CN104740024A - Antibacterial antipruritic traditional Chinese medicine lotion for treating pruritus vulvae and preparation method thereof - Google Patents
Antibacterial antipruritic traditional Chinese medicine lotion for treating pruritus vulvae and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an antibacterial antipruritic traditional Chinese medicine lotion for treating pruritus vulvae and a preparation method thereof. The antibacterial antipruritic traditional Chinese medicine lotion is prepared from the following main raw materials in parts by weight: 1-5 parts of calamine, 6-12 parts of fructus cnidii, 5-15 parts of Semen Cuscutae, 6-16 parts of tropic ageratum herb, 2-4 parts of white shell, 5-13 parts of giant knot weed, 10-20 parts of pepper, 8-20 parts of indigo naturalis, 7-14 parts of mother chrysanthemum, 4-8 parts of fructus forsythia, 8-14 parts of honeysuckle and 6-15 parts of radix sophorae flavescentis. Based on the traditional Chinese medicine pruritus vulvae treating theory, the traditional Chinese medicine materials have the sterilizing, relieving itching and anti-inflammatory functions so that the pruritus vulvae symptom of a user can be rapidly relieved; the lotion is low in cost, cannot cause the financial burden to a patient and is an ideal medicine for treating the pruritus vulvae.
Description
Technical field
The invention belongs to traditional Chinese medicine field, especially relate to a kind of bacterio static itching-relieving Chinese medicine lotion for the treatment of pruritus vulvae and preparation method thereof.
Background technology
Pruritus vulvae is a kind of symptom caused by the various different lesions of pudendum, is the general designation of labia, anus, this three places pruritus of scrotum.But also can betide the completely normal person of pudendum, when pruritus increases the weight of, the many uneasy in either sitting or lying of patient, so that affect live and work.Pruritus vulvae multidigit is in clitoris, nympha. also can involve labium majus, the perineum even skin lesion district such as crissum. and scratch for a long time and can occur scratch, blood crusts or secondary folliculitis.Pruritus vulvae is divided into light middle heavy by the order of severity: can feel to have time slight and itch, but can not bring too much influence to life and work; Certain impact is brought on your life, work; Can affect your normal life and work when having more serious again, even evening, sleep was all not sleep well for you, and this is exactly especially severe.Pruritus vulvae is not a kind of self-existent disease, and it is permitted a symptom of various diseases often, but sometimes also may can not find what reason, just simple pruritus., it but occurs whenever and wherever possible, itches and people is on tenterhooks, can't fall asleep, bring the suffering of feeling embarrassed to mention to women.Every day washes pudendum by Feminine care solution and can safeguard pudendum self-cleaning function, solves the unknown cause of pruritus vulvae.The main causes for causing a disease such as the traditional Chinese medical science is thought, ailment said due to cold or exposure, damp, pathogenic heat, blood deficiency, worm are excessive, treatment should with damp eliminating, heat-clearing and toxic substances removing, blood enriching and dryness moistening, blood circulation promoting and blood stasis dispelling for principle, to reach the antipruritic effect of righting of getting rid of evils.
The local cause that pruritus vulvae produces, common are: 1, modal local cause is leucorrhoea grow in quantity, especially the vaginitis caused by infusorian or fungal infection and nonspecific vaginitis, the leucorrhea of a large amount of exception of discharging stimulates external genital, and pudendum is itched; If 2 place some dripping of irritant drugs with sterilization medicinal liquid rinsing vulva, vagina or intravaginal, cause drug allergy, chemical irritation causes pudendum part skin allergy or generation dermatitis, causes pudendum to itch.Pudendum more can safeguard pudendum self-cleaning function with the cleaning of Ph4 weak acid formula Feminine care solution; 3, do not pay attention to sanitation and hygiene menstrual period, the sanitary towel used is unclean or irritant, causes menses or vaginal secretions to lodge in external genital for a long time, or wears chemical fibre underwear and the bad panty hose of breathability at ordinary times, external genital is often in wet with the environment of heat, pudendum often can be caused scratchy; 4, somebody is through the stronger soap of conventional alkalescence or potassium permanganate solution cleaning pudendum, causes skin of vulva dry, lacks oils and fats and itch; 5, suffer from the people of enterobiasis, because pinworm is usually climbed out of by anus, and stimulate perianal and external genital, and cause pruritus, especially to attach most importance to night, even affect sleep; 6, pruritus in various degree can not only be caused by vulval eczema, neurodermatitis, atrophic sclerosis lichen, dermatitis vulvae etc., the pudendum part skin change that also may have bleaching in various degree, atrophy or thicken simultaneously; 7, the advanced symptoms of carcinoma vulvae also has pruritus vulvae, somebody in pruritus for many years after, there occurs carcinoma vulvae.
