CN105055930A - Traditional Chinese medicine for treating infertility caused by liver stagnation and preparation method of traditional Chinese medicine - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating infertility caused by liver stagnation and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine consists of the following medicinal raw materials: deerskin, herb of manyflower tickclover, homlockleaved moonwort, digua fig stem and leaf, semen canavaliae, asiatic bilberry, herb of creeping sage, polygala arillata buch.ham., root of common apluda, fructus aristolochiae, root or stem of parthenocissus tricuspidata, root of arrowleaf abelmoschus, fruit or seed of Szechwan Cherry, russula alutacea, linseed, root or leaf of ardisia quinquegona blume, root or full grass of valerian tangutica batal. and Japanese premna root. The traditional Chinese medicine disclosed by the invention has the advantages of being concrete in curative effect, free from toxic and side effects and rapid to take effect on treating infertility caused by liver stagnation.

Description

A kind ofly treat infertile Chinese medicine of liver energy stagnation type and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to and a kind ofly treating infertile Chinese medicine of liver energy stagnation type and preparation method thereof.

Background technology

Infertility refers to woman's matrimonial cohabitation more than 1 year after marriage, and syngamy function is normal, does not practise contraception and the person of not becoming pregnant, or once bred, do not practise contraception and more than the 1 year person that do not become pregnant again, be called " infertility ", the former is called " primary infertility ", and the latter is called " secondary infertility ".Gu claims the former to be " entirely not producing ", and the latter is " breaks ".Etiology and pathogenesis: men and women contain in kidney qi, the menarche, under the condition of abundant CHONG meridian with unobstructed REN meridian, woman's regular menstrual cycle, man's spermatic ejeculation, both sexes are harmonious, and it is pregnant just can to reach agreement into tire, and visible infertile main and deficiency of kidney-QI, punching appoints disorder of QI and blood relevant.Clinically commonly to suffer from a deficiency of the kidney, the type such as stagnation of liver-QI, phlegm-damp, blood stasis.

Infertile differentiation of symptoms and signs for classification of syndrome is following type by the traditional Chinese medical science:

Renal deficiency type: card is shown in delayed period or amenorrhea, rare through the few light matter of color of row amount, accompany dizzy tinnitus, soreness of the waist and knees, hyposexuality, pale tongue with thin fur, deep-thready pulse.

Liver energy stagnation type: card is shown in delayed menstrual cycle or successively irregular, or amenorrhea, does swollen through fore udder, or lower abdominal distention pain, blockage of menstruation, or holds clot under the arm, accompanies sigh uncomfortable in chest, susceptible to lose temper due to restlessness, red tongue with thin fur, thready and stringy pulse.

Blood stasis type: card is shown in delayed menstrual cycle, or amenorrhea, through the few abdomen pain of row, dark menses folder clot, few time many during amount, blockage of menstruation, or dripping unclean, tongue limit purple is dim, thready and hesitant pulse.Phlegm stagnation syndrome type: card is shown in delayed menstrual cycle, or amenorrhea, few through row amount, the light matter of color is rare, accompanies painful abdominal mass uncomfortable in chest to hinder, abundant expectoration nausea, dizzy drowsiness, obesity, or breast galactorrhea, and tongue is greasy in vain, and tongue body is fat, and moderate pulse is sliding.Treatment adopts dissipating phlegm and resolving masses method.

Damp-heat type: card is shown in that menstruation is successively irregularly, and many through the dim red amount of color, matter is stained with dirty taste, or leukorrhagia is red mixes mutually in vain, or muddiness is as water from washing rice, red tongue with yellowish and greasy fur, soft and rapid pulse.

Summary of the invention:

Technical problem to be solved by this invention is, utilize the theory of Chinese medical science that China is traditional, provide a kind of and treat infertile Chinese medicine of liver energy stagnation type and preparation method thereof, Chinese medicine of the present invention is infertile to treatment liver energy stagnation type, with strong points, there is determined curative effect and the little advantage of toxic and side effects.

