CN105106789A - Traditional Chinese medicine composition for treating chronic bronchitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chronic bronchitis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating chronic bronchitis. The traditional Chinese medicine composition comprises fructus forsythia, coptis chinensis, rhododendron dauricum, radix stemonae, ephedra, snakegourd fruit, ginseng, flos magnolia, rhizoma belamcandae, asparagus fern, acorus tatarinowii, snakegourd peel, radix asteris and dried tangerine peel. Compared with pure western medicine treatment, the traditional Chinese medicine composition has the advantages that chronic bronchitis index can be well lowered, the clinical signs of a patient can be improved, further deterioration of the chronic bronchitis can be prevented, and meanwhile, the traditional Chinese medicine composition is free of toxic and side effects and high in safety and comfortableness.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of Chinese medicine composition being used for the treatment of chronic bronchitis and preparation method thereof.
Background technology
Chronic bronchitis is common clinical, frequently-occurring disease, because infection or non-infective agent cause the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucosa and surrounding tissue thereof.Its pathological characteristic is bronchus glandular hyperplasia, mucous secretion increases.Its course of disease is long, treatment is difficult, painful many, recurrent exerbation.Main clinical manifestation is cough, and expectoration, asthma and recurrent respiratory tract infection, can concurrent serious complication.(1) cough: the cough for a long time, repeatedly and gradually increased the weight of is the outstanding behaviours of primary disease.(2) expectoration: general expectorant is white slimy cystose.In infection or after catching cold, symptom is aggravated rapidly, amount of expectoration increases, and viscosity increases, or in yellow purulent sputum or with panting.(3) pant: when merging respiratory tract infection, due to mucous membrane of bronchiole congestion and edema, sputum blocks and bronchus luminal stenosis, can produce asthma (panting) symptom.(4) repeated infection: respiratory tract infection repeatedly occurs, patient's asthma increases the weight of, amount of expectoration showed increased and in purulence, weak with the whole province, cold syndrome of the stomach, heating etc.(5) complication: course of disease delay can concurrent obstructive emphysema, pulmonary heart disease, has a strong impact on work and healthy.
The cause of disease of chronic bronchitis is not yet completely clear, generally the cause of disease is divided into exopathogenic factor and endogenous cause of ill two aspects.Exopathogenic factor comprises: (1) smoking: containing the chemical substance such as tar, nicotine in medicated cigarette, can damage human airway epithelial cells, ciliary movement is gone down and macrophage phagocytic function reduction, causes Airway clearance function reduction.(2) infect: infection is the key factor that development occurs chronic bronchitis, mainly contains the infection such as virus, antibacterial, mycoplasma.(3) physics and chemistry: as smog, dust, harmful gas all have stimulation and cytotoxicity to air flue mucosal epithelium.(4) weather: cold is often the major reason of chronic bronchitis outbreak.(5) irritated: chronic asthmatic bronchitis patient has allergies more, in sputum, in eosinophilic granulocyte's quantity and histamine content and blood, IgE has the trend increased.
Endogenous cause of ill comprises: (1) autoimmune function is low: worn with age, chronic infection stove, malnutrition, inherited genetic factors etc. cause respiratory tract local defense to reduce.(2) autonomic nervous dysfunction: cause bronchial smooth muscle contraction, capillary permeability increase etc.The comprehensive above-mentioned cause of disease, when Abwehrkraft des Koepers weakens, there is susceptibility in various degree in patient's bronchus, and under one or more exopathogenic factors stimulate, prolonged and repeated effect, develops into chronic bronchitis gradually.
Western medical treatment chronic bronchitis is based on symptomatic treatment, and acute attack stage and chronic persistence treatment have: (1) infection control gives penicillins, cephalo-type, Macrolide or quinolone antibiotic.(2) expelling phlegm for arresting cough uses ambroxol hydrochloride, ammonium chloride, brown mixture etc.(3) spasmolytic is relievingd asthma and is selected the Drug therapy such as aminophylline, beta 2 receptor agonist.(4) gasify the Neulized inhalation such as therapy ipratropium bromide.
Paracmastic treatment comprises: (1) health invigorating: can use core cheese, transfer factor etc., to reduce flu and recurrent exerbation.(2) vaccinate: adopt the treatment of Vaccinum Bronehitidis, Nucleotide and Casein Injection, BCG (Bacille Calmette-Guerin) vaccine injection or Biostim.(3) other: give up smoking, avoid smog, strengthen physical training.
