CN105011369A - Preparation method of cigarette filter tip containing flavone flavor and application - Google Patents
Preparation method of cigarette filter tip containing flavone flavor and application Download PDFInfo
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- CN105011369A CN105011369A CN201510338813.6A CN201510338813A CN105011369A CN 105011369 A CN105011369 A CN 105011369A CN 201510338813 A CN201510338813 A CN 201510338813A CN 105011369 A CN105011369 A CN 105011369A
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- rod
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- 235000019504 cigarettes Nutrition 0.000 title claims abstract description 57
- 229930003944 flavone Natural products 0.000 title claims abstract description 47
- 235000011949 flavones Nutrition 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 title abstract description 10
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 title abstract description 10
- 239000000796 flavoring agent Substances 0.000 title abstract description 6
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- 150000002212 flavone derivatives Chemical class 0.000 title abstract 5
- 238000000605 extraction Methods 0.000 claims abstract description 22
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- AIONOLUJZLIMTK-AWEZNQCLSA-N hesperetin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-AWEZNQCLSA-N 0.000 claims abstract description 9
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- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims abstract description 9
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a preparation method of a cigarette filter tip containing flavone flavor and application. The preparation method comprises following steps: 1), weighing 10%-40% by weight of puerarin, 10%-40% by weight of quercetin, 20%-50% by weight of catechol and 20%-50% by weight of hesperetin, mixing the above, carrying out reflux extraction by using an ethanol solution as an extraction solvent and filtering the ethanol solution in order to obtain an extracting solution; 2), uniformly spraying the extracting solution to tows; 3), drying tows in the step 2); 4), sequentially utilizing shaping paper and tipping paper of the filter tip to wrap the dried tows in order to obtain the filter tip with flavone-containing flavor. The cigarette filter tip containing flavone flavor does not produce any new undesirable substance due to splitting decomposition in that the filter tip does not burn with a cigarette. Active components of the cigarette filter tip containing flavone flavor enter a human oral cavity along with smoke in the cigarette and can be directly applied to a throat and has the effect of improving comfortableness of the throat.
Description
Technical field
The invention belongs to technical field of cigarettes, be specifically related to a kind of cigarette mouth containing flavones essence rod preparation method and application.
Background technology
Natural plants is widely used in tobacco aromatics, is much wherein containing Flavonoid substances.According to the molecular characterization of Flavonoid substances and the power of interelectric active force, Primary Study finds that such material can produce furans and derivative thereof after burning cracking, these materials are the main aroma components in flue gas, camerlsed, fragrant and sweet, roasting perfume can be brought to flue gas, increase perfume quantity and aroma quality.Therefore, in the allotment of essence spice for cigarette, the use of a lot of flavonoids perfume material is had.
Much research also shows, flavone compound has multiple biologically active, except utilizing that it is antibacterial, anti-inflammatory, anti-sudden change, step-down, except the effect such as clearing heat and detoxicating, calm, diuresis, in anti-oxidant, anticancer, anti-cancer, suppresses also have remarkable result in lipase etc.It is the scavenger of most of oxygen radical, thus can the vigor of increased SOD (superoxide dismutase), reduces the generation of MDA (malondialdehyde) and OX-LDL (OxLDL ELISA).It can increase coronary flow, has antagonism to Myocardial Infarction; Protective effect is had to acute myocardial ischemia; Remarkable result is had to treatment coronary heart diseases and angina pectoris, hypertension etc.; To reduction diastolic pressure, prevent and treat arrhythmia cordis, cardiovascular disease and promoting blood circulation and removing blood stasisly also to play an important role.
A large amount of scientific researches is the important risk factor that the various diseases such as chronic respiratory disease, coronary heart disease occurs from the smog that different angles demonstrates tobacco.Long-term smoker generally has that cough, phlegm are many, the symptom of throat itch, has a strong impact on the quality of life of health and the mankind.In addition, the health of passive smoking to women also works the mischief.In order to alleviate in tobacco smog to the harm of human body, in positive publicity, Smoking is harmful to your health and while advice smoking cessation, also should have the harm reduction cigarette of the effects such as easypro larynx by active development.
Throat is the important component part of respiratory tract, is positioned at the confluce of tracheae and esophagus, is also the vitals of human body pronunciation.When smoker is in smoking, what be vulnerable to harmful substances from flue gases impact most is exactly throat.In flue gas, tar is easily trapped in the body of smoking people, is condensed into a kind of emplastic in lung, is attached to trachea-bronchial epithelial cell and the alveolar surface of smoker, produces physics, chemical stimulation, affects the breathing of human body; Long-time smoking can reduce the defense function of bottleneck throat mucous membrane, there will be the sensation such as dry cough, throat's shouting pain, or causes irascibility to cross prosperous because smoking and bring sense of discomfort to throat; So smoke for human respiratory tract, particularly the harm of throat is comparatively large, with the passing of time may cause laryngeal pathological process.
