CN105012767A - Orally-taken medicament for treating acute postinfectious glomerulonephritis and preparation method thereof - Google Patents
Orally-taken medicament for treating acute postinfectious glomerulonephritis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an orally-taken medicament for treating acute postinfectious glomerulonephritis. The orally-taken medicament is prepared from the following main raw materials in parts by weight: 3-8 parts of liquorice, 2-6 parts of radix sophorae flavescentis, 6-10 parts of cortex dictamni, 5-10 parts of lonicera japonica, 2-6 parts of portulaca oleracea, 3-7 parts of bletilla striata, 10-13 parts of cuscuta chinensis, 4-8 parts of the stir-fried root bark of the peony tree, 7-12 parts of spica prunellae, 3-5 parts of begonia fimbristipula, 8-14 parts of cynanchum otophyllum, 5-15 parts of mother-of-pearl and 5-13 parts of rhizoma imperatae. According to the orally-taken medicament for treating acute postinfectious glomerulonephritis, provided by the invention, the effects of bacteriostasis and control of hypertension are achieved, the raw material resources are easily available, the cost is low, the selected raw materials are mostly quite mild, and economical burden and physical burden of users are not increased after long-term use.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of medicinal preparation for oral administration for the treatment of acute postinfectious glomerulonephritis and preparation method thereof.
Background technology
Treatment acute postinfectious glomerulonephritis (acute post-infectious glomerulonephritis, APIGN) the one group of renal glomerular disease caused by Different Kinds of Pathogens infected by microbes is referred to, wherein most importantly acute poststreptococcal glomerulonephritis (acute poststreptococcalglomerulonephritis, APSGN).Typical clinical manifestation is acute nephritic syndrome (edema, hematuria, albuminuria, hypertension and renal function injury can appear in some patients), and pathological manifestations is proliferative lesion in blood capillary.APIGN is one of people's nephropathy of being familiar with the earliest.
Pathological manifestations: in general, APSGN is not the indication of Renal biospy, but in its atypical clinical manifestations or need because renal involvement is serious to get rid of cresentic nephritis row Renal biospy often.These atypical manifestations are as complement is normal, without provable recent streptococcal infection and renal insufficiencys such as ASO or the risings of streptozyme titre, especially GFR continued < 30 more than 1 week.Previous scholars recommends some to doubt to examine APSGN but the patient that C3 continues to decrease beyond 8 weeks carries out Renal biospy to get rid of membrano proliferative glomerulonephritis (MPGN).Although 5 routine patients have typical clinical symptoms to improve the recovery comprising albuminuria and renal function in a routine patient of research discovery 20, C3 recovered not yet after 8 weeks.In this 5 routine patient, 3 examples receive Renal biospy, still show as typical APSGN.Therefore, persistence hypocomplementemia can not get rid of the diagnosis of APSGN with the improvement of clinical symptoms, therefore can postpone Renal biospy for this part patient.Research subsequently also supports this viewpoint.Typical Renal biospy light microscopic shows as and fills the air endothelium and proliferation of mesangial cells and glomerulitis cellular infiltration.This blood capillary intraductal hyperplasia can cause the blocking in capillary loops chamber, causes renal insufficiency.Chung and Kim application cell proliferation marker Ki-67 finds, these cell proliferation are the infiltrations due to inflammatory cell.Major part APSGN patient is rare or without renal tubules, interstitial and vascular lesion.At comparatively several cases, epithelial crescent can be formed, but crescent to involve glomerule > more rare, the latter can show as radical property nephritis.Typical immunofluorescence type sees the Renal biospy of acute stage, shows as IgG and C3 and fills the air particulate deposits at blood vessel loop and mesangial region.Even but the early stage row Renal biospy of the course of disease still have an appointment 30% APSGN only have C3 and without the deposition of IgG.Sorger etc. describe typical immunofluorescence type with " starry sky type ", and " garland type " describes serious and continuous print capillary loops deposition and deposit without mesangial region.This " garland type " is relevant with the albuminuria of more and larger epithelial side hump and higher degree.But the pass between this and serious albuminuria ties up in the research reported at first between latter 20 years and is not proved.Significant pathological changes under Electronic Speculum is epithelial side hump, and the latter is found in 1962 by Kinnelstiel first time.But electron-dense thing also may betide in interior subcutaneous and film, and this deposition can not get rid of APSGN.
Treatment acute postinfectious glomerulonephritis common on market be mostly hormone medicine, easily can cause stimulation to stomach to new child and the serious patient of nephritis, increase the weight of the state of an illness.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of medicinal preparation for oral administration for the treatment of acute postinfectious glomerulonephritis, have antibacterial, control hypertensive effect, crude drug source of the present invention is easy to get, with low cost, selected raw material mostly be mild in medicine property and thing, life-time service also can not increase the burden on economy and health to user.
