CN105055956A - Medicine composition for improving gastric mobility and application of medicine composition - Google Patents
Medicine composition for improving gastric mobility and application of medicine composition Download PDFInfo
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- CN105055956A CN105055956A CN201510516702.XA CN201510516702A CN105055956A CN 105055956 A CN105055956 A CN 105055956A CN 201510516702 A CN201510516702 A CN 201510516702A CN 105055956 A CN105055956 A CN 105055956A
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Abstract
The invention discloses a medicine composition for improving gastric mobility and application of the medicine composition. The medicine composition is prepared from, by weight, 50-66 parts of wild buckwheat, 29-38 parts of cottonrose hibiscus leaf, 28-35 parts of fiveleaf akebia fruit, 21-30 parts of bower actinidia root, 1-3 parts of dung beetle, 10-16 parts of bamboo shavings, 9-15 parts of trichosanthes kirilowii maxim and 6-9 parts of fingered citron. The medicine composition can improve the gastrointestinal function, in other words, the medicine composition can promote gastric emptying and intestine boosting, and the purpose of treating functional dyspepsia is achieved.
Description
Technical field
The invention belongs to technical field of Chinese medicine, in particular to a kind of pharmaceutical composition and the application thereof that improve gastric motility.
Background technology
Along with the continuous increase of social competition and operating pressure, the Bad Eating Habit of the day by day superior formation of living condition, cause the generation of the gastropathy such as functional dyspepsia, digestive tract power are not enough, this has become an importance of gastrotherapy, the Therapeutic Method that this disease is current is mainly used to the Western medicine such as domperidone (motilium), mosapride, cisapride, but these medicines have the untoward reaction of obvious central nervous system, hormonal system and digestive system, and the defect that can not take in a large number for a long time.
A lot of medicine is had also to be used for the treatment of functional dyspepsia in the traditional Chinese medical science, as: come from the Pingwei San of the classical medical book such as treatise on Febrile Diseases, " Medical Treasures of the Golden Chamber ", " Treatise on the spleen and stomach ", " Wanbing Huichun, Curative Measures for All Diseases ", " formulary of peaceful benevolent dispensary ", Sini San, decoction of four noble drugs, banxia xiexin decoction, Xiao Jianzhong Tang, CHAIHU GUIZHI TANG, Poria drink, BANXIA HOUPU TANG, banxia baizhu tianma decoction, stomach Siberian cocklebur soup, ERCHEN TANG, Ginseng Decoction etc. respectively, most prescription can improve again the indigestion symptoms such as gastral cavity abdominal distention is vexed, inappetence while treatment gastritis, peptic ulcer.
At present, to the use of Chinese medicine prescription mainly based on decoction, but these Chinese medicine decoction have, and pharmacotoxicological effect is indefinite, dosage is inaccurate, quality control is poor and use the weak points such as inconvenient.Therefore, while people wish to avoid Western medicine toxic and side effects over the course for the treatment of, can develop to have in Chinese medicine prescription and promote digestive tract power effect, improve gastrointestinal dysfunction and the less Chinese patent medicine of toxic and side effects, reach the object of disease therapy.
Summary of the invention
For existing Chinese medicine decoction Problems existing, the object of the present invention is to provide one to have and promote digestive tract power effect, improve gastrointestinal dysfunction and the less Chinese patent medicine of toxic and side effects.
In order to realize object of the present invention, inventor, by lot of experiments research also persistent exploration, finally obtains following technical scheme:
Improve a pharmaceutical composition for gastric motility, this pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Et Rhizoma Fagopyri Tatarici 50-66 part, Folium Hibisci Mutabilis 29-38 part, Fructus Akebiae 28-35 part, macaque Radix pyri 21-30 part, Catharsii molossi 1-3 part, Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 10-16 part, Fructus Trichosanthis 9-15 part, Fructus Citri Sarcodactylis 6-9 part.
Preferably, the pharmaceutical composition of raising gastric motility described above, this pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Et Rhizoma Fagopyri Tatarici 56-60 part, Folium Hibisci Mutabilis 32-35 part, Fructus Akebiae 30-32 part, macaque Radix pyri 24-26 part, Catharsii molossi 1-3 part, Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 12-14 part, Fructus Trichosanthis 11-13 part, Fructus Citri Sarcodactylis 7-8 part.
In a most preferred embodiment of the present invention, the pharmaceutical composition of raising gastric motility described above, this pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Et Rhizoma Fagopyri Tatarici 58 parts, Folium Hibisci Mutabilis 33 parts, Fructus Akebiae 31 parts, macaque Radix pyri 25 parts, Catharsii molossi 2 parts, Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 13 parts, Fructus Trichosanthis 12 parts, Fructus Citri Sarcodactylis 7 parts.
