CN105026397B - 作为抗癌剂的9‑(芳基或杂芳基)‑2‑(吡唑基、吡咯烷基或环戊基)氨基嘌呤衍生物 - Google Patents

作为抗癌剂的9‑(芳基或杂芳基)‑2‑(吡唑基、吡咯烷基或环戊基)氨基嘌呤衍生物 Download PDF

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CN105026397B
CN105026397B CN201480012134.3A CN201480012134A CN105026397B CN 105026397 B CN105026397 B CN 105026397B CN 201480012134 A CN201480012134 A CN 201480012134A CN 105026397 B CN105026397 B CN 105026397B
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pyrazol
purin
phenyl
amine
ethyl
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CN105026397A (zh
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G.赫尔策曼
D.多施
A.韦格纳
O.珀施克
M.布施
J.塞尼萨米
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Merck Patent GmbH
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Merck Patent GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
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CN201480012134.3A 2013-03-05 2014-02-11 作为抗癌剂的9‑(芳基或杂芳基)‑2‑(吡唑基、吡咯烷基或环戊基)氨基嘌呤衍生物 Expired - Fee Related CN105026397B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13001111.7 2013-03-05
EP13001111 2013-03-05
PCT/EP2014/000371 WO2014135245A1 (en) 2013-03-05 2014-02-11 9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents

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CN105026397A CN105026397A (zh) 2015-11-04
CN105026397B true CN105026397B (zh) 2017-06-30

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EP (1) EP2964648B1 (https=)
JP (1) JP6409007B2 (https=)
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AR (1) AR094981A1 (https=)
AU (1) AU2014224976B2 (https=)
CA (1) CA2903901A1 (https=)
ES (1) ES2614872T3 (https=)
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AU2014224976A1 (en) 2015-10-22
AR094981A1 (es) 2015-09-09
ES2614872T3 (es) 2017-06-02
AU2014224976B2 (en) 2017-09-28
WO2014135245A1 (en) 2014-09-12
IL240876A0 (en) 2015-10-29
IL240876B (en) 2019-09-26
US9617266B2 (en) 2017-04-11
CA2903901A1 (en) 2014-09-12
US20160002242A1 (en) 2016-01-07
CN105026397A (zh) 2015-11-04
JP6409007B2 (ja) 2018-10-17
JP2016510045A (ja) 2016-04-04
EP2964648B1 (en) 2016-11-16

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