JP6363115B2 - 注射可能局所麻酔半固体製剤およびその組成物 - Google Patents

注射可能局所麻酔半固体製剤およびその組成物 Download PDF

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Publication number
JP6363115B2
JP6363115B2 JP2015560385A JP2015560385A JP6363115B2 JP 6363115 B2 JP6363115 B2 JP 6363115B2 JP 2015560385 A JP2015560385 A JP 2015560385A JP 2015560385 A JP2015560385 A JP 2015560385A JP 6363115 B2 JP6363115 B2 JP 6363115B2
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Prior art keywords
semi
solid
pharmaceutical composition
bupivacaine
glyceryl
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Expired - Fee Related
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JP2015560385A
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English (en)
Japanese (ja)
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JP2016510041A5 (enExample
JP2016510041A (ja
Inventor
フイ ロン シェン，
フイ ロン シェン，
ナ ガン，
ナ ガン，
Original Assignee
ミラ ファーマ コーポレイション
ミラ ファーマ コーポレイション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015560385A 2013-02-28 2014-02-28 注射可能局所麻酔半固体製剤およびその組成物 Expired - Fee Related JP6363115B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361771011P 2013-02-28 2013-02-28
US61/771,011 2013-02-28
PCT/US2014/019704 WO2014134586A2 (en) 2013-02-28 2014-02-28 Injectable long-acting local anesthetic semi-solid formulations and its compostions

Publications (3)

Publication Number Publication Date
JP2016510041A JP2016510041A (ja) 2016-04-04
JP2016510041A5 JP2016510041A5 (enExample) 2016-05-19
JP6363115B2 true JP6363115B2 (ja) 2018-07-25

Family

ID=50288331

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015560385A Expired - Fee Related JP6363115B2 (ja) 2013-02-28 2014-02-28 注射可能局所麻酔半固体製剤およびその組成物

Country Status (8)

Country Link
US (1) US10500281B2 (enExample)
EP (1) EP2961380B1 (enExample)
JP (1) JP6363115B2 (enExample)
KR (1) KR101768843B1 (enExample)
CN (1) CN105120839B (enExample)
AU (1) AU2014223993B2 (enExample)
CA (1) CA2903020C (enExample)
WO (1) WO2014134586A2 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9849180B2 (en) 2014-09-15 2017-12-26 Hui Rong Shen Long-acting semi-solid lipid formulations
EP2961380B1 (en) 2013-02-28 2020-04-08 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid formulations and its compositions
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
US20170296484A1 (en) * 2015-11-23 2017-10-19 Grace Therapeutics Llc Topical Film-Forming Spray
EP3452119A1 (en) * 2016-05-02 2019-03-13 The General Hospital Corporation Implant surfaces for pain control
EP3558279A4 (en) * 2016-12-26 2020-12-02 Cellix Bio Private Limited COMPOSITIONS AND METHODS FOR THE TREATMENT OF CHRONIC PAIN
JP7046396B2 (ja) * 2017-12-06 2022-04-04 湖州惠中濟世生物科技有限公司 注射可能な長時間作用性局所麻酔薬半固形製剤
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
CN113262302B (zh) * 2020-02-17 2022-12-09 湖州惠中济世生物科技有限公司 可注射长效半固体凝胶制剂
EP4284272A4 (en) * 2021-01-29 2024-12-25 Insitu Biologics, Inc. COMPOSITIONS AND METHODS OF SUSTAINED TREATMENT OF PAIN
JP2023027715A (ja) * 2021-08-17 2023-03-02 株式会社カネカ 医薬組成物、及び貼付剤

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US4775659A (en) * 1985-08-19 1988-10-04 Eli Lilly And Company Injectable semi-solid formulations
SE9200952D0 (sv) 1992-03-27 1992-03-27 Kabi Pharmacia Ab Pharmaceutical carrier system containing defined lipids
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
JPH08143449A (ja) * 1994-11-17 1996-06-04 Lederle Japan Ltd 徐放性局所麻酔用注射剤
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
CN1156961A (zh) 1995-06-09 1997-08-13 欧罗赛铁克股份有限公司 产生长效局部麻醉的制剂和方法
GB9610862D0 (en) * 1996-05-23 1996-07-31 Evans Brian K Pharmaceutical products
ES2373861T3 (es) 1997-09-18 2012-02-09 Pacira Pharmaceuticals, Inc. Composiciones anestésicas liposomiales de liberación sostenida.
AU781682B2 (en) * 2000-03-20 2005-06-09 Zoetis Services Llc Sustained-release compositions for parenteral administration
US6613355B2 (en) 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
GB0015617D0 (en) 2000-06-26 2000-08-16 Vectura Ltd Improved preparations for dermal delivery of active substances
DE10033059A1 (de) * 2000-07-07 2002-01-31 Wacker Chemie Gmbh Komplexe aus gamma-Cyclodextrin und Benzocain, Verfahren zu ihrer Herstellung und ihre Verwendung
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20070184089A1 (en) * 2002-07-15 2007-08-09 Alcon, Inc. Non-Polymeric Lipophilic Pharmaceutical Implant Compositions for Intraocular Use
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US7666914B2 (en) 2004-06-03 2010-02-23 Richlin David M Topical preparation and method for transdermal delivery and localization of therapeutic agents
GB0524958D0 (en) * 2005-12-07 2006-01-18 Pharmakodex Ltd Transdermal administration of active agents
PL3085363T3 (pl) 2007-03-28 2019-08-30 Innocoll Pharmaceuticals Limited Urządzenie dostarczające lek dla zapewnienia miejscowej analgezji, miejscowego znieczulenia lub blokady nerwowej
CN102458388B (zh) 2009-06-11 2016-09-28 光治疗Asa公司 半固体组合物及药物制品
WO2011075623A1 (en) 2009-12-18 2011-06-23 Latitude Pharmaceuticals, Inc. One - phase gel compos ition compri s ing phos pholi pids
SG184072A1 (en) * 2010-04-01 2012-10-30 Pharmanest Ab Bioadhesive compositions of local anaesthetics
WO2011121034A2 (en) * 2010-04-01 2011-10-06 Pharmanest Ab Water-free pharmaceutical compositions suitable for local anaesthetics
WO2011121074A1 (en) * 2010-04-01 2011-10-06 Pharmanest Ab Thermogelling anaesthetic compositions
EP2961380B1 (en) 2013-02-28 2020-04-08 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid formulations and its compositions
DK3134068T3 (da) 2014-04-21 2021-10-04 Heron Therapeutics Inc Langtidsvirkende polymerafgivelsessystemer

Also Published As

Publication number Publication date
EP2961380B1 (en) 2020-04-08
US10500281B2 (en) 2019-12-10
AU2014223993A1 (en) 2015-10-15
CN105120839A (zh) 2015-12-02
US20150366967A1 (en) 2015-12-24
JP2016510041A (ja) 2016-04-04
AU2014223993B2 (en) 2016-09-08
EP2961380A2 (en) 2016-01-06
WO2014134586A2 (en) 2014-09-04
CA2903020A1 (en) 2014-09-04
KR20150126375A (ko) 2015-11-11
KR101768843B1 (ko) 2017-08-17
CA2903020C (en) 2019-06-18
WO2014134586A3 (en) 2014-11-06
CN105120839B (zh) 2020-07-28

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