Another object of the present invention is just to provide the preparation method of the medicinal preparation for oral administration of above-mentioned treatment acute postinfectious glomerulonephritis.
Technical scheme of the present invention is:
Treat a medicinal preparation for oral administration for acute postinfectious glomerulonephritis, take off the primary raw material stating weight proportion and be prepared from: Radix Glycyrrhizae 3-8 part, Radix Sophorae Flavescentis 2-6 part, Cortex Dictamni 6-10 part, Flos Lonicerae 5-10 part, Herba portulacae 2-6 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-7 part, Semen Cuscutae 10-13 part, Cortex Moutan (stir-fry) 4-8 part, Spica Prunellae 7-12 part, Radix Semiaquilegiae 3-5 part, Radix Cynanchi Otophylli 8-14 part, Concha Margaritifera 5-15 part, Rhizoma Imperatae 5-13 part.
Treat a medicinal preparation for oral administration for acute postinfectious glomerulonephritis, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Glycyrrhizae 4-7 part, Radix Sophorae Flavescentis 3-5 part, Cortex Dictamni 7-9 part, Flos Lonicerae 6-9 part, Herba portulacae 3-5 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 part, Semen Cuscutae 11-12 part, Cortex Moutan (stir-fry) 5-7 part, Spica Prunellae 9-11 part, Radix Semiaquilegiae 3.5-4.5 part, Radix Cynanchi Otophylli 10-12 part, Concha Margaritifera 8-13 part, Rhizoma Imperatae 8-10 part.
Treat a medicinal preparation for oral administration for acute postinfectious glomerulonephritis, more preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: 5.5 parts, Radix Glycyrrhizae, Radix Sophorae Flavescentis 4 parts, Cortex Dictamni 8 parts, Flos Lonicerae 7.5 parts, Herba portulacae 4 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Semen Cuscutae 11.5 parts, Cortex Moutan (stir-fry) 6 parts, Spica Prunellae 10 parts, Radix Semiaquilegiae 4 parts, Radix Cynanchi Otophylli 11 parts, Concha Margaritifera 11 parts, Rhizoma Imperatae 9 parts.
The preparation method of the medicinal preparation for oral administration of above-mentioned treatment acute postinfectious glomerulonephritis, step is as follows:
(1) fresh white Rhizoma Imperatae is cut off fibrous root, clean, cutting, it is stand-by to be pounded thick liquid;
(2) Herba portulacae is rinsed well, be cut into filament, be pounded thick liquid and add Mel and mix thoroughly stand-by;
(3) by Radix Glycyrrhizae, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Cuscutae, Cortex Moutan (stir-fry), Spica Prunellae, Radix Semiaquilegiae, Radix Cynanchi Otophylli and Concha Margaritifera cleaning 2-6 time, be placed in container, add raw material weight 3-7 clear water doubly, 20-40 minute is soaked in sealing, filters, filtering residue adds the warm water of 30-40 DEG C, big fire decocts to boiling, after boiling 2-6 minute, turns slow fire boiling 40-60 minute, filter, filtrate is stand-by;
(4) step (3) gained filtering residue is added the clear water of 0-4 DEG C, little fire simmers 1-3 hour slowly, filters, obtains filtrate;
(5) step (3) and step (4) gained filtrate are mixed, leave standstill 2-4 hour, obtain supernatant;
(6) step (5) gained supernatant is put into marmite, big fire is heated to rapidly boiling, put into step (1) and (2) gained crude drug, decoct while slow fire boiling 5-10 minute, cross 160-200 order drainage screen, cool bottling and namely obtain medicinal preparation for oral administration.
Above-mentioned preparation method, step (3) is by Radix Glycyrrhizae, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Cuscutae, Cortex Moutan (stir-fry), Spica Prunellae, Radix Semiaquilegiae, Radix Cynanchi Otophylli and Concha Margaritifera cleaning 3-5 time (preferred, Radix Glycyrrhizae, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Cuscutae, Cortex Moutan (stir-fry), Spica Prunellae, Radix Semiaquilegiae, Radix Cynanchi Otophylli and Concha Margaritifera are cleaned 4 times).
Above-mentioned preparation method, step (3) adds raw material weight 4-6 clear water doubly, and sealing is soaked 25-35 minute (preferred, to add the clear water of raw material weight 5 times, sealing immersion 30 minutes).
Above-mentioned preparation method, step (3) filtering residue adds the warm water of 33-38 DEG C, big fire decocts to boiling, after boiling 3-5 minute, (preferred, filtering residue adds the warm water of 35 DEG C, and big fire decocts to boiling to turn slow fire boiling 45-55 minute, until boiling after 4 minutes, turn slow fire boiling 50 minutes).