The symptom of pruritus vulvae and feature: be often paroxysmal outbreak, also to can be persistence, general aggravation at night, causeless pruritus vulvae generally occurs over just childbearing age or postmenopausal women, involve whole external genital more, but also only may be confined to certain portion or one-sided pudendum, but local skin and mucosa outward appearance are normally, or only have because of the excessively scratch occurred of scratching.VVC, trichomonal vaginitis one pruritus vulvae, leucorrhoea grow in quantity are cardinal symptom.Vulva squamous epithelial proliferation is very itched as cardinal symptom, with skin of vulva depigmentation with pudendum.The pruritus vulvae that enterobiasis causes with night for very.The external cloudy skin irritation of patient's glucose in urine of diabetes, particularly during concurrent VVC, the special inflammation of pruritus vulvae, is even difficult to stand, but local skin and mucosa outward appearance are normally, or only has because of the excessively scratch occurred and the blood crusts of scratching.Jaundice, vitamin A, B lack, and when itching of vulva appears in anemia, leukemia chronic diseases patient, are often a part for whole body pruritus.In trimester of pregnancy liver and gall also can there is the whole skin pruritus comprising pudendum in cholestasis.
In the medicine of existing treatment pruritus vulvae, application publication number CN 103223110 A (application number 201310177921.0) patent discloses a kind of external medicine composition for the treatment of women's pudendal pruritus, it is characterized in that: it is formulated by the raw material of Chinese medicine of following weight, Rhizoma Picrorhizae 150 grams, Herb Polygoni Chinensis 150 grams, Rhizoma Dioscoreae Cirrhosae 150 grams, Herba Senecionis Scandentis 160 grams, Fructus Adinae 150 grams, Herba polygoni hydropiperis 120 grams, Folium Cleistocalycis Operculati 200 grams, Oletum Trogopterori 100 grams, Radix Ardisiae Crenatae 120 grams, salt efflorescence cypress 120 grams, the Radix Astragali 120 grams, Radix Angelicae Sinensis 120 grams, Rhizoma Polygonati 120 grams, Fructus Psoraleae 120 grams, Semen Cuscutae 120 grams, Radix Codonopsis Lanceolatae 120 grams, sudden Rhizoma panacis majoris 120 grams, Fructus Corni 100 grams, Fructus Schisandrae Chinensis 120 grams, Fructus Mume 120 grams, Pericarpium Granati 120 grams, Radix seu Folium Tetracerae asiaticae stem and leaf 200 grams, Herba Oxalidis Corniculatae 120 grams, Cortex Garciniae 120 grams, lantana branch and leaf 200, Fructus Evodiae 120 grams, Flos Caryophylli 120 grams, Herba Menthae 120 grams.Application publication number CN 102755577 A (application number 201210257897.7) patent discloses a kind of Chinese medicine lotion for the treatment of pudendal pruritus, it is characterized in that: be made up of the crude drug of following weight portion: Radix Sophorae Flavescentis 15-45 part, Cortex Phellodendri 5-15 part, Rhizoma Atractylodis 5-15 part, Radix Stemonae 10-30 part, Pericarpium Zanthoxyli 5-15 part, Alumen 5-15 part, Fructus Cnidii 10-30 part, ZHIXIAO 5-15 part, Radix Angelicae Dahuricae 5-15 part, Folium Artemisiae Argyi 10-30 part.
As can be seen here, Chinese medicine occupies the status of very Chinese medicine in pruritus vulvae preparing, but in existing technology, great majority are external-use lotions, and major part is being cleaned after being all through water dilution, and drug effect weakens, not as a good drug efficacy of cleaning with medicinal liquid.
Summary of the invention
For the present situation of existing treatment pruritus vulvae deficiency, an object of the present invention is to provide a kind of bacterio static itching-relieving Chinese medicine lotion for the treatment of pruritus vulvae, there is feature that is easy to operate, evident in efficacy, that have no side effect, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of the bacterio static itching-relieving Chinese medicine lotion of above-mentioned treatment pruritus vulvae.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a bacterio static itching-relieving Chinese medicine lotion for pruritus vulvae, take off the primary raw material stating weight proportion and be prepared from: Calamina 1-5 part, Fructus Cnidii 6-12 part, Semen Cuscutae 5-15 part, Herba Agerati Conyzoidis 6-16 part, white shellfish 2-4 part, Rhizoma Polygoni Cuspidati 5-13 part, Pericarpium Zanthoxyli 10-20 part, Indigo Naturalis 8-20 part, Flos Chrysanthemi Indici 7-14 part, Fructus Forsythiae 4-8 part, Flos Lonicerae 8-14 part, Radix Sophorae Flavescentis 6-15 part.
Treat a bacterio static itching-relieving Chinese medicine lotion for pruritus vulvae, optimum ratio, take off the primary raw material stating weight proportion and be prepared from: Calamina 2-4 part, Fructus Cnidii 8-10 part, Semen Cuscutae 8-13 part, Herba Agerati Conyzoidis 10-12 part, white shellfish 2.5-3.5 part, Rhizoma Polygoni Cuspidati 8-10 part, Pericarpium Zanthoxyli 13-18 part, Indigo Naturalis 12-16 part, Flos Chrysanthemi Indici 9-12 part, Fructus Forsythiae 5-7 part, Flos Lonicerae 10-12 part, Radix Sophorae Flavescentis 9-11 part.
