CN104938791B - A kind of feed crosses stomach sustained release agent and preparation method thereof with sodium bicarbonate - Google Patents
A kind of feed crosses stomach sustained release agent and preparation method thereof with sodium bicarbonate Download PDFInfo
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- CN104938791B CN104938791B CN201510319866.3A CN201510319866A CN104938791B CN 104938791 B CN104938791 B CN 104938791B CN 201510319866 A CN201510319866 A CN 201510319866A CN 104938791 B CN104938791 B CN 104938791B
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Abstract
The invention provides a kind of feed stomach sustained release agent and preparation method thereof is crossed with sodium bicarbonate.A kind of feed crosses stomach sustained release agent with sodium bicarbonate includes following component：Including core and the coating wall material for being coated on its surface, by weight, the core includes 9.5 10.5 parts of sodium bicarbonate, and 2.5 5 parts of gel-type framework material；The coating wall material is 38 parts.Its preparation method is：Step A：Sodium bicarbonate and gel-type framework material are mixed, add water granulation, then is dried, obtains matrix type particle；Step B：Coating wall material is heated to molten state, obtains coating solution；Step C：The matrix type particle is coated with the coating solution, obtains product.The present invention realizes sodium bicarbonate and crosses the low effect of stomach resolution ratio, and compared to the sustained release agent of routine, sodium bicarbonate of the invention crosses that auxiliary material used in stomach sustained release agent is few, heat endurance is more preferable, embedding rate is high, and intestines disappearance rate is high, absorbs complete, and preparation method technique is simple, cost is low.
Description
Technical field
The present invention relates to field of fodder, and stomach sustained release agent and its preparation side are crossed with sodium bicarbonate in particular to a kind of feed
Method.
Background technology
The chemical composition of sodium bicarbonate is sodium acid carbonate.In the prior art, it is small either as medicament or feed addictive
Soda all acts on stomach and is used for neutralizing hydrochloric acid in gastric juice, and can not act on enteron aisle, but its prior function is by animal intestinal tract
Absorb, in vivo as body fluid buffer.
Sodium bicarbonate exists in the form of an ion in animal body, HCO therein3 -It is the important buffer substance of animal body fluid,
After being absorbed in animal intestinal tract, the pH value of blood, milk, urine can be adjusted to optimal, enhancing body to metabolic disease, infect
Disease, the defensive ability/resistance ability of acid poisoning.Therefore sodium bicarbonate is added in animal and fowl fodder, to improving efficiency of feed utilization, energy transformation ratio, increased
Add livestock and poultry feed intake, accelerate livestock and poultry speed of weight increment, strengthen the immunity of livestock and poultry, improve the anti-stress ability of livestock and poultry, reduce disease
Generation, promote growth of animals or poultry and increase galactopoiesis, egg production to have remarkable result.
Absorption of the animal intestinal tract to nutriment is suitably in the environment of neutral meta-alkalescence, and through the food in stomach to enteron aisle
Become sour chyme, destroy this intestinal environment, influence to digest and assimilate, therefore with greater need for the neutralization hydrochloric acid in gastric juice of sodium bicarbonate in enteron aisle
Function.
Sodium bicarbonate can decompose rapidly under the sour environment of stomach, and can not or pole be not easy to reach enteron aisle, so as to can not in
With the sour chyme in enteron aisle, can not more be absorbed into animal body with HCO3 -Ionic species plays cushioning effect.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is that provide a kind of feed crosses stomach sustained release agent with sodium bicarbonate, and described sustained release agent is coating
Sodium bicarbonate is embedded in interior, heat endurance height few with auxiliary material used under wall material and the collective effect of gel-type framework material,
It is not easily decomposed in stomach, crosses stomach stabilization, be sustained in enteron aisle, can be efficiently neutralized enteron aisle acid chyme, keep enteron aisle neutrality meta-alkalescence etc.
Advantage.
The second object of the present invention is to provide the preparation method that a kind of described feed crosses stomach sustained release agent with sodium bicarbonate, is somebody's turn to do
Method can be prepared by sodium bicarbonate and cross stomach sustained release agent only with three wet granulation, melting, coating simple steps, have technique letter
Single, low cost and other advantages.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
A kind of feed crosses stomach sustained release agent, including core and the coating wall material for being coated on its surface with sodium bicarbonate,
By weight, the core includes sodium bicarbonate 9.5-10.5 parts, and gel-type framework material 2.5-5 parts；The bag
Clothing wall material is 3-8 parts.