Above-mentioned preparation method, step (4) filtering residue adds the clear water of 1-3 DEG C, and 1.5-2.5 hour (preferred, filtering residue adds the clear water of 2 DEG C, and little fire simmers 2 hours slowly) simmered slowly by little fire.
Above-mentioned preparation method, step (5) leaves standstill 2.5-3.5 hour, obtains supernatant (preferred, to leave standstill 3 hours, obtain supernatant).
Above-mentioned preparation method, step (6) decocts slow fire boiling 6-9 minute, crosses 170-190 order drainage screen (preferred, to decoct while slow fire boiling 8 minutes, 180 order drainage screens excessively).
Best using method: for making this medicine reach optimum therapeuticing effect, get medicinal preparation for oral administration 3-5ml of the present invention, the morning, noon and afternoon respectively once, 5 days are a course for the treatment of at every turn.
The pharmacological effect of each crude drug is respectively:
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae has the effect of similar adrenocortical hormone sample.Inhibitory action is had to the gastroxia that histamine causes; And have antiacid and alleviate the effect of gastrointestinal smooth muscle spasm.Licoflavone, Radix Glycyrrhizae extractum and enoxolone all have obvious antitussive effect; Phlegm-dispelling functions is also comparatively remarkable, and its action intensity is glycyrrhizic acid > licoflavone > Radix Glycyrrhizae extractum.Radix Glycyrrhizae also has antiinflammatory, anti-allergic effects, can protect throat and the tunica mucosa tracheae of inflammation.Radix Glycyrrhizae extractum and glycyrrhizic acid have the Detoxication of similar glucuronic acid to some poisonous substance.Radix Glycyrrhizae is commonly used to treat the symptom come with climacteric. because containing glycyrrhizin in Radix Glycyrrhizae, be a kind of compound of similar hormone, it contributes to balancing the hormone-content in women's body.Subacid contained by Radix Glycyrrhizae can block the effect of Induced by Carcinogen tumor growth.Pericarpium Citri Reticulatae: nature and flavor: bitter in the mouth, pungent, warm in nature.Gui Jing: return lung, spleen channel.Effect: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Cure mainly for distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Radix Sophorae Flavescentis: it is bitter, cold.There is heat clearing and damp drying, parasite killing, the merit of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.
Cortex Dictamni: another name: northern Cortex Dictamni, moss skin, pericarpium Zanthoxyli root bark, smelly root bark.Nature and flavor: bitter; Salty; Cold.Gui Jing: spleen channel; Lung meridian; Small intestine meridian; Stomach warp; Urinary bladder channel.Function: heat clearing and damp drying; Dispelling wind for relieving itching; Removing toxic substances.Cure mainly: the rubella caused by wind heat noxious dampness; Eczema; Scabies; Jaundice; Damp-heat arthralgia.
Flos Lonicerae: its effect mainly heat-clearing and toxic substances removing, cures mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle furunculosis etc.Modern study proves, Flos Lonicerae contains the pharmacological component such as chlorogenic acid, luteolin glycosides, stronger restraint is had to the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc., in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary, hypertension etc. more than 40 with other medicines compatibility and plant disease.
Herba portulacae: nature and flavor: cold in nature, sweet in the mouth acid.Gui Jing: enter heart channel, Liver Channel, spleen channel, large intestine channel.Function: heat-clearing and toxic substances removing, cooling blood for hemostasis.Cure mainly: pyretic toxicity dysentery, pyretic stranguria, urine retention, leucorrhea with red and white discharge, metrorrhagia, hemorrhoidal bleeding, skin infection carbuncle furuncle, erysipelas, scrofula, exudative dermatitis, in vain bald, dysentery (defecate half-dried half rare), toxic-heat and blood stasis, carbuncle furuncle, eczema, snake bite and insect sting, have blood in stool, metrostaxis, modern times are used for the treatment of enteritis, acute arthritis, cystitis, urethritis, anusitis, bleeding hemorrhoids etc. mostly.
The Pseudobulbus Bletillae (Rhizoma Bletillae): bitter in the mouth, sweet, puckery, cold in nature, returns lung, liver, stomach warp.Function cures mainly: astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
Semen Cuscutae: base is former: be the herb of Convolvulaceae Hellweed Semen Cuscutae.Composition: Semen Cuscutae is containing alkaloid, anthraquinone, coumarin, flavone, glycoside, sterol, tannic acid, saccharide etc.Flavonoid has: Quercetin, astragalin, hyperin; Sterols has: cholesterol, campesterol, cupreol, stigmasterol, β-Amyrin.Also trace element is contained as strontium, molybdenum, calcium, magnesium, ferrum, manganese, zinc, copper etc. and several amino acids (free amino acid in seed and the total amino acids after being hydrolyzed are 5.3%, and wherein the content of essential amino acids accounts for 42.8%).The property of medicine: micro-pungent, sweet, flat, nontoxic.Function cures mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.