In addition, the preparation method of pharmaceutical composition of the present invention comprises the steps:
(1) take Radix Et Rhizoma Fagopyri Tatarici 50-66 part and Fructus Akebiae 28-35 part, pulverize, be the alcohol reflux of 92%-96% by 6-10 times of volumetric concentration, extracting solution is concentrated into thick paste, dry, pulverize, and obtains alcohol-extracted extract powder;
(2) take Folium Hibisci Mutabilis 29-38 part, macaque Radix pyri 21-30 part, Catharsii molossi 1-3 part, Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 10-16 part, Fructus Trichosanthis 9-15 part and Fructus Citri Sarcodactylis 6-9 part, merge, pulverize, add step (1) gained filtering residue, decoct with water, decocting liquid is concentrated into thick paste, dry, pulverize, obtain the water extracted immersing paste powder;
(3) step (1) gained alcohol-extracted extract powder and step (2) gained the water extracted immersing paste powder are mixed, obtain extract dry powder.
Pharmaceutical composition of the present invention can directly use separately, also different pharmaceutic adjuvants can be used, make many kinds of solids preparation, as capsule (hard capsule, soft capsule), tablet (plain sheet, coated tablet, Film coated tablets), pill (micropill, drop pill), granule and tablet etc.Medicine of the present invention and compositions thereof use with the form of per weight dose, can oral or other form administration, carry out one or many use according to differences such as the type of age of route of administration, patient, body weight, institute's disease therapy and the orders of severity.
Compared with prior art, pharmaceutical composition of the present invention can improve gastrointestinal function, namely promotes gastric emptying, Intestinal pushing, reaches the object for the treatment of functional dyspepsia.In addition, the medicine source of prescription of the present invention is abundant, cheap, and using method is easy, and has no adverse reaction, no dependence, economic security.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
(1) Radix Et Rhizoma Fagopyri Tatarici 5.8kg and Fructus Akebiae 3.1kg is taken, pulverize, with the alcohol reflux 2 times that 70L volumetric concentration is 95%, each 1h, filters, filtering residue is for subsequent use, gained filtrate concentrating under reduced pressure under the pressure of 0.08MPa reclaims ethanol, and continues to be concentrated into thick paste, dry, pulverize 100 mesh sieves, obtain alcohol-extracted extract powder;
(2) take Folium Hibisci Mutabilis 3.3kg, macaque Radix pyri 2.5kg, Catharsii molossi 0.2kg, Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 1.3kg, Fructus Trichosanthis 1.2kg and Fructus Citri Sarcodactylis 0.7kg, merge, pulverize, add step (1) gained filtering residue, decoct with water twice, first time adds water as 12 times amount of medical material gross weight, decoct 2h, second time adds water as 10 times amount of medical material gross weight, decocts 1.5h, collecting decoction, thick paste is evaporated under the pressure of 0.08MPa, dry, pulverize 100 mesh sieves, obtain the water extracted immersing paste powder;
(3) step (1) gained alcohol-extracted extract powder and step (2) gained the water extracted immersing paste powder are mixed, obtain extract dry powder.
It should be noted that, the Chinese crude drug that the embodiment of the present invention adopts has following source: Radix Et Rhizoma Fagopyri Tatarici selects buckwheat plant sky Semen Fagopyri Esculenti Fagopyrumdibotrys(D.Don) the dry root stock of Hara..Folium Hibisci Mutabilis selects the dried leaves of Malvaceae plant Hibisci Mutabilis HibiscusmutabilisL..Fructus Akebiae selects the dry mature fruit of plants of Lardizabalaceae Caulis Akebiae Akebiaquinata (Thunb.) Decne.Macaque Radix pyri selects Actinidiaceae plant Actinidia arguta Sieb.et Zucc Actinidiaarguta(Sieb.etZucc.) dry root of Plarich.exMiq..Catharsii molossi selects the dry Scorpio of coleoptera Scarabaeidae insecticide Catharsii molossi CatharsiusmolossusL..Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) selects the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro BambusatuldoidesMunro, fries to yellow according to pharmacopeia stir-frying with ginger juice method (appendix II D).Fructus Trichosanthis selects the dry mature fruit of cucurbitaceous plant Fructus Trichosanthis TrichosantheskirilowiiMaxim..Fructus Citri Sarcodactylis selects the dry fruit of Rutaceae citrus plant Fructus Citri Sarcodactylis CitrusmedicaL.var.sarcodactylisSwingle.
Embodiment 2: the effect test that Chinese medicine advances mouse small intestine charcoal end
Get the ICR mice 32 that water is can't help in fasting, male and female half and half, weight 18 ~ 22g, is divided into following four groups at random by weight: blank group, positive controls and Chinese medicine are low, high dose group, often organizes 8.After on-test, positive controls gives domperidone 2.0mg/kg, and Chinese medicine is low, high dose group gives Chinese medicine extract 180,360mg/kg prepared by embodiment 1, and blank group gives isometric purified water.After administration after 1h, all animal gavages of each group give the 10% arabic gum suspension containing 5% charcoal end, and dosage is 40ml/kg.Put to death mice after 15min, take gastrointestinal and be laid on glass plate, measure the charcoal end displacement of head end in intestinal tube and the total length (from pylorus to ileocecus) of small intestinal, with formulae discovery charcoal end ink propulsive rate.Charcoal end propelling rate (%)=[prepared Chinese ink is in enteral advance distance (cm)/small intestinal total length (cm)] × 100%.
