CN104945384A - 5-氯-6-[(2-亚氨基-1-吡咯烷)甲基]-2,4(1h,3h)-嘧啶二酮或其盐的制备方法 - Google Patents
5-氯-6-[(2-亚氨基-1-吡咯烷)甲基]-2,4(1h,3h)-嘧啶二酮或其盐的制备方法 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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CN201410113627.8A CN104945384B (zh) | 2014-03-25 | 2014-03-25 | 5-氯-6-[(2-亚氨基-1-吡咯烷)甲基]-2,4(1h,3h)-嘧啶二酮或其盐的制备方法 |
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CN201410113627.8A CN104945384B (zh) | 2014-03-25 | 2014-03-25 | 5-氯-6-[(2-亚氨基-1-吡咯烷)甲基]-2,4(1h,3h)-嘧啶二酮或其盐的制备方法 |
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CN104945384A true CN104945384A (zh) | 2015-09-30 |
CN104945384B CN104945384B (zh) | 2018-10-16 |
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Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105906573A (zh) * | 2015-12-23 | 2016-08-31 | 嘉实(湖南)医药科技有限公司 | 一种替吡嘧啶中间体的制备方法 |
CN106632081A (zh) * | 2016-12-14 | 2017-05-10 | 四川同晟生物医药有限公司 | 一种5‑氯‑6‑(氯甲基)尿嘧啶及其制备方法 |
CN106892902A (zh) * | 2017-03-01 | 2017-06-27 | 国药心制药有限公司 | 一种盐酸替匹嘧啶及其中间体6‑氯甲基尿嘧啶的合成方法 |
CN106938987A (zh) * | 2017-01-11 | 2017-07-11 | 卡硼瑞(北京)科技有限公司 | 5‑氯‑6‑氯甲基尿嘧啶的制备方法 |
CN107118164A (zh) * | 2017-02-08 | 2017-09-01 | 卡硼瑞(北京)科技有限公司 | 5‑氯‑6‑(氯甲基)‑2,4‑(1h,3h)‑嘧啶二酮的制备方法 |
CN107298656A (zh) * | 2017-06-21 | 2017-10-27 | 四川同晟生物医药有限公司 | 替吡嘧啶中间体以及替吡嘧啶中间体、替吡嘧啶、替吡嘧啶盐酸盐的制备方法 |
CN108203437A (zh) * | 2016-12-20 | 2018-06-26 | 江苏先声药业有限公司 | 两种替吡嘧啶杂质制备方法与应用 |
WO2019002407A1 (en) | 2017-06-28 | 2019-01-03 | Amneal Pharmaceuticals Company Gmbh | PROCESS FOR THE PREPARATION OF TIPIRACIL CHLORHYDRATE |
WO2019049174A1 (en) * | 2017-09-07 | 2019-03-14 | Msn Laboratories Private Limited, R&D Center | SOLID STATE FORMS OF 5-CHLORO-6 - [(2-IMINOPYRROLIDIN-1-YL) METHYL] PYRIMIDINE-2,4- (1H, 3H) -DIONE HYDROCHLORIDE AND METHODS OF PREPARATION THEREOF |
US10457666B2 (en) | 2013-06-17 | 2019-10-29 | Taiho Pharmaceutical Co., Ltd. | Stable crystal form of tipiracil hydrochloride and crystallization method for the same |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996030346A1 (fr) * | 1995-03-29 | 1996-10-03 | Taiho Pharmaceutical Co., Ltd. | Derives d'uracile, agents de potentialisation d'effet antitumoral et agent antitumoral renfermant ces derives |
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2014
- 2014-03-25 CN CN201410113627.8A patent/CN104945384B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1996030346A1 (fr) * | 1995-03-29 | 1996-10-03 | Taiho Pharmaceutical Co., Ltd. | Derives d'uracile, agents de potentialisation d'effet antitumoral et agent antitumoral renfermant ces derives |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10457666B2 (en) | 2013-06-17 | 2019-10-29 | Taiho Pharmaceutical Co., Ltd. | Stable crystal form of tipiracil hydrochloride and crystallization method for the same |
CN105906573A (zh) * | 2015-12-23 | 2016-08-31 | 嘉实(湖南)医药科技有限公司 | 一种替吡嘧啶中间体的制备方法 |
CN106632081A (zh) * | 2016-12-14 | 2017-05-10 | 四川同晟生物医药有限公司 | 一种5‑氯‑6‑(氯甲基)尿嘧啶及其制备方法 |
CN108203437A (zh) * | 2016-12-20 | 2018-06-26 | 江苏先声药业有限公司 | 两种替吡嘧啶杂质制备方法与应用 |
CN108203437B (zh) * | 2016-12-20 | 2022-05-13 | 海南先声药业有限公司 | 两种替吡嘧啶杂质制备方法与应用 |
CN106938987A (zh) * | 2017-01-11 | 2017-07-11 | 卡硼瑞(北京)科技有限公司 | 5‑氯‑6‑氯甲基尿嘧啶的制备方法 |
CN107118164A (zh) * | 2017-02-08 | 2017-09-01 | 卡硼瑞(北京)科技有限公司 | 5‑氯‑6‑(氯甲基)‑2,4‑(1h,3h)‑嘧啶二酮的制备方法 |
CN106892902A (zh) * | 2017-03-01 | 2017-06-27 | 国药心制药有限公司 | 一种盐酸替匹嘧啶及其中间体6‑氯甲基尿嘧啶的合成方法 |
CN107298656A (zh) * | 2017-06-21 | 2017-10-27 | 四川同晟生物医药有限公司 | 替吡嘧啶中间体以及替吡嘧啶中间体、替吡嘧啶、替吡嘧啶盐酸盐的制备方法 |
WO2019002407A1 (en) | 2017-06-28 | 2019-01-03 | Amneal Pharmaceuticals Company Gmbh | PROCESS FOR THE PREPARATION OF TIPIRACIL CHLORHYDRATE |
WO2019049174A1 (en) * | 2017-09-07 | 2019-03-14 | Msn Laboratories Private Limited, R&D Center | SOLID STATE FORMS OF 5-CHLORO-6 - [(2-IMINOPYRROLIDIN-1-YL) METHYL] PYRIMIDINE-2,4- (1H, 3H) -DIONE HYDROCHLORIDE AND METHODS OF PREPARATION THEREOF |
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Address after: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant after: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant before: JIANGSU HANSOH PHARMACEUTICAL GROUP LIANYUNGANG HONGCHUANG PHARMACEUTICAL Co.,Ltd. |
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Address after: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant after: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: Jiangsu best Pharmaceutical Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address after: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant after: Jiangsu best Pharmaceutical Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: Tenth Industrial Zone, Lianyungang, Jiangsu, China, 222047 Applicant before: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. |
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