In order to solve the problems of the technologies described above, the invention provides and a kind ofly treat the infertile Chinese medicine of liver energy stagnation type, its raw medicinal material comprises: Corium Cervi, Herba desmodii multifloi, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Caulis et Folium fici Tikouae, Semen Canavaliae, Fructus Vaccinii Bracteati, province of the Yuan Dynasty grass, Radix polygalae arillatae, Radix Apludate Muticae, Fructus Aristolochiae, parthenocissus, Radix Abelmoschi Sagittifolii, Fructus seu semen pruni szechuanicae, DAHONGGU, Semen Lini, Ardisia quinquegona, Rhizoma seu Herba Valerianae Tanguticae and Radix premnae microphyllae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Corium Cervi 10 ~ 20 parts, Herba desmodii multifloi 20 ~ 30 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 5 ~ 15 parts, Caulis et Folium fici Tikouae 13 ~ 23 parts, Semen Canavaliae 15 ~ 25 parts, Fructus Vaccinii Bracteati 20 ~ 30 parts, province of the Yuan Dynasty grass 10 ~ 20 parts, Radix polygalae arillatae 20 ~ 30 parts, Radix Apludate Muticae 7 ~ 17 parts, Fructus Aristolochiae 30 ~ 40 parts, parthenocissus 12 ~ 22 parts, Radix Abelmoschi Sagittifolii 25 ~ 35 parts, Fructus seu semen pruni szechuanicae 24 ~ 34 parts, DAHONGGU 21 ~ 31 parts, Semen Lini 18 ~ 28 parts, Ardisia quinquegona 16 ~ 26 parts, Rhizoma seu Herba Valerianae Tanguticae 25 ~ 35 parts and Radix premnae microphyllae 10 ~ 20 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Corium Cervi 13 ~ 18 parts, Herba desmodii multifloi 25 ~ 30 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 8 ~ 13 parts, Caulis et Folium fici Tikouae 16 ~ 21 parts, Semen Canavaliae 17 ~ 22 parts, Fructus Vaccinii Bracteati 20 ~ 25 parts, province of the Yuan Dynasty grass 15 ~ 20 parts, Radix polygalae arillatae 23 ~ 28 parts, Radix Apludate Muticae 11 ~ 16 parts, Fructus Aristolochiae 30 ~ 35 parts, parthenocissus 14 ~ 19 parts, Radix Abelmoschi Sagittifolii 28 ~ 33 parts, Fructus seu semen pruni szechuanicae 26 ~ 31 parts, DAHONGGU 24 ~ 29 parts, Semen Lini 21 ~ 26 parts, Ardisia quinquegona 19 ~ 24 parts, Rhizoma seu Herba Valerianae Tanguticae 27 ~ 32 parts and Radix premnae microphyllae 15 ~ 20 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Corium Cervi 17 parts, Herba desmodii multifloi 26 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 12 parts, Caulis et Folium fici Tikouae 17 parts, Semen Canavaliae 21 parts, Fructus Vaccinii Bracteati 22 parts, province of the Yuan Dynasty grass 18 parts, Radix polygalae arillatae 25 parts, Radix Apludate Muticae 15 parts, Fructus Aristolochiae 33 parts, parthenocissus 18 parts, Radix Abelmoschi Sagittifolii 30 parts, Fructus seu semen pruni szechuanicae 30 parts, DAHONGGU 25 parts, Semen Lini 25 parts, Ardisia quinquegona 20 parts, Rhizoma seu Herba Valerianae Tanguticae 31 parts and Radix premnae microphyllae 16 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Corium Cervi 15 parts, Herba desmodii multifloi 28 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 9 parts, Caulis et Folium fici Tikouae 20 parts, Semen Canavaliae 18 parts, Fructus Vaccinii Bracteati 24 parts, province of the Yuan Dynasty grass 16 parts, Radix polygalae arillatae 27 parts, Radix Apludate Muticae 12 parts, Fructus Aristolochiae 34 parts, parthenocissus 15 parts, Radix Abelmoschi Sagittifolii 33 parts, Fructus seu semen pruni szechuanicae 27 parts, DAHONGGU 28 parts, Semen Lini 22 parts, Ardisia quinquegona 23 parts, Rhizoma seu Herba Valerianae Tanguticae 28 parts and Radix premnae microphyllae 18 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

Beneficial effect of the present invention: Chinese medicine of the present invention, infertile, with strong points to treatment liver energy stagnation type, there is determined curative effect, have no side effect and the advantage of instant effect.

Detailed description of the invention

The invention provides and a kind ofly treat the infertile Chinese medicine of liver energy stagnation type, its raw medicinal material comprises: Corium Cervi, Herba desmodii multifloi, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Caulis et Folium fici Tikouae, Semen Canavaliae, Fructus Vaccinii Bracteati, province of the Yuan Dynasty grass, Radix polygalae arillatae, Radix Apludate Muticae, Fructus Aristolochiae, parthenocissus, Radix Abelmoschi Sagittifolii, Fructus seu semen pruni szechuanicae, DAHONGGU, Semen Lini, Ardisia quinquegona, Rhizoma seu Herba Valerianae Tanguticae and Radix premnae microphyllae.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Corium Cervi: [source] medical material Ji Yuan: be the skin of animal in deer family Cervus nippon Temminck or Cervus elaphus linnaeus.[nature and flavor] salty in the mouth; Warm in nature.[return through] liver; Kidney channel.[function cures mainly] QI invigorating; Arresting seminal emission; Sore.Housewife female leucorrhea; Metrorrhagia; Spermatorrhea of suffering from a deficiency of the kidney and all skin ulcers are leaked.[extracts] " China's book on Chinese herbal medicine "