Above-mentioned feed is crossed in stomach sustained release agent with sodium bicarbonate, and gel-type framework material carries medicine body as basic, can both improve
The heat endurance of sodium bicarbonate, the space in its gumminess and gel can be utilized to bond sodium bicarbonate again, and be filled in gel bone
In frame, when sustained release agent in vivo when, slowly spread with the corrosion sodium bicarbonate of gel skeleton, so as to realize the effect being really sustained
Fruit.And it is as the outermost protection materials of sodium bicarbonate to be coated wall material, sustained release agent can be avoided to be rapidly decomposed under one's belt.
In addition, main body medicine and two kinds of auxiliary materials must be with 9.5-10.5:3-8:2.5-5 is combined, and just can successfully embed little Su
Beat.
As can be seen here, not only auxiliary material used is few for above-mentioned sustained release agent, and heat endurance is high, and is used for animal body as feed,
It is not easily decomposed, is sustained in enteron aisle under one's belt, can efficiently neutralizes enteron aisle acid chyme, keep enteron aisle neutrality slight alkali environment, promote
Absorption of the animal to nutriment.
Preferably, in addition to anticaking agent.Anticaking agent has larger specific surface area, be dispersed in after addition solid powder particulate it
Between, can significantly improve product free-running property.
The anticaking agent preferably uses silica, and/or sodium silicoaluminate, and addition is less than 1 part, both resistive connections
The absorption property of agent is high, and dispersive property is more excellent.
Preferably, the coating wall material is palm fatty powder, and/or glycerin monostearate.
Both the above material is hard fat, will not be melted under body temperature under one's belt, makes sodium bicarbonate is smooth to cross stomach,
Substantially reduce the resolution ratio of sodium bicarbonate under one's belt.
Not only saliva and stomach degradation rate are low for palm fatty powder, and small intestine disappearance rate is high, entirety of the animal body to palm oil
Digestion and absorptivity are that ideal stomach nutrient of crossing is coated with wall material more than 97%.In addition, palm fatty powder contains saturated fatty acid
More, stability is preferable, it is not easy to oxidation deterioration occurs, can be extended the shelf life for preparation.Palm fatty powder also has valency
Lattice are low, the advantages that being easy to transport, store and use.
Glycerin monostearate is slightly poor compared with palm fatty powder in saliva and stomach stability, but its small intestine disappearance rate is higher, holds
Easily release and absorption, it can suitably increase coating ratio or increase coating thickness, you can stomach protection was carried out to nutrient.
Certainly, ethyl cellulose and cellulose acetate etc. can also be used by being coated wall material, but these coating materials are compared to above-mentioned
Two kinds of poor-performings, coating thickness need to be increased during coating, but easily influence nutrients release with absorbing due to being coated with excessively.
Preferably, the gel-type framework material is hydroxypropyl methyl cellulose.
Above-mentioned material compares other gel-type framework materials, has good compressibility, good fluidity, Drug loading capacity strong and releases
The advantages that medicine characteristic is not influenceed by pH, is epochmaking hydrophilic support material in sustained release preparation system, and safe and non-toxic, no heat
Amount, it is non-stimulated to skin, mucous membrane contact.
Preferably, by weight, 10 parts of sodium bicarbonate, palm fatty powder and/or glycerin monostearate 3-8 parts, hydroxypropyl
Methylcellulose 2.5-5 parts.
It is high using the sustained release agent embedding rate of the formula, it at least can reach 40%, even as high as more than 95%.
Feed described above crosses the preparation method of stomach sustained release agent with sodium bicarbonate, comprises the following steps：
Step A：Sodium bicarbonate and gel-type framework material are mixed, add water granulation, then is dried, obtains matrix type particle；
Step B：Coating wall material is heated to molten state, obtains coating solution；
Step C：The matrix type particle is coated with the coating solution, obtains product.
The above method can be prepared by sodium bicarbonate sustained release agent only with three wet granulation, melting, coating simple steps, have
Have that technique is simple, low cost and other advantages.
Preferably, the coating solution obtained should be incubated preservation, avoid coating solution from condensing.
Preferably, also include after the step C：Add anticaking agent.Similarly, anticaking agent has larger specific surface area,
It is dispersed in after addition between solid powder particulate, can significantly improves product free-running property.
Preferably, the coated methods of step B are：Fluidized bed coating, this method embedding uniformity are high.
