BR112015016605A2 - método para processar partículas de um ingrediente farmacêutico em suspensão, partículas, formulação farmacêutica, aparelho para processar partículas de um ingrediente farmacêutico em suspensão, método para evitar maturação de ostwald e uso de um método para processar partículas de um ingrediente farmacêutico em forma de pó a partir de uma suspensão do ingrediente farmacêutico - Google Patents
método para processar partículas de um ingrediente farmacêutico em suspensão, partículas, formulação farmacêutica, aparelho para processar partículas de um ingrediente farmacêutico em suspensão, método para evitar maturação de ostwald e uso de um método para processar partículas de um ingrediente farmacêutico em forma de pó a partir de uma suspensão do ingrediente farmacêuticoInfo
- Publication number
- BR112015016605A2 BR112015016605A2 BR112015016605A BR112015016605A BR112015016605A2 BR 112015016605 A2 BR112015016605 A2 BR 112015016605A2 BR 112015016605 A BR112015016605 A BR 112015016605A BR 112015016605 A BR112015016605 A BR 112015016605A BR 112015016605 A2 BR112015016605 A2 BR 112015016605A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical ingredient
- particles
- suspension
- processing particles
- processing
- Prior art date
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B3/00—Drying solid materials or objects by processes involving the application of heat
- F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
- F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B1/00—Preliminary treatment of solid materials or objects to facilitate drying, e.g. mixing or backmixing the materials to be dried with predominantly dry solids
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B3/00—Drying solid materials or objects by processes involving the application of heat
- F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
- F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
- F26B3/12—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray, i.e. sprayed or dispersed emulsions or suspensions
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
resumo método para processar partículas de um ingrediente farmacêutico em suspensão, partículas, formulação farmacêutica, aparelho para processar partículas de um ingrediente farmacêutico em suspensão, método para evitar maturação de ostwald e uso de um método para processar partículas de um ingrediente farmacêutico em forma de pó a partir de uma suspensão do ingrediente farmacêutico a presente invenção relaciona-se com um processo para o controle de fenômeno de maturação de ostwald ocorrendo em suspensões de partículas sem a necessidade de adição de agentes estabilizantes, usando homogeneização a alta pressão em condições suaves de um modo que nenhum aumento ou diminuição de tamanho de partícula ocorra, permitindo assim a estabilização da suspensão durante a etapa de isolamento na forma de um pó seco.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT106738 | 2013-01-09 | ||
| PT106738A PT106738B (pt) | 2013-01-09 | 2013-01-09 | Método para o controlo do fenómeno de degradação difusional de ostwald (ostwald ripening) no processamento de partículas de um ingrediente farmacêutico |
| PCT/GB2014/050055 WO2014108687A1 (en) | 2013-01-09 | 2014-01-09 | Dynamic suspension drying (dsd) to control ostwald ripening |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015016605A2 true BR112015016605A2 (pt) | 2017-07-11 |
| BR112015016605B1 BR112015016605B1 (pt) | 2022-11-29 |
Family
ID=49999991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015016605-9A BR112015016605B1 (pt) | 2013-01-09 | 2014-01-09 | Método para processar partículas de um ingrediente farmacêutico em suspensão, método para evitar maturação de ostwald e uso de um método para processar partículas de um ingrediente farmacêutico em forma de pó a partir de uma suspensão do ingrediente farmacêutico |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10151529B2 (pt) |
| EP (1) | EP2874609B1 (pt) |
| JP (1) | JP6316847B2 (pt) |
| CN (1) | CN105007900B (pt) |
| BR (1) | BR112015016605B1 (pt) |
| CA (1) | CA2897277C (pt) |
| DK (1) | DK2874609T3 (pt) |
| ES (1) | ES2659968T3 (pt) |
| HU (1) | HUE036691T2 (pt) |
| IL (1) | IL239845B (pt) |
| PT (1) | PT106738B (pt) |
