AU2014226290B2 - Stable glucokinase activator compositions - Google Patents
Stable glucokinase activator compositions Download PDFInfo
- Publication number
- AU2014226290B2 AU2014226290B2 AU2014226290A AU2014226290A AU2014226290B2 AU 2014226290 B2 AU2014226290 B2 AU 2014226290B2 AU 2014226290 A AU2014226290 A AU 2014226290A AU 2014226290 A AU2014226290 A AU 2014226290A AU 2014226290 B2 AU2014226290 B2 AU 2014226290B2
- Authority
- AU
- Australia
- Prior art keywords
- cyclohexyl
- pharmaceutical composition
- thiazol
- acetic acid
- ureido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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Landscapes
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201361772022P | 2013-03-04 | 2013-03-04 | |
| US61/772,022 | 2013-03-04 | ||
| PCT/US2014/019349 WO2014137797A2 (en) | 2013-03-04 | 2014-02-28 | Stable glucokinase activator compositions |
Publications (2)
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| AU2014226290A1 AU2014226290A1 (en) | 2015-10-08 |
| AU2014226290B2 true AU2014226290B2 (en) | 2018-11-15 |
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| Country | Link |
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| US (1) | US20160015638A1 (enExample) |
| EP (1) | EP2964198A2 (enExample) |
| JP (1) | JP6441828B2 (enExample) |
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| IL (1) | IL240735A0 (enExample) |
| MX (1) | MX2015011109A (enExample) |
| WO (1) | WO2014137797A2 (enExample) |
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| US9359313B2 (en) | 2010-05-26 | 2016-06-07 | Vtv Therapeutics Llc | Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator |
| KR102371364B1 (ko) | 2012-05-17 | 2022-03-07 | 브이티브이 테라퓨틱스 엘엘씨 | 당뇨병 치료를 위한 글루코키나아제 활성화제 조성물 |
| CN115715762A (zh) * | 2016-12-15 | 2023-02-28 | 华领医药技术（上海）有限公司 | 葡萄糖激酶激活剂的口服制剂及其制备方法 |
| CA3093025A1 (en) | 2018-06-12 | 2019-12-19 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
| US12391658B2 (en) | 2020-02-18 | 2025-08-19 | Vtv Therapeutics Llc | Sulfoxide and sulfone glucokinase activators and methods of use thereof |
| US11857536B2 (en) | 2020-06-04 | 2024-01-02 | Hua Medicine (Shanghai) Ltd. | Glucokinase activator for treating diabetes with renal impairment |
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Also Published As
| Publication number | Publication date |
|---|---|
| US20160015638A1 (en) | 2016-01-21 |
| IL240735A0 (en) | 2015-10-29 |
| HK1213780A1 (zh) | 2016-07-15 |
| CA2903433A1 (en) | 2014-09-12 |
| AU2014226290A1 (en) | 2015-10-08 |
| JP6441828B2 (ja) | 2018-12-19 |
| JP2016513625A (ja) | 2016-05-16 |
| CN105050585A (zh) | 2015-11-11 |
| KR20150123838A (ko) | 2015-11-04 |
| WO2014137797A3 (en) | 2014-10-30 |
| EP2964198A2 (en) | 2016-01-13 |
| WO2014137797A2 (en) | 2014-09-12 |
| MX2015011109A (es) | 2015-11-16 |
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