CN104983871A

CN104983871A - Traditional Chinese medicine for treating damp-heat type acute infantile diarrhea and preparation method for traditional Chinese medicine

Info

Publication number: CN104983871A
Application number: CN201510405826.0A
Authority: CN
Inventors: 莫宗举
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-07-10
Filing date: 2015-07-10
Publication date: 2015-10-21

Abstract

The invention provides a traditional Chinese medicine for treating damp-heat type acute infantile diarrhea and a preparation method for the traditional Chinese medicine. The traditional Chinese medicine comprises the following raw medicinal materials: rhubarb stem, mirabilis jalapa root, polygonum hydropiper, memorialis, bitter evergreenchinkapin seed, vernonia patula, lysimachia capillipes hemsl, litchee root, dolichos lablab stem, dried guavas, wilson barberry, myrobalan, divaricate knotweed herb root, herba erigerontis, banyan leaves and polygala japonica. The traditional Chinese medicine provided by the invention has the advantages of high efficiency and no toxic or side effect in the treatment of the damp-heat type acute infantile diarrhea, and the damp-heat type acute infantile diarrhea is difficult to recur.

Description

A kind ofly treat Chinese medicine of damp-heat type child acute diarrhea and preparation method thereof

Technical field

The present invention relates to the medicinal preparation and preparation method thereof containing deriving from plant, animal or raw mineral materials, particularly a kind ofly treating Chinese medicine of damp-heat type child acute diarrhea and preparation method thereof.

Background technology

Children's diarrhea vein be one group by multiple cause of disease, many factors causes, and to suffer from diarrhoea as the common intestinal tract disease of department of pediatrics of cardinal symptom, is one of the principal disease threatening children's health.Rotavirus (RV) is the main cause of disease of infantile diarrhea.According to World Health Organization's statistics, the whole world has 1.3 hundred million infant to suffer from rotavirus diarrhea every year, and 87.3 ten thousand people can be caused dead.No matter developed country or developing country, the infection rate of rotavirus and sickness rate are all very high.WHO thinks that the acute diarrhea child of 90% can apply oral rehydration therapy, and antibiotic, only for bacillary dysentery and " doubtful cholera " person, is in addition applied antibiotic and is not all worth.At present specific treatment method be there is no to rotavirus diarrhea both at home and abroad.The problems such as clinical treatment is by fluid infusion, and correction electrolyte disturbance and acid base imbalance etc. to the ill support are main, and curative effect is often undesirable, and there is abuse of antibiotics, the fluid infusion of abuse vein.The ill rear state of an illness of children's is critical, and intravenously administrable has certain difficulty, and oral administration infant is often uncooperative, and curative effect is not good enough.Give in treatment and bring a lot of difficulty, make protracted inflammation, also give the head of a family and infant in spirit simultaneously, animally, economically all bring white elephant.In order to reduce the harm of abuse of antibiotics, seeking a kind of not only convenient drug administration but also having the safe administration way of significant curative effect.

Infantile diarrhea is usual diseases of childhood, frequently-occurring disease, is also one of topmost cause of death of children's.When China's treatment diarrhoea, abuse of antibiotics phenomenon is very serious, and consequence causes bacterial drug resistance to strengthen, and normal intestinal flora is disorderly, destroys physiological equilibrium, makes diarrhoea delay or increase the weight of.Western medicine can only symptomatic treatment, and curative effect is not good enough.Primary disease all can occur throughout the year, especially common with summer and autumn and cause popular.The medicine of current this type of disease of clinical treatment mostly is oral formulations, and curative effect is not satisfied.Because infant internal organs are tender and lovely, gastrointestinal function developmental immaturity, digestive system function is unsound, in gastric juice, gastric acid is few, the poor activity of digestive enzyme, and infant is in quick growth and development stage, the nutrition of needs is many, relative gastrointestinal burden is heavier, in addition children's is cold warm can not self-regulated, and diet can not from joint, therefore, be subject to pathogen invasion and attack outward, interior is easily injury due to diet.