Cortex Moutan (stir-fry): modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of Cortex Moutan has suppression Platelet; Paeonol has the effects such as central inhibitory action and atherosclerosis, diuresis, antiulcer such as calmness, cooling, antipyretic, analgesia, spasmolytic.
Spica Prunellae: stem, leaf, fringe and herb all have hypotensive effect, but the effect of fringe is more obvious; This product water decoction-alcohol sedimentation liquid mouse peritoneal is injected, and has obvious antiinflammatory action; This product decoct all has certain inhibitory action to dysentery bacterium, Bacillus typhi, vibrio cholera, escherichia coli, Bacillus proteus, staphylococcus and Bacillus tuberculosis in vitro.
Radix Semiaquilegiae: Radix Semiaquilegiae has another name called Radix Semiaquilegiae, blood skin dish, Herba Gynurae bicoloris, Radix seu Folium Alchorneae trewioidis, dichromatism Radix Gynurae, beautiful Folium Eriobotryae, YEXIAHONG etc.For Compositae Radix Gynurae belongs to perennial root evergreen herbage.The flavone battalion composition that Radix Semiaquilegiae contains, can extend ascorbic effect, be improved parasiticide and antiviral ability, and have certain anti-effect to tumor.In addition, hemoptysis, metrorrhagia, dysmenorrhea is treated in addition, effect of bronchitis, pelvic inflammatory disease, ameba, dysentery and trauma hemostasis.Often Radix Semiaquilegiae to be stopped blooding good medicine as one in south China area.
Radix Cynanchi Otophylli: Gui Jing: liver; Spleen; Kidney channel, function cures mainly: wind-damp dispelling; Yishen Jianpi stomach function regulating; Anthelmintic.Main air pain of dampness syndrome; Lumbago due to renal deficiency; Lumbar muscle strain; Falling winks frustrates; Food stagnation; Abdominal distention; Infantile malnutrition; Serpentis, lyssodexis
Concha Margaritifera: salty, cold.Return liver, heart channel, suppressing the hyperactive liver and subsiding YANG; To calm the nerves arresting convulsion; Liver heat removing and eyesight improving is investigated.Function cures mainly: suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, hemostasis.Control dizziness, tinnitus, cardiopalmus, insomnia, demented, infantile convulsion, spits blood, epistaxis, metrorrhagia.
Rhizoma Imperatae: return lung, stomach, urinary bladder channel.Effect cooling blood for hemostasis, clearing away heat and promoting diuresis.Cure mainly and spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, cough due to lung-heat, gastropyretic vomiting, jaundice due to damp-heat, edema oliguria, the puckery pain of pyretic stranguria.
The present invention treats the medicinal preparation for oral administration " more holistic " of acute postinfectious glomerulonephritis, both can cure the disease, and can keep fit again to prevent disease, and this is the large feature being different from Drug therapy.And the medicinal preparation for oral administration of this treatment acute postinfectious glomerulonephritis is prepared from according to Chinese medicine principle completely, more safe and reliable, without any side effects.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 one kinds treats the medicinal preparation for oral administration of acute postinfectious glomerulonephritis, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): 3 parts, Radix Glycyrrhizae, Radix Sophorae Flavescentis 2 parts, Cortex Dictamni 6 parts, Flos Lonicerae 5 parts, Herba portulacae 2 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3 parts, Semen Cuscutae 10 parts, Cortex Moutan (stir-fry) 4 parts, Spica Prunellae 7 parts, Radix Semiaquilegiae 3 parts, the Radix Paeoniae Alba 8 parts, Concha Margaritifera 5 parts, Rhizoma Imperatae 5 parts.
