CN104938791A - Fodder baking soda stomach-pass sustained-release agent and preparation method thereof - Google Patents
Fodder baking soda stomach-pass sustained-release agent and preparation method thereof Download PDFInfo
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Abstract
The invention provides a fodder baking soda stomach-pass sustained-release agent and a preparation method thereof. The fodder baking soda stomach-pass sustained-release agent comprises core material and coating wall material covering the surface of the core material, wherein the core material comprises the following components in parts by weight: 9.5-10.5 parts of baking soda and 2.5-5 parts of gel-type framework material; 3-8 parts of coating wall material is required. The preparation method comprises the following steps: Step A, mixing baking soda and the gel-type framework material, adding water for pelletizing, and drying to obtain framework type particles; Step B, heating the coating wall material to be molten to obtain coating liquid; Step C, covering the framework type particles with the coating liquid to obtain the fodder baking soda stomach-pass sustained-release agent. According to the invention, the effect that baking soda stomach-pass decomposition rate is low is realized; compared with conventional sustained-release agents, the fodder baking soda stomach-pass sustained-release agent uses fewer auxiliary materials, and is better in thermal stability, high in embedding rate and intestine disappearance rate and complete in absorption; in addition, the preparation method is simple in process and low in cost.
Description
Technical field
The present invention relates to field of fodder, cross stomach sustained release agent and preparation method thereof in particular to a kind of feed sodium bicarbonate.
Background technology
The chemical composition of sodium bicarbonate is sodium acid carbonate.In prior art, no matter be as medicament or feed addictive, sodium bicarbonate all act on stomach be used in and hydrochloric acid in gastric juice, and enteron aisle cannot be acted on, but its prior function is by animal intestinal absorption, in vivo as body fluid buffer.
Sodium bicarbonate exists in animal body in the form of an ion, HCO wherein
3 -be the important buffer substance of animal body fluid, after being absorbed in animal intestinal, the pH value of blood, milk, urine can be adjusted to the best, strengthen body to metabolic disease, infectious disease, acidosic defensive ability/resistance ability.Therefore sodium bicarbonate is added in animal and fowl fodder, to raising efficiency of feed utilization, energy transformation ratio, increase livestock and poultry feed intake, accelerate livestock and poultry speed of weight increment, strengthen the immunity of livestock and poultry, improve the anti-stress ability of livestock and poultry, reduce the generation of disease, promote that growth of animals or poultry and increase galactopoiesis, egg production all have remarkable result.
The absorption of animal intestinal to nutriment is suitable under the environment of neutral meta-alkalescence, and becomes sour chyme through stomach to the food in enteron aisle, and destroy this intestinal environment, impact is digested and assimilated, and therefore more needs the function with hydrochloric acid in gastric juice in sodium bicarbonate in enteron aisle.
Sodium bicarbonate can decompose rapidly under the sour environment of stomach, and cannot or pole not easily reach enteron aisle, thus cannot in and sour chyme in enteron aisle, more cannot be absorbed in animal body with HCO
3 -ionic species plays cushioning effect.
In view of this, special proposition the present invention.
Summary of the invention
The first object of the present invention is to provide a kind of feed sodium bicarbonate to cross stomach sustained release agent, described sustained release agent is in being embedded in by sodium bicarbonate under the acting in conjunction of dressing wall material and gel-type framework material, there is auxiliary material used few, heat endurance is high, not easily decompose under one's belt, cross stomach to stablize, slowly-releasing in enteron aisle, can efficient in and enteron aisle acid chyme, keep the advantages such as the neutral meta-alkalescence of enteron aisle.
The second object of the present invention is to provide a kind of described feed sodium bicarbonate to cross the preparation method of stomach sustained release agent, the method only adopts wet granulation, melting, dressing three simple steps can obtain sodium bicarbonate and cross stomach sustained release agent, has that technique is simple, low cost and other advantages.
In order to realize above-mentioned purpose of the present invention, spy by the following technical solutions:
Stomach sustained release agent crossed by a kind of feed sodium bicarbonate, comprises core and the dressing wall material being coated on its surface,
By weight, described core comprises sodium bicarbonate 9.5-10.5 part, and gel-type framework material 2.5-5 part; Described dressing wall material is 3-8 part.