Treat a bacterio static itching-relieving Chinese medicine lotion for pruritus vulvae, better preferred proportioning, take off the primary raw material stating weight proportion and be prepared from: Calamina 3 parts, Fructus Cnidii 9 parts, Semen Cuscutae 11.5 parts, Herba Agerati Conyzoidis 11 parts, white shellfish 3 parts, Rhizoma Polygoni Cuspidati 9 parts, 15 parts, Pericarpium Zanthoxyli, Indigo Naturalis 14 parts, Flos Chrysanthemi Indici 10.5 parts, Fructus Forsythiae 6 parts, Flos Lonicerae 11 parts, Radix Sophorae Flavescentis 10 parts.
The preparation method of above-mentioned treatment pruritus vulvae bacterio static itching-relieving Chinese medicine lotion, step is as follows:
(1) Calamina and Bai Bei are cleaned 1-5 time, towel off clean, tie down Calamina and Bai Bei with iron wire, it is crisp to be placed in fire door forging, dries in the air coolly to grind to form smalls, crosses 80-120 mesh sieve stand-by;
(2) Pericarpium Zanthoxyli is cleaned, be placed in crock, with Pericarpium Zanthoxyli 2-4 white vinegar doubly, soak 50-70 minute, add white vinegar weight 4-6 clear water doubly, heating 20-40 minute, takes out Pericarpium Zanthoxyli with strainer, be exposed to the sun under being placed in daylight 5-7 days, and it is stand-by to grind to form smalls, and filtrate is for subsequent use;
(3) Fructus Cnidii, Semen Cuscutae, Herba Agerati Conyzoidis, Rhizoma Polygoni Cuspidati, Flos Chrysanthemi Indici, Fructus Forsythiae, Flos Lonicerae and Radix Sophorae Flavescentis are joined in step (2) gained filtrate, big fire decocts to boiling, after boiling 2-7 minute, filter, obtain filtrate 1, filtering residue 60-90% ethanol extraction 3 times, 2 hours first times, remaining twice 1 hour, merge alcohol extract and mix with filtrate 1, obtaining mixed liquor;
(4) step (1), (2) gained smalls are added the mid-water-bath of step (3) gained mixed liquor heats 10-20 minute after add Indigo Naturalis, heating is stopped after Indigo Naturalis melting, abundant stirring 3-6 minute, ultraviolet sterilization 3-7 minute, bottle and get final product.
The preparation method of above-mentioned bacterio static itching-relieving Chinese medicine lotion, Calamina and Bai Bei are cleaned 2-4 all over (preferred, Calamina and Bai Bei are cleaned 3 times) by step (1).
The preparation method of above-mentioned bacterio static itching-relieving Chinese medicine lotion, step (2), with Pericarpium Zanthoxyli 2.5-3.5 white vinegar doubly, is soaked 55-65 minute (preferred, with the white vinegar of 3 times, Pericarpium Zanthoxyli, to soak 60 minutes).
The preparation method of above-mentioned bacterio static itching-relieving Chinese medicine lotion, step (2) adds white vinegar weight 4.5-5.5 clear water doubly, heats 25-35 minute (preferred, to add the clear water of white vinegar weight 5 times, heat 30 minutes).
The preparation method of above-mentioned bacterio static itching-relieving Chinese medicine lotion, step (3) big fire decocts to boiling, after boiling 3-6 minute, filters (preferred, big fire decocts to boiling, until boiling after 5 minutes, filters).
The preparation method of above-mentioned bacterio static itching-relieving Chinese medicine lotion, step (3) filtering residue 70-80% ethanol extraction 3 times (preferably, filtering residue 75% ethanol extraction 3 times).
The preparation method of above-mentioned bacterio static itching-relieving Chinese medicine lotion, adds Indigo Naturalis (preferred, the mid-water-bath of gained mixed liquor to be heated after 15 minutes and add Indigo Naturalis) after the mid-water-bath of step (4) gained mixed liquor heats 13-18 minute.
Using method: for making the present invention reach optimum therapeuticing effect, the lotion prepared, directly clean pudendum position, fungistatic effect is relatively good, within 3 days, is a course for the treatment of.
Treat a bacterio static itching-relieving Chinese medicine lotion for pruritus vulvae, the pharmacological effect of each crude drug is respectively:
Calamina: base is former: be carbonate calcite race's minerals smithsonite or carbonate mineral marionite.Composition: 1. Calamina is mainly old is zinc carbonate, still containing small amounts calcium 0.27%, magnesium oxide 0.45%, ferrum oxide 0.58%, manganese oxide 0.01%.Wherein zinc is often by a small amount of ferrum (bivalence) is replaced.What have still contains a small amount of cobalt, copper, cadmium, lead etc.2. Calamina main component of swimming is basic zinc carbonate, and leaded, the magazine such as cadmium, magnesium, ferrum, aluminum.The property of medicine: sweet, flat.Return liver, spleen, lung meridian.Function cures mainly: improving eyesight removing nebula, and removing dampness is antipruritic, expelling pus and promoting granulation.Cure mainly conjunctival congestion and swelling pain, marginal blepharitis eye, many tear photophobia, nebula film bulbar conjunctiva polyp, ulcer being unable to heal, skin eczema, pudendum pruritus due to damp pathogen.
