CA2897277C - Dynamic suspension drying (dsd) to control ostwald ripening - Google Patents

Dynamic suspension drying (dsd) to control ostwald ripening Download PDF

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Publication number
CA2897277C
CA2897277C CA2897277A CA2897277A CA2897277C CA 2897277 C CA2897277 C CA 2897277C CA 2897277 A CA2897277 A CA 2897277A CA 2897277 A CA2897277 A CA 2897277A CA 2897277 C CA2897277 C CA 2897277C
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CA
Canada
Prior art keywords
suspension
high pressure
pressure conditions
pharmaceutical ingredient
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2897277A
Other languages
English (en)
French (fr)
Other versions
CA2897277A1 (en
Inventor
Joaquim Pedro BOTAS
David Goncalves
David Martins
Filipe NEVES
Jose Melo
Nuno ALMEIDA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hovione International Ltd
Original Assignee
Hovione International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione International Ltd filed Critical Hovione International Ltd
Publication of CA2897277A1 publication Critical patent/CA2897277A1/en
Application granted granted Critical
Publication of CA2897277C publication Critical patent/CA2897277C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B1/00—Preliminary treatment of solid materials or objects to facilitate drying, e.g. mixing or backmixing the materials to be dried with predominantly dry solids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
    • F26B3/12—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray, i.e. sprayed or dispersed emulsions or suspensions

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2897277A 2013-01-09 2014-01-09 Dynamic suspension drying (dsd) to control ostwald ripening Active CA2897277C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT106738A PT106738B (pt) 2013-01-09 2013-01-09 Método para o controlo do fenómeno de degradação difusional de ostwald (ostwald ripening) no processamento de partículas de um ingrediente farmacêutico
PT106738 2013-01-09
PCT/GB2014/050055 WO2014108687A1 (en) 2013-01-09 2014-01-09 Dynamic suspension drying (dsd) to control ostwald ripening

Publications (2)

Publication Number Publication Date
CA2897277A1 CA2897277A1 (en) 2014-07-17
CA2897277C true CA2897277C (en) 2020-09-01

Family

ID=49999991

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2897277A Active CA2897277C (en) 2013-01-09 2014-01-09 Dynamic suspension drying (dsd) to control ostwald ripening

Country Status (13)

Country Link
US (1) US10151529B2 (enExample)
EP (1) EP2874609B1 (enExample)
JP (1) JP6316847B2 (enExample)
CN (1) CN105007900B (enExample)
BR (1) BR112015016605B1 (enExample)
CA (1) CA2897277C (enExample)
DK (1) DK2874609T3 (enExample)
ES (1) ES2659968T3 (enExample)
HU (1) HUE036691T2 (enExample)
IL (1) IL239845B (enExample)
PT (1) PT106738B (enExample)
SG (1) SG11201505370RA (enExample)
WO (1) WO2014108687A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT108368B (pt) 2015-03-31 2018-11-05 Hovione Farm S A Produção contínua de partículas

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826689A (en) 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US5665382A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US5997904A (en) * 1993-02-22 1999-12-07 American Bioscience, Inc. Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6749868B1 (en) * 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5665383A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of immunostimulating agents for in vivo delivery
US6096331A (en) * 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
NZ262679A (en) * 1993-02-22 1997-08-22 Vivorx Pharmaceuticals Inc Compositions for in vivo delivery of pharmaceutical agents where the agents are contained in a polymeric shell
HK1045646A1 (zh) * 1999-05-21 2002-12-06 Abraxis Bioscience, Llc 蛋白質穩定化的藥理學活性劑，其製備方法及其使用方法
US6318649B1 (en) * 1999-10-06 2001-11-20 Cornerstone Technologies, Llc Method of creating ultra-fine particles of materials using a high-pressure mill
EP1276465B1 (en) * 2000-04-20 2014-03-12 Jagotec AG Improved water-insoluble drug particle process
AU2001270302A1 (en) 2000-07-06 2002-01-21 Cornerstone Technologies, L.L.C. Multi-stage size reduction, blending and drying system and method
IL160103A0 (en) * 2001-08-06 2004-06-20 Astrazeneca Ab Aqueous dispersion comprising stable nanoparticles of a water-insoluble active substance and an excipient like middle chain triglycerides (mct)
AU2003283954A1 (en) * 2002-12-06 2004-06-30 Cornerstone Technologies, L.L.C. High g mill in a blending and drying system
JP5571380B2 (ja) * 2006-07-24 2014-08-13 ルミナス バイオサイエンシズ，インコーポレイテッド オストワルド熟成を減少させた水不溶性の医薬品物質の固体ナノ粒子処方物
PT105058B (pt) * 2010-04-21 2013-04-17 Hovione Farmaciencia S A Processo para processamento de partículas de ingredientes activos farmacêuticos

Also Published As

Publication number Publication date
US10151529B2 (en) 2018-12-11
WO2014108687A1 (en) 2014-07-17
CN105007900A (zh) 2015-10-28
US20150354891A1 (en) 2015-12-10
CN105007900B (zh) 2019-04-12
HUE036691T2 (hu) 2018-07-30
SG11201505370RA (en) 2015-08-28
EP2874609A1 (en) 2015-05-27
JP6316847B2 (ja) 2018-04-25
DK2874609T3 (en) 2018-04-09
BR112015016605A2 (pt) 2017-07-11
PT106738A (pt) 2014-07-09
BR112015016605B1 (pt) 2022-11-29
IL239845A0 (en) 2015-08-31
EP2874609B1 (en) 2017-12-27
PT106738B (pt) 2015-06-08
JP2016508989A (ja) 2016-03-24
IL239845B (en) 2019-05-30
ES2659968T3 (es) 2018-03-20
CA2897277A1 (en) 2014-07-17

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