Because the cause of disease is complicated, the generation development of chronic bronchitis is relevant with factors such as respiratory tract infection, chemical factors, intolerance factors, climatic factor, autonomic nervous dysfunction, respiratory tract defense function and immunologic hypofunctions, in addition prolonged application antibiotic, cause dysbacteriosis in body, immunologic function is more low, easily cause the Relapse rate of chronic bronchitis patient to show effect, and complexity complication may occur.Thus single use of western medicine treatment primary disease, relapse rate is high and side effect is many.
Chronic bronchitis belongs to the category of Chinese medicine " cough ", " phlegm retention ", " cough with asthma ", " pulmonary distension ", and its pathogenesis is deficiency in origin and excess in superficiality, and the generation development of primary disease and exopathogen are attacked repeatedly, and the dirty functional disorder of lung spleen kidney three is closely related.Insufficiency of lung-QI, weakened defensive QI, exopathogen is invaded, and does not with the passing of time heal.Specifically, initial stage great majority violate lung, impairment of purifying and descending function of the lung and cause cough due to exopathogen.And improper diet, addicted to food tobacco and wine, pungent delicious food product, also can make abnormal rising of lung-QI and cough.Exogenous cough controls as migrated mistake, evil impairing the lung gas, more easily repeatedly feels evil, and causes cough and do repeatly, transfers endogenous cough to.The lung being damaged by lasted cough, lung qi virtual loss, and then undermine spleen kidney.Insufficiency of the spleen can not transmitting and distributing the fluids, then hydrops is expectorant, and upper stain is in lung.Cough because of expectorant, the turbid heap soil or fertilizer over and around the roots lung of expectorant and breathing heavily.Expectorant is pathological product, is again paathogenic factor.Phlegm retention is cohesion, dysfunction of the spleen in transportation, and water is wet is detained, upper stain in lung, lung network of being detained, obstructing airway.Lung has retention of phlegm place to drink, and is subject to exopathogen and brings out, and causes cough with asthma repeatedly not healed." the lung being the dominator of QI, the kidney being the root of QI ", with the passing of time pneumonopathy must involve kidney, and kidney qi can not be taken the photograph and receive, so that lung qi can not be rooted in kidney, therefore breathe hard and breathe heavily, dynamic then more so.With advancing age, the state of an illness is on the rise.So-called " lung is not hindered and do not coughed, kidney do not hinder do not breathe heavily ", " vital organs of the human body, all make us coughing, and non-only lung also ".
The traditional Chinese medical science is for the treatment of chronic bronchitis, and the thought of multiplex " the body resistance strengthening and constitution consolidating ", for instructing, is suffered from a deficiency of the kidney with lung spleen and damaged as this, and stagnation of phlegm QI rising in reverse order blood stasis is mark, treating both the principal and secondary aspects of a disease.Control and relieving asthma with invigorating the spleen and benefiting QI the kidney invigorating, relieving cough and resolving phlegm, help with the Eradicates stasis of blood.In stage of attack, treating to attack heresy is master, lets out by heresy, eliminating the pathogens from the lung sending down the abnormal ascending QI, expelling phlegm for arresting cough, depressed lung-energy dispersing.In the catabasis then based on righting, primordial QI reinforcing healthy energy, invigorating spleen and kidney improve the resistance of health, prevent Relapse rate from showing effect.
Object of the present invention is exactly that existing Western medicine toxic and side effects in order to overcome for chronic bronchitis is large, therapeutic effect is difficult to continue, and the deficiency that Chinese traditional treatment effect is undesirable, according to traditional Chinese medical science prescription and preparation principle, Chinese medicine composition is developed meticulously, select there is invigorating spleen and kidney, the Chinese crude drug of the effect such as righting tonify deficiency, dispelling wind reduce phlegm, lung qi dispersing cough-relieving carries out reasonable formula, be mixed with Chinese medicine preparation for oral administration, by playing general action after gastrointestinal absorption.All medicines share, based on lung qi dispersing clearing away phlegm, relieving cough and asthma, help with invigorating the spleen and benefiting QI, tonifying kidney and nourishing yin Zhi Qiben, treating both the principal and secondary aspects of a disease, there is antiinflammatory, reduce phlegm, cough-relieving, immunity of relievining asthma, improve effect.Thus the symptom of the cough for the treatment of chronic bronchitis, excessive phlegm, asthma, and reduce the repeated infection of respiratory tract.Each component collaborative onset mutually in side, and medicine is prepared simple, rapid-action, short treating period, is had good therapeutical effect to chronic bronchitis.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition being used for the treatment of chronic bronchitis, and its more simple western medicine can better relieve chronic bronchitis, improves the clinical sign of patient, prevents chronic bronchitis from worsening further.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition being used for the treatment of chronic bronchitis, its raw material components comprises Fructus Forsythiae, Rhizoma Coptidis, Folium Rhododendri Daurici, the Radix Stemonae, Herba Ephedrae, Radix Peucedani, Fructus Trichosanthis, Radix Ginseng, Flos Magnoliae, Rhizoma Belamcandae, Radix Asparagi, Rhizoma Acori Graminei, Pericarpium Trichosanthis, Radix Asteris and Pericarpium Citri Reticulatae.