| SG (1) | SG11201505370RA (pt) |
| WO (1) | WO2014108687A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT108368B (pt) | 2015-03-31 | 2018-11-05 | Hovione Farm S A | Produção contínua de partículas |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826689A (en) | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
| US6749868B1 (en) * | 1993-02-22 | 2004-06-15 | American Bioscience, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| US6096331A (en) * | 1993-02-22 | 2000-08-01 | Vivorx Pharmaceuticals, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
| US5665382A (en) * | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of pharmaceutically active agents for in vivo delivery |
| US5916596A (en) * | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| US5650156A (en) * | 1993-02-22 | 1997-07-22 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of nutriceuticals and compositions useful therefor |
| US5665383A (en) * | 1993-02-22 | 1997-09-09 | Vivorx Pharmaceuticals, Inc. | Methods for the preparation of immunostimulating agents for in vivo delivery |
| WO1994018954A1 (en) * | 1993-02-22 | 1994-09-01 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of biologics and compositions useful therefor |
| US5997904A (en) * | 1993-02-22 | 1999-12-07 | American Bioscience, Inc. | Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof |
| US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
| EP1178786A4 (en) * | 1999-05-21 | 2006-03-01 | American Bioscience Inc | PHARMACOLOGICALLY ACTIVE PROTEIN STABILIZING AGENTS; METHODS OF MANUFACTURE AND METHODS OF USE |
| US6318649B1 (en) * | 1999-10-06 | 2001-11-20 | Cornerstone Technologies, Llc | Method of creating ultra-fine particles of materials using a high-pressure mill |
| CN1313080C (zh) * | 2000-04-20 | 2007-05-02 | 斯凯伊药品加拿大公司 | 改进的水不溶性药物粒子的制备方法 |
| WO2002004125A2 (en) | 2000-07-06 | 2002-01-17 | Cornerstone Technologies, L.L.C. | Multi-stage size reduction, blending and drying system and method |
| EP1416917B1 (en) * | 2001-08-06 | 2007-06-27 | AstraZeneca AB | Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (mct) |
| AU2003283954A1 (en) | 2002-12-06 | 2004-06-30 | Cornerstone Technologies, L.L.C. | High g mill in a blending and drying system |
| WO2008013785A2 (en) * | 2006-07-24 | 2008-01-31 | Singh-Broemer And Company, Inc. | Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening |
| PT105058B (pt) * | 2010-04-21 | 2013-04-17 | Hovione Farmaciencia S A | Processo para processamento de partículas de ingredientes activos farmacêuticos |
-
2013
- 2013-01-09 PT PT106738A patent/PT106738B/pt active IP Right Grant
-
2014
- 2014-01-09 CA CA2897277A patent/CA2897277C/en active Active
- 2014-01-09 EP EP14701124.1A patent/EP2874609B1/en active Active
- 2014-01-09 JP JP2015552139A patent/JP6316847B2/ja not_active Expired - Fee Related
- 2014-01-09 BR BR112015016605-9A patent/BR112015016605B1/pt active IP Right Grant
- 2014-01-09 DK DK14701124.1T patent/DK2874609T3/en active
- 2014-01-09 SG SG11201505370RA patent/SG11201505370RA/en unknown
- 2014-01-09 ES ES14701124.1T patent/ES2659968T3/es active Active
- 2014-01-09 WO PCT/GB2014/050055 patent/WO2014108687A1/en active Application Filing
- 2014-01-09 HU HUE14701124A patent/HUE036691T2/hu unknown
- 2014-01-09 US US14/760,095 patent/US10151529B2/en active Active
- 2014-01-09 CN CN201480011112.5A patent/CN105007900B/zh active Active
-
2015
- 2015-07-08 IL IL239845A patent/IL239845B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2897277C (en) | 2020-09-01 |
| WO2014108687A1 (en) | 2014-07-17 |
| BR112015016605B1 (pt) | 2022-11-29 |
| DK2874609T3 (en) | 2018-04-09 |
| HUE036691T2 (hu) | 2018-07-30 |
| JP6316847B2 (ja) | 2018-04-25 |
| JP2016508989A (ja) | 2016-03-24 |
| SG11201505370RA (en) | 2015-08-28 |
| EP2874609B1 (en) | 2017-12-27 |
| US10151529B2 (en) | 2018-12-11 |
| PT106738B (pt) | 2015-06-08 |
| CN105007900A (zh) | 2015-10-28 |
| IL239845A0 (en) | 2015-08-31 |
| ES2659968T3 (es) | 2018-03-20 |
| CN105007900B (zh) | 2019-04-12 |
| EP2874609A1 (en) | 2015-05-27 |
| IL239845B (en) | 2019-05-30 |
| CA2897277A1 (en) | 2014-07-17 |
| PT106738A (pt) | 2014-07-09 |
| US20150354891A1 (en) | 2015-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/01/2014, OBSERVADAS AS CONDICOES LEGAIS |