Above-mentioned feed sodium bicarbonate is crossed in stomach sustained release agent, gel-type framework material is as basic medicine carrying body, both the heat endurance of sodium bicarbonate can have been improved, can utilize again the space in its gumminess and gel that sodium bicarbonate is bondd, and be filled in gel skeleton, when sustained release agent in vivo time, along with the corrosion sodium bicarbonate of gel skeleton slowly spreads, thus realize the effect of real slowly-releasing.And dressing wall material is as the outermost protective material of sodium bicarbonate, sustained release agent can be avoided to be rapidly decomposed under one's belt.
In addition, main body medicine and two kinds of auxiliary materials must combine with 9.5-10.5:3-8:2.5-5, just successfully can embed sodium bicarbonate.
As can be seen here, above-mentioned sustained release agent not only auxiliary material used is few, and heat endurance is high, and be used for animal body as feed, not easily decompose under one's belt, slowly-releasing in enteron aisle, with enteron aisle acid chyme, maintenance enteron aisle neutrality slight alkali environment during energy is efficient, promote that animal is to the absorption of nutriment.
Preferably, also anticaking agent is comprised.Anticaking agent has larger specific area, is dispersed between pressed powder particulate after adding, and product free-running property can be made to significantly improve.
Described anticaking agent preferably adopts silica, and/or sodium silicoaluminate, and addition is less than 1 part, and the absorption property of these two kinds of anticaking agents is high, and dispersive property is more excellent.
Preferably, described dressing wall material is palm fatty powder, and/or glycerin monostearate.
Above bi-material is hard fat, under one's belt can not melting under body temperature, makes that sodium bicarbonate is smooth crosses stomach, greatly reduces sodium bicarbonate resolution ratio under one's belt.
Palm fatty powder not only saliva and stomach degradation rate low, and small intestine disappearance rate is high, and animal body more than 97%, is ideal cross stomach nutrient bag by wall material to palmitic overall absorption and digestion rate.In addition, palm fatty powder is more containing saturated fatty acid, and stability is better, oxidation deterioration is less likely to occur, can extends the shelf life for preparation.Palm fatty powder also have price low, be easy to transport, storage and the advantage such as use.
Comparatively palm fatty powder is slightly poor in saliva and stomach stability for glycerin monostearate, but its small intestine disappearance rate is higher, easy emission and absorption, suitably can strengthen bag by ratio or increase coating thickness, can carry out stomach protection to nutrient.
Certainly, dressing wall material also can adopt ethyl cellulose and cellulose acetate etc., but these coating materials compare above-mentioned two kinds of poor-performings, wrap by time need increase coating thickness, but easily because bag is excessively affected nutrients release and absorption.
Preferably, described gel-type framework material is hydroxypropyl methylcellulose.
Above-mentioned material compares other gel-type framework material, have that compressibility is good, the strong and drug release feature of good fluidity, Drug loading capacity not by advantages such as pH affect, be epochmaking hydrophilic support material in sustained release preparation system, and safety non-toxic, empty calory, contacts non-stimulated to skin, mucous membrane.
Preferably, by weight, 10 parts, sodium bicarbonate, palm fatty powder and/or glycerin monostearate 3-8 part, hydroxypropyl methylcellulose 2.5-5 part.
Adopt the sustained release agent embedding rate of this formula high, at least can reach 40%, even up to more than 95%.
The preparation method of stomach sustained release agent crossed by feed sodium bicarbonate mentioned above, comprises the following steps:
Steps A: by sodium bicarbonate and the mixing of gel-type framework material, add water and granulate, then dry, obtain matrix type particle;
Step B: dressing wall material is heated to molten state, obtains coating solution;
Step C: with described coating solution bag by described matrix type particle, obtain product.
Said method only adopts wet granulation, melting, dressing three simple steps can obtain sodium bicarbonate sustained release agent, has that technique is simple, low cost and other advantages.
Preferably, the coating solution obtained should be incubated preservation, avoids coating solution to condense.
Preferably, also comprise after described step C: add anticaking agent.In like manner, anticaking agent has larger specific area, is dispersed between pressed powder particulate after adding, and product free-running property can be made to significantly improve.
Preferably, the method for described step B bag quilt is: fluidized bed coating, and the method embedding uniformity is high.