A large amount of correlative study finds the organ that respiratory tract stimulates as direct body contact's ambient atmos, is the main recipient of tobacco infringement.And airway epithelial cell resists the first line of defence of environmental stimuli as respiratory tract, suffered harm is particularly serious.Previously the stimulation of research display cigarette can regulate alveolar epithelium and bronchiolar epithelium plasma urokinase-type plasminogen activator (Urokinase type plasminogen activator, uPA), uPAR Research (urokinase type plasminogen activator receptor, uPAR) system expression change, alveolar epithelial cells uPA and uPAR level raise more remarkable, present uPA advantage state, be beneficial to proteolysis.Bronchial epithelial cell then presents plasma urokinase-type plasminogen activator inhibitor-1 (plasminogen activator inhibitor-1, PAI-1) advantage state, is conducive to fibrillatable and is formed.Two kinds of cells to uPA system expression state is different may the reason of partial interpretation COPD patient pulmonary emphysema and these the two kinds of different pathological changes of small airway fibrillatable.The section of bibliographical information lung tissue of rats is separately had jointly to hatch with cigarette smoke extract, lung tissue of rats lactic dehydrogenase (lactatec dehydrogenate can be increased, LDH) spill and discharge with nitrite NO2-, stimulate nitric oxide synthase type (induced nitric oxidesynthase, iNOS) active increase, causes injury of lungs.As can be seen here, long-term fume exposure can cause airway epithelial cell form and function damage, thus the normal physiological function of the upper lower respiratory tract of impact, make smoker produce uncomfortable sensation, even have a strong impact on life quality (quality of life, QOF) and life security.From safeguarding consumer's interests, walking the road of reducing tar and reducing harm, is the developing direction of Chinese-style cigarette.Under the prerequisite meeting consumer's physiology, psychological needs, reduce the adverse effect that it brings consumer throat, promoting throat's comfortableness, is tobacco business scientific research personnel problem demanding prompt solution.
Throat's comfortableness well refers to that the level and smooth exquisiteness of flue gas that consumer experiences when smoking cigarette, oral cavity noresidue, nose larynx are non-stimulated, aftertaste has the impressions such as sweet sense.Laryngeal response mainly concentrates on the impression at oral cavity and respiratory system position in cigarette smoking process, be embodied in fall thorn, reduce phlegm, the improvement of the aspect such as to promote the production of body fluid, suction comfortableness can be realized preferably.
Thorn falls: excitant refers to the impact of flue gas to sense organ.Impression is divided into the stimulation of oral stimulation, nasal cavity and throat stimulate three kinds.Excitant is large, seemingly has " peppery " taste in oral cavity, to draw tears from sb or shed tears sense at nasal cavity, throat can be made to tighten cause cough in throat.
The excitant of flue gas is mainly by acid excessive and alkalescence is excessive and produce, simultaneously also relevant with the moisture, tightness etc. of cigarette in cigarette.Peppery thorn is because alkaline matter is on the high side; Thorn of choking is because Small molecular shot-like particle is on the high side; Spine (burr) is because acidic materials are on the high side.
Flavone compound has the effect of diastole bronchial smooth muscle, is added in cigarette, can weaken the draw effect of flue gas, alleviates the discomfort that smoke-shock causes throat.
Reduce phlegm: the people of long-term smoker generally has pharyngitis to a certain degree, its performance is that phlegm is many and frequently.Harmful substance in flue gas is frequently gathered in respiratory tract, caused by the wriggling accelerating villus fiber.
Flavone compound can reduce the raw phlegm material of flue gas, certainly will can reduce the accumulation of this constituents at respiratory system.In addition, flavone compound can be wriggled by speed line villus fiber, makes harmful substance get rid of external with juice fast, this effect of reducing phlegm just served to a certain extent.
Promote the production of body fluid: Tianjin is saliva, promoting the production of body fluid is exactly make to secrete saliva in oral cavity.Modern medicine is also thought, containing multiple helpful body composition in saliva, promoting the production of body fluid in mouth, it is easypro suitable to quench one's thirst.
Multiple flavone compound has nourishing Yin and promoting production of body fluid, effect that moistening lung is relieved inflammation or internal heat, interior heat is quenched one's thirst.Be added in cigarette, can stimulate oral cavity taste bud and have effect of promoting the production of body fluid, flue gas is more mellow and fuller, with returning sweet sense, reduces withered sense.