Wherein, in described Chinese medicine composition, the weight portion of each raw material components is respectively Fructus Forsythiae 10-16 weight portion, Rhizoma Coptidis 8-14 weight portion, Folium Rhododendri Daurici 6-12 weight portion, Radix Stemonae 8-15 weight portion, Herba Ephedrae 5-10 weight portion, Radix Peucedani 10-16 weight portion, Fructus Trichosanthis 9-18 weight portion, Radix Ginseng 6-14 weight portion, Flos Magnoliae 5-10 weight portion, Rhizoma Belamcandae 6-12 weight portion, Radix Asparagi 8-18 weight portion, Rhizoma Acori Graminei 8-14 weight portion, Pericarpium Trichosanthis 10-16 weight portion, Radix Asteris 6-12 weight portion, Pericarpium Citri Reticulatae 5-10 weight portion.
Preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Fructus Forsythiae 13-16 weight portion, Rhizoma Coptidis 10-14 weight portion, Folium Rhododendri Daurici 8-12 weight portion, Radix Stemonae 12-15 weight portion, Herba Ephedrae 8-10 weight portion, Radix Peucedani 12-16 weight portion, Fructus Trichosanthis 14-18 weight portion, Radix Ginseng 10-14 weight portion, Flos Magnoliae 8-10 weight portion, Rhizoma Belamcandae 10-12 weight portion, Radix Asparagi 14-18 weight portion, Rhizoma Acori Graminei 12-14 weight portion, Pericarpium Trichosanthis 13-16 weight portion, Radix Asteris 9-12 weight portion, Pericarpium Citri Reticulatae 8-10 weight portion.
Further preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Fructus Forsythiae 13 weight portion, Rhizoma Coptidis 10 weight portion, Folium Rhododendri Daurici 8 weight portion, the Radix Stemonae 12 weight portion, Herba Ephedrae 8 weight portion, Radix Peucedani 12 weight portion, Fructus Trichosanthis 14 weight portion, Radix Ginseng 10 weight portion, Flos Magnoliae 8 weight portion, Rhizoma Belamcandae 10 weight portion, Radix Asparagi 14 weight portion, Rhizoma Acori Graminei 12 weight portion, Pericarpium Trichosanthis 13 weight portion, Radix Asteris 9 weight portion, Pericarpium Citri Reticulatae 8 weight portion.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, its preparation process is:
(1) each component in described raw material components be mixed in proportion, pulverize, add 75% ethanol of medical material gross weight 4-8 times amount, reflux, extract, 3 times, each time is respectively 1.5,1,1 hours, filters, merging filtrate;
(2) 75 DEG C of concentrating under reduced pressure filtrates, concentration ratio is 1000ml medicinal liquid: 47g crude drug, then according to the amount of 60ml flocculating agent/1000ml medicinal liquid, adds 1% chitosan flocculant in 40-60 DEG C, makes its sedimentation 3 hours, high speed centrifugation;
(3) get supernatant, 75 DEG C-85 DEG C are concentrated into relative density 1.35-1.42, then add the Cordyceps mycelia powder of 1-3 weight portion, and 75 DEG C of dry 4h, obtain compound preparation extract powder;
(4) extract powder is mixed granule processed with 5-8 weight portion Icing Sugar, 7-10 weight portion dextrin, cross 14 mesh sieves, make oral granular formulation.
The present invention also provides the application of above-mentioned raw materials component in the Chinese medicine composition for the preparation for the treatment of chronic bronchitis.
Beneficial effect of the present invention:
The invention provides a kind of Chinese medicine composition being used for the treatment of chronic bronchitis, its more simple Western medicine and existing treatment by Chinese herbs can better relieve chronic bronchitis, improve the clinical sign of patient, prevent chronic bronchitis from worsening further, have no side effect simultaneously, have safety and the comfort of height.