Herba desmodii multifloi: [another name] thin wind band, angle, mountain bean, red palm grass, Radix Sophorae Tonkinensis, rotten Caragana arborescens, Radix Campylotropis Hirtella (Herba Myrsines Africanae), mountain Hirudo, sticky body grass, stomachache be careless, hang horse flower, Caulis wisteriae sinensis Desmodium caudatum (Thunb.) DC., wild Semen Glycines.[source] medical material Ji Yuan: be the Herb of leguminous plant Herba desmodii multifloi.[nature and flavor] are sweet; Bitter; Cool; Bitter.[return through] lung; Stomach; Liver; Gallbladder meridian.[function cures mainly] promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling.Main epigastric pain, infantile malnutrition, women's emaciation due to blood disorder, lumbar sprain, wound, urethritis, parotitis, venom.[extracts] " China's book on Chinese herbal medicine "

Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw.: [another name] YIDUOYUN, Jue Qi.[source] medical material Ji Yuan: be root or the herb of Botrychiaceae plant Herba pteridii latiusculi beanstalk.[nature and flavor] are bitter; Puckery; Cool; Sweet; Be slightly cold.[return through] lung; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Suppressing the hyperactive liver eliminating stagnation; Expelling wind for relieving convulsion.Main lung abscess; Venom; Conjunctival congestion; Scrofula; Cough; Serpentis poison; Acute infantile convulsion wind; Rheumatic arthralgia; Traumatic injury.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Caulis et Folium fici Tikouae: [another name] Caulis Entadae, Ipomoea hungaiensis Lingelsh. Et Borza., DIWUGONG, Cortex Ampelopsis Aconitifoliae Radicis, Radix Seu Caulis Mucunae Sempervirentis, cross SHILONG, Rhizoma et radix panici repentis, Radix Pachyrhizi Erosi stem, cattle holder nose, Radix Clematidis Clarkeanae, Nostoc commune, wild country melon vine, white slope tiger, climb ground milk, bore Pheretima, Herba hyperici elodeoidis, Caulis et Folium fici Tikouae, Folium Eriobotryae, within 10000 years, take off.[source] medical material Ji Yuan: be stem, the leaf of moraceae plants Radix Pachyrhizi Erosi banyan.Latin plant animal mineral name: FicustikouaBur.[nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove obstruction in the collateral; Removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat; Dysentery; Edema; Yellow cellulitis; Infantile dyspepsia; Rheumatalgia; Amenorrhea; Leukorrhagia; Traumatic injury; Bleeding hemorrhoids; Innominate toxic swelling.[extracts] " China's book on Chinese herbal medicine "

Semen Canavaliae: [another name] holds sword bean, Sword Jackbean Seed, great Ge Dou, large Semen Canavaliae, sheath bean, cutter phoenix bean, knife plate core bean, cutter Fructus Crotonis, Concha Solen gouldii bean, cutter training bean, card Xiao under the arm.[source] medical material Ji Yuan: be the seed of leguminous plant Semen Canavaliae and maljoe.[nature and flavor] are sweet; Temperature; Nontoxic.[return through] spleen; Stomach; Large intestine; Kidney channel.[function cures mainly] warming the middle warmer and descending qi, kidney tonifying complement.Main deficiency and coldness singultus, lumbago due to renal deficiency.[extracts] " China's book on Chinese herbal medicine "

Fructus Vaccinii Bracteati: [another name] black meal fruit, Fructus Vaccinii Fragilis.[source] medical material Ji Yuan: be the fruit of Ericaceae village thing Fructus Vaccinii Bracteati.[nature and flavor] acid; Sweet; Property is put down.[return through] liver; Kidney; Liver Channel.[function cures mainly] invigorating the liver and kidney; Bone and muscle strengthening; Controlling nocturnal emission with astringent drugs gas; Antidiarrheal dysentery.Main deficiency of the liver and kindey; Early whitening of beard and hair; Muscles and bones is unable; Chronic diarrhea nocturnal emission; Leukorrhagia is more than; The outer dysentery of chronic diarrhea.[extracts] " China's book on Chinese herbal medicine "