The preparation method of the medicinal preparation for oral administration of above-mentioned treatment acute postinfectious glomerulonephritis, step is as follows:
(1) fresh white Rhizoma Imperatae is cut off fibrous root, clean, cutting, it is stand-by to be pounded thick liquid;
(2) Herba portulacae is rinsed well, be cut into filament, be pounded thick liquid and add Mel and mix thoroughly stand-by;
(3) Radix Glycyrrhizae, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Cuscutae, Cortex Moutan (stir-fry), Spica Prunellae, Radix Semiaquilegiae, Radix Cynanchi Otophylli and Concha Margaritifera are cleaned 2 times, be placed in container, add the clear water of raw material weight 3 times, sealing immersion 20 minutes, filters, filtering residue adds the warm water of 30 DEG C, big fire decocts to boiling, until boiling after 2 minutes, turns slow fire boiling 40 minutes, filter, filtrate is stand-by;
(4) step (3) gained filtering residue is added the clear water of 0 DEG C, little fire simmers 1 hour slowly, filters, obtains filtrate;
(5) step (3) and step (4) gained filtrate are mixed, leave standstill 2 hours, obtain supernatant;
(6) step (5) gained supernatant is put into marmite, big fire is heated to rapidly boiling, puts into step (1) and (2) gained crude drug, decocts slow fire boiling 5 minutes, cross 160 order drainage screens, cool bottling and namely obtain medicinal preparation for oral administration.
Model case one: woods XX, female, 50 years old, people from Jiyang, Jinan City, Shandong Province, patient suffers from hypertension all the year round, and the often symptom of the appearance nephritis of unknown cause, sometimes drink water less or after finishing off beverage, there will be the symptom of oliguria or anuria, whenever such patient will take to boil water for Semen Coicis, take 2 symptoms can improve, but cure the symptoms, not the disease, drink water few, above-mentioned malaise symptoms returns at once and increases the weight of, after comprehensive inspection of having gone to hospital to do, be diagnosed as treatment acute postinfectious glomerulonephritis through doctor.
Take embodiment 2 gained oral formulations, take 2 days, the symptom of oliguria or anuria alleviates; Take 5 days, the malaise symptoms such as oliguria or anuria disappears, and blood pressure maintains balance; Continue to take 10 days, malaise symptoms disappears completely, has no side effect between the operating period.
Embodiment 2 one kinds treats the medicinal preparation for oral administration of acute postinfectious glomerulonephritis, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): 8 parts, Radix Glycyrrhizae, Radix Sophorae Flavescentis 6 parts, Cortex Dictamni 10 parts, Flos Lonicerae 10 parts, Herba portulacae 6 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 7 parts, Semen Cuscutae 13 parts, Cortex Moutan (stir-fry) 8 parts, Spica Prunellae 12 parts, Radix Semiaquilegiae 5 parts, the Radix Paeoniae Alba 14 parts, Concha Margaritifera 15 parts, Rhizoma Imperatae 13 parts.
The preparation method of the medicinal preparation for oral administration of above-mentioned treatment acute postinfectious glomerulonephritis, step is as follows:
(1) fresh white Rhizoma Imperatae is cut off fibrous root, clean, cutting, it is stand-by to be pounded thick liquid;
(2) Herba portulacae is rinsed well, be cut into filament, be pounded thick liquid and add Mel and mix thoroughly stand-by;
(3) Radix Glycyrrhizae, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Cuscutae, Cortex Moutan (stir-fry), Spica Prunellae, Radix Semiaquilegiae, Radix Cynanchi Otophylli and Concha Margaritifera are cleaned 6 times, be placed in container, add the clear water of raw material weight 7 times, sealing immersion 40 minutes, filters, filtering residue adds the warm water of 40 DEG C, big fire decocts to boiling, until boiling after 6 minutes, turns slow fire boiling 60 minutes, filter, filtrate is stand-by;
(4) step (3) gained filtering residue is added the clear water of 4 DEG C, little fire simmers 3 hours slowly, filters, obtains filtrate;
(5) step (3) and step (4) gained filtrate are mixed, leave standstill 4 hours, obtain supernatant;
(6) step (5) gained supernatant is put into marmite, big fire is heated to rapidly boiling, puts into step (1) and (2) gained crude drug, decocts slow fire boiling 10 minutes, cross 200 order drainage screens, cool bottling and namely obtain medicinal preparation for oral administration.
Embodiment 3 one kinds treats the medicinal preparation for oral administration of acute postinfectious glomerulonephritis, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): 4 parts, Radix Glycyrrhizae, Radix Sophorae Flavescentis 3 parts, Cortex Dictamni 7 parts, Flos Lonicerae 6 parts, Herba portulacae 3 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 4 parts, Semen Cuscutae 11 parts, Cortex Moutan (stir-fry) 5 parts, Spica Prunellae 9 parts, Radix Semiaquilegiae 3.5 parts, the Radix Paeoniae Alba 10 parts, Concha Margaritifera 8 parts, Rhizoma Imperatae 8 parts.
