CN105025887B - 新颖极低粘度酯化纤维素醚 - Google Patents

新颖极低粘度酯化纤维素醚 Download PDF

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Publication number
CN105025887B
CN105025887B CN201480011014.1A CN201480011014A CN105025887B CN 105025887 B CN105025887 B CN 105025887B CN 201480011014 A CN201480011014 A CN 201480011014A CN 105025887 B CN105025887 B CN 105025887B
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CN
China
Prior art keywords
cellulose ether
esterified cellulose
viscosity
mpa
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201480011014.1A
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English (en)
Chinese (zh)
Other versions
CN105025887A (zh
Inventor
O·彼得曼
R·B·阿佩尔
M·布拉克哈根
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Dow Global Technologies LLC
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Dow Global Technologies LLC
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Publication of CN105025887A publication Critical patent/CN105025887A/zh
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B13/00—Preparation of cellulose ether-esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480011014.1A 2013-03-07 2014-02-28 新颖极低粘度酯化纤维素醚 Expired - Fee Related CN105025887B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361774161P 2013-03-07 2013-03-07
US61/774161 2013-03-07
PCT/US2014/019266 WO2014137778A1 (en) 2013-03-07 2014-02-28 Novel esterified cellulose ethers of very low viscosity

Publications (2)

Publication Number Publication Date
CN105025887A CN105025887A (zh) 2015-11-04
CN105025887B true CN105025887B (zh) 2017-07-28

Family

ID=50439471

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480011014.1A Expired - Fee Related CN105025887B (zh) 2013-03-07 2014-02-28 新颖极低粘度酯化纤维素醚

Country Status (7)

Country Link
US (1) US9617351B2 (enExample)
EP (1) EP2964204B1 (enExample)
JP (1) JP6267239B2 (enExample)
KR (1) KR101661952B1 (enExample)
CN (1) CN105025887B (enExample)
BR (1) BR112015015846A2 (enExample)
WO (1) WO2014137778A1 (enExample)

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JP6356923B2 (ja) * 2015-03-16 2018-07-11 ダウ グローバル テクノロジーズ エルエルシー 水溶性エステル化セルロースエーテル
WO2016148976A1 (en) * 2015-03-16 2016-09-22 Dow Global Technologies Llc Gelling esterified cellulose ethers
EP3270971B1 (en) * 2015-03-16 2019-01-09 Dow Global Technologies LLC Water-soluble esterified cellulose ethers having a low degree of neutralization
US20180071396A1 (en) * 2015-03-16 2018-03-15 Dow Global Technologies Llc Aqueous solution of an esterified cellulose ether
WO2016148975A1 (en) * 2015-03-16 2016-09-22 Dow Global Technologies Llc A process for fractionating an esterified cellulose ether
MX2017011091A (es) * 2015-03-16 2017-11-10 Dow Global Technologies Llc Proceso para preparar un eter de celulosa esterificado en presencia de un acido carboxilico alifatico.
EP3463314B1 (en) 2016-05-25 2020-07-22 Dow Global Technologies LLC Aqueous solution of cellulose ether acetate
US10888525B2 (en) * 2016-11-02 2021-01-12 Shin-Etsu Chemical Co., Ltd. Hypromellose acetate succinate and method for producing the same
WO2018170060A1 (en) 2017-03-17 2018-09-20 Dow Global Technologies Llc Process for recovering an esterified cellulose ether from a reaction product mixture
WO2018170062A1 (en) 2017-03-17 2018-09-20 Dow Global Technologies Llc Process for recovering an esterified cellulose ether from a reaction product mixture
WO2018170083A1 (en) 2017-03-17 2018-09-20 Dow Global Technologies Llc Process for recovering an esterified cellulose ether from a reaction product mixture

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226981A (en) * 1977-09-28 1980-10-07 Shin-Etsu Chemical Co., Ltd. Ether-ester derivatives of cellulose and their applications
EP0219426A2 (en) * 1985-10-07 1987-04-22 Shin-Etsu Chemical Co., Ltd. A method for the preparation of an acidic dicarboxylic acid ester of cellulose ether

