CN105031187A - Liquorice fritillary bulb processed with honey and preparation method - Google Patents
Liquorice fritillary bulb processed with honey and preparation method Download PDFInfo
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- CN105031187A CN105031187A CN201510375959.8A CN201510375959A CN105031187A CN 105031187 A CN105031187 A CN 105031187A CN 201510375959 A CN201510375959 A CN 201510375959A CN 105031187 A CN105031187 A CN 105031187A
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Abstract
The invention relates to a liquorice fritillary bulb processed with honey and also provides a preparation method of the preparation. Based on a theory of traditional Chinese medicine, by using compatibility of medicines and mutual-assistance actions of moistening lung to arrest cough of honey and removing cough and stopping sputum of liquorice, lung moistening, sputum stopping and cough removing effects of fritillary bulb are improved. Through compatibility of the three medical materials and preparation of the invention, the actions of lung moistening, sputum stopping and cough removing effects of the fritillary bulb are effectively increased, performance of the fritillary bulb tends to be sweet taste and neutral nature, mouth feel of the fritillary bulb is improved, and taking people can easily take the medicine. Under same dosage, the aim of reducing toxicity and increasing effect is achieved, and great significance in protection and usage of scarce medicinal resource is realized.
Description
Technical field
The present invention relates to a kind of Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis, additionally provide the preparation method of said preparation simultaneously, belong to food and field of pharmaceutical technology.
Background technology
Bulbus Fritillariae Ussuriensis is the dry bulb of liliaceous plant Bulbus Fritillariae Ussuriensis FritillariaussuriensisMaxim..Bulbus Fritillariae Ussuriensis has another name called level ground shellfish, Bulbus Fritillariae Uninbracteatae, flat shellfish.There are clearing heat and moistening lung, the effect of relieving cough and resolving phlegm, for a kind of conventional Chinese medicine, Fritillaria is belonged to together with Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Thunbergii, but pharmaceutically there is certain difference, mainly be distributed in the Mountain Areas of Southern, the normal pulse Xiaoxinanlin Mountains, Changbai Mountain of the Northeast, the provinces such as main product Heilungkiang, Jilin, Liaoning and Shanxi, Shaanxi, Hebei.
Bulbus Fritillariae Ussuriensis pharmacological action is: 1, Bulbus Fritillariae Ussuriensis extractum has central inhibitory action to experimental animal models.Bulbus Fritillariae Ussuriensis total alkaloids, pingpeimine A all have and significantly eliminate the phlegm and hypotensive activity.2 Bulbus Fritillariae Ussuriensis total alkali 3mg/100g, 1.5mg/100g rat skin lower injections all have certain inhibitory action to pyloric ligation ulcers ulcer, lumbar injection to indometacin type ulcer and stress ulcer, and these effects may be relevant with its suppression pepsin activity.
Bulbus Fritillariae Ussuriensis meridian distribution of property and flavor: bitter, sweet, is slightly cold.Return lung, heart channel.Function cures mainly as clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.Its effect is close with Bulbus Fritillariae Cirrhosae, and medicinal effects is weak compared with Bulbus Fritillariae Cirrhosae, and in recent years because Bulbus Fritillariae Cirrhosae belongs to wild rare medicinal herbs, resource is exhausted year by year.Because its Bulbus Fritillariae Ussuriensis has ripe artificial cultivation technique, can plant in a large number, for improving the medicinal effects of Bulbus Fritillariae Ussuriensis, improve Bulbus Fritillariae Ussuriensis effect in relieving cough and asthma by traditional Chinese medicine processing method, reaching the effect close with Bulbus Fritillariae Cirrhosae.Thus raising medical value protects wild Bulbus Fritillariae Cirrhosae to have positive meaning.