The preparation method of the medicinal preparation for oral administration of above-mentioned treatment acute postinfectious glomerulonephritis, step is as follows:
(1) fresh white Rhizoma Imperatae is cut off fibrous root, clean, cutting, it is stand-by to be pounded thick liquid;
(2) Herba portulacae is rinsed well, be cut into filament, be pounded thick liquid and add Mel and mix thoroughly stand-by;
(3) Radix Glycyrrhizae, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Cuscutae, Cortex Moutan (stir-fry), Spica Prunellae, Radix Semiaquilegiae, Radix Cynanchi Otophylli and Concha Margaritifera are cleaned 3 times, be placed in container, add the clear water of raw material weight 4 times, sealing immersion 25 minutes, filters, filtering residue adds the warm water of 33 DEG C, big fire decocts to boiling, until boiling after 3 minutes, turns slow fire boiling 45 minutes, filter, filtrate is stand-by;
(4) step (3) gained filtering residue is added the clear water of 1 DEG C, little fire simmers 1.5 hours slowly, filters, obtains filtrate;
(5) step (3) and step (4) gained filtrate are mixed, leave standstill 2.5 hours, obtain supernatant;
(6) step (5) gained supernatant is put into marmite, big fire is heated to rapidly boiling, puts into step (1) and (2) gained crude drug, decocts slow fire boiling 6 minutes, cross 170 order drainage screens, cool bottling and namely obtain medicinal preparation for oral administration.
Embodiment 4 one kinds treats the medicinal preparation for oral administration of acute postinfectious glomerulonephritis, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): 7 parts, Radix Glycyrrhizae, Radix Sophorae Flavescentis 5 parts, Cortex Dictamni 9 parts, Flos Lonicerae 9 parts, Herba portulacae 5 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 6 parts, Semen Cuscutae 12 parts, Cortex Moutan (stir-fry) 7 parts, Spica Prunellae 11 parts, Radix Semiaquilegiae 4.5 parts, the Radix Paeoniae Alba 12 parts, Concha Margaritifera 13 parts, Rhizoma Imperatae 10 parts.
The preparation method of the medicinal preparation for oral administration of above-mentioned treatment acute postinfectious glomerulonephritis, step is as follows:
(1) fresh white Rhizoma Imperatae is cut off fibrous root, clean, cutting, it is stand-by to be pounded thick liquid;
(2) Herba portulacae is rinsed well, be cut into filament, be pounded thick liquid and add Mel and mix thoroughly stand-by;
(3) Radix Glycyrrhizae, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Cuscutae, Cortex Moutan (stir-fry), Spica Prunellae, Radix Semiaquilegiae, Radix Cynanchi Otophylli and Concha Margaritifera are cleaned 5 times, be placed in container, add the clear water of raw material weight 6 times, sealing immersion 35 minutes, filters, filtering residue adds the warm water of 38 DEG C, big fire decocts to boiling, until boiling after 5 minutes, turns slow fire boiling 55 minutes, filter, filtrate is stand-by;
(4) step (3) gained filtering residue is added the clear water of 3 DEG C, little fire simmers 2.5 hours slowly, filters, obtains filtrate;
(5) step (3) and step (4) gained filtrate are mixed, leave standstill 3.5 hours, obtain supernatant;
(6) step (5) gained supernatant is put into marmite, big fire is heated to rapidly boiling, puts into step (1) and (2) gained crude drug, decocts slow fire boiling 9 minutes, cross 190 order drainage screens, cool bottling and namely obtain medicinal preparation for oral administration.
Model case two: Zou XX, man, 45 years old, Pingyin, Jinan City, Shandong Province personage, patient suffers from hypertension and has a surplus for 2 years, because dinner party is gone out in meeting that requirements of one's work are frequent, and the also hypertension of little attentional manipulation oneself at ordinary times, in addition frequent staying up late and indulging in excessive drinking in evening again, start to occur dizzy, vomiting, spitting of blood before first quarter moon, the symptom such as edema, anuria, eat the medicine 2 days of inducing diuresis to remove edema, malaise symptoms improves, recurrence after excessive drinking.
Take embodiment 4 gained oral formulations, use 2 days same day, dizzy, cardiopalmus, edema, anuria symptom alleviate, and use 10 days, and patient takes embodiment 4 gained oral formulations all the time, and resistance strengthens, and appetite is also cumulative, blood pressure stabilization.
Embodiment 5 one kinds treats the medicinal preparation for oral administration of acute postinfectious glomerulonephritis, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): 5.5 parts, Radix Glycyrrhizae, Radix Sophorae Flavescentis 4 parts, Cortex Dictamni 8 parts, Flos Lonicerae 7.5 parts, Herba portulacae 4 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Semen Cuscutae 11.5 parts, Cortex Moutan (stir-fry) 6 parts, Spica Prunellae 10 parts, Radix Semiaquilegiae 4 parts, the Radix Paeoniae Alba 11 parts, Concha Margaritifera 11 parts, Rhizoma Imperatae 9 parts.