More preferably end spray type fluidized bed coating is adopted.With end spray type fluidized bed process dressing evenly, it also has other three advantages:
1. the Distance Shortened between spray gun and material, minimizing coating solution reaches the solvent evaporation before material and spraying dry phenomenon, thus is conducive to the uniformity of coating solution film forming thickness;
2. the shuttling movement that material is orderly, the direction of motion is identical with hydrojet direction, and the probability of material contact coating solution is identical, is conducive to the uniformity of dressing;
3. spacer ring inside is coating area, and material is intensive at coating area inner height, and dressing loss is few.
In addition, in preparation method, also can adopt rolling pill method dressing.
Preferably, in fluid bed, the speed pumping into coating solution to spray chamber is 5 ~ 30mL/min.Adopt this speed, can combining efficient rate and prevent the large advantage of coating solution cooling solidification two.
Preferably, described gel-type framework material is hydroxypropyl methylcellulose, and the weight ratio of the water added when granulating and solid material is 1:4 ~ 2.During wet granulation, material is moistening, bonding in order just can make for the amount of interpolation water, and can make the particle of desired particle size from discharging opening.
Preferably, the method for drying in described steps A is: dry 2 ~ 10h below 55 DEG C; Sodium bicarbonate is by thermally labile, and especially more than 55 DEG C resolution ratios are large, and therefore below 55 DEG C, drying is beneficial to protection sodium bicarbonate, and dry 2 ~ 10h makes particle surface dry.
Preferably, in described steps A, also comprise after oven dry: cross 20-60 mesh sieve.Sieve and be conducive to improving the homogeneity of Product Status, make it more even in the process of adding feed to.
Compared with prior art, beneficial effect of the present invention is:
(1) what achieve sodium bicarbonate crosses stomach not discomposing effect, reaches certain slow release effect simultaneously.
(2) compare conventional sustained release agent, sodium bicarbonate sustained release agent of the present invention auxiliary material used is few, heat endurance is better, embedding rate is high, and intestines disappearance rate is high, absorbs completely.
(3) sodium bicarbonate of the present invention crosses that preparation method's technique of stomach sustained release agent is simple, cost is low.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below.
Fig. 1 amplifies the microscope figure after 4 times for stomach sustained release agent crossed by sodium bicarbonate that embodiment 4 provides;
Fig. 2 amplifies the microscope figure after 10 times for stomach sustained release agent crossed by sodium bicarbonate that embodiment 4 provides.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting the scope of the invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, be and can buy by commercially available the conventional products obtained.
Embodiment 1
1, granulate: by load weighted sodium bicarbonate 190g; hydroxypropyl methylcellulose 50g adds in wet mixing pelletizer; premixed 5min; start to add water; amount of water is approximately 60g; transfer rapid stirring 8min to after reamer low rate mixing 3min, when adjustment reamer speed makes discharging, granularity is in 20 ~ 30 order dischargings, primary dcreening operation.
2, dry: wet granule step 1 prepared is placed in drying box inner drying immediately, regulates baking temperature 55 ± 5 DEG C, drying time about 2h, in dry run, per half an hour by material turning once, makes its moisture evaporate evenly.
3, sieve: sieved by dried material, the particle crossing 20 mesh sieves is conforming particle.For subsequent use.
4, coating solution preparation: glycerin monostearate 60g is heated to 65 ± 5 DEG C to molten condition, obtains coating solution insulation for subsequent use.
5, get the whole granules prepared and be placed in fluid bed, regulate stream temperature to 30 DEG C, dry air flow 35m
3/ h, draws the coating solution of insulation with the flow velocity of 9mL/min with peristaltic pump, spray into fluidized bed atomization room carry out atomization dressing, until coating solution is finished in the mode of end spray.Reduce stream temperature to room temperature, continue discharging after fluidisation 15min in fluid bed, be sodium bicarbonate and cross stomach sustained release agent.
Embodiment 2
1, granulate: by load weighted sodium bicarbonate 210g; ethyl cellulose 160g adds in wet mixing pelletizer; premixed 5min; start to add water; amount of water is approximately 185g; transfer rapid stirring 8min to after reamer low rate mixing 3min, when adjustment reamer speed makes discharging, granularity is in 60 ~ 70 order dischargings, primary dcreening operation.