Province of the Yuan Dynasty grass: [another name] Herba Salviae Substoloniferae, eruptive disease with purpish rashes grass, salt cough medicine, little annealing grass.[source] medical material Ji Yuan: be the herb of labiate flammule grass.[nature and flavor] mildly bitter flavor; Property is put down.[return through] liver; Kidney channel.[function cures mainly] removing heat-phlegm; Kidney tonifying; Regulating menstruation; Hemostasis.Main cough due to lung-heat; Abundant expectoration is panted; Spit blood; To suffer from a deficiency of the kidney the soreness of waist; Frequent micturition; Leukorrhagia; Menorrhagia.[extracts] " China's book on Chinese herbal medicine "

Radix polygalae arillatae: [another name] gold ovum, DIAOHUANG, Hemerocallis citrina Baroni Os Gallus domesticus, the holder of Flos Osmanthi Fragrantis rock, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), little pocket, glutinously in vain to disappear, kwan-yin falls seat, Herba Fici Simplicissimae, Radix polygalae arillatae Radix Polygalae, tree ginseng, Bao Sulian, Flos Caraganae Franchetianae, flower Rhizoma Rodgersiae, cockerel tree, Buxus sinica (Rehd.et Wils.) ginseng, chicken flower, little chicken foot is spent, old hen is chewed, chicken belly root, peppery tree, ginseng of rearing people.[source] medical material Ji Yuan: be the root of milk wort pocket Radix Polygalae Wattersii.[nature and flavor] are sweet; Micro-hardship; Flat.[function cures mainly] eliminates the phlegm dehumidifying; Tonify deficiency spleen invigorating; Mind calming is invigorated blood circulation.Main cough with copious phlegm; Rheumatic arthralgia; Urine leaching pain; Edema; Foot gas; Hepatitis; Pulmonary tuberculosis; Puerperal asthenia; Inappetence; Infantile malnutrition; Insomnia and dreamful sleep; Menoxenia; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix Apludate Muticae: [another name] silk thread grass, Herba Gonostegiae hirtae, Sorghum vulgare Pers. grass, careless, the false Herba bromi japonici of bamboo, collapse skin ulcer grass, vanillon, cusp grass.[source] medical material Ji Yuan: be root or the stem and leaf of grass Radix Apludate Muticae.[function cures mainly] putrefaction removing detoxifies; Tonifying YANG.Main lower limb fester; Snake bite and insect sting; Sexual impotence.[extracts] " China's book on Chinese herbal medicine "

Fructus Aristolochiae: [another name] Semen Oroxyli, horse pocket zero, Fructus Aristolochiae, water horse Oleum Linderae, calabash tank, smelly bell shelves, Fructus Aristolochiae fruit.[source] medical material Ji Yuan: be the fruit of aristolochiaceae plant Aristolochia contorta and Fructus Aristolochiae.[nature and flavor] are bitter; Pungent; Cold.[return through] lung meridian.[function cures mainly] lung heat clearing sending down the abnormal ascending QI; Relieving cough and asthma; Let out large intestine clearly.Main cough due to lung-heat; Expectorant stops up tachypnea; Chronic cough of deficiency lung; The hot hemorrhoidal bleeding of intestinal; Swelling and pain of hemorrhoid; Edema.[extracts] " China's book on Chinese herbal medicine "

Parthenocissus: [another name] Cortex vitis balanseanae radicis rattan, walk to swim rattan, Caulis et Folium Pothi Repentis, maple rattan, Parthenocissus tricuspidata, Radix seu Caulis Parthenocissi tricuspidatae.[source] Vitaceae Parthenocissus plant parthenocissus, is used as medicine with root and stem.Dish stem before fallen leaves, cutting is dried for subsequent use, and root can be adopted the whole year.[nature and flavor] are sweet, puckery, temperature.[function cures mainly] dispelling wind and removing obstruction in the collateral, promoting blood circulation and detoxication.For rheumatic arthritis; Traumatic injury is controlled in external, carbuncle furuncle and phyma poison.[extracts] " national Chinese herbal medicine compilation "

Radix Abelmoschi Sagittifolii: [another name] Flos Carthami horse is peaceful.[source] medical material Ji Yuan: be the root of Malvaceae plant arrowleaf abelmoschus.[nature and flavor] are sweet; Light; Flat.[return through] kidney; Stomach warp.[function cures mainly] nourishing YIN and moistening the lung; Stomach function regulating.Main xeropulmonary cough; Pulmonary tuberculosis; Stomachache; Infantile malnutrition; Neurasthenia.[extracts] " China's book on Chinese herbal medicine "