A lot of containing Flavonoid substances in tobacco aromatics, but for special for improving throat's comfortableness, there is cough-relieving, reduce phlegm, the composition of effect of relievining asthma have not been reported, and needs for further study.
Summary of the invention
For the deficiencies in the prior art, the invention provides a kind of there is cough-relieving, reduce phlegm, the rod preparation method of the cigarette mouth containing flavones essence of effect of relievining asthma and application, flavones essence is added in the tow of mouth rod, in cigarette smoking process, play the anti-inflammatory of its excellence, sharp larynx effect, thus improve throat's comfortableness of cigarette smoking, improve cigarette smoking quality.
The present invention solves the problems of the technologies described above adopted technical scheme: provide a kind of cigarette mouth containing flavones essence rod preparation method, described preparation method comprises the steps:
1) take by weight percentage the Puerarin of 10% ~ 40%, 10% ~ 40% Quercetin, the catechol of 20% ~ 50%, the hesperetin of 20% ~ 50%, mixing after ethanolic solution as Extraction solvent refluxing extraction, filter obtain extract;
2) extract is evenly sprayed in tow;
3) then by step 2) in tow dry;
4) dried tow is wrapped up with forming paper and mouth rod tipping paper successively, the obtained cigarette mouth rod containing flavones essence.
Further, the mass percentage concentration of described ethanolic solution is 70% ~ 90%.
Further, described step 1) in refluxing extraction 2 ~ 4 times, each refluxing extraction 2 ~ 4 hours.
Further, described step 3) in baking temperature be 25 DEG C ~ 40 DEG C.
A kind of cigarette, comprises cigarette mouth rod and pipe tobacco, it is characterized in that: the rod of the cigarette mouth containing flavones essence that described cigarette mouth rod is prepared for method described above.
The present invention has the following advantages:
1, the present invention does not participate in cigarette burning containing the cigarette mouth rod of flavones essence, thus can not produce new undesirable substance because of cracking, meets consumer to requirement that is healthy, low evil;
2, the present invention has excellent natural breath containing the cigarette mouth rod of flavones essence, can bring uniqueness, strong additional fragrance to cigarette;
3, the present invention enters human oral cavity with flue gas containing the active component of the cigarette mouth rod of flavones essence in cigarette, can directly act on throat, play the effect of good raising throat comfortableness;
4, the present invention is containing flavones flavor of raw material wide material sources, with low cost, easy to utilize.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment, the present invention is further elaborated.Specific embodiment described herein only in order to explain the present invention, is not intended to limit the present invention.
Embodiment 1
1) mixed according to ratio in table 1 by flavones essence, being dissolved in mass percentage concentration is in the ethanolic solution of 70%, refluxing extraction 2 times, and each extraction 3 hours, filters, is mixed to get extract;
2) by step 1) in extract be evenly sprayed in tow;
3) then by step 2) in tow dry at 25 DEG C;
4) dried tow is wrapped up with forming paper and mouth rod tipping paper successively, the obtained cigarette mouth rod containing flavones essence.
Table 1
| Flavones kind | Puerarin | Quercetin | Catechol | Hesperetin |
| Percentage by weight | 15％ | 15％ | 30％ | 40％ |
Embodiment 2
1) mixed according to ratio in table 1 by flavones essence, being dissolved in mass percentage concentration is in the ethanolic solution of 70%, refluxing extraction 2 times, and each extraction 4 hours, filters, is mixed to get extract;
2) by step 1) in extract be evenly sprayed in tow;
3) then by step 2) in tow dry at 35 DEG C;
4) dried tow is wrapped up with forming paper and mouth rod tipping paper successively, the obtained cigarette mouth rod containing flavones essence.
Table 2
| Flavones kind | Puerarin | Quercetin | Catechol | Hesperetin |
| Percentage by weight | 20％ | 20％ | 20％ | 40％ |
Embodiment 3
1) mixed according to ratio in table 1 by flavones essence, being dissolved in mass percentage concentration is in the ethanolic solution of 80%, refluxing extraction 4 times, and each extraction 2 hours, filters, is mixed to get extract;
2) by step 1) in extract be evenly sprayed in tow;
3) then by step 2) in tow dry at 35 DEG C;
4) dried tow is wrapped up with forming paper and mouth rod tipping paper successively, the obtained cigarette mouth rod containing flavones essence.
