CN105050585A - 稳定的葡萄糖激酶活化剂组合物 - Google Patents

稳定的葡萄糖激酶活化剂组合物 Download PDF

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Publication number
CN105050585A
CN105050585A CN201480011647.2A CN201480011647A CN105050585A CN 105050585 A CN105050585 A CN 105050585A CN 201480011647 A CN201480011647 A CN 201480011647A CN 105050585 A CN105050585 A CN 105050585A
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CN
China
Prior art keywords
cyclohexyl
acetic acid
propoxy
trans
ureido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480011647.2A
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English (en)
Chinese (zh)
Inventor
Y·莫
M·G·戴德希亚
A·切特里
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vTv Therapeutics LLC
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vTv Therapeutics LLC
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Publication of CN105050585A publication Critical patent/CN105050585A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480011647.2A 2013-03-04 2014-02-28 稳定的葡萄糖激酶活化剂组合物 Pending CN105050585A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361772022P 2013-03-04 2013-03-04
US61/772,022 2013-03-04
PCT/US2014/019349 WO2014137797A2 (en) 2013-03-04 2014-02-28 Stable glucokinase activator compositions

Publications (1)

Publication Number Publication Date
CN105050585A true CN105050585A (zh) 2015-11-11

Family

ID=50424705

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480011647.2A Pending CN105050585A (zh) 2013-03-04 2014-02-28 稳定的葡萄糖激酶活化剂组合物

Country Status (11)

Country Link
US (1) US20160015638A1 (enExample)
EP (1) EP2964198A2 (enExample)
JP (1) JP6441828B2 (enExample)
KR (1) KR20150123838A (enExample)
CN (1) CN105050585A (enExample)
AU (1) AU2014226290B2 (enExample)
CA (1) CA2903433A1 (enExample)
HK (1) HK1213780A1 (enExample)
IL (1) IL240735A0 (enExample)
MX (1) MX2015011109A (enExample)
WO (1) WO2014137797A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109646404A (zh) * 2016-12-15 2019-04-19 华领医药技术（上海）有限公司 葡萄糖激酶激活剂的口服制剂及其制备方法
CN116194442A (zh) * 2020-06-08 2023-05-30 维特卫治疗有限责任公司 {2-[3-环己基-3-(反式-4-丙氧基-环己基)-脲基]-噻唑-5-基硫烷基}-乙酸的盐或共晶体及其用途

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012029844A2 (pt) 2010-05-26 2015-10-13 Transtech Pharma Inc uso de metamorfina em combinação com um ativador de glucoquinase e combinações compreendendo metamorfina com um ativador de glucoquinase
EP2849776B1 (en) 2012-05-17 2021-04-21 vTv Therapeutics LLC Glucokinase activator compositions for the treatment of diabetes
EP4487909A3 (en) 2018-06-12 2025-03-19 vTv Therapeutics LLC Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
US12391658B2 (en) 2020-02-18 2025-08-19 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof
US11857536B2 (en) 2020-06-04 2024-01-02 Hua Medicine (Shanghai) Ltd. Glucokinase activator for treating diabetes with renal impairment
CA3185831A1 (en) * 2020-06-04 2021-12-09 Hua Medicine (Shanghai) Ltd. Glucokinase activator for treating diabetes with renal impairment
EP4161639A4 (en) * 2020-06-08 2024-01-17 vTv Therapeutics LLC CRYSTALLINE FORMS OF ACETIC ACID {2-[3-CYCLOHEXYL-3-(TRANS-4-PROPOXY-CYCLOHEXYL)-UREIDO]-THIAZOL-5-YLSULFANYL} AND THEIR USES
KR20240084229A (ko) * 2022-12-06 2024-06-13 유노비아 주식회사 안정성이 향상된 gpr40 효현제를 유효성분으로 포함하는 약제학적 조성물

Citations (7)