Detailed description of the invention
The weight portion that the present invention mentions is a proportionate relationship between each component.
The invention provides a kind of Chinese medicine composition being used for the treatment of chronic bronchitis, its raw material components comprises Fructus Forsythiae, Rhizoma Coptidis, Folium Rhododendri Daurici, the Radix Stemonae, Herba Ephedrae, Radix Peucedani, Fructus Trichosanthis, Radix Ginseng, Flos Magnoliae, Rhizoma Belamcandae, Radix Asparagi, Rhizoma Acori Graminei, Pericarpium Trichosanthis, Radix Asteris and Pericarpium Citri Reticulatae.
Further preferably, described Chinese medicine composition is only made up of above-mentioned raw materials component.
Chinese medicine composition compatibility of the present invention is reasonable, and action effect is remarkable, wherein:
Fructus Forsythiae: bitter, is slightly cold; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens; For carbuncle, scrofula, mastalgia, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warm people battalion, high hot excessive thirst, coma sends out speckle, the puckery pain of pyretic stranguria.
Rhizoma Coptidis: bitter, cold; Heat clearing and damp drying, eliminating fire and detoxication; For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, palpitation and uneasiness, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.
Folium Rhododendri Daurici: pungent, bitter, cold; For cough and asthma abundant expectoration.
The Radix Stemonae: sweet, bitter, tepor; Nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing delousing; Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outer for head louse, body louse, enterobiasis, pudendal pruritus.
Herba Ephedrae: pungent, micro-hardship, temperature; Diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema; For anemofrigid cold, uncomfortable in chestly to breath with cough, edema due to wind pathogen edema.
Radix Peucedani: bitter, pungent, is slightly cold; Lowering the adverse-rising QI to resolve phlegm, loose wind heat clearing away; Full for expectorant dyspnea of heat type, cough up phlegm yellow thick, cough due to pathogenic wind-heat's abundant expectoration.
Fructus Trichosanthis: sweet, micro-hardship, cold; Clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes laxation; For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, acute appendicitis, constipation.
Radix Ginseng: sweet, micro-hardship, tepor; Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid and nourish blood, Fructus Alpiniae Oxyphyllae of calming the nerves; For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, deficiency of qi and blood, prolonged illness weakness with emaciation, and palpitation with fear insomnia, sexual impotence official is cold.
Flos Magnoliae: pungent, temperature; Dispersing wind and cold, clearing the nasal passage; For headche due to wind-cold, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis.
Rhizoma Belamcandae: bitter, cold; Heat-clearing and toxic substances removing, expectorant, sore-throat relieving; For the pent-up of pyretic toxicity phlegm-fire, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma.
Radix Asparagi: sweet, bitter, cold; Nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid; For dryness of the lung dry cough, pertussis expectorant sticks, soreness of waist and knee joint, osteopyrexia and fever, and interior-heat is quenched one's thirst, and calentura Tianjin is hindered, dry throat and mouth, dryness of the intestine constipation.
Rhizoma Acori Graminei: pungent, bitter, temperature; To have one's ideas straightened out eliminating phlegm, refreshment Fructus Alpiniae Oxyphyllae, removing dampness is whetted the appetite; For coma epilepsy, forgetful insomnia, Hiccough and deaf, gastral cavity painful abdominal mass is not hungry, a mouthful dysentery of keeping silent.
Pericarpium Trichosanthis: sweet, cold; Removing heat-phlegm, promoting the circulation of QI the chest stuffiness relieving; For phlegm-heat cough, hypochondriac pain uncomfortable in chest.
Radix Asteris: pungent, bitter, temperature; Nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm; Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.
Pericarpium Citri Reticulatae: bitter, pungent, temperature; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; For distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
In described Chinese medicine composition, the weight portion of each raw material components is respectively Fructus Forsythiae 10-16 weight portion, Rhizoma Coptidis 8-14 weight portion, Folium Rhododendri Daurici 6-12 weight portion, Radix Stemonae 8-15 weight portion, Herba Ephedrae 5-10 weight portion, Radix Peucedani 10-16 weight portion, Fructus Trichosanthis 9-18 weight portion, Radix Ginseng 6-14 weight portion, Flos Magnoliae 5-10 weight portion, Rhizoma Belamcandae 6-12 weight portion, Radix Asparagi 8-18 weight portion, Rhizoma Acori Graminei 8-14 weight portion, Pericarpium Trichosanthis 10-16 weight portion, Radix Asteris 6-12 weight portion, Pericarpium Citri Reticulatae 5-10 weight portion.
Preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Fructus Forsythiae 13-16 weight portion, Rhizoma Coptidis 10-14 weight portion, Folium Rhododendri Daurici 8-12 weight portion, Radix Stemonae 12-15 weight portion, Herba Ephedrae 8-10 weight portion, Radix Peucedani 12-16 weight portion, Fructus Trichosanthis 14-18 weight portion, Radix Ginseng 10-14 weight portion, Flos Magnoliae 8-10 weight portion, Rhizoma Belamcandae 10-12 weight portion, Radix Asparagi 14-18 weight portion, Rhizoma Acori Graminei 12-14 weight portion, Pericarpium Trichosanthis 13-16 weight portion, Radix Asteris 9-12 weight portion, Pericarpium Citri Reticulatae 8-10 weight portion.
Further preferably, in described Chinese medicine composition, the weight portion of each raw material components is respectively Fructus Forsythiae 13 weight portion, Rhizoma Coptidis 10 weight portion, Folium Rhododendri Daurici 8 weight portion, the Radix Stemonae 12 weight portion, Herba Ephedrae 8 weight portion, Radix Peucedani 12 weight portion, Fructus Trichosanthis 14 weight portion, Radix Ginseng 10 weight portion, Flos Magnoliae 8 weight portion, Rhizoma Belamcandae 10 weight portion, Radix Asparagi 14 weight portion, Rhizoma Acori Graminei 12 weight portion, Pericarpium Trichosanthis 13 weight portion, Radix Asteris 9 weight portion, Pericarpium Citri Reticulatae 8 weight portion.
The Chinese medicine composition for the treatment of chronic bronchitis provided by the invention can be prepared into various peroral dosage form according to regular dosage form preparation method.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, comprising:
(1) each component in described raw material components be mixed in proportion, pulverize, add 75% ethanol of medical material gross weight 4-8 times amount, reflux, extract, 3 times, each time is respectively 1.5,1,1 hours, filters, merging filtrate;
(2) 75 DEG C of concentrating under reduced pressure filtrates, concentration ratio is 1000ml medicinal liquid: 47g crude drug, then according to the amount of 60ml flocculating agent/1000ml medicinal liquid, adds 1% chitosan flocculant in 40-60 DEG C, makes its sedimentation 3 hours, high speed centrifugation;
(3) get supernatant, 75 DEG C-85 DEG C are concentrated into relative density 1.35-1.42, then add the Cordyceps mycelia powder of 1-3 weight portion, and 75 DEG C of dry 4h, obtain compound preparation extract powder;
(4) extract powder is mixed granule processed with 5-8 weight portion Icing Sugar, 7-10 weight portion dextrin, cross 14 mesh sieves, make oral granular formulation.
The present invention also provides the application of above-mentioned raw materials component in the Chinese medicine composition for the preparation for the treatment of chronic bronchitis.
Embodiment
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1
Get Fructus Forsythiae 10 weight portion, Rhizoma Coptidis 8 weight portion, Folium Rhododendri Daurici 6 weight portion, the Radix Stemonae 8 weight portion, Herba Ephedrae 5 weight portion, Radix Peucedani 10 weight portion, Fructus Trichosanthis 9 weight portion, Radix Ginseng 6 weight portion, Flos Magnoliae 5 weight portion, Rhizoma Belamcandae 6 weight portion, Radix Asparagi 8 weight portion, Rhizoma Acori Graminei 8 weight portion, Pericarpium Trichosanthis 10 weight portion, Radix Asteris 6 weight portion, Pericarpium Citri Reticulatae 5 weight portion, be mixed in proportion, pulverize; Add 75% ethanol of medical material gross weight 4 times amount, reflux, extract, 3 times, each time is respectively 1.5,1,1 hours, filters, merging filtrate; 75 DEG C of concentrating under reduced pressure filtrates, concentration ratio is 1000ml medicinal liquid: 47g crude drug, then according to the amount of 60ml flocculating agent/1000ml medicinal liquid, adds 1% chitosan flocculant in 40 DEG C, makes its sedimentation 3 hours, high speed centrifugation; Get supernatant, 75 DEG C are concentrated into relative density 1.35, then add the Cordyceps mycelia powder of 1 weight portion, and 75 DEG C of dry 4h, obtain compound preparation extract powder; Extract powder is mixed granule processed with 5 weight portion Icing Sugar, 7 weight portion dextrin, crosses 14 mesh sieves, make oral granular formulation.