More preferably use bottom spray type fluidized bed coating.With the coating of bottom spray type fluidized bed process evenly, it also has other three
Individual advantage：
1. the distance between spray gun and material shorten, reduce that coating solution reaches the evaporation of the solvent before material and spray drying is existing
As so as to be advantageous to the uniformity of coating solution film forming thickness；
2. the orderly shuttling movement of material, the direction of motion is identical with hydrojet direction, and the probability of material contact coating solution is identical,
Be advantageous to the uniformity of coating；
3. being coating area inside spacer ring, material is intensive in coating area inner height, and coating loss is few.
In addition, in preparation method, it can also use and roll the coating of pill method.
Preferably, in fluid bed, the speed that coating solution is pumped into spray chamber is 5~30mL/min., can using the speed
To have high efficiency concurrently and prevent two big advantage of coating solution cooling solidification.
Preferably, the gel-type framework material is hydroxypropyl methyl cellulose, and the water and solid added in granulation
The weight ratio of material is 1:4~2.During wet granulation, the amount of water is added can just to make material moistening, bonding, and can be from going out
Material mouth makes the particle of required granularity.
Preferably, the method dried in the step A is：2~10h is dried below 55 DEG C；Sodium bicarbonate by thermally labile,
Especially more than 55 DEG C resolution ratios are big, therefore are dried below 55 DEG C and be beneficial to protection sodium bicarbonate, and dry 2~10h makes particle
Dry tack free.
Preferably, in the step A, also include after drying：Cross 20-60 mesh sieves.Sieving is advantageous to improve product shape
The homogeneity of state, make it more uniform during feed is added to.
Compared with prior art, beneficial effects of the present invention are：
(1) realize sodium bicarbonate crosses stomach not discomposing effect, while reach certain slow release effect.
(2) compared to conventional sustained release agent, auxiliary material used in sodium bicarbonate sustained release agent of the invention is few, heat endurance is more preferable, embedding
Rate is high, and intestines disappearance rate is high, absorbs complete.
(3) sodium bicarbonate of the invention cross stomach sustained release agent preparation method technique is simple, cost is low.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is the required accompanying drawing used in technology description to be briefly described.
Fig. 1 is the microscope figure that the sodium bicarbonate that embodiment 4 provides is crossed after 4 times of stomach sustained release agent amplification；
Fig. 2 is the microscope figure that the sodium bicarbonate that embodiment 4 provides is crossed after 10 times of stomach sustained release agent amplification.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition suggested according to normal condition or manufacturer are carried out.Agents useful for same or the unreceipted production firm person of instrument, it is
The conventional products that can be obtained by commercially available purchase.
Embodiment 1
1st, pelletize：Load weighted sodium bicarbonate 190g, hydroxypropyl methyl cellulose 50g are added in wet mixing pelletizer,
5min is pre-mixed, starts to add water, amount of water is about 60g, and reamer switchs to quickly stir 8min after mixing slowly 3min, and adjustment twists
Knife speed makes granularity during discharging be discharged in 20~30 mesh, primary dcreening operation.
2nd, dry：The wet little particle that step 1 is prepared is immediately placed in drying box and dried, and regulation drying temperature 55 ±
5 DEG C, drying time 2h or so, in the drying process, per half an hour by material turning once, make its moisture evaporation uniform.
3rd, sieve：Dried material is sieved, the particle for crossing 20 mesh sieves is conforming particle.It is standby.
4th, prepared by coating solution：Glycerin monostearate 60g is heated to 65 ± 5 DEG C to molten condition, obtains coating solution guarantor
Warm standby is used.
5th, the whole little particles prepared are taken to be placed in fluid bed, regulation stream temperature to 30 DEG C, dry air flow
35m3/ h, the coating solution of insulation is drawn with 9mL/min flow velocity with peristaltic pump, spraying into fluidized bed atomization room in a manner of bottom is sprayed enters
Row atomization coating, until coating solution is finished.Stream temperature is reduced to room temperature, continues to discharge after fluidizing 15min in fluid bed, i.e.,
Stomach sustained release agent is crossed for sodium bicarbonate.
Embodiment 2
1st, pelletize：Load weighted sodium bicarbonate 210g, ethyl cellulose 160g are added in wet mixing pelletizer, premixing
5min, start to add water, amount of water is about 185g, and reamer switchs to quickly stir 8min after mixing slowly 3min, adjustment reamer speed
Degree makes granularity during discharging be discharged in 60~70 mesh, primary dcreening operation.
