CN101611766A - A kind of production method of enteric-coated kitasamycin for feed - Google Patents
A kind of production method of enteric-coated kitasamycin for feed Download PDFInfo
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- CN101611766A CN101611766A CN200910181418A CN200910181418A CN101611766A CN 101611766 A CN101611766 A CN 101611766A CN 200910181418 A CN200910181418 A CN 200910181418A CN 200910181418 A CN200910181418 A CN 200910181418A CN 101611766 A CN101611766 A CN 101611766A
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Abstract
The present invention is a kind of production method of enteric-coated kitasamycin for feed, comprises following processing step: one, the preparation of medicine carrying micropill; Two, the internal layer sustained release coating of medicine carrying micropill prolongs kitasamycin and discharges and action time; Three, the outer enteric coating of medicine carrying micropill is to guarantee in gastric juice on a small quantity or not discharge and discharge in intestinal juice.Advantage: kitasamycin is carried out micropill granulate, the granule energy of making 99% has greatly reduced dust, and has increased flowability by 24 mesh sieves; Internal layer sustained release agent (HPMC) dressing prolongs kitasamycin and discharges and action time, reduces the medication number of times, reduces drug cost; Wrap one deck enterosoluble substance in the microparticle shell spraying---acrylic resin III number.This material can protect this alkalescent antibiotic of kitasamycin in stomach not by stomach acids destroy; the rapid disintegration of enterosoluble substance discharges kitasamycin after entering enteron aisle, and kitasamycin is absorbed by intestinal mucosa and enters the blood medicine then; can reach the breeding that suppresses pathogenic microorganism, prevent the effect of suffering from diarrhoea.The Kitasamycin coated preparation is insoluble in stomach, and stomach is not had bad stimulation, can not cause gastric disorder causing nausea and vomiting.And owing to be sustained release preparation, kitasamycin prolongs action time, reduces the medication number of times, reduces raiser's drug cost, increases economic efficiency.
Description
Technical field
What the present invention relates to is a kind of production method of enteric-coated kitasamycin for feed.Belong to feed and field of feed additive technology.
Background technology:
Kitasamycin (Kitasamycin) has another name called kitasamycin (Leucomycin), is the multi-component ten hexa-atomic macrolide antibiotics that produced by streptomysin bacterium in the north (Strepotomyces kitasatoensis), by A
1, A
2, A
3, A
4, A
5, A
6And A
7Deng composition, A wherein
1And A
5Antibacterial activity the strongest, gram-positive bacteria, part Gram-negative bacteria, Mycoplasma, rickettsia, conveyor screw are had stronger inhibitory action.Kitasamycin is unique antibiotic that can add in animal feed of macrolides Ministry of Agriculture regulation, and its effect is control pig, chicken respiratory class disease, and certain growth promoting function is arranged.In the veterinary drug quality standard of Ministry of Agriculture's promulgation, kitasamycin pre-mixing agent (formulation is a pulvis) has two kinds of content specifications, is respectively 10% and 50%, and what use always in feed factory is 50% content, because it is relatively low to add cost.Just introduce China as far back as early eighties and make feed addictive through Japan, but fail extensive use in mixed feed always, reason is that there are three big shortcomings in the former powder of kitasamycin: the effect that 1) prevents enteron aisle diarrhoea is undesirable, Kitasamycin absorbs very fast at animal intestinal, promptly be absorbed at the enteron aisle front end, can only inhibitory action be arranged to the pathogen of enteron aisle part (front portion), be difficult for evenly being covered with whole enteron aisle, thereby be difficult to pathogenic microorganism in the whole animal intestinal is played good inhibitory effect.2) strong bitter taste has stimulation to stomach, directly has influence on animal and searches for food, and adds excessive meeting and causes the animal bad reaction, as gastric disorder causing nausea, vomiting and food refusal.3) be alkalescence,,, will inevitably degrade in a large number and reduce biologically active therefore through animal stomach sour environment the time less than 5.5 o'clock active can obviously declines at pH, there are some researches show: the former powder of Kitasamycin degradation rate in the animal stomach reaches about 40%.Be limited to above-mentioned influence factor, make Kitasamycin fail well to be used always at China's feed industry.