2, dry: wet granule step 1 prepared is placed in drying box inner drying immediately, regulates baking temperature 40 ± 5 DEG C, drying time about 10h, in dry run, per half an hour by material turning once, makes its moisture evaporate evenly.
3, sieve: sieved by dried material, the particle crossing 60 mesh sieves is conforming particle.For subsequent use.
4, coating solution preparation: glycerin monostearate 100g is heated to 65 ± 5 DEG C to molten condition, obtains coating solution insulation for subsequent use.
5, get the whole granules prepared and be placed in fluid bed, regulate stream temperature to 30 DEG C, dry air flow 35m
3/ h, draws the coating solution of insulation with the flow velocity of 9mL/min with peristaltic pump, spray into fluidized bed atomization room carry out atomization dressing, until coating solution is finished in the mode of end spray.Reduce stream temperature to room temperature, continue discharging after fluidisation 15min in fluid bed, be sodium bicarbonate and cross stomach sustained release agent.
Embodiment 3
Stomach sustained release agent crossed by a kind of feed sodium bicarbonate:
1, granulate: by load weighted sodium bicarbonate 240g; hydroxypropyl methylcellulose 60g adds in wet mixing pelletizer; premixed 5min; start to add water; amount of water is approximately 100g; transfer rapid stirring 7min to after reamer low rate mixing 3min, when adjustment reamer speed makes discharging, granularity is in 20 ~ 30 order dischargings, primary dcreening operation.
2, dry: wet granule step 1 prepared is placed in drying box inner drying immediately, regulates baking temperature 50 ± 5 DEG C, drying time about 8h, in dry run, every 2h by material turning once, makes its moisture evaporate evenly.
3, sieve: sieved by dried material, the particle crossing 20 mesh sieves is conforming particle.For subsequent use.
4, coating solution preparation: palm fatty powder 120g is heated to 70 ± 5 DEG C to molten condition, obtains coating solution insulation for subsequent use.
5, get the whole granules prepared and be placed in fluid bed, regulate stream temperature to 30 DEG C, dry air flow 50m
3/ h, draws the coating solution of insulation with the flow velocity of 10mL/min with peristaltic pump, spray into fluidized bed atomization room carry out atomization dressing, until coating solution is finished in the mode of end spray.Reduce stream temperature to room temperature, continue discharging after fluidisation 15min in fluid bed, be sodium bicarbonate and cross stomach sustained release agent.
Embodiment 4
1, granulate: by load weighted sodium bicarbonate 200g; hydroxypropyl methylcellulose 100g adds in wet mixing pelletizer; premixed 5min; start to add water; amount of water is approximately 100g; transfer rapid stirring 8min to after reamer low rate mixing 3min, when adjustment reamer speed makes discharging, granularity is in 40 ~ 50 order dischargings, primary dcreening operation.
2, dry: wet granule step 1 prepared is placed in drying box inner drying immediately, regulates baking temperature 50 ± 5 DEG C, drying time about 8h, in dry run, every 2h by material turning once, makes its moisture evaporate evenly.
3, sieve: sieved by dried material, the particle crossing 40 mesh sieves is conforming particle.For subsequent use.
4, coating solution preparation: palm fatty powder 80g and glycerin monostearate 80g is mixed and heated to 70 ± 5 DEG C to molten condition, obtains coating solution insulation for subsequent use.
5, get the whole granules prepared and be placed in fluid bed, regulate stream temperature to 30 DEG C, dry air flow 40m
3/ h, draws the coating solution of insulation with the flow velocity of 9mL/min with peristaltic pump, spray into fluidized bed atomization room carry out atomization dressing, until coating solution is finished in the mode of end spray.Reduce stream temperature to room temperature, continue discharging after fluidisation 15min in fluid bed, be sodium bicarbonate and cross stomach sustained release agent.
Embodiment 5
1, granulate: by load weighted sodium bicarbonate 210g; hydroxypropyl methylcellulose 84g adds in wet mixing pelletizer; premixed 5min; start to add water; amount of water is approximately 100g; transfer rapid stirring 8min to after reamer low rate mixing 3min, when adjustment reamer speed makes discharging, granularity is in 50 ~ 60 order dischargings, primary dcreening operation.
