CN105063186A - 用于治疗、诊断和监测阿尔茨海默病的方法 - Google Patents
用于治疗、诊断和监测阿尔茨海默病的方法 Download PDFInfo
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- CN105063186A CN105063186A CN201510445488.3A CN201510445488A CN105063186A CN 105063186 A CN105063186 A CN 105063186A CN 201510445488 A CN201510445488 A CN 201510445488A CN 105063186 A CN105063186 A CN 105063186A
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/6869—Methods for sequencing
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
- G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
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- General Engineering & Computer Science (AREA)
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- Pathology (AREA)
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- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161558197P | 2011-11-10 | 2011-11-10 | |
| US61/558,197 | 2011-11-10 | ||
| US201261671531P | 2012-07-13 | 2012-07-13 | |
| US61/671,531 | 2012-07-13 | ||
| CN201280055180.2A CN103930568A (zh) | 2011-11-10 | 2012-11-09 | 用于治疗、诊断和监测阿尔茨海默病的方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280055180.2A Division CN103930568A (zh) | 2011-11-10 | 2012-11-09 | 用于治疗、诊断和监测阿尔茨海默病的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105063186A true CN105063186A (zh) | 2015-11-18 |
Family
ID=47222323
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510445488.3A Pending CN105063186A (zh) | 2011-11-10 | 2012-11-09 | 用于治疗、诊断和监测阿尔茨海默病的方法 |
| CN201610369743.5A Pending CN106011243A (zh) | 2011-11-10 | 2012-11-09 | 用于治疗、诊断和监测阿尔茨海默病的方法 |
| CN201280055180.2A Pending CN103930568A (zh) | 2011-11-10 | 2012-11-09 | 用于治疗、诊断和监测阿尔茨海默病的方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610369743.5A Pending CN106011243A (zh) | 2011-11-10 | 2012-11-09 | 用于治疗、诊断和监测阿尔茨海默病的方法 |
| CN201280055180.2A Pending CN103930568A (zh) | 2011-11-10 | 2012-11-09 | 用于治疗、诊断和监测阿尔茨海默病的方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20140371094A1 (https=) |
| EP (1) | EP2776582A2 (https=) |
| JP (2) | JP6338530B2 (https=) |
| KR (1) | KR20140089384A (https=) |
| CN (3) | CN105063186A (https=) |
| AR (1) | AR088827A1 (https=) |
| BR (1) | BR112014011127A2 (https=) |
| CA (1) | CA2854779A1 (https=) |
| HK (1) | HK1214631A1 (https=) |
| MX (1) | MX2014005683A (https=) |
| RU (1) | RU2014123511A (https=) |
| WO (1) | WO2013071119A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108753954A (zh) * | 2018-06-26 | 2018-11-06 | 中南大学湘雅医院 | 痴呆相关基因的捕获探针组、试剂盒、文库构建方法和用途 |
| CN117230184A (zh) * | 2023-11-13 | 2023-12-15 | 深圳康美生物科技股份有限公司 | 基于飞行时间核酸质谱技术检测阿尔兹海默病基因的核酸组合及应用 |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7702468B2 (en) | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
| US10522240B2 (en) | 2006-05-03 | 2019-12-31 | Population Bio, Inc. | Evaluating genetic disorders |
| WO2012018387A2 (en) | 2010-08-02 | 2012-02-09 | Population Diagnotics, Inc. | Compositions and methods for discovery of causative mutations in genetic disorders |
| EP2766483B1 (en) | 2011-10-10 | 2022-03-23 | The Hospital For Sick Children | Methods and compositions for screening and treating developmental disorders |
| EP2773779B1 (en) * | 2011-11-04 | 2020-10-14 | Population Bio, Inc. | Methods and compositions for diagnosing, prognosing, and treating neurological conditions |
| US10407724B2 (en) | 2012-02-09 | 2019-09-10 | The Hospital For Sick Children | Methods and compositions for screening and treating developmental disorders |
| DK2895621T3 (da) | 2012-09-14 | 2020-11-30 | Population Bio Inc | Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande |
| WO2014052855A1 (en) | 2012-09-27 | 2014-04-03 | Population Diagnostics, Inc. | Methods and compositions for screening and treating developmental disorders |
| US9782075B2 (en) | 2013-03-15 | 2017-10-10 | I2Dx, Inc. | Electronic delivery of information in personalized medicine |
| US11089959B2 (en) | 2013-03-15 | 2021-08-17 | I2Dx, Inc. | Electronic delivery of information in personalized medicine |
| EP3077533B1 (en) * | 2013-12-06 | 2019-04-24 | Life & Brain GmbH | Methods for establishing a clinical prognosis of diseases associated with the formation of aggregates of abeta1-42 |
| GB2558326B (en) | 2014-09-05 | 2021-01-20 | Population Bio Inc | Methods and compositions for inhibiting and treating neurological conditions |
| RU2691375C2 (ru) * | 2014-09-30 | 2019-06-11 | БиДжиАй ШЭНЬЧЖЭНЬ | Биомаркеры для ревматоидного артрита и их применение |
| JP6991134B2 (ja) * | 2015-10-09 | 2022-01-12 | ガーダント ヘルス, インコーポレイテッド | 無細胞dnaを使用する集団ベースの処置レコメンダ |
| JP2017189121A (ja) * | 2016-04-11 | 2017-10-19 | 国立大学法人旭川医科大学 | 抗TNFα抗体適応疾患の治療における抗TNFα抗体投与時反応の発症リスクを判定する方法、並びに該判定用オリゴヌクレオチドキット |
| KR102024862B1 (ko) * | 2016-10-19 | 2019-09-25 | 삼성디스플레이 주식회사 | 표시 장치 |
| US11725232B2 (en) | 2016-10-31 | 2023-08-15 | The Hong Kong University Of Science And Technology | Compositions, methods and kits for detection of genetic variants for alzheimer's disease |
| US10240205B2 (en) | 2017-02-03 | 2019-03-26 | Population Bio, Inc. | Methods for assessing risk of developing a viral disease using a genetic test |
| CN110249061A (zh) * | 2017-05-15 | 2019-09-17 | 英孚美迪泰克株式会社 | 与阿尔茨海默病风险相关的apoe启动子单核苷酸多态性及其用途 |
| WO2019178167A1 (en) * | 2018-03-13 | 2019-09-19 | I2Dx, Inc. | Electronic delivery of information in personalized medicine |
| EP4177356B1 (en) | 2018-08-08 | 2024-05-08 | PML Screening, LLC | Methods for assessing risk of developing a viral disease using a genetic test |
| WO2020143044A1 (zh) * | 2019-01-11 | 2020-07-16 | 深圳市双科生物科技有限公司 | 一种双质控检测方法 |
| WO2020231081A1 (ko) * | 2019-05-10 | 2020-11-19 | 주식회사 엠제이브레인바이오 | Top3b 유전자 변이 기반 치매 진단방법 |
| WO2021037027A1 (en) * | 2019-08-29 | 2021-03-04 | The Hong Kong University Of Science And Technology | Genetic variants for diagnosis of alzheimer's disease |
| GB202004832D0 (en) * | 2020-04-01 | 2020-05-13 | Instituto De Medicina Molecular Faculdade De Medicina Univ De Lisboa | Therapeutic agaents, pharmaceutical compositions, and associated biomarkers |
| KR102561438B1 (ko) * | 2020-11-04 | 2023-07-28 | 사회복지법인 삼성생명공익재단 | 뇌 아밀로이드 베타 축적 가능성을 예측하는 방법 |
| CN112980954B (zh) * | 2021-03-03 | 2022-02-25 | 首都医科大学宣武医院 | 一种预测神经退行性疾病风险的试剂盒及其用途 |
| IL321771A (en) * | 2023-01-09 | 2025-08-01 | Lilly Co Eli | Anti-unc5c antibodies |
| WO2025125898A1 (en) * | 2023-12-15 | 2025-06-19 | Alchemab Therapeutics Ltd | Anti-unc5c antibodies and uses thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101812525A (zh) * | 2010-04-09 | 2010-08-25 | 南通大学 | 与ad发病相关的基因网络通路分析模型的建立方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4683203A (en) | 1984-04-14 | 1987-07-28 | Redco N.V. | Immobilized enzymes, processes for preparing same, and use thereof |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5268164A (en) | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
| US5112596A (en) | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
| ATE191853T1 (de) | 1992-07-27 | 2000-05-15 | Us Health | Zielgerichte liposome zur blut-hirne schranke |
| US5498531A (en) | 1993-09-10 | 1996-03-12 | President And Fellows Of Harvard College | Intron-mediated recombinant techniques and reagents |