2nd, dry：The wet little particle that step 1 is prepared is immediately placed in drying box and dried, and regulation drying temperature 40 ±
5 DEG C, drying time 10h or so, in the drying process, per half an hour by material turning once, make its moisture evaporation uniform.
3rd, sieve：Dried material is sieved, the particle for crossing 60 mesh sieves is conforming particle.It is standby.
4th, prepared by coating solution：Glycerin monostearate 100g is heated to 65 ± 5 DEG C to molten condition, obtains coating solution guarantor
Warm standby is used.
5th, the whole little particles prepared are taken to be placed in fluid bed, regulation stream temperature to 30 DEG C, dry air flow
35m3/ h, the coating solution of insulation is drawn with 9mL/min flow velocity with peristaltic pump, spraying into fluidized bed atomization room in a manner of bottom is sprayed enters
Row atomization coating, until coating solution is finished.Stream temperature is reduced to room temperature, continues to discharge after fluidizing 15min in fluid bed, i.e.,
Stomach sustained release agent is crossed for sodium bicarbonate.
Embodiment 3
A kind of feed crosses stomach sustained release agent with sodium bicarbonate：
1st, pelletize：Load weighted sodium bicarbonate 240g, hydroxypropyl methyl cellulose 60g are added in wet mixing pelletizer,
5min is pre-mixed, starts to add water, amount of water is about 100g, and reamer switchs to quickly stir 7min after mixing slowly 3min, adjustment
Reamer speed makes granularity during discharging be discharged in 20~30 mesh, primary dcreening operation.
2nd, dry：The wet little particle that step 1 is prepared is immediately placed in drying box and dried, and regulation drying temperature 50 ±
5 DEG C, drying time 8h or so, in the drying process, make its moisture evaporation uniform per 2h by material turning once.
3rd, sieve：Dried material is sieved, the particle for crossing 20 mesh sieves is conforming particle.It is standby.
4th, prepared by coating solution：Palm fatty powder 120g is heated to 70 ± 5 DEG C to molten condition, it is standby to obtain coating solution insulation
With.
5th, the whole little particles prepared are taken to be placed in fluid bed, regulation stream temperature to 30 DEG C, dry air flow
50m3/ h, the coating solution of insulation is drawn with 10mL/min flow velocity with peristaltic pump, fluidized bed atomization room is sprayed into a manner of bottom is sprayed
Atomization coating is carried out, until coating solution is finished.Reduce stream temperature and arrive room temperature, discharged after continuing in fluid bed fluidisation 15min,
As sodium bicarbonate crosses stomach sustained release agent.
Embodiment 4
1st, pelletize：Load weighted sodium bicarbonate 200g, hydroxypropyl methyl cellulose 100g are added in wet mixing pelletizer,
5min is pre-mixed, starts to add water, amount of water is about 100g, and reamer switchs to quickly stir 8min after mixing slowly 3min, adjustment
Reamer speed makes granularity during discharging be discharged in 40~50 mesh, primary dcreening operation.
2nd, dry：The wet little particle that step 1 is prepared is immediately placed in drying box and dried, and regulation drying temperature 50 ±
5 DEG C, drying time 8h or so, in the drying process, make its moisture evaporation uniform per 2h by material turning once.
3rd, sieve：Dried material is sieved, the particle for crossing 40 mesh sieves is conforming particle.It is standby.
4th, prepared by coating solution：Palm fatty powder 80g and glycerin monostearate 80g are mixed and heated into 70 ± 5 DEG C extremely to melt
Melt state, it is standby to obtain coating solution insulation.
5th, the whole little particles prepared are taken to be placed in fluid bed, regulation stream temperature to 30 DEG C, dry air flow
40m3/ h, the coating solution of insulation is drawn with 9mL/min flow velocity with peristaltic pump, spraying into fluidized bed atomization room in a manner of bottom is sprayed enters
Row atomization coating, until coating solution is finished.Stream temperature is reduced to room temperature, continues to discharge after fluidizing 15min in fluid bed, i.e.,
Stomach sustained release agent is crossed for sodium bicarbonate.
Embodiment 5
1st, pelletize：Load weighted sodium bicarbonate 210g, hydroxypropyl methyl cellulose 84g are added in wet mixing pelletizer,
5min is pre-mixed, starts to add water, amount of water is about 100g, and reamer switchs to quickly stir 8min after mixing slowly 3min, adjustment
Reamer speed makes granularity during discharging be discharged in 50~60 mesh, primary dcreening operation.
