CN105412826A - Pharmaceutical composition for treating bronchialasthma and application thereof - Google Patents

Pharmaceutical composition for treating bronchialasthma and application thereof Download PDF

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Publication number
CN105412826A
CN105412826A CN201510925582.9A CN201510925582A CN105412826A CN 105412826 A CN105412826 A CN 105412826A CN 201510925582 A CN201510925582 A CN 201510925582A CN 105412826 A CN105412826 A CN 105412826A
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parts
radix
semen
pharmaceutical composition
asthma
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吴兴连
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Qingdao Mairuite Medicine Technology Co Ltd
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Qingdao Mairuite Medicine Technology Co Ltd
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Abstract

The invention discloses a pharmaceutical composition for treating bronchialasthma and application thereof. The pharmaceutical composition comprises the following components in parts by weight: 5-15 parts of dandelion, 5-10 parts of unibract fritillary bulb, 10-20 parts of radix astragali, 10-30 parts of codonopsis pilosula, 5-15 parts of semen cuscutae, 8-20 parts of radix scrophulariae, 3-10 parts of radix glycyrrhizae, 1-5 parts of common coltsfoot flower, 0.5-2 parts of snow pear paste, 3-15 parts of officinal magnolia bark, 6-13 parts of fructus arctii, 6-15 parts of dendrobium officinale, 5-10 parts of periostracum cicada, 2-10 parts of turmeric root-tuber, 1-5 parts of rhodiola rosea, 6-10 parts of folium eriobotryae, 4-12 parts of radish seeds, 3-10 parts of pepperweed seeds and 5-12 parts of folium mori. According to the formula, the pharmaceutical composition is made according to the Chinese traditional medicine principle and mainly has the efficacies of tonifying lung Qi, benefiting essence and blood, relieving cough and asthma, dissipating phlegm, promoting circulation of qi, clearing away heat and toxic materials, benefiting qi, nourishing blood and promoting blood circulation to remove blood stasis and further improves microcirculation of the trachea and lung tissue, so that the purpose of treatment is realized.

Description

A kind of medical composition and its use for the treatment of asthma
Technical field
The invention belongs to treatment by Chinese herbs field, be specifically related to a kind of medical composition and its use for the treatment of asthma.
Background technology
Along with present social industrial expansion, air quality change great change, the mankind are difficult to the environment of Adaptive change, and respiratory system disease constantly takes place frequently, especially asthma class disease, asthma, are a kind of commonly encountered diseases, frequently-occurring disease.At present, global asthmatic patient about 300,000,000 people, Chinese patients with asthma about 3,000 ten thousand.Asthma affects the able-bodied important diseases of people, and first Tuesday in annual May is world's the Asthma Day, is intended to remind the public to the understanding of disease, improves and prevent and treat level to asthma.
Bronchial asthma (bronchialasthma is called for short asthma) is the chronic airway inflammation disease participated in by inflammation cell in air flue and cellular component thereof.Current global asthmatic patient about about 300,000,000, prevalence reached 1%-18% prediction to 2025, and asthmatic patient will increase 1-1.5 hundred million newly, and asthma case fatality rate can reach 1/250.Asthma causes huge social economical burden, has a strong impact on personal health, has become serious public health problem.The common sympton of asthmatic patient be paroxysmally to pant, the symptom such as out of breath, uncomfortable in chest or cough, small number of patients may take also chest pain as main manifestations, these symptoms are shown effect after contacting the irritative gass such as smog, perfume, paint, dust, house pet, pollen or allergen through the patient that is everlasting, night and (or) also easily generation or the aggravation of symptom in early morning.A lot of patient is oneself audible and sound of stridulating when asthma attack.
The method of current treatment asthma is mainly taken and is controlled medicine and cushion.Controlling medicine makes asthma maintain clinic control mainly through antiinflammatory action, and cushion is mainly by removing bronchospasm rapidly thus relieving asthma symptoms.If these drug main Control of asthma clinical symptoms, can not effect a radical cure asthma, and the cost of Control of asthma is very high, such as the Western medicine preparation such as MK, budesonide, treatment by Chinese herbs is slower in effect.
Summary of the invention
For the defect of prior art, the present invention be directed to the present situation for the treatment of asthma at present, the Chinese medicine composition that a kind of safe treatment is effective is provided.
Specifically, the present invention realizes like this.