Having loose bowels is the modal disease of children's, is positioned at the second of China's common disease in children frequently-occurring disease, and be the one of the main reasons causing Infant and child deaths, the infant of less than two years old is common, and the four seasons all can occur.Increase with children's's defecation frequency, it is main manifestations that stool character changes (indigestible loose stool, watery stool, mucus just or bloody purulent stool).In addition, also can be low with appetite, often have vomiting, severe patient can spue coffee sample liquid body, and diarrhoea is frequent, and defecate every day tens times to tens times, feces is water sample or egg soup sample, outwards sputters, and outward appearance is yellow green, yellow or micro-yellow, and the water yield is many and excrement matter is few.Whole body ordinary circumstance is poor, heating, and body temperature can increase to 39 DEG C ~ 40 DEG C, minority can up to more than 41 DEG C, and children's shows as dysphoria, lethargy, haziness, even goes into a coma, along with General Symptoms aggravation, the functional disorder such as nervous system, the heart, liver, kidney can be caused.Diarrhoea the lighter affects infant nutrition and absorbs, and severe one is many because of the threat to life with dehydration, acidosis, circulatory disturbance and shock.Because primary disease can invade respiratory tract, also known as " reovirus ", there is 40% ~ 50% patient with respiratory symptoms such as coughs.Past people are accustomed to claiming infantile diarrhea for " dyspepsia " or " enteritis ", are referred to as diarrhoea in recent years.Cause the reason of infantile diarrhea, mainly being invaded by exogenous pathogen, internal injury diet, weakness of the spleen and stomach etc., its pathological changes is at taste, and because of the main digesting food of stomach, it is precise and tiny that The spleen has the function to transport and transform nutrients, if taste are by sick, then diet enters stomach, indigestion, abnormal ascent-descent between clear YANG and turbid YIN, and walks large intestine, then becomes to have loose bowels.The food of nursing that is too much, very few, variable interval, much starch class and the fats of taking food too early of taking food, and change food species suddenly, all can cause digestive functional disturbance.The a large amount of antibiotic of prolonged application causes dysbacteriosis also can cause bacterial diarrhea.Infantile diarrhea can be divided into again " infectious diarrhea " and " noninfectious diarrhea " according to its different pathogeny.Infect in the main duodenum 12 road of infectious diarrhea, can be caused by virus, antibacterial, fungus etc.; Noninfectious diarrhea is often with nursing, dietary factor is relevant with climate change.Viral diarrhea can be caused by virus, especially common with rotavirus infection, betides well the infant of 6 months to 2 years old, and within less than 6 months, children's is because there being the antibody of mother, general little morbidity.The treatment of infantile diarrhea follows the principle of prevention or correct dehydration, continuation diet, rational use of drug for light-duty Diarrhea, generally soon can rehabilitation.Doctor trained in Western medicine to the treatment of infantile diarrhea, main symptomatic treatment, fluid infusion (oresol), various diarrhea, antibiotic, as bactrim, furazolidone, amino benzylpenicillin etc. are selected in coli-infection; Infection of staphylococcus aureus can select penicillin or erythromycin; Fungal infection should select nystatin or clotrimazole, though can reach the effect controlling symptom, because toxic and side effects is large, makes patient be difficult to accept.