2, dry: wet granule step 1 prepared is placed in drying box inner drying immediately, regulates baking temperature 50 ± 5 DEG C, drying time about 8h, in dry run, every 2h by material turning once, makes its moisture evaporate evenly.
3, sieve: sieved by dried material, the particle crossing 50 mesh sieves is conforming particle.For subsequent use.
4, coating solution preparation: glycerin monostearate 126g is heated to 65 ± 5 DEG C to molten condition, obtains coating solution insulation for subsequent use.
5, get the whole granules prepared and be placed in fluid bed, regulate stream temperature to 30 DEG C, dry air flow 35m
3/ h, draws the coating solution of insulation with the flow velocity of 9mL/min with peristaltic pump, spray into fluidized bed atomization room carry out atomization dressing, until coating solution is finished in the mode of end spray.Reduce stream temperature to room temperature, continue discharging after fluidisation 15min in fluid bed, be sodium bicarbonate and cross stomach sustained release agent.
Embodiment 6
1, granulate: by load weighted sodium bicarbonate 200g; hydroxypropyl methylcellulose 100g adds in wet mixing pelletizer; premixed 5min; start to add water; amount of water is approximately 100g; transfer rapid stirring 8min to after reamer low rate mixing 3min, when adjustment reamer speed makes discharging, granularity is in 40 ~ 50 order dischargings, primary dcreening operation.
2, dry: wet granule step 1 prepared is placed in drying box inner drying immediately, regulates baking temperature 50 ± 5 DEG C, drying time about 8h, in dry run, every 2h by material turning once, makes its moisture evaporate evenly.
3, sieve: sieved by dried material, the particle crossing 40 mesh sieves is conforming particle.For subsequent use.
4, coating solution preparation: palm fatty powder 80g and glycerin monostearate 80g is mixed and heated to 70 ± 5 DEG C to molten condition, obtains coating solution insulation for subsequent use.
5, get the whole granules prepared and be placed in fluid bed, regulate stream temperature to 30 DEG C, dry air flow 40m
3/ h, draws the coating solution of insulation with the flow velocity of 9mL/min with peristaltic pump, spray into fluidized bed atomization room carry out atomization dressing, until coating solution is finished in the mode of end spray.Add 20g silica again, drop to room temperature, be sodium bicarbonate and cross stomach sustained release agent.
Embodiment 7
1, granulate: by load weighted sodium bicarbonate 200g; hydroxypropyl methylcellulose 100g adds in wet mixing pelletizer; premixed 5min; start to add water; amount of water is approximately 100g; transfer rapid stirring 8min to after reamer low rate mixing 3min, when adjustment reamer speed makes discharging, granularity is in 40 ~ 50 order dischargings, primary dcreening operation.
2, dry: wet granule step 1 prepared is placed in drying box inner drying immediately, regulates baking temperature 50 ± 5 DEG C, drying time about 8h, in dry run, every 2h by material turning once, makes its moisture evaporate evenly.
3, sieve: sieved by dried material, the particle crossing 40 mesh sieves is conforming particle.For subsequent use.
4, coating solution preparation: palm fatty powder 80g and glycerin monostearate 80g is mixed and heated to 70 ± 5 DEG C to molten condition, obtains coating solution insulation for subsequent use.
5, get the whole granules prepared and be placed in fluid bed, regulate stream temperature to 30 DEG C, dry air flow 40m
3/ h, draws the coating solution of insulation with the flow velocity of 9mL/min with peristaltic pump, spray into fluidized bed atomization room carry out atomization dressing, until coating solution is finished in the mode of end spray.Add 20g sodium silicoaluminate again, drop to room temperature, be sodium bicarbonate and cross stomach sustained release agent.
Embodiment 8
1, granulate: by load weighted sodium bicarbonate 200g; hydroxypropyl methylcellulose 100g adds in wet mixing pelletizer; premixed 5min; start to add water; amount of water is approximately 100g; transfer rapid stirring 8min to after reamer low rate mixing 3min, when adjustment reamer speed makes discharging, granularity is in 40 ~ 50 order dischargings, primary dcreening operation.
2, dry: wet granule step 1 prepared is placed in drying box inner drying immediately, regulates baking temperature 50 ± 5 DEG C, drying time about 8h, in dry run, every 2h by material turning once, makes its moisture evaporate evenly.