First, the invention provides a kind of pharmaceutical composition for the treatment of asthma, the Chinese crude drug comprised has: Herba Taraxaci, Bulbus Fritillariae Cirrhosae, the Radix Astragali, Radix Codonopsis, Semen Cuscutae, Radix Scrophulariae, Radix Glycyrrhizae, Flos Farfarae, snow pear paste, Cortex Magnoliae Officinalis, Fructus Arctii, Herba Dendrobii, Periostracum Cicadae, Radix Curcumae, Radix Rhodiolae, Folium Eriobotryae, Semen Raphani, Semen Lepidii (Semen Descurainiae), Folium Mori.
Medical material selected is above all that the conventional medicine of medicine is used as medicine, then, inventor provides a kind of pharmaceutical composition for the treatment of asthma according to drug matching experience, each raw material dosage of prescription all has good curative effect in weight portion scope of the present invention, described formula and weight portion are: Herba Taraxaci 5-15 part, Bulbus Fritillariae Cirrhosae 5-10 part, Radix Astragali 10-20 part, Radix Codonopsis 10-30 part, Semen Cuscutae 5-15 part, Radix Scrophulariae 8-20 part, Radix Glycyrrhizae 3-10 part, Flos Farfarae 1-5 part, snow pear paste 0.5-2 part, Cortex Magnoliae Officinalis 3-15 part, Fructus Arctii 6-13 part, Herba Dendrobii 6-15 part, Periostracum Cicadae 5-10 part, Radix Curcumae 2-10 part, Radix Rhodiolae 1-5 part, Folium Eriobotryae 6-10 part, Semen Raphani 4-12 part, Semen Lepidii (Semen Descurainiae) 3-10 part, Folium Mori 5-12 part.
Carry out preferably to the formula of above-mentioned weight portion, reach better technique effect, preferred formula is: Herba Taraxaci 10 parts, Bulbus Fritillariae Cirrhosae 7.5 parts, the Radix Astragali 15 parts, Radix Codonopsis 20 parts, Semen Cuscutae 10 parts, Radix Scrophulariae 14 parts, 6.5 parts, Radix Glycyrrhizae, Flos Farfarae 3.5 parts, snow pear paste 1 part, Cortex Magnoliae Officinalis 9 parts, Fructus Arctii 8.5 parts, Herba Dendrobii 10.5 parts, Periostracum Cicadae 7.5 parts, Radix Curcumae 6 parts, Radix Rhodiolae 3 parts, Folium Eriobotryae 8 parts, Semen Raphani 8 parts, Semen Lepidii (Semen Descurainiae) 6.5 parts, 8.5 parts, Folium Mori.
Carry out preferably to the formula of above-mentioned weight portion, reach better technique effect, preferred formula is: Herba Taraxaci 12 parts, Bulbus Fritillariae Cirrhosae 8 parts, the Radix Astragali 16 parts, Radix Codonopsis 20 parts, Semen Cuscutae 12 parts, Radix Scrophulariae 16 parts, 8 parts, Radix Glycyrrhizae, Flos Farfarae 5 parts, snow pear paste 1.5 parts, Cortex Magnoliae Officinalis 10 parts, Fructus Arctii 11 parts, Herba Dendrobii 12 parts, Periostracum Cicadae 8 parts, Radix Curcumae 8 parts, Radix Rhodiolae 4 parts, Folium Eriobotryae 9 parts, Semen Raphani 10 parts, Semen Lepidii (Semen Descurainiae) 7.5 parts, 10 parts, Folium Mori.
The function of each taste Chinese crude drug used in the Chinese medicine composition for the treatment of asthma of the present invention is as follows:
Herba Taraxaci: bitter in the mouth, cold in nature.
Gui Jing: return liver, stomach warp.
Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome, for furuncle swelling toxin, and acute mastitis scrofula, conjunctival congestion pharyngalgia, lung, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Bulbus Fritillariae Cirrhosae: bitter in the mouth, cold in nature.
Gui Jing: return lung, heart channel.
Function cures mainly: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, for lung-heat type cough, and the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.
The Radix Astragali: sweet in the mouth, warm in nature.
Gui Jing: enter lung, spleen channel.
Function cures mainly: tonifying Qi and lifting yang, and consolidating superficial resistance, by antiperspirant, holds in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.
Radix Codonopsis: sweet in the mouth, property is put down.
Gui Jing: return spleen, lung meridian.
Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Semen Cuscutae: sweet in the mouth, warm in nature.
