CN104939092A - Composite pericarp extract product having heat clearing and lung moistening efficacy - Google Patents
Composite pericarp extract product having heat clearing and lung moistening efficacy Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
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- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a composite pericarp extract product having heat clearing and lung moistening efficacy. By aiming the phenomenon that a lot of pericarp and fruit stone is waste during a fruit and vegetable product processing process, snow pear peel, mangosteen pericarp, banana peel and loquat nucleus are taken as raw materials, and the composite pericarp extract product is made by steps of extraction, freeze drying, crushing and mixing. The composite pericarp extract product has good heat clearing and lung moistening efficacy, and can effectively alleviate symptoms of swollen sore throat and thirsty due to cough with lung heat, can be used for preparing the cough-relieving medicine or health food having heat clearing and lung moistening efficacy such as cold tea, and has wide market prospect.
Description
Technical field
The invention belongs to Medicines and Health Product technical field, be specifically related to a kind of composite fruit bark extract with clearing heat and moistening lung effect.
Background technology
Snow pear has been recognized effects such as having moistening lung is dry clearly, relieving cough and reducing sputum, nourishing blood and promoting granulation, but snow pear is cool in nature, should not eat more, and this is because pears meat is cold in nature cold, and many foods can cause deficiency-cold in spleen and stomach, even occurs diarrhoea.And pears skin belongs to positive, its property is more flat, and its also there is heat-clearing, moistening lung, the effect such as to promote the production of body fluid, not only can be relieving cough and reducing sputum after edible, also can not produce diarrhoea.But at present in the process containing pears food, beverage, process after often snow pear being removed the peel, which results in a large amount of pears skin discarded object.Mangosteen taste is sour-sweet, is famous tropical fruit (tree), its rich in nutrition content, and has the effects such as invigorating the spleen is promoted the production of body fluid, clearing away heat to stop diarrhea, has the title of " in fruit queen ".Mangosteen peel is abundant, and most people all can be thrown away mangosteen peel after eating mangosteen, but the nutrient contained in mangosteen peel not only can clearing heat and removing internal heat, also can effectively relieving cough time throat very thirsty symptom, have better effects to improving illness.Banana is a kind of fruit that people often eat, and being also proposed a large amount of on the market take banana as the leisure food of raw material, and a large amount of banana skin is dropped in its process.Containing nutritional labelings such as pectin, phenols, protein and sugar classes in banana skin, except there is anti-oxidant, antibacterial, antineoplastic effect, also there is effect of only polydipsia, moistening lung intestines.The present invention makes full use of the nutritive value of pericarp and fruit stone, and with snow pear skin, mangosteen peel, banana skin, loquat seed for raw material, the composite fruit bark extract through extracting, being mixed has good lowering fat and protecting liver effect.
Summary of the invention
The object of the present invention is to provide a kind of composite fruit bark extract with clearing heat and moistening lung effect, its phenomenon be wasted for pericarp a large amount of in existing fruit and vegetable food process and fruit stone, prepares a kind of composite fruit bark extract with good clearing heat and moistening lung effect with snow pear skin, mangosteen peel, banana skin, loquat seed for raw material.
For achieving the above object, the present invention adopts following technical scheme:
There is the composite fruit bark extract of clearing heat and moistening lung effect, be after snow pear skin, mangosteen peel, banana skin, loquat seed are extracted respectively through freeze drying, pulverize, be mixed; Described component comprises by weight: snow pear skin 10-15 part, mangosteen peel 5-8 part, banana skin 3-5 part, loquat seed 3-5 part.
The extracting method of described snow pear skin is: shred after the snow pear skin cleaning of reclaiming, add raw material weight 3-5 water doubly, ultrasonic extraction 40-60min at 30-50 DEG C, filter; Filter residue add raw material weight 2-3 doubly, mass concentration is the ethanol of 60-70%, ultrasonic extractions 30-40min at 30-50 DEG C, filtration; Be evaporated to dry after merging filtrate.
The extracting method of described mangosteen peel is: cleaned by the mangosteen peel reclaimed, dry rear coarse crushing, put into extraction kettle and carry out supercritical CO
2extraction, extraction kettle temperature is 50 ~ 80 DEG C, and pressure is 10 ~ 20MPa, extraction time 1 ~ 2h; Then extract is flowed into separating still and carry out the second-order separation, first order separating pressure 8 ~ 10MPa, separation temperature 50 ~ 80 DEG C, second level separating pressure 4 ~ 8MPa, separation temperature 40 ~ 60 DEG C; Gained parting liquid adds suction filtration after activated carbon decolorizing, and filtrate reduced in volume is to dry.