Table 3
| Flavones kind | Puerarin | Quercetin | Catechol | Hesperetin |
| Percentage by weight | 30％ | 30％ | 20％ | 20％ |
Embodiment 4
1) mixed according to ratio in table 1 by flavones essence, being dissolved in mass percentage concentration is in the ethanolic solution of 80%, refluxing extraction 2 times, and each extraction 4 hours, filters, is mixed to get extract;
2) by step 1) in extract be evenly sprayed in tow;
3) then by step 2) in tow dry at 35 DEG C;
4) dried tow is wrapped up with forming paper and mouth rod tipping paper successively, the obtained cigarette mouth rod containing flavones essence.
Table 4
| Flavones kind | Puerarin | Quercetin | Catechol | Hesperetin |
| Percentage by weight | 10％ | 30％ | 40％ | 20％ |
Embodiment 5
1) mixed according to ratio in table 1 by flavones essence, being dissolved in mass percentage concentration is in the ethanolic solution of 90%, refluxing extraction 2 times, and each extraction 2 hours, filters, is mixed to get extract;
2) by step 1) in extract be evenly sprayed in tow;
3) then by step 2) in tow dry at 40 DEG C;
4) dried tow is wrapped up with forming paper and mouth rod tipping paper successively, the obtained cigarette mouth rod containing flavones essence.
Table 5
| Flavones kind | Puerarin | Quercetin | Catechol | Hesperetin |
| Percentage by weight | 10％ | 40％ | 20％ | 30％ |
Embodiment 6
1) mixed according to ratio in table 1 by flavones essence, being dissolved in mass percentage concentration is in the ethanolic solution of 90%, refluxing extraction 4 times, and each extraction 2 hours, filters, is mixed to get extract;
2) by step 1) in extract be evenly sprayed in tow;
3) then by step 2) in tow dry at 40 DEG C;
4) dried tow is wrapped up with forming paper and mouth rod tipping paper successively, the obtained cigarette mouth rod containing flavones essence.
Table 6
| Flavones kind | Puerarin | Quercetin | Catechol | Hesperetin |
| Percentage by weight | 40％ | 10％ | 20％ | 30％ |
For caused by smoking " cough, phlegm is many, pant " three large symptoms; with reference to classical respiratory tract antibechic, eliminate the phlegm, on the basis of pharmacodynamic evaluation method of relievining asthma; from multiple different living model, the method being applicable to natural plant extracts respiratory tract protected effect and evaluating is set up in screening, utilizes ammonia induced cough in mice evaluation antitussive effect, the phenol red excretion method of mouse evaluates phlegm-dispelling functions, Guinea pig isolated trachea spiral strip method evaluates antiasthmatic effect.
The rod of the cigarette mouth containing flavones essence prepared in above 6 embodiments is engaged with pipe tobacco and makes cigarette, detection of exhaust gas compositions is carried out to cigarette, and carry out phenol reduced rate and compare, specifically see the following form 7
Table 7
* P<0.05, * * P<0.01 compares with the blank cigarette group of equal number
Engaged with pipe tobacco by the rod of the cigarette mouth containing flavones essence prepared in above 6 embodiments and make cigarette, carry out detection of exhaust gas compositions to cigarette, and carry out phenol reduced rate and compare, specifically see the following form, result is as table 8
Table 8
The above; be only the specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, anyly belongs to those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claim.
Claims (5)
1., containing a cigarette mouth rod preparation method for flavones essence, it is characterized in that: described preparation method comprises the steps:
1) take by weight percentage the Puerarin of 10% ~ 40%, 10% ~ 40% Quercetin, the catechol of 20% ~ 50%, the hesperetin of 20% ~ 50%, mixing after ethanolic solution as Extraction solvent refluxing extraction, filter obtain extract;
2) extract is evenly sprayed in tow;
3) then by step 2) in tow dry;
4) dried tow is wrapped up with forming paper and mouth rod tipping paper successively, the obtained cigarette mouth rod containing flavones essence.
2. the rod of the cigarette mouth containing flavones essence preparation method according to claim 1, is characterized in that: the mass percentage concentration of described ethanolic solution is 70% ~ 90%.
3. the cigarette mouth rod preparation method containing flavones essence according to claim 1 and 2, is characterized in that: described step 1) in refluxing extraction 2 ~ 4 times, each refluxing extraction 2 ~ 4 hours.
4. the cigarette mouth rod preparation method containing flavones essence according to claim 1 and 2, is characterized in that: described step 3) in baking temperature be 25 DEG C ~ 40 DEG C.
5. a cigarette, comprises cigarette mouth rod and pipe tobacco, it is characterized in that: described cigarette mouth rod is the rod of the cigarette mouth containing flavones essence prepared by the arbitrary described method of Claims 1 to 4.
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Cited By (1)
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| CN107400107A (en) * | 2017-07-26 | 2017-11-28 | 云南中烟工业有限责任公司 | A kind of flavone compound in rose waste residue and preparation method and application |
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