Fructus seu semen pruni szechuanicae: [another name] twines strip.[source] medical material Ji Yuan: be fruit or the peel of rosaceous plant Sichuan Fructus Pruni pseudocerasi, serration Fructus Pruni pseudocerasi.[nature and flavor] are sweet; Micro-cool.[return through] lung; Kidney channel.[function cures mainly] removing heat from the lung and relieving sorethroat, cough-relieving.Main laryngopharynx swelling and pain, hoarseness, cough.[extracts] " China's book on Chinese herbal medicine "

DAHONGGU: [another name] Russula, Zhu mushroom.[source] medical material Ji Yuan: be the sporophore of Russulaceae fungus DAHONGGU.Latin plant animal mineral name: Russularubra (Krom.) Bres.[nature and flavor] are sweet; Slightly warm in nature.[function cures mainly] nourishes blood; Removing blood stasis; Dispel the wind.Main blood deficiency and yellow complexion; Prolonged lochia; Joint aches.[extracts] " China's book on Chinese herbal medicine "

Semen Lini: [another name] Semen Lini, tick linum, core of Caulis et Folium Lini, large linum, Semen Lini.[source] medical material Ji Yuan: be the seed of flax family (Linaceae) plant Caulis et Folium Lini LinumusitatissimumL..[nature and flavor] sweet in the mouth; Property is put down.[return through] liver; Stomach; Large intestine channel.[function cures mainly] nourishing blood to expel wind; Moistening dryness for relaxing bowels.Djumah wind; Xerosis cutis; Pruritus; Alopecia; Skin infection eczema; Dryness of the intestine constipation.[extracts] " China's book on Chinese herbal medicine "

Ardisia quinquegona: [another name] ferrum Brassaiopsis glomerulata (Bl.) Regel, chopsticks root, high foot sunshade, fiery dung charcoal tree, fire bubble tree, clavus tree, Linesless charcoal tree tree.[source] medical material Ji Yuan: be stem and leaf or the root of Myrsinacea plant Ardisia quinquegona.Latin plant animal mineral name: ArdisiaquinquegonaBl.[nature and flavor] are bitter; Pungent; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Eliminating stasis to stop pain.Main laryngopharynx swelling and pain; Furuncle carbuncle; Traumatic injury; Rheumatic arthralgia.[extracts] " China's book on Chinese herbal medicine "

Rhizoma seu Herba Valerianae Tanguticae: [another name] Rhizoma et radix valerianae is young, Common Rue Herb.[source] medical material Ji Yuan: be root or the herb of the little Rhizoma et radix valerianae of Valerianaceae plant.Latin plant animal mineral name: ValerianatanguticaBatal.[nature and flavor] sweet in the mouth; Micro-pungent; Property is put down.[function cures mainly] cough-relieving; Hemostasis; Dissipating blood stasis; Pain relieving.Main cough; Hemoptysis; Spit blood; Epistaxis; Metrostaxis; Rheumatic arthralgia; Fracture.[extracts] " China's book on Chinese herbal medicine "

Radix premnae microphyllae: [another name] little QINGGEN, Herba Fici Simplicissimae.[source] medical material Ji Yuan: be the root of Verbenaceae Herba Premnae Microphyllae.Latin plant animal mineral name: PremnamicrophyllaTurcz.[nature and flavor] bitter in the mouth; Cold in nature.[return through] spleen channel.[function cures mainly] heat-clearing and toxic substances removing.Main malaria; Infantile Summer Fever; Rheumatic arthralgia; Acute toothache; Traumatic injury; Burn due to hot liquid or fire.[extracts] " China's book on Chinese herbal medicine "