The preparation method of the medicinal preparation for oral administration of above-mentioned treatment acute postinfectious glomerulonephritis, step is as follows:
(1) fresh white Rhizoma Imperatae is cut off fibrous root, clean, cutting, it is stand-by to be pounded thick liquid;
(2) Herba portulacae is rinsed well, be cut into filament, be pounded thick liquid and add Mel and mix thoroughly stand-by;
(3) Radix Glycyrrhizae, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Cuscutae, Cortex Moutan (stir-fry), Spica Prunellae, Radix Semiaquilegiae, Radix Cynanchi Otophylli and Concha Margaritifera are cleaned 4 times, be placed in container, add the clear water of raw material weight 5 times, sealing immersion 30 minutes, filters, filtering residue adds the warm water of 35 DEG C, big fire decocts to boiling, until boiling after 4 minutes, turns slow fire boiling 50 minutes, filter, filtrate is stand-by;
(4) step (3) gained filtering residue is added the clear water of 2 DEG C, little fire simmers 2 hours slowly, filters, obtains filtrate;
(5) step (3) and step (4) gained filtrate are mixed, leave standstill 3 hours, obtain supernatant;
(6) step (5) gained supernatant is put into marmite, big fire is heated to rapidly boiling, puts into step (1) and (2) gained crude drug, decocts slow fire boiling 8 minutes, cross 180 order drainage screens, cool bottling and namely obtain medicinal preparation for oral administration.
The clinical practice of medicinal preparation for oral administration of test example 1 embodiment 5 gained treatment acute postinfectious glomerulonephritis: we have randomly drawed 400 patients and have tested (400 patients have treatment acute postinfectious glomerulonephritis in various degree), be divided into experimental group and matched group, wherein female 200 example, man 200 example.Before test, carry out Continuous Observation to this crowd, record symptom and change, be divided into two groups, experimental group and matched group at random, and experimental group uses embodiment 5 products obtained therefrom, and matched group is only with the medicine for the treatment of acute postinfectious glomerulonephritis.
Using method: for making this medicine reach optimum therapeuticing effect, at every turn get medicinal preparation for oral administration 3-5ml of the present invention, the morning, noon and afternoon respectively once, 5 days are a course for the treatment of.
Curative effect situation criterion: 1, cure: use after this product, malaise symptoms all disappears, 2, effectively, after using this product, malaise symptoms alleviates or partial disappearance; 3, invalid, after using this product, malaise symptoms is unchanged.We have carried out accurate statistics and mathematical analysis to experimental data.Specific experiment result is as following table:
Table 1: two groups of Clinical efficacy comparison [example] tables 1
Table 1
Interpretation of result: experimental group and matched group all can reach within the observation period treats acute postinfectious glomerulonephritis effect, but the obvious effective rate of experimental group and total effective rate are apparently higher than matched group, and in matched group, have also appeared the case of untoward reaction, so the embodiment of the present invention 5 gained medicinal preparation for oral administration has significant curative effect in treatment acute postinfectious glomerulonephritis, and all select pure natural Raw through the suitable process of preparing Chinese medicine due to this product, easy to use, and it is without any side effects, also can not cause burden to nervous system, can not dependence and addiction be caused.
Claims (10)
1. treat a medicinal preparation for oral administration for acute postinfectious glomerulonephritis, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Radix Glycyrrhizae 3-8 part, Radix Sophorae Flavescentis 2-6 part, Cortex Dictamni 6-10 part, Flos Lonicerae 5-10 part, Herba portulacae 2-6 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-7 part, Semen Cuscutae 10-13 part, Cortex Moutan (stir-fry) 4-8 part, Spica Prunellae 7-12 part, Radix Semiaquilegiae 3-5 part, Radix Paeoniae Alba 8-14 part, Concha Margaritifera 5-15 part, Rhizoma Imperatae 5-13 part.
2. the medicinal preparation for oral administration for the treatment of acute postinfectious glomerulonephritis according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Radix Glycyrrhizae 4-7 part, Radix Sophorae Flavescentis 3-5 part, Cortex Dictamni 7-9 part, Flos Lonicerae 6-9 part, Herba portulacae 3-5 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 4-6 part, Semen Cuscutae 11-12 part, Cortex Moutan (stir-fry) 5-7 part, Spica Prunellae 9-11 part, Radix Semiaquilegiae 3.5-4.5 part, Radix Paeoniae Alba 10-12 part, Concha Margaritifera 8-13 part, Rhizoma Imperatae 8-10 part.