Summary of the invention:
The objective of the invention is to defective at above-mentioned existence; a kind of production method of improved enteric-coated kitasamycin for feed is proposed; the protection this alkalescent antibiotic of kitasamycin and make it in stomach not by stomach acids destroy; the rapid disintegration of enterosoluble substance after entering enteron aisle; discharge kitasamycin; in enteron aisle, entered blood then, bring into play its antibacterial action by the intestinal mucosa absorption.Make sustained release agent simultaneously, medicine prolongs action time, reduces the medication number of times, reduces raiser's drug cost, increases economic efficiency.
Technical solution of the present invention: process is divided following three steps:
One, the preparation of medicine carrying micropill, employing is extruded round as a ball comminutor and is prepared the medicine carrying micropill, specifically is to take by weighing recipe quantity kitasamycin and auxiliary material earlier, crosses 60 mesh sieves and mixes, add water (6%～8%) and make softwood, be extruded into the suitable strip of diameter through extruding sieve plate (aperture 0.8mm); Advance spheronizator again and make particle round as a ball fully,, get 24 order micropills and carry out dressing in 40 ℃ of oven dry.
Two, add sustained release agent, in intestinal juice, slowly discharge to guarantee kitasamycin.
Take by weighing the good pill of granulating, put in the fluidized bed airflow coating device, make the internal layer sustained release coating, 40 ℃ of temperature, dry about 10min with 3.0%HPMC (hydroxypropyl methylcellulose) aqueous solution.
Three, the outer enteric coating of medicine carrying micropill adopts acrylic resin (enteric solubility) to do coating material, the fluidized-bed coating machine dressing.The ratio of medicine carrying micropill and coating material is 100: (5-10).
Advantage of the present invention: kitasamycin is carried out micropill granulate, the granule energy of making 99% has greatly reduced dust, and has increased flowability by 24 mesh sieves; Internal layer sustained release agent (HPMC) dressing prolongs kitasamycin and discharges and action time, reduces the medication number of times, reduces drug cost; Then wrap one deck enterosoluble substance in the microparticle shell spraying---acrylic resin III number.This material can protect this alkalescent antibiotic of kitasamycin in stomach not by stomach acids destroy; enterosoluble substance disintegration after entering enteron aisle; then internal layer HPMC dissolves gradually and discharges kitasamycin thereupon, and kitasamycin is absorbed by intestinal mucosa and enters the blood medicine then, and brings into play its antibacterial action for a long time.
Effect to the animal intestinal pathogenic microorganism: the Kitasamycin coated preparation is insoluble in stomach, slowly-releasing behind the arrival animal intestinal can be distributed to whole enteron aisle equably, fully contacts with pathogenic microorganism, thereby reach the breeding that suppresses pathogenic microorganism, prevent the effect of suffering from diarrhoea.
To animal gastrointestinal stimulation situation: through behind the enteric coating stomach is not had bad stimulation, can not cause gastric disorder causing nausea and vomiting.
Aspect the anti-acid environment characteristic: enteric coating is not damaged at the stomach acidity environment, and active ingredient can all accurately arrive enteron aisle and play a role.
The strong bitter taste of kitasamycin is to the influence of feed palatability: the covered strong bitter taste in the coated back of kitasamycin does not influence the palatability of feed.
Use cost is low: use that former powder or particle are minimum will to improve 40% addition, add the 60ppm kitasamycin of dressing as feed per ton, be equivalent to former powder of Kitasamycin or the particle of 100ppm.
Accompanying drawing is technological process of production figure of the present invention.