Although the medicine of Chinese traditional treatment infantile diarrhea is a lot, as Chinese patent medicine: PIKEXIN, Jianpi Zhixie Powder by HPLC, changweikang granule etc., those chronic diarrhea are not healed, or with vomiting, difficult infant of taking medicine, control symptom and produce effects slowly, be difficult to tackle the problem at its root.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of effective percentage high and Chinese medicine of the treatment damp-heat type child acute diarrhea that toxic and side effects is little and preparation method thereof.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of damp-heat type child acute diarrhea, its raw medicinal material comprises: Caulis Rhei, Radix Mirabilis, Herba Polygoni hydropiperis, Herba Gonostegiae hirtae, Semen castanopsis sclerophyllae, Herba Vernoniae Patulae, Herba lysimachiae capillipedis, Radix Litchi, Caulis Dolichoris, Fructus psidii guajavae immaturus, Radix Berberidis wilsonae, Fructus chebulae immaturus, Radix polygoni divaricati, Herba Erigerontis, Folium fici microcarpae and Herba Polygalae Japonicae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Caulis Rhei 10 ~ 20 parts, Radix Mirabilis 12 ~ 22 parts, Herba Polygoni hydropiperis 18 ~ 28 parts, Herba Gonostegiae hirtae 23 ~ 33 parts, Semen castanopsis sclerophyllae 20 ~ 30 parts, Herba Vernoniae Patulae 10 ~ 20 parts, Herba lysimachiae capillipedis 10 ~ 20 parts, Radix Litchi 30 ~ 40 parts, Caulis Dolichoris 20 ~ 30 parts, Fructus psidii guajavae immaturus 15 ~ 25 parts, Radix Berberidis wilsonae 22 ~ 33 parts, Fructus chebulae immaturus 28 ~ 38 parts, Radix polygoni divaricati 20 ~ 30 parts, Herba Erigerontis 13 ~ 23 parts, Folium fici microcarpae 20 ~ 30 parts and Herba Polygalae Japonicae 15 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Caulis Rhei 12 ~ 17 parts, Radix Mirabilis 10 ~ 15 parts, Herba Polygoni hydropiperis 19 ~ 24 parts, Herba Gonostegiae hirtae 25 ~ 30 parts, Semen castanopsis sclerophyllae 20 ~ 25 parts, Herba Vernoniae Patulae 15 ~ 20 parts, Herba lysimachiae capillipedis 10 ~ 15 parts, Radix Litchi 30 ~ 35 parts, Caulis Dolichoris 22 ~ 27 parts, Fructus psidii guajavae immaturus 16 ~ 21 parts, Radix Berberidis wilsonae 24 ~ 29 parts, Fructus chebulae immaturus 31 ~ 36 parts, Radix polygoni divaricati 20 ~ 25 parts, Herba Erigerontis 15 ~ 20 parts, Folium fici microcarpae 25 ~ 30 parts and Herba Polygalae Japonicae 17 ~ 22 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Caulis Rhei 16 parts, Radix Mirabilis 12 parts, Herba Polygoni hydropiperis 23 parts, Herba Gonostegiae hirtae 26 parts, Semen castanopsis sclerophyllae 24 parts, Herba Vernoniae Patulae 17 parts, Herba lysimachiae capillipedis 15 parts, Radix Litchi 32 parts, Caulis Dolichoris 25 parts, Fructus psidii guajavae immaturus 17 parts, Radix Berberidis wilsonae 28 parts, Fructus chebulae immaturus 32 parts, Radix polygoni divaricati 24 parts, Herba Erigerontis 17 parts, Folium fici microcarpae 29 parts and Herba Polygalae Japonicae 19 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Caulis Rhei 13 parts, Radix Mirabilis 14 parts, Herba Polygoni hydropiperis 20 parts, Herba Gonostegiae hirtae 29 parts, Semen castanopsis sclerophyllae 21 parts, Herba Vernoniae Patulae 18 parts, Herba lysimachiae capillipedis 12 parts, Radix Litchi 34 parts, Caulis Dolichoris 23 parts, Fructus psidii guajavae immaturus 20 parts, Radix Berberidis wilsonae 25 parts, Fructus chebulae immaturus 35 parts, Radix polygoni divaricati 22 parts, Herba Erigerontis 19 parts, Folium fici microcarpae 26 parts and Herba Polygalae Japonicae 21 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is membranous patch, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;

Second step, powder 6.5 ~ 7.5 weight portion prepared by the first step, polyvinyl alcohol 2 ~ 3 weight portion, the abundant mix and blend of glycerol 0.5 ~ 1 weight portion, produces to without minute bubbles, leaves standstill 20 ~ 30 minutes, obtained mixing paste;

3rd step, the mixing paste film-making machine even spread masking prepared by second step, under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the mode that both sides are fixing, containing powder sticking glass paper, obtains membranous patch.

Beneficial effect of the present invention: Chinese medicine of the present invention, to treatment damp-heat type child acute diarrhea, has the advantage that effective percentage is high, have no side effect and not easily recur.

Detailed description of the invention

Embodiments provide a kind of Chinese medicine for the treatment of damp-heat type child acute diarrhea, its raw medicinal material comprises: Caulis Rhei, Radix Mirabilis, Herba Polygoni hydropiperis, Herba Gonostegiae hirtae, Semen castanopsis sclerophyllae, Herba Vernoniae Patulae, Herba lysimachiae capillipedis, Radix Litchi, Caulis Dolichoris, Fructus psidii guajavae immaturus, Radix Berberidis wilsonae, Fructus chebulae immaturus, Radix polygoni divaricati, Herba Erigerontis, Folium fici microcarpae and Herba Polygalae Japonicae.