Gui Jing: return liver,kidney,spleen warp.
Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Radix Scrophulariae: sweet in the mouth, cold in nature.
Gui Jing: return lung, stomach, kidney channel.
Function cures mainly: removing heat from blood YIN nourishing, eliminating fire and detoxication.For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
Radix Glycyrrhizae: sweet in the mouth, property is put down.
Gui Jing: enter spleen, stomach, the heart, lung meridian.
Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain.
Flos Farfarae: acrid in the mouth, warm in nature.
Gui Jing: enter lung meridian.
Function cures mainly: main cough with dyspnea, kind breathes heavily, sore throat, all infantile convulsion, cold and heat pathogen, falls that punching is inverse and antitussive is breathed heavily, and opens numbness plug and throat.
Snow pear paste: sweet in the mouth, property is put down.
Function cures mainly: nourishing YIN and clearing away lung-heat, relieving restlessness cough-relieving.Cure mainly xeropulmonary cough, spit blood, spitting of blood, heart-fire is irritated, and thirsty larynx is done, and except pleura expectorant heat.
Cortex Magnoliae Officinalis: bitter in the mouth, warm in nature.
Gui Jing: return spleen, stomach, lung, large intestine channel.
Function cures mainly: dampness expectorant, and the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Fructus Arctii: acrid in the mouth, cold in nature.
Gui Jing: attach to the lung and stomach meridians.
Function cures mainly: dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.
Herba Dendrobii: sweet in the mouth, cold in nature.
Gui Jing: return stomach, kidney channel.
Function cures mainly: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.
Periostracum Cicadae: sweet in the mouth, cold in nature.
Gui Jing: return lung, Liver Channel.
Function cures mainly: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic, for anemopyretic cold, and pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.
Folium Mori: sweet in the mouth, cold in nature.
Gui Jing: return lung, Liver Channel.
Function cures mainly: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, and for anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.
Folium Eriobotryae: bitter in the mouth, cold in nature.
Gui Jing: attach to the lung and stomach meridians.
Function cures mainly: clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.For cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastric heat vomiting, dysphoria with smothery sensation is thirsty.
Semen Raphani: acrid in the mouth, property is put down.
Gui Jing: return lung, spleen, stomach warp.
Function cures mainly: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.
Semen Lepidii (Semen Descurainiae): acrid in the mouth, cold in nature.
Gui Jing: return lung, urinary bladder channel.
Function cures mainly: eliminating pathogen from the lung for relieving asthma, line water detumescence.Stop up lung for sputum, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down sleeping, and ascites pleural fluid swells, dysuria; Pulmonary heart disease edema.
Radix Curcumae: acrid in the mouth, cold in nature.
Gui Jing: return liver, the heart, lung meridian.
Function cures mainly: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Radix Rhodiolae: sweet in the mouth, cold in nature.
Gui Jing: lung meridian.
Function cures mainly: QI invigorating lung heat clearing, and Fructus Alpiniae Oxyphyllae is nourished heart, hemostasis with astringents, dissipating blood stasis for subsidence of swelling.Main deficiency of vital energy and physically weak, after being ill fear of cold, shortness of breath and fatigue, cough due to lung-heat, spitting of blood; Leucorrhea is suffered from diarrhoea, traumatic injury.
Described Chinese medicine composition can be prepared into the pharmaceutically acceptable dosage forms such as tablet, capsule, pill, granule.
The application of described Chinese medicine composition in preparation treatment asthmatic medicament, is especially applicable to the application in preparation treatment bronchus medicine.
