CN105106762A - Medicinal preparation for treating acne - Google Patents
Medicinal preparation for treating acne Download PDFInfo
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- CN105106762A CN105106762A CN201510643151.3A CN201510643151A CN105106762A CN 105106762 A CN105106762 A CN 105106762A CN 201510643151 A CN201510643151 A CN 201510643151A CN 105106762 A CN105106762 A CN 105106762A
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Abstract
The invention belongs to the field of traditional Chinese medicinal preparations, and particularly provides a medicinal preparation for treating acne. The medicinal preparation is prepared by adopting the following raw materials: 28 parts of sanicula lamelligera hance, 25 parts of akebia trifoliata, 20 parts of indigofera fortunei craib, 15 parts of broussonetia Kazinoki, 25 parts of lonicera japonica, 28 parts of sculellaria barbata, 15 parts of fructus forsythia, 15 parts of atractylodes, 20 parts of astragalus membranaceus, 25 parts of salvia miltiorrhiza, 20 parts of coix seeds, 25 parts of cordate houttuynia, 20 parts of chinese pulsatilla root, 15 parts of schizonepeta, 15 parts of kudzuvine root, 15 parts of radix bupleuri, 25 parts of dayflower, 15 parts of mulberry leaves and 5 parts of liquorice. The medicinal preparation can treat acne.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of acne and its preparation method and application.
Background technology
Acne is that a kind of chronic inflammatory skin of pilosebaceous unit is sick, is mainly apt to occur in teenager, and clinical manifestation is to be apt to occur in the pleomorphism skin lesion such as acne, pimple, pustule, tuberosity of face for feature.The western medical treatment of method many employings drug of topical application external treatment of Acne treatment and treatment by oral administration of medicines of taking medicine, there is the large and expensive shortcoming of curative effect instability, side effect in the medicine of existing Acne treatment.For this reason, the needs that the medicine developing more Acne treatments safely and effectively meets clinical treatment are bursting to.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of can the Chinese medicine preparation of Acne treatment disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of acne, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: sanicula lamelligera Hance 28 parts, fried 25 parts of August, indigofera fortunei Craib 20 parts, paddy skin set 15 parts, Flos Lonicerae 25 parts, Herba Scutellariae Barbatae 28 parts, Fructus Forsythiae 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, the Radix Astragali 20 parts, Radix Salviae Miltiorrhizae 25 parts, Semen Coicis 20 parts, Herba Houttuyniae 25 parts, the Radix Pulsatillae 20 parts, Herba Schizonepetae 15 parts, Radix Puerariae 15 parts, Radix Bupleuri 15 parts, Herba Commelinae 25 parts, 15 parts, Folium Mori, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of acne, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of acne, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The application in Retinoids, Retin-A, Renova, Accutane is being prepared in the described pharmaceutical preparation being used for the treatment of acne.
Sanicula lamelligera Hance is Umbelliferae sanicle platymiscium sanicula lamelligera Hance SaniculalamelligeraHance, with all herbal medicine, and cold expelling cough-relieving, promoting the circulation of blood dysmenorrhea.For cough due to wind and cold, pertussis, menoxenia, amenorrhea, lumbago.
August explodes, Classification system HolboelliafargesiiReaub., is fallen leaves woody climber, high 10m.Bark has obvious point-like protruding, the brown or brown of branch; Minor matters place has place to deposit perula, and bottom person is slightly with wooden, top papery, all without hair.Trifoliolate leaf, cluster in branch end, petiole is thin and delicate, long 6 ~ 8cm, vanelets oval, width egg shape or long oval etc., length and width change greatly, the blunt circle of tip, central nick or the short point of tool, basal circular or wide wedge shape, sometimes in micro-heart, full edge or in wavy, lateral vein is usual 5 ~ 6 right.Flower unisexuality, hermaphroditism, aubergine, raceme axil is raw, and be about 8cm, male flower is less, and most, and be born in inflorescence top, tool squamella, perianth 3, stamen 6, filigree is flat; Female flower 1 ~ 3, and is born in inflorescence bottom, bract wire lanceolar, perianth 3, stamen 6, and filigree is flat; Female flower 1 ~ 3, and is born in inflorescence bottom, bract wire lanceolar, perianth 3, and wide ellipse is blunt nosed, tool staminodium 6, carpel 3 ~ 12, and from life, stigma head, ovary cylindrical shape or slightly bending, upper Room 1, parietal placenta, ovule is most.Follicle radish sarcocarp matter, oblong, aubergine time ripe, ftractures along ventral suture.Seed sealene triangle, slightly flat, rufous, it is fine and closely woven and glossy that tool indulges wrinkle, and be embedded in canescence fruit flesh, hilum is slightly partial to, the spongy strophiole of its other visible white.4 ~ May of florescence, really 8 ~ October of phase.Soothing the liver, the kidney invigorating, pain relieving, diuresis, parasite killing.Cure mainly: stomachache, colic, painful and swollen testis, lumbago, seminal emission, menoxenia, leucorrhea, uterine prolapse.For gastral cavity side of body distending pain, amenorrhea dysmenorrhea, dysuria, snake bite and insect sting.
Indigofera fortunei Craib is pulse family anil indigofera fortunei Craib IndigoferafortuneiCraib, is used as medicine with root and leaf.Spring and autumn adopts, and cleans chopping, dries.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Epidemic encephalitis type B, laryngopharynx swelling and pain, pneumonia, venom.The present invention adopts all herbal medicine.