In above-mentioned Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Caulis Rhei: [source] medical material Ji Yuan: be the aerial stem of plant or the tender Seedling of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale etc.[nature and flavor] are bitter; Acid; Cold in nature.[function cures mainly] pathogenic fire purging; Relieving constipation.Main excess-heat constipation.[extracts] " China's book on Chinese herbal medicine "

Radix Mirabilis: [another name] is spent ginseng, Steamed dumpling with pork，mushrooms and bamboo shoots root in vain, is entered DILAOSHU, pollen head, pigment head, powder head, kermes fresh idea, white lead root, white lead angle.[source] medical material Ji Yuan: be the root of Nyctaginaceae plant Mirabilis jalapa.Latin plant animal mineral name: Radix Mirabilis Jalapae.[nature and flavor] are sweet; Light; Cold nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances is invigorated blood circulation.Main pyretic stranguria; Nebulousurine; Edema; Leucorrhea with red and white discharge; Arthralgia; Carbuncle pyogenic infections from tumour or sore; Acute mastitis; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Herba Polygoni hydropiperis: [another name] knotweed, rose, rose anxiety, anxiety knotweed, damp knotweed, Herba polygoni hydropiperis, willow knotweed, river are few, medicine Herba Polygoni gracilis, smartweed Radix Glycyrrhizae, white Herba polygoni hydropiperis, recklessly Herba polygoni hydropiperis, Herba polygoni hydropiperis, peppery willow herb, pinch Hu, Herba galinsogae parviflorae, Herba Polygoni Orientalis, Herba Polygoni flaccidi, water Herba polygoni hydropiperis.[source] medical material Ji Yuan: be the aerial parts of polygonaceae plant Herba Polygoni hydropiperis.[nature and flavor] are pungent; Bitter; Property is put down.[return through] spleen; Stomach; Large intestine channel.The stagnant removing dampness of [function cures mainly] row; Dissipating blood stasis stops blooding; Dispelling wind for relieving itching; Removing toxic substances.Main humidity hysteresis internal resistance; The vexed stomachache of gastral cavity; Have loose bowels; Dysentery; Infantile malnutrition; Metrorrhagia; Amenorrhea due to stagnation of blood dysmenorrhea; Traumatic injury; Rheumatic arthralgia; Have blood in stool; Traumatic hemorrhage; Skin pruritus; Eczema; Rubella; Tinea pedis; Carbuncle; Venom.[extracts] " China's book on Chinese herbal medicine "

Herba Gonostegiae hirtae: the celestial rope of [another name] bundle, Oryza glutinosa Lay, Herba Gonostegiae hirtae, Rice & peanut milk rattan, rawly pull, pail dustpan rattan, iron hoop MANCAO, profound Radix Cannabis, red rice rattan, red meal rattan, Herba Pouzolziae Zeylanicae, add rattan, climing Radix Boehmeriae, red stone potato, porkling dish, transversal grass, little iron hoop, little sticky medicine, reddish tone band, JIUGUNIU, little Herba Sidae Szechuensis, heart rattan of anticipating from dissipation, ferrum knotweed, soil.[source] medical material Ji Yuan: be the whole herb with root of contrayerva Herba Gonostegiae Hirtae.[nature and flavor] are sweet; Micro-hardship; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Spleen invigorating removing food stagnancy; Inducing diuresis and reducing edema; Dissipating blood stasis stops blooding.Main acute mastitis; Toxic swelling; Dysentery; Dyspepsia; Abdominal pain due to retention of food; Glycoside amasss; Leukorrhagia; Edema; Dysuria; Dysmenorrhea; Traumatic injury; Hemoptysis; Spit blood; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Semen castanopsis sclerophyllae: [source] medical material Ji Yuan: be the kernel in the bitter sweet oak evergreen chinquapin of Fagaceae, Cyclobalanopsis gracilis or Qinggang.[nature and flavor] are sweet; Bitter; Puckery; Property is put down.[function cures mainly] relieving diarrhea with astringents; Promoting the production of body fluid to quench thirst.Master has loose bowels; Dysentery; Tianjin wound is thirsty; Get sick from drinking too much wine.[extracts] " China's book on Chinese herbal medicine "

Herba Vernoniae Patulae: [another name] great Ye Herba Vernoniae Patulae, the young dish of Canis familiaris L., Eragrostis amabilis, Calotropis gigantea(L.) Dry. ex Ait. f. var. procera (Ait.), Wan Chonghua, the sub-grass of Testis Et penis Bovis seu Bubali, fine dragonfly meal, the young grass of honeybee.[source] medical material Ji Yuan: be the herb of feverfew Herba Vernoniae Patulae.[nature and flavor] bitter in the mouth; Pungent; Property is put down.The heat clearing away of [function cures mainly] fresh breeze; Eliminating damp, detoxifying; Dissipating blood stasis for subsidence of swelling.Main cold, fever; Malaria; Close pain; Hypertension; Have loose bowels; Dysentery; Rheumatic arthralgia; Eczema; Herba Urticae Cannabinae is examined; Furuncle; Mastitis; The tuberculosis of cervical lymph nodes; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Herba lysimachiae capillipedis: [another name] row perfume, Lysimachia capillipes Hemsl, Rhizoma et radix valerianae, Herba lysimachiae capillipedis, hair handle Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), conjunction blood grass, MANSHANXIANG.[source] medical material Ji Yuan: be the herb of Ofthe Primulaceae Herba lysimachiae capillipedis.Latin plant animal mineral name: Lysimachia capillipes Hemsl.[nature and flavor] are sweet; Property is put down.[function cures mainly] expelling wind and removing dampness; Promoting the circulation of QI to relieve pain; Regulating menstruation; Removing toxic substances.Main flu; Cough; Rheumatic arthralgia; Institute's abdominal distention and pain; Menoxenia; Furuncle; Venom.[extracts] " China's book on Chinese herbal medicine "