Can be found out by the test statistics result of table 1, compared with blank group, positive controls and Chinese medicine of the present invention is low, the charcoal of high dose group end propelling rate significantly improves, has Tong meter and learns Yi Yi ﹙
p< 0.05 or
p< 0.01 ﹚.
Table 1 respectively group mouse small intestine charcoal end propelling rate compares
Embodiment 3: the effect test that Chinese medicine is emptying to Mouse Stomach
Get the ICR mice 32 that water is can't help in fasting, male and female half and half, weight 18 ~ 22g, is divided into following four groups at random by weight: blank group, positive controls and Chinese medicine are low, high dose group, often organizes 8.After on-test, positive controls gives domperidone 2.0mg/kg, and Chinese medicine is low, high dose group gives Chinese medicine extract 180,360mg/kg prepared by embodiment 1, and blank group gives isometric purified water, administration every day 1 time.Administration fasting but can't help water 12h after 6 days, and be administered once again, after last administration 1h, gavage 0.1% methyl orange 0.2mL/ is only, and after 20min, cervical dislocation puts to death mice, ligation cardia and pylorus, get stomach in 10mL distilled water, along greater gastric curvature, place cuts off, and is fully washed in distilled water by gastric content, add 0.5% soda solution 5, mixing, the centrifugal 10min of 2000r/min, gets supernatant 721 spectrophotometers and measures optical density in 420nm wavelength place.And add 10mL distilled water using 0.1% methyl orange 0.2mL and shake up its optical density of rear survey as radix methyl orange trap, calculate methyl orange Stomach residue rate.Methyl orange Stomach residue rate (%)=(methyl orange optical density in stomach/radix methyl orange optical density) × 100%.
Can be found out by the test statistics result of table 2, compared with blank group, positive controls and Chinese medicine of the present invention is low, the methyl orange Stomach residue rate of high dose group obviously reduces, has Tong meter and learns Yi Yi ﹙
p< 0.05 or
p< 0.01 ﹚.This further illustrates pharmaceutical composition of the present invention and has the effect promoting gastric emptying.
The table 2 respectively emptying situation of group Mouse Stomach compares
Claims (5)
1. one kind is improved the pharmaceutical composition of gastric motility, it is characterized in that, this pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Et Rhizoma Fagopyri Tatarici 50-66 part, Folium Hibisci Mutabilis 29-38 part, Fructus Akebiae 28-35 part, macaque Radix pyri 21-30 part, Catharsii molossi 1-3 part, Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 10-16 part, Fructus Trichosanthis 9-15 part, Fructus Citri Sarcodactylis 6-9 part.
2. improve the pharmaceutical composition of gastric motility according to claim 1, it is characterized in that, this pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Et Rhizoma Fagopyri Tatarici 56-60 part, Folium Hibisci Mutabilis 32-35 part, Fructus Akebiae 30-32 part, macaque Radix pyri 24-26 part, Catharsii molossi 1-3 part, Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 12-14 part, Fructus Trichosanthis 11-13 part, Fructus Citri Sarcodactylis 7-8 part.
3. improve the pharmaceutical composition of gastric motility according to claim 2, it is characterized in that, this pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Radix Et Rhizoma Fagopyri Tatarici 58 parts, Folium Hibisci Mutabilis 33 parts, Fructus Akebiae 31 parts, macaque Radix pyri 25 parts, Catharsii molossi 2 parts, Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 13 parts, Fructus Trichosanthis 12 parts, Fructus Citri Sarcodactylis 7 parts.
4. claim 1 or the pharmaceutical composition described in 2 or 3 application in the medicine of preparation treatment functional dyspepsia.
5. claim 1 or the pharmaceutical composition described in 2 or 3 improve the application in the medicine of gastric motility in preparation.
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| CN201510516702.XA CN105055956A (en) | 2015-08-21 | 2015-08-21 | Medicine composition for improving gastric mobility and application of medicine composition |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530572A (en) * | 2009-04-07 | 2009-09-16 | 王超美 | Gastro-enteritis decoction |
| CN102987192A (en) * | 2012-08-15 | 2013-03-27 | 明光市昊昊蜂业有限公司 | Thick honey juice capable of promoting gastrointestinal motility and preparation method of thick honey juice |
-
2015
- 2015-08-21 CN CN201510516702.XA patent/CN105055956A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530572A (en) * | 2009-04-07 | 2009-09-16 | 王超美 | Gastro-enteritis decoction |
| CN102987192A (en) * | 2012-08-15 | 2013-03-27 | 明光市昊昊蜂业有限公司 | Thick honey juice capable of promoting gastrointestinal motility and preparation method of thick honey juice |
Non-Patent Citations (4)
| Title |
|---|
| 何萍等: "《一贯煎》", 31 January 2013, 中国医药科技出版社 * |
| 江苏新医学院编: "《中药大辞典（全两册）.下册》", 30 June 1986, 上海科学技术出版社 * |
| 谭同来: "《中医腹诊与用药》", 31 July 2007, 山西科学技术出版社 * |
| 陈伟民等: ""慢性胃炎辨证施治424例临床分析"", 《中国医药学报》 * |
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Application publication date: 20151118 |
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