AU2014226290B2 - Stable glucokinase activator compositions - Google Patents
Stable glucokinase activator compositions Download PDFInfo
- Publication number
- AU2014226290B2 AU2014226290B2 AU2014226290A AU2014226290A AU2014226290B2 AU 2014226290 B2 AU2014226290 B2 AU 2014226290B2 AU 2014226290 A AU2014226290 A AU 2014226290A AU 2014226290 A AU2014226290 A AU 2014226290A AU 2014226290 B2 AU2014226290 B2 AU 2014226290B2
- Authority
- AU
- Australia
- Prior art keywords
- cyclohexyl
- pharmaceutical composition
- thiazol
- acetic acid
- ureido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/426—1,3-Thiazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US201361772022P | 2013-03-04 | 2013-03-04 | |
| US61/772,022 | 2013-03-04 | ||
| PCT/US2014/019349 WO2014137797A2 (en) | 2013-03-04 | 2014-02-28 | Stable glucokinase activator compositions |
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| AU2014226290A1 AU2014226290A1 (en) | 2015-10-08 |
| AU2014226290B2 true AU2014226290B2 (en) | 2018-11-15 |
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| Country | Link |
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| US (1) | US20160015638A1 (enExample) |
| EP (1) | EP2964198A2 (enExample) |
| JP (1) | JP6441828B2 (enExample) |
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| MX (1) | MX2015011109A (enExample) |
| WO (1) | WO2014137797A2 (enExample) |
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| NZ603614A (en) | 2010-05-26 | 2014-10-31 | Transtech Pharma Llc | Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator |
| BR112014028622A2 (pt) | 2012-05-17 | 2017-06-27 | Transtech Pharma Llc | composições de ativador de glucoquinase para o tratamento de diabetes |
| EP3556354B1 (en) * | 2016-12-15 | 2025-05-21 | Hua Medicine (Shanghai) Ltd. | Oral preparation of glucokinase activator and preparation method therefor |
| CN112040945A (zh) | 2018-06-12 | 2020-12-04 | Vtv治疗有限责任公司 | 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途 |
| US12391658B2 (en) | 2020-02-18 | 2025-08-19 | Vtv Therapeutics Llc | Sulfoxide and sulfone glucokinase activators and methods of use thereof |
| CA3185831A1 (en) * | 2020-06-04 | 2021-12-09 | Hua Medicine (Shanghai) Ltd. | Glucokinase activator for treating diabetes with renal impairment |
| US11857536B2 (en) | 2020-06-04 | 2024-01-02 | Hua Medicine (Shanghai) Ltd. | Glucokinase activator for treating diabetes with renal impairment |
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Also Published As
| Publication number | Publication date |
|---|---|
| HK1213780A1 (zh) | 2016-07-15 |
| US20160015638A1 (en) | 2016-01-21 |
| JP6441828B2 (ja) | 2018-12-19 |
| WO2014137797A2 (en) | 2014-09-12 |
| CN105050585A (zh) | 2015-11-11 |
| KR20150123838A (ko) | 2015-11-04 |
| AU2014226290A1 (en) | 2015-10-08 |
| MX2015011109A (es) | 2015-11-16 |
| EP2964198A2 (en) | 2016-01-13 |
| WO2014137797A3 (en) | 2014-10-30 |
| CA2903433A1 (en) | 2014-09-12 |
| JP2016513625A (ja) | 2016-05-16 |
| IL240735A0 (en) | 2015-10-29 |
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