Fructus Cnidii: nature and flavor: warm in nature, bitter in the mouth.Function cures mainly: warming the kidney to invigorate YANG, and dampness is dispeled the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.
Semen Cuscutae: base is former: be the herb of Convolvulaceae Hellweed Semen Cuscutae.Composition: Semen Cuscutae is containing alkaloid, anthraquinone, coumarin, flavone, glycoside, sterol, tannic acid, saccharide etc.Flavonoid has: Quercetin, astragalin, hyperin; Sterols has: cholesterol, campesterol, cupreol, stigmasterol, β-Amyrin.Also trace element is contained as strontium, molybdenum, calcium, magnesium, ferrum, manganese, zinc, copper etc. and several amino acids (free amino acid in seed and the total amino acids after being hydrolyzed are 5.3%, and wherein the content of essential amino acids accounts for 42.8%).The property of medicine: micro-pungent, sweet, flat, nontoxic.Function cures mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.
Herba Agerati Conyzoidis: be the herb of Compositae Ageratum plant Ageratum conyzoides.Composition: herb contains flavonoid, alkaloid, triterpenoid compound, volatile oil.Aerial parts I have chromene class.Pharmacology: have stimulation to cardiac muscle, has inhibitory action to smooth muscle, has the effect of anti-inflammatory and antalgic, has antibacterial effect.The property of medicine: micro-hardship, pungent, cool.Function cures mainly: heat-clearing and toxic substances removing, hemostasis, pain relieving.
White shellfish: base is former: for dotey can belong to the shell of animal Cypraeamoneta, ring grain Cypraeamoneta etc. by Cypraeamoneta.Composition: ring grain Cypraeamoneta shell is containing high amount of acids acidic amino acid.All containing calcium carbonate, macroelement sodium, potassium, magnesium, aluminum, ferrum etc., trace element strontium, phosphorus, titanium, lead, pungent etc., and containing about 14 kinds aminoacid, what wherein content was larger has aspartic acid, glutamic acid.The property of medicine: salty, cool.Return bladder, Liver Channel.Function cures mainly: clearing away heat and promoting diuresis, improving acuity of vision and removing nebula.Cure mainly aqueous vapor edema, drench pain hematuria, urinary obstruction, cataracta of looking unfamiliar, nasal sinusitis pus and blood, the primary sore erosion of vulva.
The effects such as Indigo Naturalis: nature and flavor are salty-cold, has heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, pathogenic fire purging arresting convulsion.It is mainly used in epidemic febrile disease intenseness of heat, macule, and spit blood, spit blood, pharyngalgia aphtha, pediatric epilepsy scared, skin ulcer swells, erysipelas, snake bite and insect sting etc.
Pericarpium Zanthoxyli: return spleen, stomach, kidney channel.Effect warming middle-JIAO to relieve pain, killing parasites for relieving itching.Cure mainly for coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation; External: eczema, pudendal pruritus.
Rhizoma Polygoni Cuspidati: there is dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, effect of relieving cough and resolving phlegm.For jaundice due to damp-heat, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, burn due to hot liquid or fire, amenorrhea, lump in the abdomen, instep plays damage, cough due to lung-heat.
Flos Chrysanthemi Indici: the leaf of Herba Dendranthematis indici, flower and all herbal medicine.Bitter in the mouth, pungent, cool, heat-clearing and toxic substances removing, wind-dispelling heat-dissipating, dissipating blood stasis, improving eyesight, blood pressure lowering.Prevent and treat epidemic cerebrospinal meningitis, prevention influenza, flu, treatment hypertension, hepatitis, dysentery, carbuncle furuncle treatment skin ulcer have positive effect.The immersion of Flos Chrysanthemi Indici is to killing wriggler and fly larvae is also very effective.
Fructus Forsythiae: bitter, cool, heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.
Flos Lonicerae: Flos Lonicerae, having another name called Radix Ophiopogonis " Flos Lonicerae " one comes from Compendium of Material Medica, owing to opening as white at the beginning of Flos Lonicerae, after transfer yellow to, hence obtain one's name Flos Lonicerae.Medical material Flos Lonicerae is Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or is with the flower just opened.Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Resisting pathogenic microbes effect: experiment in vitro shows, flower and rattan to various pathogens as staphylococcus aureus, Hemolytic streptococcus, escherichia coli, dysentery bacterium, vibrio cholera, Bacillus typhi, Salmonella paratyphi etc. all have certain inhibitory action, also effective to streptococcus pneumoniae, meningococcus, bacillus pyocyaneus, tubercule bacillus.
Radix Sophorae Flavescentis: it is bitter, cold.There is heat clearing and damp drying, parasite killing, the merit of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.