Summary of the invention
The invention provides a kind of Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis, the effect of Bulbus Fritillariae Ussuriensis in cough-relieving can be strengthened with crossing the present invention, add the effect of relievining asthma simultaneously.
a kind of Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis of the present invention, it is characterized in that being made up by ratio of weight and the number of copies of following medicine:
Mel 5 ~ 60, Radix Glycyrrhizae 5 ~ 30, Bulbus Fritillariae Ussuriensis 5 ~ 100.
the preparation method of a kind of Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis of the present invention, comprises the steps:
1) to make even Bulbus Fritillariae Uninbracteatae raw material, pick decontamination, clean by the method for wash quickly, be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 1 hour, be dried to water content less than 20%;
2) choose Mel and add heating in pot, refine the goods obtained to 105 ~ 110 DEG C, refined honey water content is more than 30%, and color and luster is without significant change, and slightly sticking refined honey is for subsequent use;
3) dry rhizome and the root of choosing glycyrrhizic legume clean, infiltrate, cut into slices, and add 3 ~ 6 times of soak by water 2 ~ 3 times, each 15 ~ 30 minutes, filter, collecting decoction and Sucus Glycyrrhizae;
4) by step 2) and 3) to obtain refined honey Sucus Glycyrrhizae for subsequent use for mix homogeneously;
5) Bulbus Fritillariae Ussuriensis is put into refined honey Sucus Glycyrrhizae temperature prepared by step 4) to control 10 ~ 30 DEG C of infuses 2 ~ 48 hours, period stirred 1 time every 6 hours, made it be evenly distributed, and soaked into Bulbus Fritillariae Ussuriensis and absorbed refined honey Sucus Glycyrrhizae completely;
6) Bulbus Fritillariae Ussuriensis after step 5) infuse is dried to water content less than 15%, obtains final product.
In above-mentioned any technical scheme, refined honey is 5 ~ 60 weight portions, preferably 1 ~ 40 weight portion, more preferably 5 ~ 20 weight portions, more preferably 10 ~ 20 weight portions; Sucus Glycyrrhizae is 5 ~ 30 weight portions, preferably 5 ~ 20 weight portions, more preferably 5 ~ 15 weight portions, more preferably 6 ~ 10 weight portions; Bulbus Fritillariae Ussuriensis raw material is 5 ~ 100 weight portions, preferably 20 ~ 100 weight portions, more preferably 30 ~ 70 weight portions, more preferably 40 ~ 70 weight portions.
Preparation method of the present invention also can adopt the preparation method of the conventional formulation of medicine and pharmacology.
[usage and dosage] 3 ~ 9g; Levigation is taken after mixing it with water, a 1 ~ 2g.
[indication] function cures mainly clearing heat and moistening lung, reduces phlegm, cough-relieving.For lung-heat type cough, dry cough insufficiency of blood, deficiency of YIN chronic cough, sputum with blood.
[attention] should not with Radix Aconiti, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata should not with Aconitum medical material with use with using.
pharmacological effect side of the present invention separates as follows:
Mel, performance: sweet in the mouth, flat; Return taste, lung and large intestine channel.Function invigorating middle warmer, cough-relieving, moisturizes, removing toxic substances.For the processing aids of nourishing the lung to arrest cough, invigorating the spleen and replenishing QI medicine, in order to potentiation, moisturize and correct mouthfeel.As Radix Ginseng (processed with honey), the processed with honey Radix Stemonae, Radix Asteris (processed with honey), processed with honey Flos Farfarae, processed with honey Folium Mori, processed with honey Cortex Mori, processed with honey Fructus Schisandrae Chinensis, Radix Glycyrrhizae (processed with honey) etc.
Bulbus Fritillariae Ussuriensis, performance: bitter, sweet, is slightly cold.Return lung, heart channel.Clearing heat and moistening lung, reduce phlegm, cough-relieving.For lung-heat type cough, dry cough insufficiency of blood, deficiency of YIN chronic cough, sputum with blood.
Radix Glycyrrhizae, another name: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet root.Pulse family, Glycyrrhiza perennial herb, root and root stock sturdy, be a kind of tonification Chinese herbal medicine.To the good a kind of medicine of human body, medicinal part is root and rhizome.Sweet in the mouth, flat, GUIXIN, lung, spleen, stomach warp, tool invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, the effect of relieving spasm to stop pain.Medicine can relax the property of medicine after Sucus Glycyrrhizae system, reduces toxicity.As Sucus Glycyrrhizae boils Radix Polygalae, Fructus Evodiae.