The extracting method of described banana skin is: select that epidermis complete, immaculate banana skin is cleaned, stripping and slicing, pulls out after putting into boiling water blanching 2-3min, add banana skin weight 1-2 doubly, mass concentration is making beating after the aqueous citric acid solution mixing of 0.3%-0.5%; Add mixed enzyme enzymolysis 1-2h at 35-38 DEG C of slurry weight 3%-5% again, centrifugal, gained supernatant add its volume 3-5 doubly, mass concentration is after the ethanolic solution mixing of 70%-90%, 0-4 DEG C of left overnight, centrifugal, it is for subsequent use to get precipitation;
Wherein, described mixed enzyme is by weight 1:1:1 mixing by cellulase, protease, pectase.
The extracting method of described loquat seed is: after being cleaned by the loquat seed of recovery, smashing to pieces, add its weight 3-5 doubly, mass concentration is the ethanolic solution of 70%-90%, ultrasonic extraction 2-3 time at 30-50 DEG C, each 30-40min, filter, merging filtrate, is evaporated to dry; After adding ether by mass volume ratio 1:2, ultrasonic extraction 20-30min, suction filtration, filter cake distilled water flushing 2-3 time.
The described composite fruit bark extract with clearing heat and moistening lung effect can be used for the health food prepared cough-relieving medicine or have heat-clearing, moistening lung effect.
remarkable advantage of the present invention is:present invention achieves the recycling of fruit and vegetable food process mesocarp, fruit stone discarded object, not only can effectively reduce the wasting of resources and environmental pollution, also take full advantage of the nutritional labeling in pericarp, fruit stone, gained composite fruit bark extract is made to have good clearing heat and moistening lung effect, and effectively can alleviate abscess of throat, the very thirsty symptom that cough with lung heat causes, can be used for the health food such as cold tea prepared cough-relieving medicine or there is heat-clearing, moistening lung effect, wide market, and provide new direction for industry deep processing.
Detailed description of the invention
More being convenient to make content of the present invention understand, below in conjunction with detailed description of the invention, technical solutions according to the invention are described further, but the present invention being not limited only to this.
Embodiment 1
A kind of preparation method with the composite fruit bark extract of clearing heat and moistening lung effect comprises the steps:
1) preparation of snow pear bark extract: chopping after the snow pear skin cleaning of being reclaimed by 1.0 kg, adds the water of raw material weight 3 times, ultrasonic extraction 40min at 50 DEG C, filter; Filter residue adds raw material weight 2 times, mass concentration is the ethanol of 70%, ultrasonic extraction 40min at 30 DEG C, filters; Be evaporated to dry after merging filtrate;
2) preparation of mangosteen peel extracts: the mangosteen peel reclaimed by 0.5 kg is cleaned, dry rear coarse crushing, puts into extraction kettle and carries out supercritical CO
2extraction, extraction kettle temperature is 50 DEG C, and pressure is 20MPa, extraction time 1h; Then extract is flowed into separating still and carry out the second-order separation, first order separating pressure 8MPa, separation temperature 80 DEG C, second level separating pressure 4MPa, separation temperature 60 DEG C; Gained parting liquid adds suction filtration after activated carbon decolorizing, and filtrate reduced in volume is to dry;
3) preparation of banana tegument extract: selection epidermis complete, immaculate banana skin 0.3 kg cleans, stripping and slicing, pulls out after putting into boiling water blanching 2min, adds banana skin weight 1 times, mass concentration is making beating after the aqueous citric acid solution mixing of 0.5%; Add mixed enzyme enzymolysis 2h at 35 DEG C of slurry weight 3% again, centrifugal, gained supernatant add its volume 3 times, mass concentration be 90% ethanolic solution mixing after, 0 DEG C of left overnight, centrifugal, get precipitation for subsequent use; Described mixed enzyme is by weight 1:1:1 mixing by cellulase, protease, pectase.
4) preparation of loquat seed extract: after the loquat seed that 0.3 kg reclaims is cleaned, smashed to pieces, add its weight 3 times, mass concentration is the ethanolic solution of 90%, ultrasonic extraction 3 times at 30 DEG C, each 30min, filter, merging filtrate, is evaporated to dry; After adding ether by mass volume ratio 1:2, ultrasonic extraction 20min, suction filtration, filter cake distilled water flushing 2 times.
5) preparation of pericarp compound: the mixing after freeze drying, ultramicro grinding cross 200-300 mesh sieve of gained snow pear bark extract, mangosteen peel extracts, banana tegument extract, loquat seed extract is obtained finished product.