| EP2369007B1 (en) | 1996-05-29 | 2015-07-29 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| AU2001265121A1 (en) | 2000-05-30 | 2001-12-11 | Applera Corporation | Methods for detecting target nucleic acids using coupled ligation and amplification |
| US6514221B2 (en) | 2000-07-27 | 2003-02-04 | Brigham And Women's Hospital, Inc. | Blood-brain barrier opening |
| US20030083299A1 (en) | 2000-11-04 | 2003-05-01 | Ferguson Ian A. | Non-invasive delivery of polypeptides through the blood-brain barrier |
| DE10121982B4 (de) | 2001-05-05 | 2008-01-24 | Lts Lohmann Therapie-Systeme Ag | Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung |
| US20030119004A1 (en) | 2001-12-05 | 2003-06-26 | Wenz H. Michael | Methods for quantitating nucleic acids using coupled ligation and amplification |
| JP4995423B2 (ja) | 2002-12-03 | 2012-08-08 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 物質を血液−脳関門を渡って輸送するための人工低密度リポタンパク質キャリア |
| DK2282779T3 (da) * | 2008-04-29 | 2013-05-27 | Pharnext | Nye terapeutiske fremgangsmåder til behandling af alzheimer sygdom og beslægtede lidelser gennem en modulation af cellestress-respons |
-
2012
- 2012-11-09 RU RU2014123511/10A patent/RU2014123511A/ru unknown
- 2012-11-09 CN CN201510445488.3A patent/CN105063186A/zh active Pending
- 2012-11-09 CA CA2854779A patent/CA2854779A1/en not_active Abandoned
- 2012-11-09 EP EP12791045.3A patent/EP2776582A2/en not_active Withdrawn
- 2012-11-09 AR ARP120104237A patent/AR088827A1/es unknown
- 2012-11-09 US US14/357,192 patent/US20140371094A1/en not_active Abandoned
- 2012-11-09 MX MX2014005683A patent/MX2014005683A/es unknown
- 2012-11-09 CN CN201610369743.5A patent/CN106011243A/zh active Pending
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- 2012-11-09 BR BR112014011127A patent/BR112014011127A2/pt not_active IP Right Cessation
- 2012-11-09 KR KR1020147014033A patent/KR20140089384A/ko not_active Withdrawn
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- 2012-11-09 JP JP2014541330A patent/JP6338530B2/ja not_active Expired - Fee Related
-
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-
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- 2018-05-08 JP JP2018090050A patent/JP2018166507A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101812525A (zh) * | 2010-04-09 | 2010-08-25 | 南通大学 | 与ad发病相关的基因网络通路分析模型的建立方法 |
Non-Patent Citations (2)
| Title |
|---|
| WANG ET AL: "Interleukin-6 receptor gene polymorphisms were associated with sporadic Alzheimer"s disease in Chinese Han", 《BRAIN RESEARCH》 * |
| 马中华 等: "Nicastrin启动子区多态性与散发阿尔茨海默病相关性研究", 《中国神经精神疾病杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108753954A (zh) * | 2018-06-26 | 2018-11-06 | 中南大学湘雅医院 | 痴呆相关基因的捕获探针组、试剂盒、文库构建方法和用途 |
| CN117230184A (zh) * | 2023-11-13 | 2023-12-15 | 深圳康美生物科技股份有限公司 | 基于飞行时间核酸质谱技术检测阿尔兹海默病基因的核酸组合及应用 |
| CN117230184B (zh) * | 2023-11-13 | 2024-03-19 | 深圳康美生物科技股份有限公司 | 基于飞行时间核酸质谱技术检测阿尔兹海默病基因的核酸组合及应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014005683A (es) | 2015-01-22 |
| WO2013071119A2 (en) | 2013-05-16 |
| BR112014011127A2 (pt) | 2017-05-16 |
| US20140371094A1 (en) | 2014-12-18 |
| EP2776582A2 (en) | 2014-09-17 |
| CA2854779A1 (en) | 2013-05-16 |
| WO2013071119A3 (en) | 2013-07-11 |
| AR088827A1 (es) | 2014-07-10 |
| RU2014123511A (ru) | 2015-12-20 |
| JP6338530B2 (ja) | 2018-06-06 |
| CN106011243A (zh) | 2016-10-12 |
| JP2014533949A (ja) | 2014-12-18 |
| JP2018166507A (ja) | 2018-11-01 |
| CN103930568A (zh) | 2014-07-16 |
| KR20140089384A (ko) | 2014-07-14 |
| HK1214631A1 (zh) | 2016-07-29 |
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