3, sieve: sieved by dried material, the particle crossing 40 mesh sieves is conforming particle.For subsequent use.
4, coating solution preparation: palm fatty powder 80g and glycerin monostearate 80g is mixed and heated to 70 ± 5 DEG C to molten condition, obtains coating solution insulation for subsequent use.
5, get the whole granules prepared and be placed in fluid bed, regulate stream temperature to 30 DEG C, dry air flow 40m
3/ h, draws the coating solution of insulation with the flow velocity of 5mL/min with peristaltic pump, spray into fluidized bed atomization room carry out atomization dressing, until coating solution is finished in the mode of end spray.Reduce stream temperature to room temperature, continue discharging after fluidisation 15min in fluid bed, be sodium bicarbonate and cross stomach sustained release agent.
Embodiment 9
1, granulate: by load weighted sodium bicarbonate 200g; hydroxypropyl methylcellulose 100g adds in wet mixing pelletizer; premixed 5min; start to add water; amount of water is approximately 100g; transfer rapid stirring 8min to after reamer low rate mixing 3min, when adjustment reamer speed makes discharging, granularity is in 40 ~ 50 order dischargings, primary dcreening operation.
2, dry: wet granule step 1 prepared is placed in drying box inner drying immediately, regulates baking temperature 50 ± 5 DEG C, drying time about 8h, in dry run, every 2h by material turning once, makes its moisture evaporate evenly.
3, sieve: sieved by dried material, the particle crossing 40 mesh sieves is conforming particle.For subsequent use.
4, coating solution preparation: palm fatty powder 80g and glycerin monostearate 80g is mixed and heated to 70 ± 5 DEG C to molten condition, obtains coating solution insulation for subsequent use.
5, get the whole granules prepared and be placed in fluid bed, regulate stream temperature to 30 DEG C, dry air flow 40m
3/ h, draws the coating solution of insulation with the flow velocity of 30mL/min with peristaltic pump, spray into fluidized bed atomization room and carry out atomization dressing, until coating solution is finished, is sodium bicarbonate and crosses stomach sustained release agent in the mode of end spray.
Test embedding rate and SGF 3 hours dissolution rates of above embodiment, result is as shown in table 1.
SGF dissolution rate experiment in 3 hours: take in feed at gastric digestion 3h for pig, mensuration sodium bicarbonate digests the dissolution rate after 3h in SGF, shows it and crosses stomach effect.
Simulated intestinal fluid dissolution rate experiment in 24 hours: take in feed for pig and digest 24h in enteron aisle, sodium bicarbonate detects digest 24h in simulated intestinal fluid after, and the dissolution rate that result shows all embodiments is 100%, proves that its intestines disappearance rate is high.
The embedding rate of table 1 embodiment 1-9 and SGF 3 hours dissolution rates
With the sustained release agent finished product of microscopic examination embodiment 4, as shown in Figure 1-2, as seen from the figure, sodium bicarbonate is successfully embedded into graininess, but not the lenticular of sodium acid carbonate.
Although illustrate and describe the present invention with specific embodiment, however it will be appreciated that can to make when not deviating from the spirit and scope of the present invention many other change and amendment.Therefore, this means to comprise all such changes and modifications belonged in the scope of the invention in the following claims.
Claims (10)
1. a stomach sustained release agent crossed by feed sodium bicarbonate, it is characterized in that, comprises core and the dressing wall material being coated on its surface,
By weight, described core comprises sodium bicarbonate 9.5-10.5 part, and gel-type framework material 2.5-5 part; Described dressing wall material is 3-8 part.
2. stomach sustained release agent crossed by feed sodium bicarbonate according to claim 1, it is characterized in that, described dressing wall material surface is with anticaking agent.
3. stomach sustained release agent crossed by feed sodium bicarbonate according to claim 1, it is characterized in that, described dressing wall material is palm fatty powder, and/or glycerin monostearate; Preferably, described gel-type framework material is hydroxypropyl methylcellulose.
4. stomach sustained release agent crossed by feed sodium bicarbonate according to claim 2, it is characterized in that, described anticaking agent is silica, and/or sodium silicoaluminate, and addition is less than 1 part.