Embodiment 2
A kind of preparation method with the composite fruit bark extract of clearing heat and moistening lung effect comprises the steps:
1) preparation of snow pear bark extract: chopping after the snow pear skin cleaning of being reclaimed by 1.2 kg, adds the water of raw material weight 4 times, ultrasonic extraction 50min at 40 DEG C, filter; Filter residue adds raw material weight 2 times, mass concentration is the ethanol of 65%, ultrasonic extraction 35min at 40 DEG C, filters; Be evaporated to dry after merging filtrate;
2) preparation of mangosteen peel extracts: the mangosteen peel reclaimed by 0.6 kg is cleaned, dry rear coarse crushing, puts into extraction kettle and carries out supercritical CO
2extraction, extraction kettle temperature is 60 DEG C, and pressure is 10MPa, extraction time 2h; Then extract is flowed into separating still and carry out the second-order separation, first order separating pressure 9MPa, separation temperature 60 DEG C, second level separating pressure 6MPa, separation temperature 50 DEG C; Gained parting liquid adds suction filtration after activated carbon decolorizing, and filtrate reduced in volume is to dry;
3) preparation of banana tegument extract: selection epidermis complete, immaculate banana skin 0.4 kg cleans, stripping and slicing, pulls out after putting into boiling water blanching 2min, adds banana skin weight 2 times, mass concentration is making beating after the aqueous citric acid solution mixing of 0.4%; Add mixed enzyme enzymolysis 1h at 36 DEG C of slurry weight 4% again, centrifugal, gained supernatant add its volume 4 times, mass concentration be 80% ethanolic solution mixing after, 2 DEG C of left overnight, centrifugal, get precipitation for subsequent use; Described mixed enzyme is by weight 1:1:1 mixing by cellulase, protease, pectase.
4) preparation of loquat seed extract: after the loquat seed that 0.4 kg reclaims is cleaned, smashed to pieces, add its weight 4 times, mass concentration is the ethanolic solution of 80%, ultrasonic extraction 3 times at 40 DEG C, each 35min, filter, merging filtrate, is evaporated to dry; After adding ether by mass volume ratio 1:2, ultrasonic extraction 25min, suction filtration, filter cake distilled water flushing 2 times.
5) preparation of pericarp compound: the mixing after freeze drying, ultramicro grinding cross 200-300 mesh sieve of gained snow pear bark extract, mangosteen peel extracts, banana tegument extract, loquat seed extract is obtained finished product.
Embodiment 3
A kind of preparation method with the composite fruit bark extract of clearing heat and moistening lung effect comprises the steps:
1) preparation of snow pear bark extract: chopping after the snow pear skin cleaning of being reclaimed by 1.5 kg, adds the water of raw material weight 5 times, ultrasonic extraction 40min at 50 DEG C, filter; Filter residue adds raw material weight 3 times, mass concentration is the ethanol of 60%, ultrasonic extraction 30min at 50 DEG C, filters; Be evaporated to dry after merging filtrate;
2) preparation of mangosteen peel extracts: the mangosteen peel reclaimed by 0.8 kg is cleaned, dry rear coarse crushing, puts into extraction kettle and carries out supercritical CO
2extraction, extraction kettle temperature is 80 DEG C, and pressure is 10MPa, extraction time 2h; Then extract is flowed into separating still and carry out the second-order separation, first order separating pressure 10MPa, separation temperature 50 DEG C, second level separating pressure 8MPa, separation temperature 60 DEG C; Gained parting liquid adds suction filtration after activated carbon decolorizing, and filtrate reduced in volume is to dry;
3) preparation of banana tegument extract: selection epidermis complete, immaculate banana skin 0.5 kg cleans, stripping and slicing, pulls out after putting into boiling water blanching 3min, adds banana skin weight 2 times, mass concentration is making beating after the aqueous citric acid solution mixing of 0.3%; Add mixed enzyme enzymolysis 1h at 38 DEG C of slurry weight 5% again, centrifugal, gained supernatant add its volume 5 times, mass concentration be 70% ethanolic solution mixing after, 4 DEG C of left overnight, centrifugal, get precipitation for subsequent use; Described mixed enzyme is by weight 1:1:1 mixing by cellulase, protease, pectase.
4) preparation of loquat seed extract: after the loquat seed that 0.5 kg reclaims is cleaned, smashed to pieces, add its weight 5 times, mass concentration is the ethanolic solution of 70%, ultrasonic extraction 2 times at 50 DEG C, each 30min, filter, merging filtrate, is evaporated to dry; After adding ether by mass volume ratio 1:2, ultrasonic extraction 30min, suction filtration, filter cake distilled water flushing 3 times.
5) preparation of pericarp compound: the mixing after freeze drying, ultramicro grinding cross 200-300 mesh sieve of gained snow pear bark extract, mangosteen peel extracts, banana tegument extract, loquat seed extract is obtained finished product.