Usage and consumption: every day twice, sooner or later respectively once.
Taboo: (1) avoids eating anything raw or cold food; (2) diet raw meat thing; (3) internal and external haemorrhage disease, ulcerate disease tool avoid clothes first; (4) female menstrual period, the pregnancy period is not used.
Embodiment 2
Get Fructus Forsythiae 16 weight portion, Rhizoma Coptidis 14 weight portion, Folium Rhododendri Daurici 12 weight portion, the Radix Stemonae 15 weight portion, Herba Ephedrae 10 weight portion, Radix Peucedani 16 weight portion, Fructus Trichosanthis 18 weight portion, Radix Ginseng 14 weight portion, Flos Magnoliae 10 weight portion, Rhizoma Belamcandae 12 weight portion, Radix Asparagi 18 weight portion, Rhizoma Acori Graminei 14 weight portion, Pericarpium Trichosanthis 16 weight portion, Radix Asteris 12 weight portion, Pericarpium Citri Reticulatae 10 weight portion, be mixed in proportion, pulverize; Add 75% ethanol of medical material gross weight 8 times amount, reflux, extract, 3 times, each time is respectively 1.5,1,1 hours, filters, merging filtrate; 75 DEG C of concentrating under reduced pressure filtrates, concentration ratio is 1000ml medicinal liquid: 47g crude drug, then according to the amount of 60ml flocculating agent/1000ml medicinal liquid, adds 1% chitosan flocculant in 60 DEG C, makes its sedimentation 3 hours, high speed centrifugation; Get supernatant, 85 DEG C are concentrated into relative density 1.42, then add the Cordyceps mycelia powder of 3 weight portions, and 75 DEG C of dry 4h, obtain compound preparation extract powder; Extract powder is mixed granule processed with 8 weight portion Icing Sugar, 10 weight portion dextrin, crosses 14 mesh sieves, make oral granular formulation.
Usage and consumption, avoid same embodiment 1.
Embodiment 3
Get Fructus Forsythiae 13 weight portion, Rhizoma Coptidis 10 weight portion, Folium Rhododendri Daurici 8 weight portion, the Radix Stemonae 12 weight portion, Herba Ephedrae 8 weight portion, Radix Peucedani 12 weight portion, Fructus Trichosanthis 14 weight portion, Radix Ginseng 10 weight portion, Flos Magnoliae 8 weight portion, Rhizoma Belamcandae 10 weight portion, Radix Asparagi 14 weight portion, Rhizoma Acori Graminei 12 weight portion, Pericarpium Trichosanthis 13 weight portion, Radix Asteris 9 weight portion, Pericarpium Citri Reticulatae 8 weight portion, be mixed in proportion, pulverize; Each component in described raw material components be mixed in proportion, pulverize, add 75% ethanol of medical material gross weight 6 times amount, reflux, extract, 3 times, each time is respectively 1.5,1,1 hours, filters, merging filtrate; 75 DEG C of concentrating under reduced pressure filtrates, concentration ratio is 1000ml medicinal liquid: 47g crude drug, then according to the amount of 60ml flocculating agent/1000ml medicinal liquid, adds 1% chitosan flocculant in 50 DEG C, makes its sedimentation 3 hours, high speed centrifugation; Get supernatant, 80 DEG C are concentrated into relative density 1.39, then add the Cordyceps mycelia powder of 2 weight portions, and 75 DEG C of dry 4h, obtain compound preparation extract powder; Extract powder is mixed granule processed with 7 weight portion Icing Sugar, 9 weight portion dextrin, crosses 14 mesh sieves, make oral granular formulation.
Usage and consumption, avoid same embodiment 1.
The toxicity test of embodiment 4, Chinese medicine composition of the present invention
Below test, without special instruction, all use the Chinese medicine composition that the embodiment of the present invention 3 is obtained.
The maximum tolerated dose of animal acute toxicity test display Mouse oral this product more than 60 times, and observes one week, the behavior of mice outward appearance, main organs no abnormality seen.
Long-term toxicity test for animals with Wistar rat for animal subject, namely be equivalent to 60 times and 20 times of clinical dosage with 30g/kg and 10g/kg and gavage 50 days continuously to rat, result shows that administration group rat general behavior, hemogram, hepatic and renal function, organ coefficient compare no significant difference with blank group.The histological examination heart, liver, spleen, lung, kidney, adrenal gland, thymus, uterus and testis there are no significant compared with blank treated animal difference.