The present invention is according to theory of Chinese medical science basis, utilizes said medicine compatibility relationship that dispelling of the nourishing the lung to arrest cough of Mel and Radix Glycyrrhizae is coughed the mutual-assistance effect of only expectorant, improves the lung moistening of Bulbus Fritillariae Ussuriensis, eliminates the phlegm, cough-relieving effect, adds the effect of relievining asthma simultaneously.Three taste medicines by compatibility, after the present invention's preparation, reach effectively increase Bulbus Fritillariae Ussuriensis lung moistening, eliminate the phlegm, cough-relieving, antiasthmatic effect simultaneously, make the performance of Bulbus Fritillariae Ussuriensis be tending towards sweet flat, improve the mouthfeel of Bulbus Fritillariae Ussuriensis, the crowd of taking more easily is taken.
for proving that the effectiveness of this invention has carried out pharmacological evaluation from pharmacodynamics aspect, be reported as follows:
1, see the following form in cough-relieving experiment (ammonia draws the method for coughing) [1]:
Bulbus Fritillariae Ussuriensis, liquorice liquid, Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis cough-relieving Benefit Transfer
Note: compare with model control group: * p<0.05.
Bulbus Fritillariae Ussuriensis, liquorice liquid, Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis all can reduce mouse cough response rate as seen from the above table, with model control group comparing difference significance (p<0.05), and Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis group antitussive action is better than Bulbus Fritillariae Ussuriensis group and liquorice liquid group, and suitable with codeine group.
2, to eliminate the phlegm experiment (phenol red method) [1]
Bulbus Fritillariae Ussuriensis, liquorice liquid, Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis phlegm-dispelling functions compare (
)
Compare with model control group: * p<0.05, * * p<0.01; Compare with Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis group: #p<0.05
As seen from the above table: the OD value of each administration group compares with model control group that there were significant differences (p<0.05 or p<0.01), illustrative experiment group all has good phlegm-dispelling functions, and the phlegm-dispelling functions of Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis group is obviously better than Bulbus Fritillariae Ussuriensis group and Radix Glycyrrhizae group.
3, to relieving asthma experiment (spraying causes the method for breathing heavily)
Bulbus Fritillariae Ussuriensis, liquorice liquid, Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis antiasthmatic effect compare (
)
Compare with model group: * p<0.05, * * p<0.01; Compare with Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis group: #p<0.05
As seen from the above table: Bulbus Fritillariae Ussuriensis group and Radix Glycyrrhizae group mice occur
order reaction has prolongation trend incubation period, but not obvious with model control group comparing difference (p>0.05), Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis group then obviously can extend mice
order reaction incubation period (p<0.05), points out its antiasthmatic effect to be obviously better than Bulbus Fritillariae Ussuriensis group and Radix Glycyrrhizae group.
The cough-relieving of the Bulbus Fritillariae Ussuriensis of comprehensive above 3 pharmacological action contrast experiments after the present invention concocts, eliminate the phlegm, antiasthmatic effect has the effect significantly strengthened compared with Bulbus Fritillariae Ussuriensis primary crude drug and Radix Glycyrrhizae.
good effect of the present invention is further illustrated below in conjunction with clinical:
One, diagnostic criteria
:
Be diagnosed as according to " Diagnostics of Chinese Medicine ": lung-heat type cough, dry cough insufficiency of blood, deficiency of YIN chronic cough, sputum with blood.
Two, inclusive criteria:
The above-mentioned standard of all genus all can be included in clinical.Three, using method:
In composition of prescription, compatibility uses or folk prescription use.Four, curative effect judging standard:
Patients symptomatic is improved by all reaching after Bulbus Fritillariae Ussuriensis treatment processed.
good effect of the present invention is:the present invention is according to theory of Chinese medical science basis, utilizes said medicine compatibility relationship that dispelling of the nourishing the lung to arrest cough of Mel and Radix Glycyrrhizae is coughed the mutual-assistance effect of only expectorant, improves the lung moistening of Bulbus Fritillariae Ussuriensis, eliminates the phlegm, cough-relieving effect.Three taste medicines by compatibility, after the present invention's preparation, reach effectively increase Bulbus Fritillariae Ussuriensis lung moistening, eliminate the phlegm, antitussive action simultaneously, make the performance of Bulbus Fritillariae Ussuriensis be tending towards sweet flat, improve the mouthfeel of Bulbus Fritillariae Ussuriensis, the crowd of taking more easily is taken.Under same dose, the object of attenuation synergistic can be reached, to the rare medicine resource of conservation and utilization, there is very big meaning.