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JPS4819231B1 (enExample) 1970-03-06 1973-06-12
US4365060A (en) 1979-04-28 1982-12-21 Shin-Etsu Chemical Co. Ltd. Enterosoluble capsules
JPS59167521A (ja) * 1983-03-14 1984-09-21 Shin Etsu Chem Co Ltd 腸溶性コ−テイング剤組成物
JP3149122B2 (ja) 1994-11-07 2001-03-26 信越化学工業株式会社 固形腸溶製剤のコーティング用基剤
JPH10167959A (ja) * 1996-12-04 1998-06-23 Zensei Yakuhin Kogyo Kk ジクロフェナクナトリウムの徐放性カプセル製剤
EP0872233A1 (en) 1997-04-14 1998-10-21 Janssen Pharmaceutica N.V. Antiretroviral compositions with improved bioavailability
ATE364374T1 (de) 1997-08-11 2007-07-15 Pfizer Prod Inc Feste pharmazeutische dispersionen mit erhöhter bioverfügbarkeit
KR100387126B1 (ko) * 2001-04-19 2003-06-12 삼성정밀화학 주식회사 히드록시프로필메틸 셀룰로오스 프탈레이트의 분리정제방법
DE10141680B4 (de) * 2001-08-25 2004-02-26 Clariant Gmbh Verfahren zur Herstellung niederviskoser Celluloseether durch sauer-oxidativen Abbau von gemahlenen und getrockneten Celluloseethern
SI1517899T1 (sl) 2002-05-17 2008-02-29 Tibotec Pharm Ltd Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji
CN1681479A (zh) 2002-08-12 2005-10-12 辉瑞产品公司 半有序药物和聚合物的药物组合物
WO2005115330A2 (en) 2004-05-28 2005-12-08 Pfizer Products Inc. Pharmaceutical compositions with enhanced performance
KR101597992B1 (ko) * 2007-11-09 2016-02-26 유니온 카바이드 케미칼즈 앤드 플라스틱스 테크날러지 엘엘씨 초저점도 셀룰로스 에테르의 제조 방법 및 생성물
US8920553B2 (en) 2007-11-09 2014-12-30 Dow Global Technologies Llc Cellulose ether coating compositions and method
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JP2015512456A (ja) 2012-03-27 2015-04-27 ダウ グローバル テクノロジーズ エルエルシー セルロースエーテルのエステルの製造方法
EP2836205B1 (en) * 2012-04-11 2016-10-19 Dow Global Technologies LLC Esterified cellulose ethers having a specific substituent distribution
KR102138545B1 (ko) * 2012-08-24 2020-07-28 다우 글로벌 테크놀로지스 엘엘씨 고분자량 및 높은 균일성을 갖는 신규한 에스테르화된 셀룰로즈 에테르
US9745387B2 (en) * 2012-08-24 2017-08-29 Dow Global Technologies Llc Partially cross-linked esterified cellulose ethers
JP6215945B2 (ja) 2012-08-24 2017-10-18 ダウ グローバル テクノロジーズ エルエルシー 新規ヒドロキシアルキルメチルセルロースアセテートサクシネート

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226981A (en) * 1977-09-28 1980-10-07 Shin-Etsu Chemical Co., Ltd. Ether-ester derivatives of cellulose and their applications
EP0219426A2 (en) * 1985-10-07 1987-04-22 Shin-Etsu Chemical Co., Ltd. A method for the preparation of an acidic dicarboxylic acid ester of cellulose ether

Also Published As

Publication number Publication date
BR112015015846A2 (pt) 2017-07-11
JP2016516835A (ja) 2016-06-09
US20150376299A1 (en) 2015-12-31
CN105025887A (zh) 2015-11-04
US9617351B2 (en) 2017-04-11
KR20150119472A (ko) 2015-10-23
JP6267239B2 (ja) 2018-01-24
WO2014137778A1 (en) 2014-09-12
KR101661952B1 (ko) 2016-10-04
EP2964204B1 (en) 2017-01-04
EP2964204A1 (en) 2016-01-13

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Granted publication date: 20170728

Termination date: 20200228