2nd, dry：The wet little particle that step 1 is prepared is immediately placed in drying box and dried, and regulation drying temperature 50 ±
5 DEG C, drying time 8h or so, in the drying process, make its moisture evaporation uniform per 2h by material turning once.
3rd, sieve：Dried material is sieved, the particle for crossing 50 mesh sieves is conforming particle.It is standby.
4th, prepared by coating solution：Glycerin monostearate 126g is heated to 65 ± 5 DEG C to molten condition, obtains coating solution guarantor
Warm standby is used.
5th, the whole little particles prepared are taken to be placed in fluid bed, regulation stream temperature to 30 DEG C, dry air flow
35m3/ h, the coating solution of insulation is drawn with 9mL/min flow velocity with peristaltic pump, spraying into fluidized bed atomization room in a manner of bottom is sprayed enters
Row atomization coating, until coating solution is finished.Stream temperature is reduced to room temperature, continues to discharge after fluidizing 15min in fluid bed, i.e.,
Stomach sustained release agent is crossed for sodium bicarbonate.
Embodiment 6
1st, pelletize：Load weighted sodium bicarbonate 200g, hydroxypropyl methyl cellulose 100g are added in wet mixing pelletizer,
5min is pre-mixed, starts to add water, amount of water is about 100g, and reamer switchs to quickly stir 8min after mixing slowly 3min, adjustment
Reamer speed makes granularity during discharging be discharged in 40~50 mesh, primary dcreening operation.
2nd, dry：The wet little particle that step 1 is prepared is immediately placed in drying box and dried, and regulation drying temperature 50 ±
5 DEG C, drying time 8h or so, in the drying process, make its moisture evaporation uniform per 2h by material turning once.
3rd, sieve：Dried material is sieved, the particle for crossing 40 mesh sieves is conforming particle.It is standby.
4th, prepared by coating solution：Palm fatty powder 80g and glycerin monostearate 80g are mixed and heated into 70 ± 5 DEG C extremely to melt
Melt state, it is standby to obtain coating solution insulation.
5th, the whole little particles prepared are taken to be placed in fluid bed, regulation stream temperature to 30 DEG C, dry air flow
40m3/ h, the coating solution of insulation is drawn with 9mL/min flow velocity with peristaltic pump, spraying into fluidized bed atomization room in a manner of bottom is sprayed enters
Row atomization coating, until coating solution is finished.20g silica is added, drops to room temperature, as sodium bicarbonate crosses stomach sustained release agent.
Embodiment 7
1st, pelletize：Load weighted sodium bicarbonate 200g, hydroxypropyl methyl cellulose 100g are added in wet mixing pelletizer,
5min is pre-mixed, starts to add water, amount of water is about 100g, and reamer switchs to quickly stir 8min after mixing slowly 3min, adjustment
Reamer speed makes granularity during discharging be discharged in 40~50 mesh, primary dcreening operation.
2nd, dry：The wet little particle that step 1 is prepared is immediately placed in drying box and dried, and regulation drying temperature 50 ±
5 DEG C, drying time 8h or so, in the drying process, make its moisture evaporation uniform per 2h by material turning once.
3rd, sieve：Dried material is sieved, the particle for crossing 40 mesh sieves is conforming particle.It is standby.
4th, prepared by coating solution：Palm fatty powder 80g and glycerin monostearate 80g are mixed and heated into 70 ± 5 DEG C extremely to melt
Melt state, it is standby to obtain coating solution insulation.
5th, the whole little particles prepared are taken to be placed in fluid bed, regulation stream temperature to 30 DEG C, dry air flow
40m3/ h, the coating solution of insulation is drawn with 9mL/min flow velocity with peristaltic pump, spraying into fluidized bed atomization room in a manner of bottom is sprayed enters
Row atomization coating, until coating solution is finished.20g sodium silicoaluminates are added, drop to room temperature, as sodium bicarbonate crosses stomach sustained release agent.
Embodiment 8
1st, pelletize：Load weighted sodium bicarbonate 200g, hydroxypropyl methyl cellulose 100g are added in wet mixing pelletizer,
5min is pre-mixed, starts to add water, amount of water is about 100g, and reamer switchs to quickly stir 8min after mixing slowly 3min, adjustment
Reamer speed makes granularity during discharging be discharged in 40~50 mesh, primary dcreening operation.