Detailed description of the invention
Following embodiment and case application, be only for example of the present invention is clearly described, and be not limitation of the invention.For those of ordinary skill in the field, other multi-form change or variations can also be made on the basis of the above description.And thus the apparent change of amplifying out or variation be still among protection scope of the present invention.
embodiment 1:
1, get 50g Bulbus Fritillariae Ussuriensis medical material, the removal of impurity, clean by the method for wash quickly, be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 1 hour, be dried to water content 20%;
2, getting 10g Mel refines 4 minutes refined honey water is for subsequent use temperature 110 DEG C;
3, choose the cleaning of 30g Radix Glycyrrhizae, infiltrate, cut into slices, add 120g soak by water 2 times, each 15 minutes, filter, collecting decoction and Sucus Glycyrrhizae;
4, step 2 and 3 mix homogeneously are obtained refined honey Sucus Glycyrrhizae for subsequent use;
5, the Bulbus Fritillariae Ussuriensis raw material of step 1 drying being placed in step 4) refined honey Sucus Glycyrrhizae stirs constant temperature 25 DEG C of infuses 8 hours, and period stirred 1 time every 4 hours, made it be evenly distributed, and soaks into Bulbus Fritillariae Ussuriensis and absorbs refined honey Sucus Glycyrrhizae completely;
6, step 5 is processed the Bulbus Fritillariae Ussuriensis obtained and be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 3 hours, be dried to water content 15%, obtain final product.
embodiment 2:
1, get 300g Bulbus Fritillariae Ussuriensis medical material, the removal of impurity, clean by the method for wash quickly, be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 1 hour, be dried to water content 20%;
2, getting 200g Mel refines 10 minutes refined honey water is for subsequent use temperature 110 DEG C;
3, choose the cleaning of 150g Radix Glycyrrhizae, infiltrate, cut into slices, add 900g soak by water 3 times, each 15 minutes, filter, collecting decoction and Sucus Glycyrrhizae;
4, step 2 and 3 mix homogeneously are obtained refined honey Sucus Glycyrrhizae for subsequent use;
5, the Bulbus Fritillariae Ussuriensis raw material of step 1 drying being placed in step 4) refined honey Sucus Glycyrrhizae stirs constant temperature 22 DEG C of infuses 12 hours, and period stirred 1 time every 4 hours, made it be evenly distributed, and soaks into Bulbus Fritillariae Ussuriensis and absorbs refined honey Sucus Glycyrrhizae completely;
6, step 5 is processed the Bulbus Fritillariae Ussuriensis obtained and be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 5 hours, be dried to water content 15%, obtain final product.
embodiment 3:
1, get 100g Bulbus Fritillariae Ussuriensis medical material, the removal of impurity, clean by the method for wash quickly, be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 1 hour, be dried to water content 20%;
2, getting 80g Mel refines 7 minutes refined honey water is for subsequent use temperature 110 DEG C;
3, choose the cleaning of 50g Radix Glycyrrhizae, infiltrate, cut into slices, add 200g soak by water 2 times, each 15 minutes, filter, collecting decoction and Sucus Glycyrrhizae;
4, step 2 and 3 mix homogeneously are obtained refined honey Sucus Glycyrrhizae for subsequent use;
5, the Bulbus Fritillariae Ussuriensis raw material of step 1 drying being placed in step 4) refined honey Sucus Glycyrrhizae stirs constant temperature 18 DEG C of infuses 8 hours, and period stirred 1 time every 4 hours, made it be evenly distributed, and soaks into Bulbus Fritillariae Ussuriensis and absorbs refined honey Sucus Glycyrrhizae completely;
6, step 5 is processed the Bulbus Fritillariae Ussuriensis obtained and be placed in low-temperature vacuum drying case, through low temperature 25 DEG C of dryings 2 hours, be dried to water content 15%, obtain final product.
the therapeutic effect of medicine of the present invention is shown further by following model case:
case 1
Certain female, 53 years old, tcm diagnosis: pulse condition, number is thin; Red tongue with thin fur; Dry cough, without expectorant, few and sticky or expectorant such as the line powder of expectorant not easily brings up, and tcm diagnosis is lung-heat type cough.