Bacterio static itching-relieving Chinese medicine lotion of the present invention is based on the principle of traditional Chinese medical herbal treatment pruritus vulvae, the Chinese medicinal material selected has effect of sterilization, antipruritic, antiinflammatory, can the symptom of rapid recovery user pruritus vulvae, and it is cheap, life-time service also can not cause the financial burden of patient, is to treat the ideal medicine of pruritus vulvae.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 one kinds treatment pruritus vulvae bacterio static itching-relieving Chinese medicine lotion, takes off and states raw material of Chinese medicine medicine (getting 20g for every part): Calamina 1 part, Fructus Cnidii 6 parts, Semen Cuscutae 5 parts, Herba Agerati Conyzoidis 6 parts, white shellfish 2 parts, Rhizoma Polygoni Cuspidati 5 parts, 10 parts, Pericarpium Zanthoxyli, Indigo Naturalis 8 parts, Flos Chrysanthemi Indici 7 parts, Fructus Forsythiae 4 parts, Flos Lonicerae 8 parts, Radix Sophorae Flavescentis 6 parts.
The preparation method of above-mentioned bacterio static itching-relieving Chinese medicine lotion, step is:
(1) Calamina and Bai Bei are cleaned 1 time, towel off clean, tie down Calamina and Bai Bei with iron wire, it is crisp to be placed in fire door forging, dries in the air coolly to grind to form smalls, crosses 80 mesh sieves stand-by;
(2) cleaned by Pericarpium Zanthoxyli, be placed in crock, with the white vinegar of 2 times, Pericarpium Zanthoxyli, soak 50 minutes, add the clear water of white vinegar weight 4 times, heat 20 minutes, taken out by Pericarpium Zanthoxyli with strainer, be exposed to the sun 5 days under being placed in daylight, it is stand-by to grind to form smalls, and filtrate is for subsequent use;
(3) Fructus Cnidii, Semen Cuscutae, Herba Agerati Conyzoidis, Rhizoma Polygoni Cuspidati, Flos Chrysanthemi Indici, Fructus Forsythiae, Flos Lonicerae and Radix Sophorae Flavescentis are joined in step (2) gained filtrate, big fire decocts to boiling, until boiling after 2 minutes, filter, obtain filtrate 1, filtering residue 60% ethanol extraction 3 times, 2 hours first times, remaining twice 1 hour, merge alcohol extract and mix with filtrate 1, obtaining mixed liquor;
(4) step (1), (2) gained smalls are added heating in the mid-water-bath of step (3) gained mixed liquor and add Indigo Naturalis after 10 minutes, heating is stopped after Indigo Naturalis melting, abundant stirring 3 minutes, ultraviolet sterilization 3 minutes, bottles and get final product.
Model case one Liu XX, female, 28 years old, postgraduate graduates, and before half a year, pruritus vulvae appears in patient, night, symptom aggravation, often itched be unable to bear going to grab with hands, usually cannot good sleep, once oral Chinese medicine was attempted, or smear for a long time hormonal medicine fail cure, go to see a doctor subsequently, diagnosis is pruritus vulvae, under the suggestion of doctor, sufferer has taken the bacterio static itching-relieving Chinese medicine lotion obtained by the present invention.
Use the decoction of gained in embodiment 1, use the same day, a night in bed, does not all feel pruritus vulvae, and use use 3 days, symptom thoroughly disappears; Adhere to use 7 days, drug withdrawal is so far without recurrence.
Embodiment 2 one kinds treatment pruritus vulvae bacterio static itching-relieving Chinese medicine lotion, takes off and states raw material of Chinese medicine medicine (getting 20g for every part) Calamina 5 parts, Fructus Cnidii 12 parts, Semen Cuscutae 15 parts, Herba Agerati Conyzoidis 16 parts, white shellfish 4 parts, Rhizoma Polygoni Cuspidati 13 parts, 20 parts, Pericarpium Zanthoxyli, Indigo Naturalis 20 parts, Flos Chrysanthemi Indici 14 parts, Fructus Forsythiae 8 parts, Flos Lonicerae 14 parts, Radix Sophorae Flavescentis 15 parts.
The preparation method of above-mentioned bacterio static itching-relieving Chinese medicine lotion, step is:
(1) Calamina and Bai Bei are cleaned 5 times, towel off clean, tie down Calamina and Bai Bei with iron wire, it is crisp to be placed in fire door forging, dries in the air coolly to grind to form smalls, crosses 120 mesh sieves stand-by;
(2) cleaned by Pericarpium Zanthoxyli, be placed in crock, with the white vinegar of 4 times, Pericarpium Zanthoxyli, soak 70 minutes, add the clear water of white vinegar weight 6 times, heat 40 minutes, taken out by Pericarpium Zanthoxyli with strainer, be exposed to the sun 7 days under being placed in daylight, it is stand-by to grind to form smalls, and filtrate is for subsequent use;
(3) Fructus Cnidii, Semen Cuscutae, Herba Agerati Conyzoidis, Rhizoma Polygoni Cuspidati, Flos Chrysanthemi Indici, Fructus Forsythiae, Flos Lonicerae and Radix Sophorae Flavescentis are joined in step (2) gained filtrate, big fire decocts to boiling, until boiling after 7 minutes, filter, obtain filtrate 1, filtering residue 90% ethanol extraction 3 times, 2 hours first times, remaining twice 1 hour, merge alcohol extract and mix with filtrate 1, obtaining mixed liquor;
(4) step (1), (2) gained smalls are added heating in the mid-water-bath of step (3) gained mixed liquor and add Indigo Naturalis after 20 minutes, heating is stopped after Indigo Naturalis melting, abundant stirring 6 minutes, ultraviolet sterilization 7 minutes, bottles and get final product.
