JP6363115B2 - 注射可能局所麻酔半固体製剤およびその組成物 - Google Patents

注射可能局所麻酔半固体製剤およびその組成物 Download PDF

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Publication number
JP6363115B2
JP6363115B2 JP2015560385A JP2015560385A JP6363115B2 JP 6363115 B2 JP6363115 B2 JP 6363115B2 JP 2015560385 A JP2015560385 A JP 2015560385A JP 2015560385 A JP2015560385 A JP 2015560385A JP 6363115 B2 JP6363115 B2 JP 6363115B2
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Prior art keywords
semi
solid
pharmaceutical composition
bupivacaine
glyceryl
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Expired - Fee Related
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JP2015560385A
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English (en)
Japanese (ja)
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JP2016510041A (ja
JP2016510041A5 (enExample
Inventor
フイ ロン シェン，
フイ ロン シェン，
ナ ガン，
ナ ガン，
Original Assignee
ミラ ファーマ コーポレイション
ミラ ファーマ コーポレイション
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pain & Pain Management (AREA)
JP2015560385A 2013-02-28 2014-02-28 注射可能局所麻酔半固体製剤およびその組成物 Expired - Fee Related JP6363115B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361771011P 2013-02-28 2013-02-28
US61/771,011 2013-02-28
PCT/US2014/019704 WO2014134586A2 (en) 2013-02-28 2014-02-28 Injectable long-acting local anesthetic semi-solid formulations and its compostions

Publications (3)

Publication Number Publication Date
JP2016510041A JP2016510041A (ja) 2016-04-04
JP2016510041A5 JP2016510041A5 (enExample) 2016-05-19
JP6363115B2 true JP6363115B2 (ja) 2018-07-25

Family

ID=50288331

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015560385A Expired - Fee Related JP6363115B2 (ja) 2013-02-28 2014-02-28 注射可能局所麻酔半固体製剤およびその組成物

Country Status (8)

Country Link
US (1) US10500281B2 (enExample)
EP (1) EP2961380B1 (enExample)
JP (1) JP6363115B2 (enExample)
KR (1) KR101768843B1 (enExample)
CN (1) CN105120839B (enExample)
AU (1) AU2014223993B2 (enExample)
CA (1) CA2903020C (enExample)
WO (1) WO2014134586A2 (enExample)

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KR101768843B1 (ko) 2013-02-28 2017-08-17 미라 파마 코포레이션 주사가능 장기-작용 국소 마취제 반고체 제형 및 이의 조성물
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
US9849180B2 (en) * 2014-09-15 2017-12-26 Hui Rong Shen Long-acting semi-solid lipid formulations
US20170296484A1 (en) * 2015-11-23 2017-10-19 Grace Therapeutics Llc Topical Film-Forming Spray
WO2017192347A1 (en) * 2016-05-02 2017-11-09 The General Hospital Corporation Implant surfaces for pain control
CA3048485C (en) * 2016-12-26 2022-07-19 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
JP7046396B2 (ja) * 2017-12-06 2022-04-04 湖州惠中濟世生物科技有限公司 注射可能な長時間作用性局所麻酔薬半固形製剤
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
KR102928295B1 (ko) 2018-09-07 2026-02-13 알.피.쉐러 테크놀러지즈 엘엘씨 경화 및 낮은 hlb 계면 활성제(들)의 첨가를 통한 고체 또는 반고체 지질 기반 제형 안정화
CN113262302B (zh) * 2020-02-17 2022-12-09 湖州惠中济世生物科技有限公司 可注射长效半固体凝胶制剂
JP2024505227A (ja) * 2021-01-29 2024-02-05 インシツ バイオロジクス、インク． 疼痛の持続的治療のための組成物および方法
EP4294367A4 (en) * 2021-02-18 2025-02-12 Navin Saxena Research and Technology Private Limited Non-aqueous injectable composition for sustained release of buprenorphine and use thereof
JP7802471B2 (ja) * 2021-08-17 2026-01-20 株式会社カネカ 貼付剤、貼付剤の製造方法、加水分解抑制剤、及び加水分解抑制方法
CA3249951A1 (en) * 2022-01-28 2023-08-03 Rebel Medicine Inc Injectable pharmaceutical compositions for treating pain
CN121909022A (zh) * 2024-08-20 2026-04-21 南光化学制药股份有限公司 医药组成物及其粒剂与针剂

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GB0015617D0 (en) 2000-06-26 2000-08-16 Vectura Ltd Improved preparations for dermal delivery of active substances
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KR101768843B1 (ko) 2013-02-28 2017-08-17 미라 파마 코포레이션 주사가능 장기-작용 국소 마취제 반고체 제형 및 이의 조성물
CN106535886A (zh) 2014-04-21 2017-03-22 赫伦治疗有限公司 长效聚合物输送系统

Also Published As

Publication number Publication date
WO2014134586A2 (en) 2014-09-04
EP2961380B1 (en) 2020-04-08
US10500281B2 (en) 2019-12-10
CN105120839B (zh) 2020-07-28
WO2014134586A3 (en) 2014-11-06
JP2016510041A (ja) 2016-04-04
AU2014223993B2 (en) 2016-09-08
CA2903020C (en) 2019-06-18
CN105120839A (zh) 2015-12-02
EP2961380A2 (en) 2016-01-06
US20150366967A1 (en) 2015-12-24
AU2014223993A1 (en) 2015-10-15
KR20150126375A (ko) 2015-11-11
CA2903020A1 (en) 2014-09-04
KR101768843B1 (ko) 2017-08-17

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