The present invention is to above prescription through conscientious research, and according to the reasonability of middle medical drugs, invention proposes concrete a kind of preparation method for the treatment of the pharmaceutical composition of asthma, concrete steps:
(1), by the Radix Astragali, Radix Codonopsis, Cortex Magnoliae Officinalis, Fructus Arctii, Herba Taraxaci and Bulbus Fritillariae Cirrhosae pulverize 80 orders, then extracted 2 times in the ethanol of 75%, each 1-3 hour, merged medicinal liquid, leave standstill 24 hours, for subsequent use;
(2), Semen Cuscutae, Radix Scrophulariae, Radix Glycyrrhizae, Flos Farfarae, snow pear paste, Herba Dendrobii, Periostracum Cicadae, Radix Curcumae, Radix Rhodiolae, Folium Eriobotryae, Semen Raphani, Semen Lepidii (Semen Descurainiae) and Folium Mori add cold water higher than powder immersion 0.5-1 hour, big fire is boiled, little fire boils 20-30 minute, and filter and remove residue obtains medicinal liquid; Decoct twice, boil after being mixed by the medicinal liquid of twice, little fire boils 10-15 minute, to obtain final product again;
(3), get supernatant obtained in (1) and (2) step, be evaporated to 60 DEG C-70 DEG C, density is the extractum of 1.03-1.09, for subsequent use after dry;
(4), the weight of determination step (3), add the lactose of its weight 5% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 2:1; Stir and be heated to 80-90 DEG C, cross 120 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
A kind of pharmaceutical composition for the treatment of asthma of the present invention, compared with prior art, main technological merit is:
(1), prescription of the present invention according to Chinese traditional medicine principle formula, led tonifying the lung gas benefiting essence-blood, effect of relieving cough and asthma, the promoting the circulation of QI that reduces phlegm, heat-clearing and toxic substances removing, benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, improved trachea and lung tissue microcirculation further, thus reach the object for the treatment of.
(2), the Chinese medicine cost for the treatment of asthma provided by the invention is low, thus reach the object comprehensively recovering trachea and the various physiological function of lung tissue, the present invention is by the synergism of multi-medicament, improve the drug effect of Drug therapy, and reduce and even eliminate side effects of pharmaceutical drugs, can fundamentally treat asthma.
Specific embodiment
Embodiment 1, a kind of pharmaceutical composition for the treatment of asthma, comprise following weight portion:
Herba Taraxaci 5 parts, Bulbus Fritillariae Cirrhosae 5 parts, the Radix Astragali 10 parts, Radix Codonopsis 10 parts, Semen Cuscutae 5 parts, Radix Scrophulariae 8 parts, 3 parts, Radix Glycyrrhizae, Flos Farfarae 1 part, snow pear paste 0.5 part, Cortex Magnoliae Officinalis 3 parts, Fructus Arctii 6 parts, Herba Dendrobii 6 parts, Periostracum Cicadae 5 parts, Radix Curcumae 2 parts, Radix Rhodiolae 1 part, Folium Eriobotryae 6 parts, Semen Raphani 4 parts, Semen Lepidii (Semen Descurainiae) 3 parts, 5 parts, Folium Mori.
Concrete preparation method is:
(1), by the Radix Astragali, Radix Codonopsis, Cortex Magnoliae Officinalis, Fructus Arctii, Herba Taraxaci and Bulbus Fritillariae Cirrhosae pulverize 80 orders, then extracted 2 times in the ethanol of 75%, each 1-3 hour, merged medicinal liquid, leave standstill 24 hours, for subsequent use;
(2), Semen Cuscutae, Radix Scrophulariae, Radix Glycyrrhizae, Flos Farfarae, snow pear paste, Herba Dendrobii, Periostracum Cicadae, Radix Curcumae, Radix Rhodiolae, Folium Eriobotryae, Semen Raphani, Semen Lepidii (Semen Descurainiae) and Folium Mori add cold water higher than powder immersion 0.5-1 hour, big fire is boiled, little fire boils 20-30 minute, and filter and remove residue obtains medicinal liquid; Decoct twice, boil after being mixed by the medicinal liquid of twice, little fire boils 10-15 minute, to obtain final product again;
(3), get supernatant obtained in (1) and (2) step, be evaporated to 60 DEG C-70 DEG C, density is the extractum of 1.03-1.09, for subsequent use after dry;
(4), the weight of determination step (3), add the lactose of its weight 5% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 2:1; Stir and be heated to 80-90 DEG C, cross 120 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 2, a kind of pharmaceutical composition for the treatment of asthma, comprise following weight portion:
Herba Taraxaci 15 parts, Bulbus Fritillariae Cirrhosae 10 parts, the Radix Astragali 20 parts, Radix Codonopsis 30 parts, Semen Cuscutae 15 parts, Radix Scrophulariae 20 parts, 10 parts, Radix Glycyrrhizae, Flos Farfarae 5 parts, snow pear paste 2 parts, Cortex Magnoliae Officinalis 15 parts, Fructus Arctii 13 parts, Herba Dendrobii 15 parts, Periostracum Cicadae 10 parts, Radix Curcumae 10 parts, Radix Rhodiolae 5 parts, Folium Eriobotryae 10 parts, Semen Raphani 12 parts, Semen Lepidii (Semen Descurainiae) 10 parts, 12 parts, Folium Mori.