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Corium Cervi 10 ~ 20 parts, Herba desmodii multifloi 20 ~ 30 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 5 ~ 15 parts, Caulis et Folium fici Tikouae 13 ~ 23 parts, Semen Canavaliae 15 ~ 25 parts, Fructus Vaccinii Bracteati 20 ~ 30 parts, province of the Yuan Dynasty grass 10 ~ 20 parts, Radix polygalae arillatae 20 ~ 30 parts, Radix Apludate Muticae 7 ~ 17 parts, Fructus Aristolochiae 30 ~ 40 parts, parthenocissus 12 ~ 22 parts, Radix Abelmoschi Sagittifolii 25 ~ 35 parts, Fructus seu semen pruni szechuanicae 24 ~ 34 parts, DAHONGGU 21 ~ 31 parts, Semen Lini 18 ~ 28 parts, Ardisia quinquegona 16 ~ 26 parts, Rhizoma seu Herba Valerianae Tanguticae 25 ~ 35 parts and Radix premnae microphyllae 10 ~ 20 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Corium Cervi 13 ~ 18 parts, Herba desmodii multifloi 25 ~ 30 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 8 ~ 13 parts, Caulis et Folium fici Tikouae 16 ~ 21 parts, Semen Canavaliae 17 ~ 22 parts, Fructus Vaccinii Bracteati 20 ~ 25 parts, province of the Yuan Dynasty grass 15 ~ 20 parts, Radix polygalae arillatae 23 ~ 28 parts, Radix Apludate Muticae 11 ~ 16 parts, Fructus Aristolochiae 30 ~ 35 parts, parthenocissus 14 ~ 19 parts, Radix Abelmoschi Sagittifolii 28 ~ 33 parts, Fructus seu semen pruni szechuanicae 26 ~ 31 parts, DAHONGGU 24 ~ 29 parts, Semen Lini 21 ~ 26 parts, Ardisia quinquegona 19 ~ 24 parts, Rhizoma seu Herba Valerianae Tanguticae 27 ~ 32 parts and Radix premnae microphyllae 15 ~ 20 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Corium Cervi 17 parts, Herba desmodii multifloi 26 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 12 parts, Caulis et Folium fici Tikouae 17 parts, Semen Canavaliae 21 parts, Fructus Vaccinii Bracteati 22 parts, province of the Yuan Dynasty grass 18 parts, Radix polygalae arillatae 25 parts, Radix Apludate Muticae 15 parts, Fructus Aristolochiae 33 parts, parthenocissus 18 parts, Radix Abelmoschi Sagittifolii 30 parts, Fructus seu semen pruni szechuanicae 30 parts, DAHONGGU 25 parts, Semen Lini 25 parts, Ardisia quinquegona 20 parts, Rhizoma seu Herba Valerianae Tanguticae 31 parts and Radix premnae microphyllae 16 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Corium Cervi 15 parts, Herba desmodii multifloi 28 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 9 parts, Caulis et Folium fici Tikouae 20 parts, Semen Canavaliae 18 parts, Fructus Vaccinii Bracteati 24 parts, province of the Yuan Dynasty grass 16 parts, Radix polygalae arillatae 27 parts, Radix Apludate Muticae 12 parts, Fructus Aristolochiae 34 parts, parthenocissus 15 parts, Radix Abelmoschi Sagittifolii 33 parts, Fructus seu semen pruni szechuanicae 27 parts, DAHONGGU 28 parts, Semen Lini 22 parts, Ardisia quinquegona 23 parts, Rhizoma seu Herba Valerianae Tanguticae 28 parts and Radix premnae microphyllae 18 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: injectable powder

Get Corium Cervi 150g, Herba desmodii multifloi 280g, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 90g, Caulis et Folium fici Tikouae 200g, Semen Canavaliae 180g, Fructus Vaccinii Bracteati 240g, the province of the Yuan Dynasty grass 160g, Radix polygalae arillatae 270g, Radix Apludate Muticae 120g, Fructus Aristolochiae 340g, parthenocissus 150g, Radix Abelmoschi Sagittifolii 330g, Fructus seu semen pruni szechuanicae 270g, DAHONGGU 280g, Semen Lini 220g, Ardisia quinquegona 230g, Rhizoma seu Herba Valerianae Tanguticae 280g and Radix premnae microphyllae 180g;

Prepare according to the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 5 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 hours under the condition of 8 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 2 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g needle-use activated carbon, fully stirs 30 minutes; Decarbonization filtering; With 0.22 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 2: granule

Get Corium Cervi 170g, Herba desmodii multifloi 260g, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 120g, Caulis et Folium fici Tikouae 170g, Semen Canavaliae 210g, Fructus Vaccinii Bracteati 220g, the province of the Yuan Dynasty grass 180g, Radix polygalae arillatae 250g, Radix Apludate Muticae 150g, Fructus Aristolochiae 330g, parthenocissus 180g, Radix Abelmoschi Sagittifolii 300g, Fructus seu semen pruni szechuanicae 300g, DAHONGGU 250g, Semen Lini 250g, Ardisia quinquegona 200g, Rhizoma seu Herba Valerianae Tanguticae 310g and Radix premnae microphyllae 160g;

Prepare according to the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.05, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.1 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 18 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 2, (concentration is 7.26g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.3 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>36.3 crude drug/kg of the present invention, every day, maximum dosage-feeding was 72.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 6.2g crude drug/day/people, adult body weight in 60KG, average dosage is 0.103g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 705 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 2 granule of the present invention presses 13.25,19.36 and 32.65g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 100 routine cases are in February, 2013 to 2014 year December and carry out the medical Sterility patient of my institute's department of obstetrics and gynecology.100 people are divided into matched group and treatment group at random, matched group 50 people, wherein the oldest person 41 years old, reckling 26 years old; Fertility person 23 example, infertility 27 example; Course of disease > 2 years and < 3 years persons 20 example, >=3 years and < 4 years person 24 examples, more than 4 years and 4 years person 6 examples.Treatment group 50 people, the oldest person 40 years old, reckling 25 years old; Fertility person 24 example, infertility person 26 example; Course of disease > 2 years and < 3 years persons 22 example, >=3 years and < 4 years person 23 examples, 4 years and above person 5 example.Two groups of patient data's no significant difference (P > 0.05), have comparability.