Radix Litchi: [source] medical material Ji Yuan: be the root of sapindaceous plant Fructus Litchi.Latin plant animal mineral name: Litchi chinensis Sonn.[nature and flavor] micro-hardship; Puckery; Temperature.[return through] stomach; Spleen; Kidney channel.[function cures mainly] regulating QI to relieve pain; Removing toxic substances and promoting subsidence of swelling.Main stomachache; Hernia; Laryngopharynx swelling and pain.[extracts] " China's book on Chinese herbal medicine "

Caulis Dolichoris: [source] medical material Ji Yuan: be the ratan of leguminous plant Seem Lablab Album.Latin plant animal mineral name: Dolichos lablab L.[nature and flavor] are sweet; Tepor; Flat.[return through] heart; Large intestine channel.[function cures mainly] removing dampness for regulating stomach.Main heat-damp in summer is vomited and diarrhoea more than.[extracts] " China's book on Chinese herbal medicine "

Fructus psidii guajavae immaturus: [source] medical material Ji Yuan: be the dry young fruit of myrtle Fructus psidii guajavae immaturus.Latin plant animal mineral name: Psidium guajava L.[nature and flavor] puckery; Property is put down.[function cures mainly] astringing to arrest diarrhea; Hemostasis.Main dysentery is immoderate; Metrorrhagia.[extracts] " China's book on Chinese herbal medicine "

Radix Berberidis wilsonae: [another name] little Rhizoma Coptidis, three-jaw Rhizoma Coptidis, little Rhizoma Coptidis thorn, sour mew, CIHUANQIN, Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori), mouse thorn, little chicken foot Huang thorn.[source] medical material Ji Yuan: be the root of Berberidaceae plant JINHUA Radix Berberidis Amurensis.Latin plant animal mineral name: Berberis wilsonae Hemsl.et Wils.[nature and flavor] bitter in the mouth; Cold in nature.[return through] heart, lung, large intestine channel.[function cures mainly] heat clearing and damp drying; Eliminating fire and detoxication.Main damp-heat dysentery; Jaundice; Cough due to lung-heat; Conjunctival congestion and swelling pain; Oral aphthae in children; Pyretic toxicity carbuncle.[extracts] " China's book on Chinese herbal medicine "

Fructus chebulae immaturus: [another name] Tibet Fructus Canarii, FRUCTUS TERMINALIAE IMMATURUS.[source] medical material Ji Yuan: for Combretum Racemosum plant is the young fruit of Combretum Racemosum Fructus Chebulae.Latin plant animal mineral name: Terminalia chebula Retz.[nature and flavor] bitter in the mouth; Micro-sweet; Puckery; Cold nature.[function cures mainly] clearing away heat and promoting production of body fluid; Liyan jiedu.Main deficiency syndrome diphtheria; Tonsillitis; Bacillary dysentery; Dysentery; Enteritis.[extracts] " China's book on Chinese herbal medicine "

Radix polygoni divaricati: [source] medical material Ji Yuan: be the root of polygonaceae plant fork point knotweed.Latin plant animal mineral name: Polygonum divaricatum L.[nature and flavor] acid; Sweet; Warm in nature.[return through] spleen; Kidney channel.[function cures mainly] warming kidney for dispelling cold; To regulate the flow of vital energy upper pain; Antidiarrheal dysentery relieving.Main colic of cold type; Scrotum antiperspirant goes out; Stomachache; Diarrhoea; Dysentery.[extracts] " China's book on Chinese herbal medicine "