Concrete preparation method is:
(1), by the Radix Astragali, Radix Codonopsis, Cortex Magnoliae Officinalis, Fructus Arctii, Herba Taraxaci and Bulbus Fritillariae Cirrhosae pulverize 80 orders, then extracted 2 times in the ethanol of 75%, each 1-3 hour, merged medicinal liquid, leave standstill 24 hours, for subsequent use;
(2), Semen Cuscutae, Radix Scrophulariae, Radix Glycyrrhizae, Flos Farfarae, snow pear paste, Herba Dendrobii, Periostracum Cicadae, Radix Curcumae, Radix Rhodiolae, Folium Eriobotryae, Semen Raphani, Semen Lepidii (Semen Descurainiae) and Folium Mori add cold water higher than powder immersion 0.5-1 hour, big fire is boiled, little fire boils 20-30 minute, and filter and remove residue obtains medicinal liquid; Decoct twice, boil after being mixed by the medicinal liquid of twice, little fire boils 10-15 minute, to obtain final product again;
(3), get supernatant obtained in (1) and (2) step, be evaporated to 60 DEG C-70 DEG C, density is the extractum of 1.03-1.09, for subsequent use after dry;
(4), the weight of determination step (3), add the lactose of its weight 5% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 2:1; Stir and be heated to 80-90 DEG C, cross 120 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 3, a kind of pharmaceutical composition for the treatment of asthma, comprise following weight portion:
Herba Taraxaci 10 parts, Bulbus Fritillariae Cirrhosae 7.5 parts, the Radix Astragali 15 parts, Radix Codonopsis 20 parts, Semen Cuscutae 10 parts, Radix Scrophulariae 14 parts, 6.5 parts, Radix Glycyrrhizae, Flos Farfarae 3.5 parts, snow pear paste 1 part, Cortex Magnoliae Officinalis 9 parts, Fructus Arctii 8.5 parts, Herba Dendrobii 10.5 parts, Periostracum Cicadae 7.5 parts, Radix Curcumae 6 parts, Radix Rhodiolae 3 parts, Folium Eriobotryae 8 parts, Semen Raphani 8 parts, Semen Lepidii (Semen Descurainiae) 6.5 parts, 8.5 parts, Folium Mori.
Concrete preparation method is:
(1), by the Radix Astragali, Radix Codonopsis, Cortex Magnoliae Officinalis, Fructus Arctii, Herba Taraxaci and Bulbus Fritillariae Cirrhosae pulverize 80 orders, then extracted 2 times in the ethanol of 75%, each 1-3 hour, merged medicinal liquid, leave standstill 24 hours, for subsequent use;
(2), Semen Cuscutae, Radix Scrophulariae, Radix Glycyrrhizae, Flos Farfarae, snow pear paste, Herba Dendrobii, Periostracum Cicadae, Radix Curcumae, Radix Rhodiolae, Folium Eriobotryae, Semen Raphani, Semen Lepidii (Semen Descurainiae) and Folium Mori add cold water higher than powder immersion 0.5-1 hour, big fire is boiled, little fire boils 20-30 minute, and filter and remove residue obtains medicinal liquid; Decoct twice, boil after being mixed by the medicinal liquid of twice, little fire boils 10-15 minute, to obtain final product again;
(3), get supernatant obtained in (1) and (2) step, be evaporated to 60 DEG C-70 DEG C, density is the extractum of 1.03-1.09, for subsequent use after dry;
(4), the weight of determination step (3), add the lactose of its weight 5% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 2:1; Stir and be heated to 80-90 DEG C, cross 120 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 4, a kind of pharmaceutical composition for the treatment of asthma, comprise following weight portion:
Herba Taraxaci 12 parts, Bulbus Fritillariae Cirrhosae 8 parts, the Radix Astragali 16 parts, Radix Codonopsis 20 parts, Semen Cuscutae 12 parts, Radix Scrophulariae 16 parts, 8 parts, Radix Glycyrrhizae, Flos Farfarae 5 parts, snow pear paste 1.5 parts, Cortex Magnoliae Officinalis 10 parts, Fructus Arctii 11 parts, Herba Dendrobii 12 parts, Periostracum Cicadae 8 parts, Radix Curcumae 8 parts, Radix Rhodiolae 4 parts, Folium Eriobotryae 9 parts, Semen Raphani 10 parts, Semen Lepidii (Semen Descurainiae) 7.5 parts, 10 parts, Folium Mori.