Standards of Chinese Medical Syndrome Differentiation: with reference to " Chinese medical disease Standardization of diagnosis and curative effect " relevant criterion: the women of child-bearing age marry more than 1 year, matrimonial cohabitation, syngamy function is normal, and not practising contraception and fail the person of becoming pregnant, is fertility.Once there is motherhood history, and continued and more than 1 year, interval, do not practise contraception and not conceived person, be called infertility.

Liver energy stagnation type: card is shown in delayed menstrual cycle or successively irregular, or amenorrhea, does swollen through fore udder, or lower abdominal distention pain, blockage of menstruation, or holds clot under the arm, accompanies sigh uncomfortable in chest, susceptible to lose temper due to restlessness, red tongue with thin fur, thready and stringy pulse.

Exclusion standard: (1) does not meet diagnostic criteria person; (2) other reasons such as women's systemic disease and reproductive malformation, tuberculosis, inflammation, tumor causes infertile person; (3) below 20 years old or more than 50 years old person; (4) general disease and the male that get rid of impact fertility are abnormal; (5) not by regulation medication, curative effect cannot be judged, or the not congruent judgement person that affects the treatment of data.

Therapeutic Method:

Treatment group: give the embodiment of the present invention 2 granule, each 10g, every day 3 times.1 menstrual cycle was 1 course for the treatment of, took 6 courses for the treatment of continuously, and premenstrual 1 week starts to take, and clothes were to premenstrual 1 week of next time altogether, not drug withdrawal in menstrual period, and in drug administration process, pregnant person stops using.

Matched group: oral clomiphene citrate capsules (clomiphene), menstrual cycle starts to take medicine on the 5th day, and 50mg/d, is used in conjunction 5 days; If anovulation, each cycle progressively increases 50mg/d, maximal dose 150mg/d, is used in conjunction 5 days.A menstrual cycle is a course for the treatment of, takes 6 courses for the treatment of altogether.If find conceived, then withdrawal.

Curative effect judging standard: curative effect determinate standard is with reference to evaluation infertile in " Chinese medical disease Standardization of diagnosis and curative effect ".Cure: treatment cycle is become pregnant, clinical disease disappears.Take a turn for the better: treatment cycle unpregnancy, in treatment cycle, at least 2 menstrual cycle have ovulation sign, and clinical disease is clearly better (comprising symptom, sign and lab testing etc.).Invalid: treatment cycle unpregnancy, in treatment cycle, there is ovulation sign in the menolipsis cycle, and clinical disease does not disappear or increases the weight of.

Therapeutic outcome: two groups treat 6 months respectively after, statistical result is see table 1 and table 2.As can be seen from Table 1, adopt treatment by Chinese herbs liver energy stagnation type of the present invention infertile, relative to matched group, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs liver energy stagnation type of the present invention infertile, relative to matched group, the course for the treatment of significantly shortens.

A table 1 liang group treats two groups of comparitive study (example) after 6 months respectively:

Group	n	Cure	Take a turn for the better	Invalid	Effectively total
						Treatment group	50	38	9	3	47(94％)
Matched group	50	27	12	11	39(78％)

Table 2 liang group is treated respectively after 6 months and is cured number and cure rate comparative example (%) stage by stage:

Group	n	Treat 2 months	Treat 4 months	Treat 6 months
					Treatment group	38	8(16％)	26(52％)	38(76％)
Matched group	27	3(6％)	18(36％)	27(54％)

According to the clinical statistics in above table, Chinese medicine provided by the invention has rapid-action, cure rate and effective percentage is high, the advantage of safe without toxic side effect.

Untoward reaction: the routine patient for the treatment of group 50 all has no adverse reaction after taking the embodiment of the present invention 2 granule.The routine patient of matched group 50, there is stomachache or lower abdominal pain in 7 examples, 3 examples occur that nausea and vomiting reacts, and 1 example occurs that the eye reacts to light, and psychentonia appears in 1 example.

Concrete case: remaining certain, women, 31 years old, 2 years after marriage half unpregnancies and seeing a doctor, checked that card is shown in menstruation successively irregularly, do swollen, blockage of menstruation, or hold clot under the arm, sigh uncomfortable in chest, susceptible to lose temper due to restlessness, red tongue with thin fur, thready and stringy pulse, be diagnosed as liver energy stagnation type infertility through fore udder.Give granule of the present invention oral, each 10g, every day 3 times, premenstrual 1 week starts to take, clothes extremely next premenstrual 1 week, not drug withdrawal in menstrual period.Treat after 3 months, patient is conceived.