Embodiment 3 one kinds treatment pruritus vulvae bacterio static itching-relieving Chinese medicine lotion, takes off and states raw material of Chinese medicine medicine (getting 20g for every part): Calamina 2 parts, Fructus Cnidii 8 parts, Semen Cuscutae 8 parts, Herba Agerati Conyzoidis 10 parts, white shellfish 2.5 parts, Rhizoma Polygoni Cuspidati 8 parts, 13 parts, Pericarpium Zanthoxyli, Indigo Naturalis 12 parts, Flos Chrysanthemi Indici 9 parts, Fructus Forsythiae 5 parts, Flos Lonicerae 10 parts, Radix Sophorae Flavescentis 9 parts.
The preparation method of above-mentioned bacterio static itching-relieving Chinese medicine lotion, step is:
(1) Calamina and Bai Bei are cleaned 2 times, towel off clean, tie down Calamina and Bai Bei with iron wire, it is crisp to be placed in fire door forging, dries in the air coolly to grind to form smalls, crosses 90 mesh sieves stand-by;
(2) cleaned by Pericarpium Zanthoxyli, be placed in crock, with the white vinegar of 2.5 times, Pericarpium Zanthoxyli, soak 55 minutes, add the clear water of white vinegar weight 4.5 times, heat 25 minutes, taken out by Pericarpium Zanthoxyli with strainer, be exposed to the sun 5 days under being placed in daylight, it is stand-by to grind to form smalls, and filtrate is for subsequent use;
(3) Fructus Cnidii, Semen Cuscutae, Herba Agerati Conyzoidis, Rhizoma Polygoni Cuspidati, Flos Chrysanthemi Indici, Fructus Forsythiae, Flos Lonicerae and Radix Sophorae Flavescentis are joined in step (2) gained filtrate, big fire decocts to boiling, until boiling after 3 minutes, filter, obtain filtrate 1, filtering residue 70% ethanol extraction 3 times, 2 hours first times, remaining twice 1 hour, merge alcohol extract and mix with filtrate 1, obtaining mixed liquor;
(4) step (1), (2) gained smalls are added heating in the mid-water-bath of step (3) gained mixed liquor and add Indigo Naturalis after 13 minutes, heating is stopped after Indigo Naturalis melting, abundant stirring 4 minutes, ultraviolet sterilization 4 minutes, bottles and get final product.
Model case two Zou XX, female, 38 years old, chemical plant financial executive, nearly 3 years of patient's pruritus vulvae, pruritus vulvae symptom was aggravated, and pudendum is usually very itched unbearably, and after scratching, the pain increased.Vulvar disease pachyderma, have pleat like leather protuberance, and occur that eczema sample changes, surface color is dark red, goes to see a doctor, and diagnosis is pruritus vulvae.
Use 3 days, pruritis has obvious alleviation; Use 5 days, except still having slight pruritis night, no longer there is pruritus vulvae symptom in daytime; Use 8 days, pruritis disappears completely; Continuing to strengthen use 10 days, without recurrence, there is not any side effect in drug withdrawal so far between the operating period.
Embodiment 4 one kinds treatment pruritus vulvae bacterio static itching-relieving Chinese medicine lotion, takes off and states raw material of Chinese medicine medicine (getting 20g for every part): Calamina 4 parts, Fructus Cnidii 10 parts, Semen Cuscutae 13 parts, Herba Agerati Conyzoidis 12 parts, white shellfish 3.5 parts, Rhizoma Polygoni Cuspidati 10 parts, 18 parts, Pericarpium Zanthoxyli, Indigo Naturalis 16 parts, Flos Chrysanthemi Indici 12 parts, Fructus Forsythiae 7 parts, Flos Lonicerae 12 parts, Radix Sophorae Flavescentis 11 parts.
The preparation method of above-mentioned bacterio static itching-relieving Chinese medicine lotion, step is:
(1) Calamina and Bai Bei are cleaned 4 times, towel off clean, tie down Calamina and Bai Bei with iron wire, it is crisp to be placed in fire door forging, dries in the air coolly to grind to form smalls, crosses 110 mesh sieves stand-by;
(2) cleaned by Pericarpium Zanthoxyli, be placed in crock, with the white vinegar of 3.5 times, Pericarpium Zanthoxyli, soak 65 minutes, add the clear water of white vinegar weight 5.5 times, heat 35 minutes, taken out by Pericarpium Zanthoxyli with strainer, be exposed to the sun 7 days under being placed in daylight, it is stand-by to grind to form smalls, and filtrate is for subsequent use;
(3) Fructus Cnidii, Semen Cuscutae, Herba Agerati Conyzoidis, Rhizoma Polygoni Cuspidati, Flos Chrysanthemi Indici, Fructus Forsythiae, Flos Lonicerae and Radix Sophorae Flavescentis are joined in step (2) gained filtrate, big fire decocts to boiling, until boiling after 6 minutes, filter, obtain filtrate 1, filtering residue 80% ethanol extraction 3 times, 2 hours first times, remaining twice 1 hour, merge alcohol extract and mix with filtrate 1, obtaining mixed liquor;
(4) step (1), (2) gained smalls are added heating in the mid-water-bath of step (3) gained mixed liquor and add Indigo Naturalis after 18 minutes, heating is stopped after Indigo Naturalis melting, abundant stirring 5 minutes, ultraviolet sterilization 6 minutes, bottles and get final product.