Herba Erigerontis: [another name] push up grass, be exposed to the sun Herba Erigerontis, two sunflower, Aster dubius (Thunb.) Onno, oil lamp grass, tooth fall into medicine, pottle grass.[source] medical material Ji Yuan: be root and the herb of feverfew Erigeron breviscapus (Vant.) Hand.-Mazz..[nature and flavor] acrid in the mouth; Micro-hardship; Temperature.[return through] returns lung; Stomach; Tripe warp.[function cures mainly] expelling cold and relieving exterior syndrome; Expelling wind and removing dampness; Activating collaterals to relieve pain; Removing food stagnancy.Main flu; Rheumatic arthralgia; Paralysis; Stomachache; Toothache; Infantile malnutrition; Osteomyelitis; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Folium fici microcarpae: [another name] little Folium fici microcarpae, Habenaria aitchisonii.[source] medical material Ji Yuan: be the leaf of moraceae plants Ficus microcarpa Linn. f.[nature and flavor] are light; Cool in nature.[function cures mainly] heat clearing away is delivered; Removing toxic substances and promoting subsidence of swelling; Damp-clearing pain-relieving.Main flow sense; Slow raw tracheitis; Pertussis; Tonsillitis; Conjunctival congestion; Toothache; Bacillary dysentery; Intestinal is scorching; Acute mastitis; Scald; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Herba Polygalae Japonicae: [another name] fourth Artemisia, Polygala amara, JINSUOSHI, god's sand grass, ground rattan grass, Radix Polygalae grass, mountain Rhizoma Coptidis, Semen Benincasae grass, little Jin basin, chicken claps wing, leaf Herba Violae, Radix cycleae barbatae, iron wire wind, Semen Benincasae lotus, Radix Berchemiae Yunnanensis, destroy malaria grass, Radix Ardisiae Punctatae, lobule Herba Violae, lobule Semen Benincasae grass, high foot Semen Benincasae grass, ferrum milling grass, general character grass, Fructus Cucumidis sativi position grass, synthetism is red, ground emaciation due to emotional upset, ferrum arrow wind, Herba Polygalae megalophae, little Rohdea japonica Roth, blue flower Herba Violae, fire weed bar, intermittent infantile convulsion medicine, Herba Violae, Herba Polygalae Telephioidis, upright Herba Violae, Herba Violae, Herba vallisneriae Spiralis, cinnabar grass, Herba Thalictri elati, melon rice Herba Asari, Herba Swertiae davidi, seven cun of gold, the young grass of buffalo gnat, crampon pole, armor grass, Zijin flower, little Radix Polygalae.[source] medical material Ji Yuan: be root and the herb of milk wort Herba Polygalae Japonicae.[nature and flavor] bitter in the mouth; Micro-pungent; Property is put down.[return through] lung; Stomach; Heart channel.[function cures mainly] expelling phlegm for arresting cough; Dissipating blood stasis stops blooding; Mind tranquilizing and the heart calming; Removing toxic substances and promoting subsidence of swelling.Main cough with copious phlegm; Traumatic injury, rheumatic arthralgia; Spit blood; Have blood in stool; Cardiopalmus; Insomnia; Laryngopharynx swelling and pain; Carbuncle skin infection; Venom.[extracts] " China's book on Chinese herbal medicine "

Embodiment 1: granule

Get Caulis Rhei 130g, Radix Mirabilis 140g, Herba Polygoni hydropiperis 200g, Herba Gonostegiae hirtae 290g, Semen castanopsis sclerophyllae 210g, Herba Vernoniae Patulae 180g, Herba lysimachiae capillipedis 120g, Radix Litchi 340g, Caulis Dolichoris 230g, Fructus psidii guajavae immaturus 200g, Radix Berberidis wilsonae 250g, Fructus chebulae immaturus 350g, Radix polygoni divaricati 220g, Herba Erigerontis 190g, Folium fici microcarpae 260g and Herba Polygalae Japonicae 210g;

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 90%, be heated to boiling reflux 3 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.05, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.2 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Embodiment 2: membranous patch

Get Caulis Rhei 160g, Radix Mirabilis 120g, Herba Polygoni hydropiperis 230g, Herba Gonostegiae hirtae 260g, Semen castanopsis sclerophyllae 240g, Herba Vernoniae Patulae 170g, Herba lysimachiae capillipedis 150g, Radix Litchi 320g, Caulis Dolichoris 250g, Fructus psidii guajavae immaturus 170g, Radix Berberidis wilsonae 280g, Fructus chebulae immaturus 320g, Radix polygoni divaricati 240g, Herba Erigerontis 170g, Folium fici microcarpae 290g and Herba Polygalae Japonicae 190g;