Claims (9)

1. treat the Chinese medicine that liver energy stagnation type is infertile, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Corium Cervi, Herba desmodii multifloi, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., Caulis et Folium fici Tikouae, Semen Canavaliae, Fructus Vaccinii Bracteati, province of the Yuan Dynasty grass, Radix polygalae arillatae, Radix Apludate Muticae, Fructus Aristolochiae, parthenocissus, Radix Abelmoschi Sagittifolii, Fructus seu semen pruni szechuanicae, DAHONGGU, Semen Lini, Ardisia quinquegona, Rhizoma seu Herba Valerianae Tanguticae and Radix premnae microphyllae.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Corium Cervi 10 ~ 20 parts, Herba desmodii multifloi 20 ~ 30 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 5 ~ 15 parts, Caulis et Folium fici Tikouae 13 ~ 23 parts, Semen Canavaliae 15 ~ 25 parts, Fructus Vaccinii Bracteati 20 ~ 30 parts, province of the Yuan Dynasty grass 10 ~ 20 parts, Radix polygalae arillatae 20 ~ 30 parts, Radix Apludate Muticae 7 ~ 17 parts, Fructus Aristolochiae 30 ~ 40 parts, parthenocissus 12 ~ 22 parts, Radix Abelmoschi Sagittifolii 25 ~ 35 parts, Fructus seu semen pruni szechuanicae 24 ~ 34 parts, DAHONGGU 21 ~ 31 parts, Semen Lini 18 ~ 28 parts, Ardisia quinquegona 16 ~ 26 parts, Rhizoma seu Herba Valerianae Tanguticae 25 ~ 35 parts and Radix premnae microphyllae 10 ~ 20 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Corium Cervi 13 ~ 18 parts, Herba desmodii multifloi 25 ~ 30 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 8 ~ 13 parts, Caulis et Folium fici Tikouae 16 ~ 21 parts, Semen Canavaliae 17 ~ 22 parts, Fructus Vaccinii Bracteati 20 ~ 25 parts, province of the Yuan Dynasty grass 15 ~ 20 parts, Radix polygalae arillatae 23 ~ 28 parts, Radix Apludate Muticae 11 ~ 16 parts, Fructus Aristolochiae 30 ~ 35 parts, parthenocissus 14 ~ 19 parts, Radix Abelmoschi Sagittifolii 28 ~ 33 parts, Fructus seu semen pruni szechuanicae 26 ~ 31 parts, DAHONGGU 24 ~ 29 parts, Semen Lini 21 ~ 26 parts, Ardisia quinquegona 19 ~ 24 parts, Rhizoma seu Herba Valerianae Tanguticae 27 ~ 32 parts and Radix premnae microphyllae 15 ~ 20 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Corium Cervi 17 parts, Herba desmodii multifloi 26 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 12 parts, Caulis et Folium fici Tikouae 17 parts, Semen Canavaliae 21 parts, Fructus Vaccinii Bracteati 22 parts, province of the Yuan Dynasty grass 18 parts, Radix polygalae arillatae 25 parts, Radix Apludate Muticae 15 parts, Fructus Aristolochiae 33 parts, parthenocissus 18 parts, Radix Abelmoschi Sagittifolii 30 parts, Fructus seu semen pruni szechuanicae 30 parts, DAHONGGU 25 parts, Semen Lini 25 parts, Ardisia quinquegona 20 parts, Rhizoma seu Herba Valerianae Tanguticae 31 parts and Radix premnae microphyllae 16 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Corium Cervi 15 parts, Herba desmodii multifloi 28 parts, Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw. 9 parts, Caulis et Folium fici Tikouae 20 parts, Semen Canavaliae 18 parts, Fructus Vaccinii Bracteati 24 parts, province of the Yuan Dynasty grass 16 parts, Radix polygalae arillatae 27 parts, Radix Apludate Muticae 12 parts, Fructus Aristolochiae 34 parts, parthenocissus 15 parts, Radix Abelmoschi Sagittifolii 33 parts, Fructus seu semen pruni szechuanicae 27 parts, DAHONGGU 28 parts, Semen Lini 22 parts, Ardisia quinquegona 23 parts, Rhizoma seu Herba Valerianae Tanguticae 28 parts and Radix premnae microphyllae 18 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

8. the preparation method of Chinese medicine as described in claim 1 to 5, it is characterized in that, the dosage form of described Chinese medicine is injectable powder, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.