Embodiment 5 one kinds treatment pruritus vulvae bacterio static itching-relieving Chinese medicine lotion, takes off and states raw material of Chinese medicine medicine (getting 20g for every part): Calamina 3 parts, Fructus Cnidii 9 parts, Semen Cuscutae 11.5 parts, Herba Agerati Conyzoidis 11 parts, white shellfish 3 parts, Rhizoma Polygoni Cuspidati 9 parts, 15 parts, Pericarpium Zanthoxyli, Indigo Naturalis 14 parts, Flos Chrysanthemi Indici 10.5 parts, Fructus Forsythiae 6 parts, Flos Lonicerae 11 parts, Radix Sophorae Flavescentis 10 parts.
The preparation method of above-mentioned bacterio static itching-relieving Chinese medicine lotion, step is:
(1) Calamina and Bai Bei are cleaned 3 times, towel off clean, tie down Calamina and Bai Bei with iron wire, it is crisp to be placed in fire door forging, dries in the air coolly to grind to form smalls, crosses 100 mesh sieves stand-by;
(2) cleaned by Pericarpium Zanthoxyli, be placed in crock, with the white vinegar of 3 times, Pericarpium Zanthoxyli, soak 60 minutes, add the clear water of white vinegar weight 5 times, heat 30 minutes, taken out by Pericarpium Zanthoxyli with strainer, be exposed to the sun 6 days under being placed in daylight, it is stand-by to grind to form smalls, and filtrate is for subsequent use;
(3) Fructus Cnidii, Semen Cuscutae, Herba Agerati Conyzoidis, Rhizoma Polygoni Cuspidati, Flos Chrysanthemi Indici, Fructus Forsythiae, Flos Lonicerae and Radix Sophorae Flavescentis are joined in step (2) gained filtrate, big fire decocts to boiling, until boiling after 5 minutes, filter, obtain filtrate 1, filtering residue 75% ethanol extraction 3 times, 2 hours first times, remaining twice 1 hour, merge alcohol extract and mix with filtrate 1, obtaining mixed liquor;
(4) step (1), (2) gained smalls are added heating in the mid-water-bath of step (3) gained mixed liquor and add Indigo Naturalis after 15 minutes, heating is stopped after Indigo Naturalis melting, abundant stirring 4.5 minutes, ultraviolet sterilization 5 minutes, bottles and get final product.
Experimental example: the clinical practice of embodiment 5 gained treatment pruritus vulvae bacterio static itching-relieving Chinese medicine lotion: screen 400 routine patients in 10 hospitals, selected scope: the people having pruritus vulvae, before test 1 day, Continuous Observation is carried out to this crowd, record symptom and change, experimental group 200 people, matched group 200 people, experimental group uses gained bacterio static itching-relieving Chinese medicine lotion of the present invention, and matched group uses the cured substance of other treatment pruritus vulvae: after using this product, and malaise symptoms disappears; Effective: after using this product, malaise symptoms disappears substantially; Invalid: after using this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1:
Take period self-induction symptom and physical change of spirit as shown in table 2.
Table 2:
Prove through clinical trial, bacterio static itching-relieving Chinese medicine lotion of the present invention is to pruritus vulvae Be very effective, total effective rate is 99%, general patient just can have significant curative effect in 3 days in use, and bacterio static itching-relieving Chinese medicine lotion multiselect of the present invention with can heat-clearing and toxic substances removing, can carry out antipruritic, Aloe Extract and antibacterial fast, a kind of bacterio static itching-relieving Chinese medicine lotion for the treatment of pruritus vulvae, wherein monarch drug is: Herba Agerati Conyzoidis, Indigo Naturalis, Pericarpium Zanthoxyli, Radix Sophorae Flavescentis and Semen Cuscutae, and ministerial drug is Fructus Cnidii and Flos Chrysanthemi Indici, and Rhizoma Polygoni Cuspidati, Fructus Forsythiae are adjuvant drug.Monarch drug carries attending effectiveness in the present invention; Ministerial drug is the medicine that auxiliary monarch drug strengthens the main disease for the treatment of and main symptom; Adjuvant drug treatment is held concurrently disease, slows down the strong of monarch drug and ministerial drug; Residual drug, as making medicine, plays a part guiding drug.