Prepare according to the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, is ground into 50 object powder, and adding relative to the determining alcohol of mixture quality 2 times is the ethanol of 85%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 times again, reflux 1.5 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 200 object powder;

Second step, powder 7 weight portion prepared by the first step, polyvinyl alcohol 2 weight portion, the abundant mix and blend of glycerol 1 weight portion, produces to without minute bubbles, leaves standstill 25 minutes, obtained mixing paste;

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 8.82g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 44.1 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage membranous patch LD50>44.1 crude drug/kg of the present invention, every day, maximum dosage-feeding was 88.2 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.8g crude drug/day/people, adult body weight in 60KG, average dosage is 0.147g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 25g) oral administration gavage Chinese medicine of the present invention is 600 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: the granule of Chinese medicine embodiment 1 of the present invention presses 15.78,23.45 and 45.11g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 90 routine cases are my Out-patient Department patient of in April, 2013 ~ 2015 year January, 2 ~ 14 years old age, man 47 example, female 43 example.Be divided into treatment group and matched group at random, wherein treatment group 45 people, male 24 people, women 21 people, 2 ~ 13 years old age; Light-duty diarrhoea 11 example, medium-sized diarrhoea 25 example, heavy diarrhoea 9 example; Matched group 45 people, male 23 people, women 22 people, 3 ~ 14 years old age.Light-duty diarrhoea 12 example, medium-sized diarrhoea 23 example, heavy diarrhoea 10 example; Two groups in age, sex, clinical manifestation etc. through statistical analysis there was no significant difference (p>0.05).

Diagnostic criteria: Western medicine diagnose standard: acute onset, diarrhoea number of times at least 4 ~ 5 times/day, feces character be loose stool, watery stool or desalination sample just; The visible a small amount of leukocyte of stool routine examination inspection and Oil globule, without erythrocyte and pus cell, stool is cultivated negative; Can with heating and vomiting, syneresis in various degree; The course of disease≤2 week, and get rid of dysentery, severe malnutrition and other systemic diseases.

Syndrome Types of TCM standard: damp-heat type: stool water sample, or as egg soup sample, rush down urgently lower, repeatedly frequently, abnormal smells from the patient is smelly dirty, or sees a little mucus for amount, do during stomachache, inappetence, or with vomiting and nausea, spiritlessness and weakness, or heating is tired noisy, thirsty; oliguria with yellow urine, red tongue, and yellow and greasy fur, slippery and rapid pulse, fingerprint is purple.

The state of an illness is classified: light-duty diarrhoea: without dehydration, without poisoning symptom.Medium-sized diarrhoea: some dewaters or has calomel poisoning symptom.Heavy diarrhoea: severe dehydration or obviously poisoning symptom (agitation, lethargy, drowsiness, pale complexion, Gao Re or body temperature do not rise, peripheral leukocytes counts and obviously increase).

Therapeutic Method:

Treatment group: the injection embodiment of the present invention 1 granule, every day 3 times, each 15g, treats 3 days;

Matched group: oral dioctahedral smectite montmorillonite powder, every day 3 times, treats 3 days by each 1 bag.

Curative effect judging standard: effective: treat feces character and number of times in 72 hours and recover normal, General Symptoms disappears.Effective: treatment 72 little fecal shape and number of times are constantly clearly better, and General Symptoms obviously improves.Invalid: treatment 72 little fecal shape, number of times and General Symptomies constantly even worsen without improvement.

Therapeutic outcome: Comparison of therapeutic situation before and after two groups of patient treatments, in table 1.

Comparison of therapeutic situation before and after table 1 liang group patient treatment:

Group	n	Effective	Effectively	Invalid	Total effective rate
						Treatment group	45	33	11	1	44(97.8％)
Matched group	45	28	9	8	37(82.2％)

As shown in Table 1, treatment group curative effect is higher than matched group.Namely Chinese medicine provided by the invention has that effective percentage is high, the advantage of safe without toxic side effect; Follow up a case by regular visits to 1 month respectively to the effective 33 routine patients for the treatment of group and the effective 28 routine patients of matched group, result is added up, and treatment group is without recurrence, and relapse rate is 0% simultaneously; The routine patient of matched group 28, recurs 3 people, relapse rate 10.7%.