Paddy skin tree belongs to the little Broussonetia papyrifera BroussonetiakazinokiSieb.etZucc. of moraceae plants for structure, is used as medicine with root, root bark, bark and leaf.The present invention is used as medicine with root.Root, root bark: eliminating stasis to stop pain.For traumatic injury, lumbago.Leaf, bark juice: removing toxic substances, parasite killing.Neurodermatitis is controlled in external, stubborn dermatitis.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, acne mostly is lung meridian intrinsic heat and does, sanicula lamelligera Hance of the present invention, August fried, indigofera fortunei Craib, Gu Pishu, Flos Lonicerae, Herba Scutellariae Barbatae, Fructus Forsythiae, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali, Radix Salviae Miltiorrhizae, Semen Coicis heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating be monarch drug, Herba Houttuyniae, the Radix Pulsatillae, Herba Schizonepetae, Radix Puerariae, Radix Bupleuri, Herba Commelinae, Folium Mori wind-dispelling heat-dissipating are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, clearing away heat-damp and promoting diuresis, depressed liver-energy dispersing and QI regulating, Acne treatment successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get sanicula lamelligera Hance 28g, August explodes 25g, indigofera fortunei Craib 20g, paddy skin tree 15g, Flos Lonicerae 25g, Herba Scutellariae Barbatae 28g, Fructus Forsythiae 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Astragali 20g, Radix Salviae Miltiorrhizae 25g, Semen Coicis 20g, Herba Houttuyniae 25g, Radix Pulsatillae 20g, Herba Schizonepetae 15g, Radix Puerariae 15g, Radix Bupleuri 15g, Herba Commelinae 25g, Folium Mori 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get sanicula lamelligera Hance 28g, August explodes 25g, indigofera fortunei Craib 20g, paddy skin tree 15g, Flos Lonicerae 25g, Herba Scutellariae Barbatae 28g, Fructus Forsythiae 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Astragali 20g, Radix Salviae Miltiorrhizae 25g, Semen Coicis 20g, Herba Houttuyniae 25g, Radix Pulsatillae 20g, Herba Schizonepetae 15g, Radix Puerariae 15g, Radix Bupleuri 15g, Herba Commelinae 25g, Folium Mori 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get sanicula lamelligera Hance 28g, August explodes 25g, indigofera fortunei Craib 20g, paddy skin tree 15g, Flos Lonicerae 25g, Herba Scutellariae Barbatae 28g, Fructus Forsythiae 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Astragali 20g, Radix Salviae Miltiorrhizae 25g, Semen Coicis 20g, Herba Houttuyniae 25g, Radix Pulsatillae 20g, Herba Schizonepetae 15g, Radix Puerariae 15g, Radix Bupleuri 15g, Herba Commelinae 25g, Folium Mori 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation Acne treatment of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation cases of acne 40 example, 15 ~ 35 years old age.The shortest person of the course of disease 4 months, most elder reaches 1 year.
4.2 diagnostic criterias: (1) diagnosis is with reference to " clinical dermatology ", " People's Republic of China's traditional Chinese medicine industry standard-TCM Dermatology disease Standardization of diagnosis and curative effect ": have typical clinical symptoms and sign, skin lesion is mainly being dispersed in property blackhead, inflamed papules, pustule, tuberosity, the cyst of involving facial area, is diagnosed as acne person.(2) exclusion standard: 1. with infectious disease person, as: hepatitis, syphilis, acquired immune deficiency syndrome (AIDS) etc.; 2. can not chronotherapeutic person on demand; 3. the person that accepts other treatment in therapeutic process.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: formulate " Chinese medicine (new drug) guideline of clinical investigations " with reference to Ministry of Health of the People's Republic of China: recovery from illness: facial acne erythra all disappears, and occurs, only stay pigmentation without new breakout; Effective: acne deflorescence more than 70%, inflammation obviously alleviates, and occurs without new erythra; Effective: acne erythra obviously disappears 20%-70%, there is a small amount of new erythra to occur; Invalid: acne erythra obviously disappears 20%, or still have new erythra to occur.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
Treatment group | 20 | 5 | 12 | 3 | 85 |
Blank group | 20 | 1 | 0 | 19 | 5 |
Visible, the medicine that the present invention obtains can safe and effective Acne treatment, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of acne, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: sanicula lamelligera Hance 28 parts, fried 25 parts of August, indigofera fortunei Craib 20 parts, paddy skin set 15 parts, Flos Lonicerae 25 parts, Herba Scutellariae Barbatae 28 parts, Fructus Forsythiae 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, the Radix Astragali 20 parts, Radix Salviae Miltiorrhizae 25 parts, Semen Coicis 20 parts, Herba Houttuyniae 25 parts, the Radix Pulsatillae 20 parts, Herba Schizonepetae 15 parts, Radix Puerariae 15 parts, Radix Bupleuri 15 parts, Herba Commelinae 25 parts, 15 parts, Folium Mori, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of acne as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of acne as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in Retinoids, Retin-A, Renova, Accutane of acne according to claim 1.
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CN201510643151.3A CN105106762A (en) | 2015-10-03 | 2015-10-03 | Medicinal preparation for treating acne |
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CN201510643151.3A CN105106762A (en) | 2015-10-03 | 2015-10-03 | Medicinal preparation for treating acne |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103877455A (en) * | 2014-04-18 | 2014-06-25 | 山东省千佛山医院 | Chinese medicinal composition for treating acne |
CN104645146A (en) * | 2015-03-26 | 2015-05-27 | 黄淑娟 | Chinese medicine composition for treating acne |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103877455A (en) * | 2014-04-18 | 2014-06-25 | 山东省千佛山医院 | Chinese medicinal composition for treating acne |
CN104645146A (en) * | 2015-03-26 | 2015-05-27 | 黄淑娟 | Chinese medicine composition for treating acne |
Non-Patent Citations (1)
Title |
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余晓琳等: "从肝郁肾虚论治寻常性痤疮48例", 《辽宁中医药大学学报》 * |
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Application publication date: 20151202 |