Clinical research safety detects, and do not find that it is to the heart, liver, kidney, the conventional toxic and side effects of urine, feces and mucocutaneous untoward reaction, the safety of display this product is high.
Embodiment 5, Chinese medicine composition of the present invention are on the impact on rat capillary tube method expectoration amount
Rat is divided into 5 groups at random: blank group (isometric(al) normal saline), ammonium chloride group (1.0g/kg), Chinese medicine composition of the present invention large (3.0g crude drug/kg), in (1.0g crude drug/kg), little (0.33g crude drug/kg) three dosage groups.
Experimental technique: chloral hydrate (Solution on Chemical Reagents in Shanghai company of China Drug Co., chemical pure) the 0.4g/kg intraperitoneal injection of anesthesia (pre-operative anxiety 12h) of 10%.Rat dorsal position is fixed on operation plate, and cervical region 75% cotton ball soaked in alcohol is sterilized, and medisection is about the long otch of 1cm, find trachea, under cricoid cartilage, on trachea, prick a hole with syringe needle, subsequently the capillary tube of diameter 0.5mm is inserted trachea, to just contacting trachea.Capillary tube is taken out, the length of juice in measuring tube after 2 hours; Gavage gives Chinese medicine composition of the present invention, ammonium chloride or 0.5%CMC-Na respectively again, then inserts capillary tube, observes 2 hours, measures length.
Experimental result: the large, medium and small dosage of Chinese medicine composition of the present invention all obviously can increase Hair of Rat tubule expectoration amount, all has significance with matched group comparing difference; Heavy dose of Chinese medicine composition effect of the present invention is better than ammonium chloride group, and this difference all has significance.(see table 1).
Table 1: Chinese medicine composition of the present invention is on the impact of rat capillary tube method expectoration amount
Compare with matched group,
*p<0.01,
*p<0.05, compares with ammonium chloride group,
#p<0.05,
##p<0.01.
Embodiment 6, clinical experiment
1, inclusion criteria: meet modern medicine " chronic bronchitis " diagnostic criteria, and meet the traditional Chinese medical science " cough, pulmonary distension " diagnosis, 200 routine chronic bronchitis patients of dialectical genus " expectorant hot Tianjin wound, yin asthenia generating intrinsic heat ".
2, therapeutic scheme:
200 routine chronic bronchitis patients are divided into treatment group and matched group at random, often organize each 100 examples.Two groups of sexes, age and courses of disease, through statistics there was no significant difference (P > 0.05), have comparability.
Treatment group: take Chinese medicine composition of the present invention, every day, sooner or later respectively once each 3-5 grain, being used in conjunction 7 days was a course for the treatment of.I.e. withdrawal after curing.
Matched group: the peaceful granule of Chinese patent medicine GANMAO QINGRE KELI, lung, or add Western medicine oral antibiotic 7 days is observation course for the treatment of.
3, the standard of curative effect evaluation: " disease of tcm Standardization of diagnosis and curative effect " and the national chronic bronchitis clinical efficacy evaluation criteria formulated with reference to State Administration of Traditional Chinese Medicine:
(1) effective: cough, expectorant, breathe heavily, the cardinal symptom basic controlling such as scorching or greatly alleviate, stable disease, without recidivist;
(2) effective: to cough, expectorant, asthma shape and attack times minimizing;
(3) invalid: to cough, expectorant, asthma shape and attack times be all without changer.
4, statistical procedures:
Experimental result is in table 2.Total effective rate=(effective number of cases+effectively number of cases)/total number of cases.
Table 2: the comparison of two groups of patient clinical curative effects after treatment
| Group | Total number of cases | Effective number of cases (%) | Effective number of cases (%) | Invalid number of cases (%) | Total effective rate (%) |
| Treatment group | 100 | 33(33) | 58(58) | 9(9) | 91 ** |
| Matched group | 100 | 20(20) | 33(33) | 47(47) | 53 |
Note: compare with matched group:
*p < 0.01.