5. stomach sustained release agent crossed by feed sodium bicarbonate according to claim 1, it is characterized in that, by weight, and 10 parts, sodium bicarbonate, palm fatty powder and/or glycerin monostearate 3-8 part, hydroxypropyl methylcellulose 2.5-5 part.
6. the preparation method of stomach sustained release agent crossed by the feed sodium bicarbonate described in any one of claim 1-5, it is characterized in that, comprises the following steps:
Steps A: by sodium bicarbonate and the mixing of gel-type framework material, add water and granulate, then dry, obtain matrix type particle;
Step B: dressing wall material is heated to molten state, obtains coating solution;
Step C: with described coating solution bag by described matrix type particle, obtain product.
7. the preparation method of stomach sustained release agent crossed by feed sodium bicarbonate according to claim 6, it is characterized in that, also comprises: add anticaking agent after described step C.
8. the preparation method of stomach sustained release agent crossed by feed sodium bicarbonate according to claim 6, it is characterized in that, the method for described step B bag quilt is: fluidized bed coating; Preferably, in fluid bed, the speed pumping into coating solution to spray chamber is 5 ~ 30mL/min.
9. the preparation method of stomach sustained release agent crossed by feed sodium bicarbonate according to claim 6, it is characterized in that, described gel-type framework material is hydroxypropyl methylcellulose, and the weight ratio of the water added when granulating and solid material is 1:4 ~ 2.
10. the preparation method of stomach sustained release agent crossed by feed sodium bicarbonate according to claim 6, it is characterized in that, the method for drying in described steps A is: dry 2 ~ 10h below 55 DEG C; Preferably, in described steps A, also comprise after oven dry: cross 20-60 mesh sieve.
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| CN105310055A (en) * | 2015-11-02 | 2016-02-10 | 长江大学 | Alkaline leavening agent microcapsule and preparation method thereof |
| CN105310055B (en) * | 2015-11-02 | 2018-11-27 | 长江大学 | Alkaline leavening agent microcapsules and preparation method thereof |
| CN107821788A (en) * | 2017-10-18 | 2018-03-23 | 潍坊加易加生物科技有限公司 | Small molecular organic acid type acid supplement coated slow release formulation |
| CN108902486A (en) * | 2018-09-18 | 2018-11-30 | 廊坊市绿康生物科技股份有限公司 | High yield cow summer heat stress feed |
| CN109601763A (en) * | 2018-12-20 | 2019-04-12 | 浙江大学 | A kind of high stability aquatic feeds particle and preparation method thereof |
| CN109730212A (en) * | 2018-12-20 | 2019-05-10 | 浙江大学 | A kind of black porgy fish health-care feed and preparation method thereof |
| CN111202175A (en) * | 2020-01-10 | 2020-05-29 | 安徽东方天合生物技术有限责任公司 | Novel rumen-bypass biotin |
| CN111202175B (en) * | 2020-01-10 | 2023-05-05 | 安徽东方天合生物技术有限责任公司 | Rumen bypass biotin |
| WO2022068459A1 (en) * | 2020-09-29 | 2022-04-07 | 厦门汇盛生物有限公司 | Preparation of compound rumen-protected polyunsaturated fatty acid powder and use thereof |
| CN114568594A (en) * | 2022-03-28 | 2022-06-03 | 上海美农生物科技股份有限公司 | Additive for slow-release nitrogen source feed and preparation method thereof |
| CN114568594B (en) * | 2022-03-28 | 2023-12-01 | 苏州美农生物科技有限公司 | Additive for slow-release nitrogen source feed and preparation method thereof |
| CN115448316A (en) * | 2022-09-21 | 2022-12-09 | 江西联锴科技有限公司 | Preparation method of large-aperture spherical silicon dioxide |
| CN115448316B (en) * | 2022-09-21 | 2024-02-27 | 江西联锴化学有限公司 | Preparation method of large-aperture spherical silicon dioxide |
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Effective date of registration: 20200311 Address after: No. 666, Shunhe West Road, Xintai Development Zone, Tai'an City, Shandong Province Patentee after: Taian peptide protein Co., Ltd Address before: 518000, Guangdong, Shenzhen Province, Longhua New District Guanlan chapter community, old village east, No. 10, 73, 9 B noodles Patentee before: SHENZHEN YUNONG SCIENCE & TECHNOLOGY CORP., LTD. |
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