CN104955950B - 具有改善的脱靶特征谱的寡核苷酸 - Google Patents

具有改善的脱靶特征谱的寡核苷酸 Download PDF

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CN104955950B
CN104955950B CN201380057694.6A CN201380057694A CN104955950B CN 104955950 B CN104955950 B CN 104955950B CN 201380057694 A CN201380057694 A CN 201380057694A CN 104955950 B CN104955950 B CN 104955950B
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CN104955950A (zh
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T·莫勒
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Guangdong Maijinjia Biotechnology Co Ltd
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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CN201380057694.6A 2012-09-26 2013-09-26 具有改善的脱靶特征谱的寡核苷酸 Active CN104955950B (zh)

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US201261705668P 2012-09-26 2012-09-26
DKPA201200587 2012-09-26
DKPA201200587 2012-09-26
US61/705,668 2012-09-26
PCT/DK2013/050308 WO2014048441A1 (en) 2012-09-26 2013-09-26 Oligomers with improved off-target profile

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JP6430945B2 (ja) 2012-10-02 2018-11-28 センテナリ インスティテュート オブ キャンサー メディシン アンド セル バイオロジーＣｅｎｔｅｎａｒｙ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｃａｎｃｅｒ Ｍｅｄｉｃｉｎｅ Ａｎｄ Ｃｅｌｌ Ｂｉｏｌｏｇｙ Ｒｎａ活性及び血管透過性の調節
UA116639C2 (uk) 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Способи лікування синдрому альпорта
TW201446791A (zh) 2013-05-01 2014-12-16 Regulus Therapeutics Inc 用於調節mir-122之微小rna化合物及方法
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JP6804975B2 (ja) * 2014-06-13 2020-12-23 東レ株式会社 乳がんの検出キット又はデバイス及び検出方法
CN106460068B (zh) * 2014-06-16 2024-08-23 东丽株式会社 胃癌的检测试剂盒或装置以及检测方法
CN119842899A (zh) 2014-06-18 2025-04-18 东丽株式会社 肝癌的检测试剂盒或装置以及检测方法
JP6385732B2 (ja) * 2014-06-27 2018-09-05 国立大学法人北海道大学 免疫応答制御剤
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BR112017003608B1 (pt) * 2014-09-16 2023-11-07 Toray Industries, Inc MÉTODO PARA A ANÁLISE COMPARATIVA DO NÍVEL DE EXPRESSÃO DE miRNA(S) ALVO(S) E CHIP PARA ANÁLISE DA EXPRESSÃO DE miRNA
WO2016115609A1 (en) * 2015-01-20 2016-07-28 Katholieke Universiteit Leuven Colon cancer
WO2016137235A2 (ko) 2015-02-25 2016-09-01 (주)바이오니아 마이크로 rna를 유효 성분으로 포함하는 암 치료용 약학 조성물
CN104826133B (zh) * 2015-05-01 2020-11-24 北京博奥医学检验所有限公司 一种与肺腺癌有关的miRNA及其药物组合物
CN107058470B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过联合miR-136和miR-4791预测急性高山病发病风险的诊断试剂盒
CN107058472B (zh) * 2016-11-03 2020-10-27 中国人民解放军陆军军医大学 一种通过四种血浆microRNA联合诊断急性高山病的诊断试剂盒
CN107058471B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过四种microRNA生物标志物联合预测急性高山病发病风险的试剂盒
CN107058475B (zh) * 2016-11-03 2020-10-27 中国人民解放军陆军军医大学 一种联合miR-676、miR-181b和miR-193b诊断急性高山病的试剂盒
CN107058474B (zh) * 2016-11-03 2020-09-01 中国人民解放军陆军军医大学 一种通过血浆microRNA-3591-3p诊断急性高山病的诊断试剂盒
CN107058473B (zh) * 2016-11-03 2020-10-27 中国人民解放军陆军军医大学 一种联合miR-676、miR-181b和miR-3591诊断急性高山病的试剂盒
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CN108295260A (zh) * 2017-01-13 2018-07-20 彭长庚 通过miR-1915-3p进行抗癌的方法和药物及其应用
CN108310381A (zh) * 2017-01-16 2018-07-24 昆山彭济凯丰生物科技有限公司 通过miR-6511b-3p进行抗癌的方法和药物及其应用
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KR102070969B1 (ko) * 2018-04-10 2020-01-29 한국한의학연구원 통증 판별용 마커
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CA2886116A1 (en) 2014-04-03
CA2886116C (en) 2022-06-07
AU2013324716A1 (en) 2015-04-09
EP2900822A4 (en) 2016-05-25
EP2900822B1 (en) 2021-11-24
JP2016513950A (ja) 2016-05-19
JP6352269B2 (ja) 2018-07-04
AU2013324716B2 (en) 2019-06-13
WO2014048441A1 (en) 2014-04-03
US9725721B2 (en) 2017-08-08
US20160145620A1 (en) 2016-05-26
CN104955950A (zh) 2015-09-30
EP2900822A1 (en) 2015-08-05

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