2nd, dry：The wet little particle that step 1 is prepared is immediately placed in drying box and dried, and regulation drying temperature 50 ±
5 DEG C, drying time 8h or so, in the drying process, make its moisture evaporation uniform per 2h by material turning once.
3rd, sieve：Dried material is sieved, the particle for crossing 40 mesh sieves is conforming particle.It is standby.
4th, prepared by coating solution：Palm fatty powder 80g and glycerin monostearate 80g are mixed and heated into 70 ± 5 DEG C extremely to melt
Melt state, it is standby to obtain coating solution insulation.
5th, the whole little particles prepared are taken to be placed in fluid bed, regulation stream temperature to 30 DEG C, dry air flow
40m3/ h, the coating solution of insulation is drawn with 5mL/min flow velocity with peristaltic pump, spraying into fluidized bed atomization room in a manner of bottom is sprayed enters
Row atomization coating, until coating solution is finished.Stream temperature is reduced to room temperature, continues to discharge after fluidizing 15min in fluid bed, i.e.,
Stomach sustained release agent is crossed for sodium bicarbonate.
Embodiment 9
1st, pelletize：Load weighted sodium bicarbonate 200g, hydroxypropyl methyl cellulose 100g are added in wet mixing pelletizer,
5min is pre-mixed, starts to add water, amount of water is about 100g, and reamer switchs to quickly stir 8min after mixing slowly 3min, adjustment
Reamer speed makes granularity during discharging be discharged in 40~50 mesh, primary dcreening operation.
2nd, dry：The wet little particle that step 1 is prepared is immediately placed in drying box and dried, and regulation drying temperature 50 ±
5 DEG C, drying time 8h or so, in the drying process, make its moisture evaporation uniform per 2h by material turning once.
3rd, sieve：Dried material is sieved, the particle for crossing 40 mesh sieves is conforming particle.It is standby.
4th, prepared by coating solution：Palm fatty powder 80g and glycerin monostearate 80g are mixed and heated into 70 ± 5 DEG C extremely to melt
Melt state, it is standby to obtain coating solution insulation.
5th, the whole little particles prepared are taken to be placed in fluid bed, regulation stream temperature to 30 DEG C, dry air flow
40m3/ h, the coating solution of insulation is drawn with 30mL/min flow velocity with peristaltic pump, fluidized bed atomization room is sprayed into a manner of bottom is sprayed
Atomization coating is carried out, until coating solution is finished, as sodium bicarbonate crosses stomach sustained release agent.
3 hours dissolution rates of embedding rate and simulate the gastric juice of above example are tested, as a result as shown in table 1.
Simulate the gastric juice dissolution rate experiment in 3 hours：So that pig takes in feed in gastric digestion 3h as an example, measure sodium bicarbonate is being simulated
The dissolution rate after 3h is digested in gastric juice, shows that it crosses stomach effect.
Simulated intestinal fluid dissolution rate experiment in 24 hours：So that pig intake feed digests 24h in enteron aisle as an example, sodium bicarbonate is being simulated
Detected after digesting 24h in intestinal juice, the dissolution rate for as a result showing all embodiments is 100%, it was demonstrated that its intestines disappearance rate is high.
The embodiment 1-9 of table 13 hours dissolution rates of embedding rate and simulate the gastric juice
With the sustained release agent finished product of micro- sem observation embodiment 4, as shown in Figure 1-2, as seen from the figure, sodium bicarbonate is successfully embedded
Into the lenticular of graininess, rather than sodium acid carbonate.
Although illustrate and describing the present invention with specific embodiment, but will be appreciated that without departing substantially from the present invention's
Many other change and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (11)
1. a kind of feed crosses stomach sustained release agent with sodium bicarbonate, it is characterised in that including core and the coating wall material for being coated on its surface,
By weight, the core includes sodium bicarbonate 9.5-10.5 parts and gel-type framework material 2.5-5 parts；The coating wall material
For 3-8 parts；
The matrix type particle that the core obtains for wet granulation after sodium bicarbonate and the mixing of gel-type framework material.
2. feed according to claim 1 crosses stomach sustained release agent with sodium bicarbonate, it is characterised in that the coating wall material surface is attached
There is anticaking agent.
3. feed according to claim 1 crosses stomach sustained release agent with sodium bicarbonate, it is characterised in that the coating wall material is palm
Fatty powder and/or glycerin monostearate；The gel-type framework material is hydroxypropyl methyl cellulose.
