CN105007900B - 控制奥斯特瓦尔德熟化的动态悬浮液干燥(dsd) - Google Patents

控制奥斯特瓦尔德熟化的动态悬浮液干燥(dsd) Download PDF

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Publication number
CN105007900B
CN105007900B CN201480011112.5A CN201480011112A CN105007900B CN 105007900 B CN105007900 B CN 105007900B CN 201480011112 A CN201480011112 A CN 201480011112A CN 105007900 B CN105007900 B CN 105007900B
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CN
China
Prior art keywords
suspension
high pressure
particle size
particle
pressure conditions
Prior art date
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Expired - Fee Related
Application number
CN201480011112.5A
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English (en)
Chinese (zh)
Other versions
CN105007900A (zh
Inventor
J·P·博塔斯
D·贡萨尔维斯
D·马丁斯
F·内维斯
J·梅洛
N·阿尔梅达
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Hovione International Ltd
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Hovione International Ltd
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Publication of CN105007900A publication Critical patent/CN105007900A/zh
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Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B1/00—Preliminary treatment of solid materials or objects to facilitate drying, e.g. mixing or backmixing the materials to be dried with predominantly dry solids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
    • F26B3/12—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray, i.e. sprayed or dispersed emulsions or suspensions

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480011112.5A 2013-01-09 2014-01-09 控制奥斯特瓦尔德熟化的动态悬浮液干燥(dsd) Expired - Fee Related CN105007900B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP106738 2013-01-09
PT106738A PT106738B (pt) 2013-01-09 2013-01-09 Método para o controlo do fenómeno de degradação difusional de ostwald (ostwald ripening) no processamento de partículas de um ingrediente farmacêutico
PCT/GB2014/050055 WO2014108687A1 (en) 2013-01-09 2014-01-09 Dynamic suspension drying (dsd) to control ostwald ripening

Publications (2)

Publication Number Publication Date
CN105007900A CN105007900A (zh) 2015-10-28
CN105007900B true CN105007900B (zh) 2019-04-12

Family

ID=49999991

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480011112.5A Expired - Fee Related CN105007900B (zh) 2013-01-09 2014-01-09 控制奥斯特瓦尔德熟化的动态悬浮液干燥(dsd)

Country Status (13)

Country Link
US (1) US10151529B2 (enExample)
EP (1) EP2874609B1 (enExample)
JP (1) JP6316847B2 (enExample)
CN (1) CN105007900B (enExample)
BR (1) BR112015016605B1 (enExample)
CA (1) CA2897277C (enExample)
DK (1) DK2874609T3 (enExample)
ES (1) ES2659968T3 (enExample)
HU (1) HUE036691T2 (enExample)
IL (1) IL239845B (enExample)
PT (1) PT106738B (enExample)
SG (1) SG11201505370RA (enExample)
WO (1) WO2014108687A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT108368B (pt) 2015-03-31 2018-11-05 Hovione Farm S A Produção contínua de partículas

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004125A2 (en) * 2000-07-06 2002-01-17 Cornerstone Technologies, L.L.C. Multi-stage size reduction, blending and drying system and method
CN1437464A (zh) * 2000-04-20 2003-08-20 斯凯伊药品加拿大公司 改进的水不溶性药物粒子的制备方法
WO2004052567A2 (en) * 2002-12-06 2004-06-24 Cornerstone Technologies, L.L.C. High g mill in a blending and drying system
WO2011131947A2 (en) * 2010-04-21 2011-10-27 Hovione Inter Ltd A process for particle processing of active pharmaceutical ingredients

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826689A (en) 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
PT693924E (pt) * 1993-02-22 2004-09-30 American Biosciences Processos para administracao (in vivo) de substancias biologicas e composicoes utilizadas nestes processos
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6096331A (en) * 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5665382A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5665383A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of immunostimulating agents for in vivo delivery
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US6749868B1 (en) * 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5997904A (en) * 1993-02-22 1999-12-07 American Bioscience, Inc. Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
EP1178786A4 (en) * 1999-05-21 2006-03-01 American Bioscience Inc PHARMACOLOGICALLY ACTIVE PROTEIN STABILIZING AGENTS; METHODS OF MANUFACTURE AND METHODS OF USE
US6318649B1 (en) * 1999-10-06 2001-11-20 Cornerstone Technologies, Llc Method of creating ultra-fine particles of materials using a high-pressure mill
PT1416917E (pt) * 2001-08-06 2007-08-16 Astrazeneca Ab ''dispersão aquosa compreendendo nanopartículas estáveis de um triglicérido de cadeia média (mct) activo insolúvel em água e um do tipo excipiente''
EP2054036B1 (en) * 2006-07-24 2019-12-18 Singh-Broemer and Company, Inc. Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1437464A (zh) * 2000-04-20 2003-08-20 斯凯伊药品加拿大公司 改进的水不溶性药物粒子的制备方法
WO2002004125A2 (en) * 2000-07-06 2002-01-17 Cornerstone Technologies, L.L.C. Multi-stage size reduction, blending and drying system and method
WO2004052567A2 (en) * 2002-12-06 2004-06-24 Cornerstone Technologies, L.L.C. High g mill in a blending and drying system
WO2011131947A2 (en) * 2010-04-21 2011-10-27 Hovione Inter Ltd A process for particle processing of active pharmaceutical ingredients

Also Published As

Publication number Publication date
CN105007900A (zh) 2015-10-28
CA2897277C (en) 2020-09-01
IL239845A0 (en) 2015-08-31
EP2874609A1 (en) 2015-05-27
PT106738A (pt) 2014-07-09
BR112015016605B1 (pt) 2022-11-29
SG11201505370RA (en) 2015-08-28
JP6316847B2 (ja) 2018-04-25
WO2014108687A1 (en) 2014-07-17
HUE036691T2 (hu) 2018-07-30
EP2874609B1 (en) 2017-12-27
IL239845B (en) 2019-05-30
US20150354891A1 (en) 2015-12-10
PT106738B (pt) 2015-06-08
JP2016508989A (ja) 2016-03-24
ES2659968T3 (es) 2018-03-20
CA2897277A1 (en) 2014-07-17
BR112015016605A2 (pt) 2017-07-11
DK2874609T3 (en) 2018-04-09
US10151529B2 (en) 2018-12-11

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