Bulbus fritilariae snow pear paste is the classical Chinese patent drug kind that pharmacopeia is recorded, have better moisten the lung and relieve the cough, effect of secretion replenishing and throat moistening.Jointly carry out mouse cough experiment with embodiment 3 gained composite fruit bark extract and commercially available bulbus fritilariae snow pear paste, experimental technique is:
1. animal: healthy kunming mice 20, body weight 18 ~ 22g, is divided into test group and control group at random, often organizes 10.
2. medication: fasting is after 12 hours, test group presses 0.5ml/20g gavage 2ml composite fruit bark extract, control group presses 0.5ml/20g gavage 2ml bulbus fritilariae snow pear paste, adopt sulfur dioxide to draw the method for coughing after administration 30min and carry out antibechic test, namely in closed glass container, sulfur dioxide gas is full of, mouse is put into glass container, records and add up in mouse cough incubation period and 2 minutes number of times of coughing, the results are shown in Table 1.
Table 1 mouse cough incubation period and cough number of times comparative test result
From table 1 result, compared with commercially available bulbus fritilariae snow pear paste, composite fruit bark extract of the present invention can extend mouse cough incubation period, reduces cough number of times, has better antitussive action to the mouse cough that sulfur dioxide causes.
The foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.
Claims (6)
1. there is the composite fruit bark extract of clearing heat and moistening lung effect, it is characterized in that: after snow pear skin, mangosteen peel, banana skin, loquat seed are extracted respectively through freeze drying, pulverize, be mixed;
Described component comprises by weight: snow pear skin 10-15 part, mangosteen peel 5-8 part, banana skin 3-5 part, loquat seed 3-5 part.
2. there is the composite fruit bark extract of clearing heat and moistening lung effect according to claim 1, it is characterized in that: the extracting method of described snow pear skin is: shred after the snow pear skin cleaning of reclaiming, add raw material weight 3-5 water doubly, ultrasonic extraction 40-60min at 30-50 DEG C, filter; Filter residue add raw material weight 2-3 doubly, mass concentration is the ethanol of 60-70%, ultrasonic extractions 30-40min at 30-50 DEG C, filtration; Be evaporated to dry after merging filtrate.
3. there is the composite fruit bark extract of clearing heat and moistening lung effect according to claim 1, it is characterized in that: the extracting method of described mangosteen peel is: the mangosteen peel reclaimed is cleaned, dries rear coarse crushing, put into extraction kettle and carry out supercritical CO
2extraction, extraction kettle temperature is 50 ~ 80 DEG C, and pressure is 10 ~ 20MPa, extraction time 1 ~ 2h; Then extract is flowed into separating still and carry out the second-order separation, first order separating pressure 8 ~ 10MPa, separation temperature 50 ~ 80 DEG C, second level separating pressure 4 ~ 8MPa, separation temperature 40 ~ 60 DEG C; Gained parting liquid adds suction filtration after activated carbon decolorizing, and filtrate reduced in volume is to dry.
4. there is the composite fruit bark extract of clearing heat and moistening lung effect according to claim 1, it is characterized in that: the extracting method of described banana skin is: complete, the immaculate banana skin of selection epidermis is cleaned, stripping and slicing, pull out after putting into boiling water blanching 2-3min, add banana skin weight 1-2 doubly, mass concentration is making beating after the aqueous citric acid solution mixing of 0.3%-0.5%; Add mixed enzyme enzymolysis 1-2h at 35-38 DEG C of slurry weight 3%-5% again, centrifugal, gained supernatant add its volume 3-5 doubly, mass concentration is after the ethanolic solution mixing of 70%-90%, 0-4 DEG C of left overnight, centrifugal, it is for subsequent use to get precipitation;
Wherein, described mixed enzyme is by weight 1:1:1 mixing by cellulase, protease, pectase.
5. there is the composite fruit bark extract of clearing heat and moistening lung effect according to claim 1, it is characterized in that: the extracting method of described loquat seed is: after the loquat seed of recovery is cleaned, smashing to pieces, add its weight 3-5 doubly, mass concentration is the ethanolic solution of 70%-90%, ultrasonic extraction 2-3 time at 30-50 DEG C, each 30-40min, filter, merging filtrate, is evaporated to dry; After adding ether by mass volume ratio 1:2, ultrasonic extraction 20-30min, suction filtration, filter cake distilled water flushing 2-3 time.
6. there is an application for the composite fruit bark extract of clearing heat and moistening lung effect as claimed in claim 1, it is characterized in that: described composite fruit bark extract is for the preparation of cough-relieving medicine or the health food with heat-clearing, moistening lung effect.
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