Treatment: Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis 6 grams prepared by the embodiment of the present invention 1, grinding is taken after mixing it with water, every day 3 times.
Effect: take 3 days afterwards cough improve adhering to taking after 2 weeks and fully recover.
case 2
Certain man, 42 years old; Tcm diagnosis: shortness of breath and fatigue, deficiency of lung-YIN chronic cough, thready and weak pulse.
Treatment: Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis 6 grams prepared by the embodiment of the present invention 2, soaked every day 3 times, 14 days courses for the treatment of.
Effect: invention enhances antitussive action, simultaneously honey has effect of lung moistening, takes transference cure of coughing after 1 month, and take chronic cough symptom recovery from illness after two courses for the treatment of, shortness of breath and fatigue obtains good improvement.
case 3
Certain man, 60 years old; Tcm diagnosis, red tongue with a little fluid, thready pulse sinks, and belongs to prolonged illness impairment of YIN, deficiency of body fluid, causes dryness of the lung dry cough, and expectorant is even without expectorant less.
Treatment: liquorice root honey Bulbus Fritillariae Ussuriensis 6 grams prepared by the embodiment of the present invention 3, grinds into powder and takes after mixing it with water, 3 times on the one.
Effect: have good lung moistening function while the present invention strengthens antitussive action, takes dry cough after 1 week and obviously alleviates and continue to take symptom after 1 month and disappear completely.
Claims (2)
1. a Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis, it is characterized in that being made up by ratio of weight and the number of copies of following medicine:
Mel 5 ~ 60, Radix Glycyrrhizae 5 ~ 30, Bulbus Fritillariae Ussuriensis 5 ~ 100.
2. the preparation method of a kind of Radix Glycyrrhizae processed with honey Bulbus Fritillariae Ussuriensis described in claims 1, comprises the steps:
1) to make even Bulbus Fritillariae Uninbracteatae raw material, pick decontamination, clean by the method for wash quickly, be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 1 hour, be dried to water content less than 20%;
2) choose Mel and add heating in pot, refine the goods obtained to 105 ~ 110 DEG C, refined honey water content is more than 30%, and color and luster is without significant change, and slightly sticking refined honey is for subsequent use;
3) dry rhizome and the root of choosing glycyrrhizic legume clean, infiltrate, cut into slices, and add 3 ~ 6 times of soak by water 2 ~ 3 times, each 15 ~ 30 minutes, filter, collecting decoction and Sucus Glycyrrhizae;
4) by step 2) and 3) to obtain refined honey Sucus Glycyrrhizae for subsequent use for mix homogeneously;
5) Bulbus Fritillariae Ussuriensis is put into refined honey Sucus Glycyrrhizae temperature prepared by step 4) to control 10 ~ 30 DEG C of infuses 2 ~ 48 hours, period stirred 1 time every 6 hours, made it be evenly distributed, and soaked into Bulbus Fritillariae Ussuriensis and absorbed refined honey Sucus Glycyrrhizae completely;
6) Bulbus Fritillariae Ussuriensis after step 5) infuse is dried to water content less than 15%, obtains final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107343916A (en) * | 2016-12-29 | 2017-11-14 | 浙江知元堂生物药业有限公司 | A kind of fritillaria thunbergii Preparation process method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147333A (en) * | 2014-07-28 | 2014-11-19 | 四川藏域川贝生物研究中心有限公司 | Preparation formula of bulbus fritillariae cirrhosae processed with honey and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147333A (en) * | 2014-07-28 | 2014-11-19 | 四川藏域川贝生物研究中心有限公司 | Preparation formula of bulbus fritillariae cirrhosae processed with honey and preparation method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107343916A (en) * | 2016-12-29 | 2017-11-14 | 浙江知元堂生物药业有限公司 | A kind of fritillaria thunbergii Preparation process method |
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