3. the medicinal preparation for oral administration for the treatment of acute postinfectious glomerulonephritis according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: 5.5 parts, Radix Glycyrrhizae, Radix Sophorae Flavescentis 4 parts, Cortex Dictamni 8 parts, Flos Lonicerae 7.5 parts, Herba portulacae 4 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Semen Cuscutae 11.5 parts, Cortex Moutan (stir-fry) 6 parts, Spica Prunellae 10 parts, Radix Semiaquilegiae 4 parts, the Radix Paeoniae Alba 11 parts, Concha Margaritifera 11 parts, Rhizoma Imperatae 9 parts.
4. the preparation method of the medicinal preparation for oral administration of the treatment acute postinfectious glomerulonephritis according to any one of claim 1-3, is characterized in that: step is as follows:
(1) fresh white Rhizoma Imperatae is cut off fibrous root, clean, cutting, it is stand-by to be pounded thick liquid;
(2) Herba portulacae is rinsed well, be cut into filament, be pounded thick liquid and add Mel and mix thoroughly stand-by;
(3) by Radix Glycyrrhizae, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Cuscutae, Cortex Moutan (stir-fry), Spica Prunellae, Radix Semiaquilegiae, Radix Cynanchi Otophylli and Concha Margaritifera cleaning 2-6 time, be placed in container, add raw material weight 3-7 clear water doubly, 20-40 minute is soaked in sealing, filters, filtering residue adds the warm water of 30-40 DEG C, big fire decocts to boiling, after boiling 2-6 minute, turns slow fire boiling 40-60 minute, filter, filtrate is stand-by;
(4) step (3) gained filtering residue is added the clear water of 0-4 DEG C, little fire simmers 1-3 hour slowly, filters, obtains filtrate;
(5) step (3) and step (4) gained filtrate are mixed, leave standstill 2-4 hour, obtain supernatant;
(6) step (5) gained supernatant is put into marmite, big fire is heated to rapidly boiling, put into step (1) and (2) gained crude drug, decoct while slow fire boiling 5-10 minute, cross 160-200 order drainage screen, cool bottling and namely obtain medicinal preparation for oral administration.
5. preparation method according to claim 4, it is characterized in that: step (3) is by Radix Glycyrrhizae, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Cuscutae, Cortex Moutan (stir-fry), Spica Prunellae, Radix Semiaquilegiae, Radix Cynanchi Otophylli and Concha Margaritifera cleaning 3-5 time (preferred, Radix Glycyrrhizae, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Cuscutae, Cortex Moutan (stir-fry), Spica Prunellae, Radix Semiaquilegiae, Radix Cynanchi Otophylli and Concha Margaritifera are cleaned 4 times).
6. preparation method according to claim 4, is characterized in that: step (3) adds raw material weight 4-6 clear water doubly, and sealing is soaked 25-35 minute (preferred, to add the clear water of raw material weight 5 times, sealing immersion 30 minutes).
7. preparation method according to claim 4, it is characterized in that: step (3) filtering residue adds the warm water of 33-38 DEG C, big fire decocts to boiling, after boiling 3-5 minute, (preferred, filtering residue adds the warm water of 35 DEG C, and big fire decocts to boiling to turn slow fire boiling 45-55 minute, until boiling after 4 minutes, turn slow fire boiling 50 minutes).
8. preparation method according to claim 4, is characterized in that: step (4) filtering residue adds the clear water of 1-3 DEG C, and 1.5-2.5 hour (preferred, filtering residue adds the clear water of 2 DEG C, and little fire simmers 2 hours slowly) simmered slowly by little fire.
9. preparation method according to claim 4, is characterized in that: step (5) leaves standstill 2.5-3.5 hour, obtains supernatant (preferred, to leave standstill 3 hours, obtain supernatant).
10. preparation method according to claim 4, it is characterized in that: step (6) decocts slow fire boiling 6-9 minute, cross 170-190 order drainage screen (preferred, to decoct slow fire boiling 8 minutes, cross 180 order drainage screens).
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| CN102671067A (en) * | 2012-05-18 | 2012-09-19 | 宋协勘 | Chinese medicament for treating acute glomerulonephritis |
| CN102895550A (en) * | 2012-11-15 | 2013-01-30 | 李凯 | Traditional Chinese medicine for treating glomerulonephritis |
| CN104173878A (en) * | 2014-09-02 | 2014-12-03 | 张震 | Traditional Chinese medicine for treating acute glomerulonephritis |
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| CN102671067A (en) * | 2012-05-18 | 2012-09-19 | 宋协勘 | Chinese medicament for treating acute glomerulonephritis |
| CN102895550A (en) * | 2012-11-15 | 2013-01-30 | 李凯 | Traditional Chinese medicine for treating glomerulonephritis |
| CN104173878A (en) * | 2014-09-02 | 2014-12-03 | 张震 | Traditional Chinese medicine for treating acute glomerulonephritis |
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