其粒剂与针剂 |
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| US4775659A (en) * | 1985-08-19 | 1988-10-04 | Eli Lilly And Company | Injectable semi-solid formulations |
| SE9200952D0 (sv) * | 1992-03-27 | 1992-03-27 | Kabi Pharmacia Ab | Pharmaceutical carrier system containing defined lipids |
| US5700485A (en) | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
| JPH08143449A (ja) * | 1994-11-17 | 1996-06-04 | Lederle Japan Ltd | 徐放性局所麻酔用注射剤 |
| US6413536B1 (en) | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| US5942241A (en) | 1995-06-09 | 1999-08-24 | Euro-Celtique, S.A. | Formulations and methods for providing prolonged local anesthesia |
| GB9610862D0 (en) * | 1996-05-23 | 1996-07-31 | Evans Brian K | Pharmaceutical products |
| US6045824A (en) | 1997-09-18 | 2000-04-04 | Skyepharma Inc. | Sustained-release liposomal anesthetic compositions |
| AU781682B2 (en) * | 2000-03-20 | 2005-06-09 | Zoetis Services Llc | Sustained-release compositions for parenteral administration |
| US6613355B2 (en) | 2000-05-11 | 2003-09-02 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| GB0015617D0 (en) | 2000-06-26 | 2000-08-16 | Vectura Ltd | Improved preparations for dermal delivery of active substances |
| DE10033059A1 (de) * | 2000-07-07 | 2002-01-31 | Wacker Chemie Gmbh | Komplexe aus gamma-Cyclodextrin und Benzocain, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE10041478A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| US20040001889A1 (en) * | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| US20070184089A1 (en) * | 2002-07-15 | 2007-08-09 | Alcon, Inc. | Non-Polymeric Lipophilic Pharmaceutical Implant Compositions for Intraocular Use |
| US8221778B2 (en) | 2005-01-12 | 2012-07-17 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
| US7666914B2 (en) | 2004-06-03 | 2010-02-23 | Richlin David M | Topical preparation and method for transdermal delivery and localization of therapeutic agents |
| GB0524958D0 (en) * | 2005-12-07 | 2006-01-18 | Pharmakodex Ltd | Transdermal administration of active agents |
| SI2139457T1 (sl) * | 2007-03-28 | 2016-09-30 | Innocoll Pharmaceutical Limited | Naprava za dajanje zdravila za zagotavljanje lokalne analgezije, lokalne anestezije ali živčne blokade |
| WO2010142457A1 (en) | 2009-06-11 | 2010-12-16 | Photocure Asa | Semi-solid compositions and pharmaceutical products |
| WO2011075623A1 (en) | 2009-12-18 | 2011-06-23 | Latitude Pharmaceuticals, Inc. | One - phase gel compos ition compri s ing phos pholi pids |
| EP2552408A2 (en) * | 2010-04-01 | 2013-02-06 | Pharmanest AB | Water-free pharmaceutical compositions suitable for local anaesthetics |
| RS55544B1 (sr) * | 2010-04-01 | 2017-05-31 | Pharmanest Ab | Termogelirajuće anestetičke kompozicije |
| MX2012011261A (es) | 2010-04-01 | 2012-12-05 | Pharmanest Ab | Composiciones bioadhesivas de anestesicos locales. |
| KR101768843B1 (ko) | 2013-02-28 | 2017-08-17 | 미라 파마 코포레이션 | 주사가능 장기-작용 국소 마취제 반고체 제형 및 이의 조성물 |
| CN106535886A (zh) | 2014-04-21 | 2017-03-22 | 赫伦治疗有限公司 | 长效聚合物输送系统 |
-
2014
- 2014-02-28 KR KR1020157026862A patent/KR101768843B1/ko not_active Expired - Fee Related
- 2014-02-28 JP JP2015560385A patent/JP6363115B2/ja not_active Expired - Fee Related
- 2014-02-28 AU AU2014223993A patent/AU2014223993B2/en not_active Ceased
- 2014-02-28 CN CN201480011256.0A patent/CN105120839B/zh active Active
- 2014-02-28 CA CA2903020A patent/CA2903020C/en not_active Expired - Fee Related
- 2014-02-28 EP EP14710751.0A patent/EP2961380B1/en active Active
- 2014-02-28 WO PCT/US2014/019704 patent/WO2014134586A2/en not_active Ceased
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2015
- 2015-08-28 US US14/839,352 patent/US10500281B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014134586A2 (en) | 2014-09-04 |
| EP2961380B1 (en) | 2020-04-08 |
| US10500281B2 (en) | 2019-12-10 |
| CN105120839B (zh) | 2020-07-28 |
| WO2014134586A3 (en) | 2014-11-06 |
| JP2016510041A (ja) | 2016-04-04 |
| AU2014223993B2 (en) | 2016-09-08 |
| CN105120839A (zh) | 2015-12-02 |
| EP2961380A2 (en) | 2016-01-06 |
| US20150366967A1 (en) | 2015-12-24 |
| JP6363115B2 (ja) | 2018-07-25 |
| AU2014223993A1 (en) | 2015-10-15 |
| KR20150126375A (ko) | 2015-11-11 |
| CA2903020A1 (en) | 2014-09-04 |
| KR101768843B1 (ko) | 2017-08-17 |
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