4. feed according to claim 2 crosses stomach sustained release agent with sodium bicarbonate, it is characterised in that the anticaking agent is titanium dioxide
Silicon and/or sodium silicoaluminate, and addition is less than 1 part.
5. feed according to claim 1 crosses stomach sustained release agent with sodium bicarbonate, it is characterised in that by weight, sodium bicarbonate 10
Part, palm fatty powder and/or glycerin monostearate 3-8 parts, hydroxypropyl methyl cellulose 2.5-5 parts.
6. the feed described in claim any one of 1-5 crosses the preparation method of stomach sustained release agent with sodium bicarbonate, it is characterised in that including
The following steps：
Step A：Sodium bicarbonate and gel-type framework material are mixed, add water granulation, then is dried, obtains matrix type particle；
Step B：Coating wall material is heated to molten state, obtains coating solution；
Step C：The matrix type particle is coated with the coating solution, obtains product.
7. feed according to claim 6 crosses the preparation method of stomach sustained release agent with sodium bicarbonate, it is characterised in that in the step
Also include after rapid C：Add anticaking agent.
8. feed according to claim 6 crosses the preparation method of stomach sustained release agent with sodium bicarbonate, it is characterised in that the step
The coated methods of C are：Fluidized bed coating；Specifically, in fluid bed, to spray chamber be pumped into the speed of coating solution for 5 ~
30mL/min。
9. feed according to claim 6 crosses the preparation method of stomach sustained release agent with sodium bicarbonate, it is characterised in that the gel
Type framework material is hydroxypropyl methyl cellulose, and the water and the weight ratio of solid material that are added in granulation are 1:4~2.
10. feed according to claim 6 crosses the preparation method of stomach sustained release agent with sodium bicarbonate, it is characterised in that the step
The method dried in rapid A is：2 ~ 10h is dried below 55 DEG C.
11. feed according to claim 10 crosses the preparation method of stomach sustained release agent with sodium bicarbonate, it is characterised in that the step
In rapid A, also include after drying：Cross 20-60 mesh sieves.
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| CN105310055B (en) * | 2015-11-02 | 2018-11-27 | 长江大学 | Alkaline leavening agent microcapsules and preparation method thereof |
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| CN111202175B (en) * | 2020-01-10 | 2023-05-05 | 安徽东方天合生物技术有限责任公司 | Rumen bypass biotin |
| CN112167165B (en) * | 2020-09-29 | 2022-02-11 | 厦门汇盛生物有限公司 | Preparation and application of compound rumen-bypass polyunsaturated fatty acid powder |
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| CN115448316B (en) * | 2022-09-21 | 2024-02-27 | 江西联锴化学有限公司 | Preparation method of large-aperture spherical silicon dioxide |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101516352A (en) * | 2006-08-30 | 2009-08-26 | 雅戈泰克股份公司 | Controlled release solid oral dosage formulations comprising nisoldipine |
| CN101611766A (en) * | 2009-07-16 | 2009-12-30 | 无锡正大畜禽有限公司 | A kind of production method of enteric-coated kitasamycin for feed |
| CN103948556A (en) * | 2014-04-08 | 2014-07-30 | 闻晓光 | Novel controlled release tablet |
| CN104304681A (en) * | 2014-10-31 | 2015-01-28 | 广东绿生源饲料科技有限公司 | Slow-release granule type phosphoric acid for feed and preparation method thereof |
-
2015
- 2015-06-11 CN CN201510319866.3A patent/CN104938791B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101516352A (en) * | 2006-08-30 | 2009-08-26 | 雅戈泰克股份公司 | Controlled release solid oral dosage formulations comprising nisoldipine |
| CN101611766A (en) * | 2009-07-16 | 2009-12-30 | 无锡正大畜禽有限公司 | A kind of production method of enteric-coated kitasamycin for feed |
| CN103948556A (en) * | 2014-04-08 | 2014-07-30 | 闻晓光 | Novel controlled release tablet |
| CN104304681A (en) * | 2014-10-31 | 2015-01-28 | 广东绿生源饲料科技有限公司 | Slow-release granule type phosphoric acid for feed and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 过瘤胃养分包被壁材人工睡液、瘤胃稳定性及小肠释放性能的研究;王帅等;《饲料研究》;20150207(第3期);第40-43页 * |
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