* Cited by examiner, † Cited by third party
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US20060246141A1 (en) * 2005-04-12 2006-11-02 Elan Pharma International, Limited Nanoparticulate lipase inhibitor formulations
WO2008079787A2 (en) * 2006-12-20 2008-07-03 Takeda San Diego, Inc. Glucokinase activators
CN101829061A (zh) * 2010-05-14 2010-09-15 无锡纳生生物科技有限公司 一种紫杉醇纳米颗粒组合物及其制备方法
CN102497858A (zh) * 2009-06-19 2012-06-13 纳米模型匈牙利有限公司 纳米颗粒替米沙坦组合物及其制备方法
CN102516240A (zh) * 2004-01-06 2012-06-27 诺和诺德公司 杂芳基脲及其作为葡糖激酶活化剂的用途
CN102802609A (zh) * 2009-06-18 2012-11-28 雅培制药有限公司 稳定的纳米颗粒药物悬浮液

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MY152749A (en) * 2008-05-16 2014-11-28 Takeda California Inc Pyrazole and fused pyrazole glucokinase activators
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BR112012029844A2 (pt) * 2010-05-26 2015-10-13 Transtech Pharma Inc uso de metamorfina em combinação com um ativador de glucoquinase e combinações compreendendo metamorfina com um ativador de glucoquinase

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0499299A2 (en) * 1991-01-25 1992-08-19 NanoSystems L.L.C. Surface modified drug nanoparticles
CN102516240A (zh) * 2004-01-06 2012-06-27 诺和诺德公司 杂芳基脲及其作为葡糖激酶活化剂的用途
US20060246141A1 (en) * 2005-04-12 2006-11-02 Elan Pharma International, Limited Nanoparticulate lipase inhibitor formulations
WO2008079787A2 (en) * 2006-12-20 2008-07-03 Takeda San Diego, Inc. Glucokinase activators
CN102802609A (zh) * 2009-06-18 2012-11-28 雅培制药有限公司 稳定的纳米颗粒药物悬浮液
CN102497858A (zh) * 2009-06-19 2012-06-13 纳米模型匈牙利有限公司 纳米颗粒替米沙坦组合物及其制备方法
CN101829061A (zh) * 2010-05-14 2010-09-15 无锡纳生生物科技有限公司 一种紫杉醇纳米颗粒组合物及其制备方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109646404A (zh) * 2016-12-15 2019-04-19 华领医药技术（上海）有限公司 葡萄糖激酶激活剂的口服制剂及其制备方法
CN109674752A (zh) * 2016-12-15 2019-04-26 华领医药技术（上海）有限公司 葡萄糖激酶激活剂的口服制剂及其制备方法
US11266630B2 (en) 2016-12-15 2022-03-08 Hua Medicine (Shanghai) Ltd. Oral preparation of glucokinase activator and preparation method therefor
CN109646404B (zh) * 2016-12-15 2022-10-04 华领医药技术（上海）有限公司 葡萄糖激酶激活剂的口服制剂及其制备方法
CN109674752B (zh) * 2016-12-15 2022-10-11 华领医药技术（上海）有限公司 葡萄糖激酶激活剂的口服制剂及其制备方法
CN116194442A (zh) * 2020-06-08 2023-05-30 维特卫治疗有限责任公司 {2-[3-环己基-3-(反式-4-丙氧基-环己基)-脲基]-噻唑-5-基硫烷基}-乙酸的盐或共晶体及其用途

Also Published As

Publication number Publication date
EP2964198A2 (en) 2016-01-13
IL240735A0 (en) 2015-10-29
WO2014137797A3 (en) 2014-10-30
AU2014226290B2 (en) 2018-11-15
KR20150123838A (ko) 2015-11-04
MX2015011109A (es) 2015-11-16
AU2014226290A1 (en) 2015-10-08
WO2014137797A2 (en) 2014-09-12
HK1213780A1 (zh) 2016-07-15
JP2016513625A (ja) 2016-05-16
JP6441828B2 (ja) 2018-12-19
CA2903433A1 (en) 2014-09-12
US20160015638A1 (en) 2016-01-21

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