Concrete preparation method is:
(1), by the Radix Astragali, Radix Codonopsis, Cortex Magnoliae Officinalis, Fructus Arctii, Herba Taraxaci and Bulbus Fritillariae Cirrhosae pulverize 80 orders, then extracted 2 times in the ethanol of 75%, each 1-3 hour, merged medicinal liquid, leave standstill 24 hours, for subsequent use;
(2), Semen Cuscutae, Radix Scrophulariae, Radix Glycyrrhizae, Flos Farfarae, snow pear paste, Herba Dendrobii, Periostracum Cicadae, Radix Curcumae, Radix Rhodiolae, Folium Eriobotryae, Semen Raphani, Semen Lepidii (Semen Descurainiae) and Folium Mori add cold water higher than powder immersion 0.5-1 hour, big fire is boiled, little fire boils 20-30 minute, and filter and remove residue obtains medicinal liquid; Decoct twice, boil after being mixed by the medicinal liquid of twice, little fire boils 10-15 minute, to obtain final product again;
(3), get supernatant obtained in (1) and (2) step, be evaporated to 60 DEG C-70 DEG C, density is the extractum of 1.03-1.09, for subsequent use after dry;
(4), the weight of determination step (3), add the lactose of its weight 7% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 2:1; Stir and be heated to 80-90 DEG C, cross 120 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
Embodiment 5: animal model test
Oralbumin (OVA) is the inductive substance of the most frequently used asthmatic model, can be divided into simple and compound two kinds of forms, can copy the various models such as asthma active chronic inflammation and Airway Remodeling with it both at home and abroad.Conventional is use the OVA of aluminium hydroxide emulsifying by abdominal cavity or subcutaneous repeatedly sensitization now, and then collunarium or Neulized inhalation excite, and 10gOVA are dissolved in the sensitization liquid that normal saline 100ml configures 10% concentration, with front instant configuration.
Menglusitena LTRA, can suppress in air flue cysteinyl leukotriene (CysLT1) receptor by specificity, thus reaches and improve airway inflammation, effective Control of asthma symptom.The only long-term control medicine that can apply separately, can be used as the replacement therapy medicine of mild asthma and the therapeutic alliance medication of middle severe asthma.In the present invention as positive controls.
5.1, animal model and administration
120 male BALB/C mice of cleaning grade, 6 groups: A is divided into be blank group at random, B is asthmatic model group, C positive controls (0.15mg/kg), dosage group (3g/kg), F Chinese medicine composition low dose group (1g/kg) in D Chinese medicine composition high dose group (6g/kg), E Chinese medicine composition, often organize 20, except blank group, every mice respectively at the 1st day with 10%OVA mixed liquor of normal saline 1ml, lumbar injection sensitization; Each group of mice is placed in hermetic container by the 25th day every day, with 5%OVA normal saline ultrasound atomizer atomization asthma, and every day 1 time, continuous 7 days.Blank group is carried out lumbar injection and Neulized inhalation sensitization with normal saline and is excited mice medication respectively to organize all common nursing.After 7 days, after abdominal cavity sensitization, there is weight loss in B, C, D, E, F group mice; After antigen stimulation, there is the symptoms such as the tic of dysphoria, rapid breathing, abdominal muscle, gatism, hairs, activity and diet minimizing, cyanosis that severe patient mouth and nose are slight; A group calling is inhaled steadily, fur is smooth, activity is quick, diet is normal, body weight increases.Mice modeling success.
Each group starts medication in sensitization after 2 weeks, every day 1 time, totally 4 weeks.Each group gives following medicine respectively:
A group: isopyknic normal saline
B group: isopyknic normal saline
C group: gavage gives 0.15mg/kg ginsenoside
D group: gavage gives 6g/kg Chinese medicine composition
E group: gavage gives 3g/kg Chinese medicine composition
F group: gavage gives 1g/kg Chinese medicine composition
5.2, sign and MIP-1 α detect
The generation of MIP-1 α and various respiratory systemic disease, develop relevant, obviously raise through the content MIP-1 α detecting the bronchoalveolar lavage fluid and peripheral blood of suffering from the individuality of respiratory system disease.