Through treating and following up a case by regular visits to, result display treatment group total effective rate 94%, be significantly better than matched group, P<0.01, difference has statistical significance, and abundant proved invention Chinese medicine composition has significant clinical efficacy to chronic bronchitis.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. be used for the treatment of a Chinese medicine composition for chronic bronchitis, it is characterized in that: raw material components comprises Fructus Forsythiae, Rhizoma Coptidis, Folium Rhododendri Daurici, the Radix Stemonae, Herba Ephedrae, Radix Peucedani, Fructus Trichosanthis, Radix Ginseng, Flos Magnoliae, Rhizoma Belamcandae, Radix Asparagi, Rhizoma Acori Graminei, Pericarpium Trichosanthis, Radix Asteris and Pericarpium Citri Reticulatae.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that: the weight portion of each raw material components is respectively Fructus Forsythiae 10-16 weight portion, Rhizoma Coptidis 8-14 weight portion, Folium Rhododendri Daurici 6-12 weight portion, Radix Stemonae 8-15 weight portion, Herba Ephedrae 5-10 weight portion, Radix Peucedani 10-16 weight portion, Fructus Trichosanthis 9-18 weight portion, Radix Ginseng 6-14 weight portion, Flos Magnoliae 5-10 weight portion, Rhizoma Belamcandae 6-12 weight portion, Radix Asparagi 8-18 weight portion, Rhizoma Acori Graminei 8-14 weight portion, Pericarpium Trichosanthis 10-16 weight portion, Radix Asteris 6-12 weight portion, Pericarpium Citri Reticulatae 5-10 weight portion.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: the weight portion of each raw material components is respectively Fructus Forsythiae 13-16 weight portion, Rhizoma Coptidis 10-14 weight portion, Folium Rhododendri Daurici 8-12 weight portion, Radix Stemonae 12-15 weight portion, Herba Ephedrae 8-10 weight portion, Radix Peucedani 12-16 weight portion, Fructus Trichosanthis 14-18 weight portion, Radix Ginseng 10-14 weight portion, Flos Magnoliae 8-10 weight portion, Rhizoma Belamcandae 10-12 weight portion, Radix Asparagi 14-18 weight portion, Rhizoma Acori Graminei 12-14 weight portion, Pericarpium Trichosanthis 13-16 weight portion, Radix Asteris 9-12 weight portion, Pericarpium Citri Reticulatae 8-10 weight portion.
4. the Chinese medicine composition as described in claims 1 to 3, is characterized in that: the weight portion of each raw material components is respectively Fructus Forsythiae 13 weight portion, Rhizoma Coptidis 10 weight portion, Folium Rhododendri Daurici 8 weight portion, the Radix Stemonae 12 weight portion, Herba Ephedrae 8 weight portion, Radix Peucedani 12 weight portion, Fructus Trichosanthis 14 weight portion, Radix Ginseng 10 weight portion, Flos Magnoliae 8 weight portion, Rhizoma Belamcandae 10 weight portion, Radix Asparagi 14 weight portion, Rhizoma Acori Graminei 12 weight portion, Pericarpium Trichosanthis 13 weight portion, Radix Asteris 9 weight portion, Pericarpium Citri Reticulatae 8 weight portion.
5. the preparation method of Chinese medicine composition described in Claims 1-4, is characterized in that, preparation process is:
(1) each component in described raw material components be mixed in proportion, pulverize, add 75% ethanol of medical material gross weight 4-8 times amount, reflux, extract, 3 times, each time is respectively 1.5,1,1 hours, filters, merging filtrate;
(2) 75 DEG C of concentrating under reduced pressure filtrates, concentration ratio is 1000ml medicinal liquid: 47g crude drug, then according to the amount of 60ml flocculating agent/1000ml medicinal liquid, adds 1% chitosan flocculant in 40-60 DEG C, makes its sedimentation 3 hours, high speed centrifugation;
(3) get supernatant, 75 DEG C-85 DEG C are concentrated into relative density 1.35-1.42, then add the Cordyceps mycelia powder of 1-3 weight portion, and 75 DEG C of dry 4h, obtain compound preparation extract powder;
(4) extract powder is mixed granule processed with 5-8 weight portion Icing Sugar, 7-10 weight portion dextrin, cross 14 mesh sieves, make oral granular formulation.
6. the application of the raw material components any one of claim 1-4 in the Chinese medicine composition for the preparation for the treatment of chronic bronchitis.
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Effective date of registration: 20160205 Address after: 266000 Shandong province Qingdao City, Shandong Road No. 109 Building No. 3 3102 Taiwan Jing Applicant after: QINGDAO JINZHI HIGH AND NEW TECHNOLOGY CO., LTD. Address before: 266000 Shandong province Qingdao City, Shandong Road No. 109 Jing No. 3 building 3102 room Applicant before: Jiang Shufen |
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