CN105055300A - 用于预防脑血管痉挛的药物递送系统 - Google Patents
用于预防脑血管痉挛的药物递送系统 Download PDFInfo
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- CN105055300A CN105055300A CN201510300314.8A CN201510300314A CN105055300A CN 105055300 A CN105055300 A CN 105055300A CN 201510300314 A CN201510300314 A CN 201510300314A CN 105055300 A CN105055300 A CN 105055300A
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- therapeutic agent
- calcium channel
- vasospasm
- cerebral
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- 238000012377 drug delivery Methods 0.000 title abstract description 8
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 37
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- 229940127291 Calcium channel antagonist Drugs 0.000 claims description 115
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
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| US94312407P | 2007-06-11 | 2007-06-11 | |
| US60/943124 | 2007-06-11 | ||
| US97690207P | 2007-10-29 | 2007-10-29 | |
| US60/976902 | 2007-10-29 | ||
| CN200880101555.8A CN101873858B (zh) | 2007-06-11 | 2008-06-11 | 用于预防脑血管痉挛的药物递送系统 |
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| CN200880101555.8A Division CN101873858B (zh) | 2007-06-11 | 2008-06-11 | 用于预防脑血管痉挛的药物递送系统 |
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| CN105055300A true CN105055300A (zh) | 2015-11-18 |
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| CN201510300314.8A Pending CN105055300A (zh) | 2007-06-11 | 2008-06-11 | 用于预防脑血管痉挛的药物递送系统 |
| CN200880101555.8A Expired - Fee Related CN101873858B (zh) | 2007-06-11 | 2008-06-11 | 用于预防脑血管痉挛的药物递送系统 |
| CN201610281218.8A Pending CN105963242A (zh) | 2007-06-11 | 2008-06-11 | 用于预防脑血管痉挛的药物递送系统 |
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| CN200880101555.8A Expired - Fee Related CN101873858B (zh) | 2007-06-11 | 2008-06-11 | 用于预防脑血管痉挛的药物递送系统 |
| CN201610281218.8A Pending CN105963242A (zh) | 2007-06-11 | 2008-06-11 | 用于预防脑血管痉挛的药物递送系统 |
Country Status (10)
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| US (2) | US8303974B2 (https=) |
| EP (1) | EP2164497B1 (https=) |
| JP (1) | JP5576790B2 (https=) |
| KR (3) | KR101554258B1 (https=) |
| CN (3) | CN105055300A (https=) |
| AU (1) | AU2008261668C1 (https=) |
| CA (1) | CA2690600C (https=) |
| IL (1) | IL202647A (https=) |
| NZ (2) | NZ581836A (https=) |
| WO (1) | WO2008154585A1 (https=) |
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| WO2008154585A1 (en) * | 2007-06-11 | 2008-12-18 | Macdonald R Loch | A drug delivery system for the prevention of cerebral vasospasm |
| US10092524B2 (en) * | 2008-06-11 | 2018-10-09 | Edge Therapeutics, Inc. | Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage |
| EP2308478A1 (en) | 2009-10-06 | 2011-04-13 | Abbott GmbH & Co. KG | Delivery system for sustained release of a calcium-channel blocking agent |
| EP2538956A4 (en) * | 2010-02-22 | 2015-04-22 | Edge Therapeutics Inc | METHODS AND COMPOSITIONS FOR TREATING HEMORRHAGIC BRAIN DISORDERS |
| PL2627173T5 (pl) | 2010-10-12 | 2019-11-29 | Chiesi Farm Spa | Formulacje emulsyjne klewidypiny zawierające środki przeciw mikrobom |
| US8658676B2 (en) * | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
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| KR20150061031A (ko) | 2015-06-03 |
| KR101554250B1 (ko) | 2015-09-18 |
| EP2164497A4 (en) | 2013-05-29 |
| US20080305147A1 (en) | 2008-12-11 |
| KR20150015514A (ko) | 2015-02-10 |
| AU2008261668C1 (en) | 2014-01-16 |
| IL202647A0 (en) | 2010-06-30 |
| JP2010529205A (ja) | 2010-08-26 |
| IL202647A (en) | 2015-02-26 |
| KR101554258B1 (ko) | 2015-09-18 |
| KR101607244B1 (ko) | 2016-03-30 |
| CN101873858A (zh) | 2010-10-27 |
| CN105963242A (zh) | 2016-09-28 |
| NZ599430A (en) | 2014-03-28 |
| WO2008154585A1 (en) | 2008-12-18 |
| AU2008261668B2 (en) | 2013-08-29 |
| AU2008261668A1 (en) | 2008-12-18 |
| EP2164497B1 (en) | 2018-08-15 |
| EP2164497A1 (en) | 2010-03-24 |
| KR20100055385A (ko) | 2010-05-26 |
| US8303974B2 (en) | 2012-11-06 |
| NZ581836A (en) | 2012-07-27 |
| US20130022660A1 (en) | 2013-01-24 |
| CA2690600C (en) | 2016-10-11 |
| CN101873858B (zh) | 2016-05-25 |
| JP5576790B2 (ja) | 2014-08-20 |
| CA2690600A1 (en) | 2008-12-18 |
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