Claims (10)
1. treat a bacterio static itching-relieving Chinese medicine lotion for pruritus vulvae, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Calamina 1-5 part, Fructus Cnidii 6-12 part, Semen Cuscutae 5-15 part, Herba Agerati Conyzoidis 6-16 part, white shellfish 2-4 part, Rhizoma Polygoni Cuspidati 5-13 part, Pericarpium Zanthoxyli 10-20 part, Indigo Naturalis 8-20 part, Flos Chrysanthemi Indici 7-14 part, Fructus Forsythiae 4-8 part, Flos Lonicerae 8-14 part, Radix Sophorae Flavescentis 6-15 part.
2. the bacterio static itching-relieving Chinese medicine lotion for the treatment of pruritus vulvae according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Calamina 2-4 part, Fructus Cnidii 8-10 part, Semen Cuscutae 8-13 part, Herba Agerati Conyzoidis 10-12 part, white shellfish 2.5-3.5 part, Rhizoma Polygoni Cuspidati 8-10 part, Pericarpium Zanthoxyli 13-18 part, Indigo Naturalis 12-16 part, Flos Chrysanthemi Indici 9-12 part, Fructus Forsythiae 5-7 part, Flos Lonicerae 10-12 part, Radix Sophorae Flavescentis 9-11 part.
3. the bacterio static itching-relieving Chinese medicine lotion for the treatment of pruritus vulvae according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Calamina 3 parts, Fructus Cnidii 9 parts, Semen Cuscutae 11.5 parts, Herba Agerati Conyzoidis 11 parts, white shellfish 3 parts, Rhizoma Polygoni Cuspidati 9 parts, 15 parts, Pericarpium Zanthoxyli, Indigo Naturalis 14 parts, Flos Chrysanthemi Indici 10.5 parts, Fructus Forsythiae 6 parts, Flos Lonicerae 11 parts, Radix Sophorae Flavescentis 10 parts.
4. the preparation method of the treatment pruritus vulvae bacterio static itching-relieving Chinese medicine lotion according to any one of claim 1-3, is characterized in that: step is as follows:
(1) Calamina and Bai Bei are cleaned 1-5 time, towel off clean, tie down Calamina and Bai Bei with iron wire, it is crisp to be placed in fire door forging, dries in the air coolly to grind to form smalls, crosses 80-120 mesh sieve stand-by;
(2) Pericarpium Zanthoxyli is cleaned, be placed in crock, with Pericarpium Zanthoxyli 2-4 white vinegar doubly, soak 50-70 minute, add white vinegar weight 4-6 clear water doubly, heating 20-40 minute, takes out Pericarpium Zanthoxyli with strainer, be exposed to the sun under being placed in daylight 5-7 days, and it is stand-by to grind to form smalls, and filtrate is for subsequent use;
(3) Fructus Cnidii, Semen Cuscutae, Herba Agerati Conyzoidis, Rhizoma Polygoni Cuspidati, Flos Chrysanthemi Indici, Fructus Forsythiae, Flos Lonicerae and Radix Sophorae Flavescentis are joined in step (2) gained filtrate, big fire decocts to boiling, after boiling 2-7 minute, filter, obtain filtrate 1, filtering residue 60-90% ethanol extraction 3 times, 2 hours first times, remaining twice 1 hour, merge alcohol extract and mix with filtrate 1, obtaining mixed liquor;
(4) step (1), (2) gained smalls are added the mid-water-bath of step (3) gained mixed liquor heats 10-20 minute after add Indigo Naturalis, heating is stopped after Indigo Naturalis melting, abundant stirring 3-6 minute, ultraviolet sterilization 3-7 minute, bottle and get final product.
5. the preparation method of bacterio static itching-relieving Chinese medicine lotion according to claim 4, is characterized in that: Calamina and Bai Bei are cleaned 2-4 all over (preferred, Calamina and Bai Bei are cleaned 3 times) by step (1).
6. the preparation method of bacterio static itching-relieving Chinese medicine lotion according to claim 4, is characterized in that: step (2), with Pericarpium Zanthoxyli 2.5-3.5 white vinegar doubly, is soaked 55-65 minute (preferred, with the white vinegar of 3 times, Pericarpium Zanthoxyli, to soak 60 minutes).
7. the preparation method of bacterio static itching-relieving Chinese medicine lotion according to claim 4, it is characterized in that: step (2) adds white vinegar weight 4.5-5.5 clear water doubly, heat 25-35 minute (preferred, to add the clear water of white vinegar weight 5 times, heat 30 minutes).
8. the preparation method of bacterio static itching-relieving Chinese medicine lotion according to claim 4, is characterized in that: step (3) big fire decocts to boiling, after boiling 3-6 minute, filter (preferred, big fire decocts to boiling, until boiling after 5 minutes, filters).
9. the preparation method of bacterio static itching-relieving Chinese medicine lotion according to claim 4, is characterized in that: step (3) filtering residue 70-80% ethanol extraction 3 times (preferred, filtering residue 75% ethanol extraction 3 times).
10. the preparation method of bacterio static itching-relieving Chinese medicine lotion according to claim 4, it is characterized in that: after the mid-water-bath of step (4) gained mixed liquor heats 13-18 minute, add Indigo Naturalis (preferred, the mid-water-bath of gained mixed liquor to be heated after 15 minutes and add Indigo Naturalis).
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