Concrete case: high certain, man, 9 years old, suffering from diarrhoea is admitted to hospital for 3 days saw a doctor, every day suffers from diarrhoea 5-7 time, mild diarrhea, and stool, as egg soup sample, is rushed down urgently lower, repeatedly frequently, abnormal smells from the patient is smelly dirty for amount, and visible a little mucus, does during stomachache, inappetence, with vomiting and nausea, spiritlessness and weakness, thirsty; oliguria with yellow urine, red tongue, yellow and greasy fur; slippery and rapid pulse, fingerprint is purple, is diagnosed as damp-heat type child acute diarrhea.Take the embodiment of the present invention 1 granule, every day 3 times, each 15g, treat 2 days feces character and number of times and recover normal, General Symptoms disappears, and follows up a case by regular visits to and does not recur for 1 month.

Claims

1. treat a Chinese medicine for damp-heat type child acute diarrhea, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Caulis Rhei, Radix Mirabilis, Herba Polygoni hydropiperis, Herba Gonostegiae hirtae, Semen castanopsis sclerophyllae, Herba Vernoniae Patulae, Herba lysimachiae capillipedis, Radix Litchi, Caulis Dolichoris, Fructus psidii guajavae immaturus, Radix Berberidis wilsonae, Fructus chebulae immaturus, Radix polygoni divaricati, Herba Erigerontis, Folium fici microcarpae and Herba Polygalae Japonicae.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Caulis Rhei 10 ~ 20 parts, Radix Mirabilis 12 ~ 22 parts, Herba Polygoni hydropiperis 18 ~ 28 parts, Herba Gonostegiae hirtae 23 ~ 33 parts, Semen castanopsis sclerophyllae 20 ~ 30 parts, Herba Vernoniae Patulae 10 ~ 20 parts, Herba lysimachiae capillipedis 10 ~ 20 parts, Radix Litchi 30 ~ 40 parts, Caulis Dolichoris 20 ~ 30 parts, Fructus psidii guajavae immaturus 15 ~ 25 parts, Radix Berberidis wilsonae 22 ~ 33 parts, Fructus chebulae immaturus 28 ~ 38 parts, Radix polygoni divaricati 20 ~ 30 parts, Herba Erigerontis 13 ~ 23 parts, Folium fici microcarpae 20 ~ 30 parts and Herba Polygalae Japonicae 15 ~ 25 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Caulis Rhei 12 ~ 17 parts, Radix Mirabilis 10 ~ 15 parts, Herba Polygoni hydropiperis 19 ~ 24 parts, Herba Gonostegiae hirtae 25 ~ 30 parts, Semen castanopsis sclerophyllae 20 ~ 25 parts, Herba Vernoniae Patulae 15 ~ 20 parts, Herba lysimachiae capillipedis 10 ~ 15 parts, Radix Litchi 30 ~ 35 parts, Caulis Dolichoris 22 ~ 27 parts, Fructus psidii guajavae immaturus 16 ~ 21 parts, Radix Berberidis wilsonae 24 ~ 29 parts, Fructus chebulae immaturus 31 ~ 36 parts, Radix polygoni divaricati 20 ~ 25 parts, Herba Erigerontis 15 ~ 20 parts, Folium fici microcarpae 25 ~ 30 parts and Herba Polygalae Japonicae 17 ~ 22 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Caulis Rhei 16 parts, Radix Mirabilis 12 parts, Herba Polygoni hydropiperis 23 parts, Herba Gonostegiae hirtae 26 parts, Semen castanopsis sclerophyllae 24 parts, Herba Vernoniae Patulae 17 parts, Herba lysimachiae capillipedis 15 parts, Radix Litchi 32 parts, Caulis Dolichoris 25 parts, Fructus psidii guajavae immaturus 17 parts, Radix Berberidis wilsonae 28 parts, Fructus chebulae immaturus 32 parts, Radix polygoni divaricati 24 parts, Herba Erigerontis 17 parts, Folium fici microcarpae 29 parts and Herba Polygalae Japonicae 19 parts.

5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Caulis Rhei 13 parts, Radix Mirabilis 14 parts, Herba Polygoni hydropiperis 20 parts, Herba Gonostegiae hirtae 29 parts, Semen castanopsis sclerophyllae 21 parts, Herba Vernoniae Patulae 18 parts, Herba lysimachiae capillipedis 12 parts, Radix Litchi 34 parts, Caulis Dolichoris 23 parts, Fructus psidii guajavae immaturus 20 parts, Radix Berberidis wilsonae 25 parts, Fructus chebulae immaturus 35 parts, Radix polygoni divaricati 22 parts, Herba Erigerontis 19 parts, Folium fici microcarpae 26 parts and Herba Polygalae Japonicae 21 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is membranous patch, and its preparation method comprises the following steps:

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is membranous patch, and its preparation method comprises the following steps: