CN102805766B - Chinese medicinal composition and preparation method thereof - Google Patents
Chinese medicinal composition and preparation method thereof Download PDFInfo
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- CN102805766B CN102805766B CN201210177474.4A CN201210177474A CN102805766B CN 102805766 B CN102805766 B CN 102805766B CN 201210177474 A CN201210177474 A CN 201210177474A CN 102805766 B CN102805766 B CN 102805766B
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Abstract
The invention relates to a Chinese medicinal composition and a preparation method thereof and belongs to the technical field of Chinese medicines. According to a formula, a preparation consists of Chinese thorowax root, honeysuckle flower and other medicinal materials; and the medicinal materials can be prepared into pharmaceutically allowable preparations. The preparation is high in stability and bioavailability, convenient to take, and attractive and clean in appearance, and can be accepted by patients easily; and the required preparation can be effectively prepared by the preparation method, and the production process of the obtained preparation is scientific and reasonable.
Description
Technical field
The present invention is a kind of Chinese medicine composition and preparation method thereof, belongs to the technical field of Chinese medicine.
Technical background
Wind heat described in the traditional Chinese medical science, shows as heating weight, micro evil wind, distending pain in the head, has that antiperspirant, red swelling and pain of throat, cough, expectorant are sticky or yellow, the yellow thick nasal discharge of having a stuffy nose, thirst and liking drink, the tip of the tongue limit are red, the micro-Huang of white and thin fur.Due to evil criminal's table of wind heat, lung qi are become estranged.
Such as common acute pharyngitis due to wind-heat refers to by wind-heat evil toxin, attack, lung stomach has heat and the laryngopharyngeal diseases that causes.The red swelling of the pharynx of take is its cardinal symptom bitterly, similar with the acute pharyngitis of doctor trained in Western medicine.Primary disease be take spring autumn and winter as common, and complication has bulge of the ear, deafness, glue ear, cold, anxious aphonia due to larynx disease, nasal sinusitis, cough with asthma.
In addition, acute tonsillitis caused by pathogenic windheat, anemopyretic cold, wind-warm lung-heat, pestilence visitor defend due to the disease such as heating, red swelling and pain of throat, cough be also frequently-occurring disease.And acute tonsillitis, acute pharyngolaryngitis, upper respiratory tract infection, flu, influenza described in modern medicine, and pneumonia, measles, parotitis from the beginning of, belong to heresy or the evil poison invasion and attack of the pestilence lung person of defending of wind heat.
This type of disease of Chinese traditional treatment, adopts the rule for the treatment of of relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing more.Current commercially available relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and detoxifying herb preparation are a lot of, but normal heat-clearing and toxic substances removing simply in legislation is too cold and cool, have the fraud of cold coagulation ice volt, especially unfavorable to pediatric patient.
The main cause that causes the problems referred to above is exactly that prescription is unreasonable, so in view of such circumstances, it is the thing of being badly in need of solution that a kind of determined curative effect, toxic and side effects tcm product little, taking convenience are provided.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition and method for making thereof; The present invention is directed to prior art, the product determined curative effect, the toxic and side effects that provide are little, taking convenience.
Technical scheme of the present invention is to form like this: described Chinese medicine composition is comprised of following raw materials according: Radix Bupleuri 8-20 part, Flos Lonicerae 5-20 part, Fructus Forsythiae 5-20 part, Bombyx Batryticatus 3-12 part, Periostracum Cicadae 3-12 part, Radix Scutellariae 5-15 part.Furtherly: Radix Bupleuri 10-16 part, Flos Lonicerae 9-15 part, Fructus Forsythiae 9-15 part, Bombyx Batryticatus 6-10.7 part, Periostracum Cicadae 5-9.3 part, Radix Scutellariae 9-13.3 part.Specifically: 12 parts of Radix Bupleuri, 10 parts of Flos Loniceraes, 10 parts of Fructus Forsythiaes, 8 parts of Bombyx Batryticatus, 7 parts of Periostracum Cicadaes, 10 parts of Radix Scutellariaes.
The preparation method of described Chinese medicine composition: the raw material of getting it filled, make respectively multiple peroral dosage form, comprising: tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, drop pill, gel, oral liquid.Be preferably granule, oral liquid.
The preparation method of described Chinese medicine composition: the raw material of getting it filled, decoct with water, collecting decoction, filters, concentrated, dry, granulates, and obtains granule.
The preparation method of described Chinese medicine composition: the raw material of getting it filled, decoct with water, collecting decoction, filters, concentrated, obtains oral liquid.
We are comprised of kinds of traditional Chinese medicines such as Radix Bupleuri, Flos Loniceraes, have antipyretic expelling pathogenic factors from the exterior, the effect of sore-throat relieving eliminating stagnation.
In side, Radix Bupleuri hardship is slightly cold, kind can be antipyretic, Flos Lonicerae is sweet cold, wind-heat dissipating and detoxifying.Radix Scutellariae clearing away lung-heat, Fructus Forsythiae detoxicating and resolving stagnation of pathogens, is all the product of light weight gas perfume (or spice) with Flos Lonicerae, so evacuate expelling pathogenic factors from the exterior, to ward off dirtyization turbid; Bombyx Batryticatus dispelling pathogenic wind and eliminating phlegm eliminating stagnation, the Periostracum Cicadae wind heat extraction sore-throat relieving that falls apart, the two You is Shenged Cheongju sun, the loose stagnant merit of removing toxic substances.
In research process, adopt the modern pharmacology methods such as zoopery to generating heat due to yeast to screen prescription, verify curative effect.
Dry yeast is caused to the impact of rat fever: rat adapts to and raises 3d in laboratory environment, use electric body-temperature instrumentation anus temperature 2 times every day, choose self body temperature and change the animal that is no more than 0.3 ℃, random packet, every group 8, be respectively model control group, aspirin positive controls and administration group (12 parts of Radix Bupleuri, 10 parts of Flos Loniceraes, 10 parts of Fructus Forsythiaes, 8 parts of Bombyx Batryticatus, 7 parts of Periostracum Cicadaes, 10 parts of granule water liquid of making of Radix Scutellariae).Ig administration.Every day 1 time, successive administration 3d; The distilled water of model control group ig equal volume.The same day was measured every rat temperature 2 times (two minor tick 1h) in experiment, averaged as normal body temperature.Rat back subcutaneous injection 20% sterilised yeast suspension 10mL/kg, administration in the 6th hour after injection yeast, measures after administration 1,2,3h body temperature changes.
Result shows: this prescription has and to a certain degree suppresses rat temperature rising effect.
Concrete embodiment
Embodiment 1: Radix Bupleuri 8g, Flos Lonicerae 5g, Fructus Forsythiae 5g, Bombyx Batryticatus 3g, Periostracum Cicadae 3g, Radix Scutellariae 5g
The raw material of getting it filled, decocts with water, and collecting decoction filters, concentrated, dry, granulates, and obtains granule.Every day three times, a 5g.
Embodiment 2: Radix Bupleuri 20g, Flos Lonicerae 20g, Fructus Forsythiae 20g, Bombyx Batryticatus 12g, Periostracum Cicadae 12g, Radix Scutellariae 15g
Above flavour of a drug, decoct with water twice, add for the first time 4 times of water gagings and decoct 1 hour, add for the second time 3 times of water gagings, decoct 1 hour, and collecting decoction, filters, concentrated, dry, granulates, and obtains granule.
Embodiment 3: Radix Bupleuri 10g, Flos Lonicerae 9g, Fructus Forsythiae 9g, Bombyx Batryticatus 6g, Periostracum Cicadae 5g, Radix Scutellariae 9g
Above flavour of a drug, decoct with water twice, add for the first time 5 times of water gagings and decoct 2 hours, add for the second time 4 times of water gagings, decoct 1 hour, and collecting decoction, filters, concentrated, dry, granulates, encapsulated, obtains capsule.
Embodiment 4: Radix Bupleuri 16g, Flos Lonicerae 15g, Fructus Forsythiae 15g, Bombyx Batryticatus 10.7g, Periostracum Cicadae 9.3g, Radix Scutellariae 13.3g
The raw material of getting it filled, decocts with water, and collecting decoction filters, concentrated, obtains oral liquid.
Embodiment 5: Radix Bupleuri 12g, Flos Lonicerae 10g, Fructus Forsythiae 10g, Bombyx Batryticatus 8g, Periostracum Cicadae 7g, Radix Scutellariae 10g
Above flavour of a drug, decoct with water twice, add for the first time 6 times of water gagings and decoct 1 hour, add for the second time 5 times of water gagings, decoct collecting decoction 2 hours, filter, filtrate decompression concentrates to obtain thick paste, vacuum drying, pulverize, sieve, by medication amount: substrate amount=1: 1.2 add soybean oil, mix, pill, obtains soft capsule.
Embodiment 6: Radix Bupleuri 16g, Flos Lonicerae 13.3g, Fructus Forsythiae 13.3g, Bombyx Batryticatus 10.7g, Periostracum Cicadae 9.3g, Radix Scutellariae 13.3g
Above flavour of a drug are ground into fine powder, mix, and obtain powder.
Embodiment 7: Radix Bupleuri 12g, Flos Lonicerae 9g, Fructus Forsythiae 9g, Bombyx Batryticatus 6g, Periostracum Cicadae 5g, Radix Scutellariae 9g
Above flavour of a drug are ground into fine powder, mix, and tabletting, obtains tablet.
Embodiment 8: Radix Bupleuri 16g, Flos Lonicerae 12g, Fructus Forsythiae 12g, Bombyx Batryticatus 8g, Periostracum Cicadae 6.7g, Radix Scutellariae 12g
The raw material of getting it filled, decocts with water, and collecting decoction filters, concentrated, dry, pulverize, and tabletting, obtains tablet.
Embodiment 9: Radix Bupleuri 10g, Flos Lonicerae 15g, Fructus Forsythiae 15g, Bombyx Batryticatus 10g, Periostracum Cicadae 6g, Radix Scutellariae 10g
The raw material of getting it filled, adds ethanol extraction, and merge extractive liquid, filters, concentrated, dry, granulates, and obtains granule.
Embodiment 10: Radix Bupleuri 10g, Flos Lonicerae 10g, Fructus Forsythiae 10g, Bombyx Batryticatus 10g, Periostracum Cicadae 6g, Radix Scutellariae 10g
The raw material of getting it filled, adds ethanol extraction, and merge extractive liquid, filters, concentrated, dry, granulates, and tabletting, obtains tablet.
Claims (7)
1. a Chinese medicine composition, is characterized in that it is comprised of following raw materials according: Radix Bupleuri 10-16 part, Flos Lonicerae 9-15 part, Fructus Forsythiae 9-15 part, Bombyx Batryticatus 6-10.7 part, Periostracum Cicadae 5-9.3 part, Radix Scutellariae 9-13.3 part.
2. according to Chinese medicine composition claimed in claim 1, it is characterized in that: it is comprised of following raw materials according: 12 parts of Radix Bupleuri, 10 parts of Flos Loniceraes, 10 parts of Fructus Forsythiaes, 8 parts of Bombyx Batryticatus, 7 parts of Periostracum Cicadaes, 10 parts of Radix Scutellariaes.
3. according to the preparation method of the Chinese medicine composition described in claim 1 or 2, it is characterized in that: the raw material of getting it filled, make respectively multiple peroral dosage form, comprising: tablet, capsule, granule, pill, powder, drop pill, gel, oral liquid.
4. according to the preparation method of Chinese medicine composition claimed in claim 3, it is characterized in that: the get it filled agent of raw material granulation, oral liquid.
5. according to the preparation method of Chinese medicine composition claimed in claim 3, it is characterized in that: described tablet comprises dispersible tablet, described capsule comprises soft capsule.
6. according to the preparation method of Chinese medicine composition claimed in claim 3, it is characterized in that: the raw material of getting it filled, decoct with water, collecting decoction, filters, concentrated, dry, granulates, and obtains granule.
7. according to the preparation method of Chinese medicine composition claimed in claim 3, it is characterized in that: the raw material of getting it filled, decoct with water, collecting decoction, filters, concentrated, obtains oral liquid.
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| CN201210177474.4A CN102805766B (en) | 2011-06-01 | 2012-06-01 | Chinese medicinal composition and preparation method thereof |
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| CN201110145684.0 | 2011-06-01 | ||
| CN201110145684 | 2011-06-01 | ||
| CN201210177474.4A CN102805766B (en) | 2011-06-01 | 2012-06-01 | Chinese medicinal composition and preparation method thereof |
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| CN102805766B true CN102805766B (en) | 2014-11-05 |
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| CN101406526A (en) * | 2007-10-10 | 2009-04-15 | 中国中医科学院中药研究所 | Compound scutellaria microemulsion formulation and preparation method thereof |
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Effective date of registration: 20200608 Address after: Room 315, No.8, Hangfeng Road, Fengtai Science City, Fengtai District, Beijing 100070 (Park) Patentee after: BEIJING JIAHE LEKANG TECHNOLOGY Co.,Ltd. Address before: 100070, room 8, No. 317, Feng Feng Road, Fengtai District science and Technology Park, Beijing Patentee before: BEIJING LIUSHENGHE MEDICAL TECHNOLOGY Co.,Ltd. |