Table 1 is group 4 weeks rear bronchoalveolar lavage fluids of MIP-1 α and the content of peripheral blood respectively
Compare with B group ▲p<0.05, ▲ ▲p<0.01;
Compare with C group #p<0.05, ##p<0.01
Obviously raised by the MIP-1 α of table 1 result display model mice and show model modeling success.And B group and D, E, F tri-groups all can reduce MIP-1 alpha content very much, wherein E group has significant difference compared with B group, and this shows that the MIP-1 α of E group to immunodeficiency models is lower than B group, and Chinese medicine composition is dose-dependence to MIP-1 α height.
Embodiment 6: clinical trial
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
6.1, physical data
Inventor collects the out-patient of 120 routine asthma altogether, is divided at random: treatment group 60 example, matched group 60 example.The data such as two groups of sexes, age, state of an illness there are no significant difference, has comparability.
6.2, test method
Matched group: oral MK sheet, sleep first 1, severe patient adds budesonide spray, uses to specifications, 1 month course for the treatment of;
Treatment group: the granule that oral the present invention obtains according to specific embodiment 3, every bu is taken for 2 times, each 5 grams, 1 month course for the treatment of.
6.3, criterion of therapeutical effect and therapeutic outcome
6.3.1, criterion of therapeutical effect
Formulate with reference to " Chinese medicine Clinical Researches of New Drugs guideline ":
Cure: the symptoms of asthma complete incidence graph such as cough, asthma, pulmonary's rale disappears.
Effective: the symptoms of asthma outbreaks such as cough, asthma obviously alleviate before comparatively treating, and pulmonary's rale disappears substantially.
Take a turn for the better: symptoms of asthma alleviates to some extent, but still has the symptoms such as cough, asthma, and pulmonary's rale is obvious.
Invalid: clinical symptoms and pulmonary's rale are without improvement or increase the weight of on the contrary.
6.3.2, therapeutic outcome
Check therapeutic outcome after 4 weeks, detailed results is in table 2.
Table 2 treatment group and treatment of control group effectiveness comparison
Group Cure Effective Take a turn for the better Invalid Effective percentage (%)
Treatment group 36 13 10 1 98.3
Matched group 21 10 12 17 71.7
As can be seen from Table 2, the therapeutic effect for the treatment of group of the present invention is obviously better than matched group, and the effective percentage for the treatment of group is 98.3%, and the effective percentage of matched group is 71.7%.Thus, Chinese medicine composition of the present invention can be applied at clinical further genralrlization.
6.4, classical case
Case 1: spend certain, female 51 years old, patient's private prosecution suffers from asthma 8 years, cough, asthma shows effect everyday, especially increase the weight of evening, nearest evening, frequent hypopnea and waking up with a start, used mist agent alleviation and symptom management, the therapeutic effect do not obtained, take the granule of Medications Example 3 of the present invention, one day 2 doses, each 5 grams, it within 15 days, is a course for the treatment of, a course for the treatment of, patient slept obviously much happy, Stable asthma, after rear patient continues to take 2 courses for the treatment of, patient returns to one's perfect health, and within 6 months, Effect of follow-up visit by telephone does not recur so far.
Case 2: sternly certain, man 43 years old, patient's private prosecution repeated cold, sneeze, cough seriously, have chest pain symptom, affect work and sleep, take budesonide inhalation in treatment, alleviate to some extent, but do not treat at all, take the granule of Medications Example 4 of the present invention, one day 2 doses, each 5 grams, within 15 days, be a course for the treatment of, one the course for the treatment of patient's sneeze, cough phenomenon alleviate to some extent, after rear patient continues to take 2 courses for the treatment of, return to one's perfect health, within 6 months, Effect of follow-up visit by telephone does not recur so far.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.

Claims (7)

1. treat the pharmaceutical composition of asthma for one kind, it is characterized in that, comprise following crude drug: Herba Taraxaci, Bulbus Fritillariae Cirrhosae, the Radix Astragali, Radix Codonopsis, Semen Cuscutae, Radix Scrophulariae, Radix Glycyrrhizae, Flos Farfarae, snow pear paste, Cortex Magnoliae Officinalis, Fructus Arctii, Herba Dendrobii, Periostracum Cicadae, Radix Curcumae, Radix Rhodiolae, Folium Eriobotryae, Semen Raphani, Semen Lepidii (Semen Descurainiae), Folium Mori.
2. pharmaceutical composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Herba Taraxaci 5-15 part, Bulbus Fritillariae Cirrhosae 5-10 part, Radix Astragali 10-20 part, Radix Codonopsis 10-30 part, Semen Cuscutae 5-15 part, Radix Scrophulariae 8-20 part, Radix Glycyrrhizae 3-10 part, Flos Farfarae 1-5 part, snow pear paste 0.5-2 part, Cortex Magnoliae Officinalis 3-15 part, Fructus Arctii 6-13 part, Herba Dendrobii 6-15 part, Periostracum Cicadae 5-10 part, Radix Curcumae 2-10 part, Radix Rhodiolae 1-5 part, Folium Eriobotryae 6-10 part, Semen Raphani 4-12 part, Semen Lepidii (Semen Descurainiae) 3-10 part, Folium Mori 5-12 part.
3. pharmaceutical composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Herba Taraxaci 10 parts, Bulbus Fritillariae Cirrhosae 7.5 parts, the Radix Astragali 15 parts, Radix Codonopsis 20 parts, Semen Cuscutae 10 parts, Radix Scrophulariae 14 parts, 6.5 parts, Radix Glycyrrhizae, Flos Farfarae 3.5 parts, snow pear paste 1 part, Cortex Magnoliae Officinalis 9 parts, Fructus Arctii 8.5 parts, Herba Dendrobii 10.5 parts, Periostracum Cicadae 7.5 parts, Radix Curcumae 6 parts, Radix Rhodiolae 3 parts, Folium Eriobotryae 8 parts, Semen Raphani 8 parts, Semen Lepidii (Semen Descurainiae) 6.5 parts, 8.5 parts, Folium Mori.
4. pharmaceutical composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Herba Taraxaci 12 parts, Bulbus Fritillariae Cirrhosae 8 parts, the Radix Astragali 16 parts, Radix Codonopsis 20 parts, Semen Cuscutae 12 parts, Radix Scrophulariae 16 parts, 8 parts, Radix Glycyrrhizae, Flos Farfarae 5 parts, snow pear paste 1.5 parts, Cortex Magnoliae Officinalis 10 parts, Fructus Arctii 11 parts, Herba Dendrobii 12 parts, Periostracum Cicadae 8 parts, Radix Curcumae 8 parts, Radix Rhodiolae 4 parts, Folium Eriobotryae 9 parts, Semen Raphani 10 parts, Semen Lepidii (Semen Descurainiae) 7.5 parts, 10 parts, Folium Mori.
5. prepare a preparation method for the pharmaceutical composition described in any one of claim 1-4, it is characterized in that, concrete step is:
1) Radix Astragali, Radix Codonopsis, Cortex Magnoliae Officinalis, Fructus Arctii, Herba Taraxaci and Bulbus Fritillariae Cirrhosae are pulverized 80 orders, then extracted 2 times in the ethanol of 75%, each 1-3 hour, merged medicinal liquid, leave standstill 24 hours, for subsequent use;
2) Semen Cuscutae, Radix Scrophulariae, Radix Glycyrrhizae, Flos Farfarae, snow pear paste, Herba Dendrobii, Periostracum Cicadae, Radix Curcumae, Radix Rhodiolae, Folium Eriobotryae, Semen Raphani, Semen Lepidii (Semen Descurainiae) and Folium Mori add cold water higher than powder immersion 0.5-1 hour, big fire is boiled, little fire boils 20-30 minute, and filter and remove residue obtains medicinal liquid; Decoct twice, boil after being mixed by the medicinal liquid of twice, little fire boils 10-15 minute, to obtain final product again;
3) the 1st is got) and 2) supernatant obtained in step, be evaporated to 60 DEG C-70 DEG C, density is the extractum of 1.03-1.09, for subsequent use after dry;
4) determination step 3) weight, add the lactose of its weight 5% and the mixture of dextrin, in the mixture of wherein lactose and dextrin, the weight ratio of lactose and dextrin is 2:1; Stir and be heated to 80-90 DEG C, cross 120 mesh sieves, obtain extract powder with spray dryer, namely subpackage obtains granule.
6. pharmaceutical composition according to claim 1, is characterized in that: the application of described pharmaceutical composition in preparation treatment asthmatic medicament.
7. pharmaceutical composition according to claim 1, is characterized in that: the application of described pharmaceutical composition in preparation treatment bronchial asthma medicine.
CN201510925582.9A 2015-12-10 2015-12-10 Pharmaceutical composition for treating bronchialasthma and application thereof Pending CN105412826A (en)

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