Concrete implementing method:
Embodiment 1
Add 55.5kg starch, 6.5kg dextrin, 3kg sweet dew alcoholase with the kitasamycin of 35kg and cross 60 mesh sieves and mix, add water 8% and make softwood, be extruded into the suitable strip of diameter through extruding sieve plate (aperture 0.8mm).Advance spheronizator again and make particle round as a ball fully,, get 24 order micropills and carry out dressing in 40 ℃ of oven dry.Earlier make sustained release coating, 40 ℃ of dry about 10min of temperature with 3.0%HPMC (hydroxypropyl methylcellulose) aqueous solution.Use 7kg acrylic resin (enteric solubility) to do coating material again and carry out enteric coating, all use the fluidized-bed coating machine dressing.The art for coating condition is as follows: blower frequency: 27.5Hz; Whiff pressure: 0.2MPa; Hydrojet flow velocity: 1 ml/min; Stream temperature: 33 ℃.
Embodiment 2
Add 60kg starch, 6.5kg dextrin, 3.5kg sweet dew alcoholase with the kitasamycin of 30kg and cross 60 mesh sieves and mix, add water 7% and make softwood, be extruded into the suitable strip of diameter through extruding sieve plate (aperture 0.8mm).Advance spheronizator again and make particle round as a ball fully,, get 24 order micropills and carry out dressing in 40 ℃ of oven dry.Earlier make sustained release coating, 40 ℃ of dry about 10min of temperature with 3.0%HPMC (hydroxypropyl methylcellulose) aqueous solution.Use 6kg acrylic resin (enteric solubility) to do coating material again and carry out enteric coating, all use the fluidized-bed coating machine dressing.The art for coating condition is as follows: blower frequency: 27.5Hz; Whiff pressure: 0.2MPa; Hydrojet flow velocity: 1 ml/min; Stream temperature: 33 ℃.
Embodiment 3
Add 64kg starch, 7.5kg dextrin, 3.5kg sweet dew alcoholase with the kitasamycin of 25kg and cross 60 mesh sieves and mix, add water 6% and make softwood, be extruded into the suitable strip of diameter through extruding sieve plate (aperture 0.8mm).Advance spheronizator again and make particle round as a ball fully,, get 24 order micropills and carry out dressing in 40 ℃ of oven dry.Make sustained release coating with 3.0%HPMC (hydroxypropyl methylcellulose) aqueous solution, 40 ℃ of dry about 10min of temperature.Do coating material with 5kg acrylic resin (enteric solubility) and carry out enteric coating, all use the fluidized-bed coating machine dressing.The art for coating condition is as follows: blower frequency: 27.5Hz; Whiff pressure: 0.2MPa; Hydrojet flow velocity: 1 ml/min; Stream temperature: 33 ℃.
Claims (4)
1, a kind of production method of enteric-coated kitasamycin for feed is characterized in that this method comprises following processing step:
One, the preparation of medicine carrying micropill, employing is extruded round as a ball comminutor and is prepared the medicine carrying micropill, specifically is to take by weighing recipe quantity kitasamycin and auxiliary material earlier, crosses 60 mesh sieves and mixes, and adds water an amount of (6%～8%) and makes softwood, and through extruding sieve plate, aperture 0.8mm is extruded into strip; Advance spheronizator again and make particle round as a ball fully,, get 24 order medicine carrying micropills and carry out dressing in 40 ℃ of oven dry (moisture≤10.0%);
Two, add the sustained release agent internal layer coating, in intestinal juice, slowly discharge, keep the blood concentration of homogeneous to guarantee kitasamycin.Take by weighing the good medicine carrying micropill of granulating, put in the fluidized bed airflow coating device, make sustained release coating, 40 ℃ of temperature, dry about 10min with hydroxypropyl methylcellulose (HPMC) 3.0% aqueous solution;
Three, the outer enteric coating of medicine carrying micropill adopts the enteric solubility acrylic resin to do coating material, through the fluidized-bed coating machine dressing; The part by weight of medicine carrying micropill and coating material is 100: (5-10).
2, the production method of a kind of enteric-coated kitasamycin for feed according to claim 1, it is characterized in that the 24 order medicine carrying micropills of getting described in the processing step one carry out dressing, earlier (carry out internal layer coating as sustained release agent, the usefulness enteric solubility acrylic resin that accounts for 20% kitasamycin carries out outer dressing again with 3.0% hydroxypropyl methylcellulose (HPMC) aqueous solution.
3, the production method of a kind of enteric-coated kitasamycin for feed according to claim 1 is characterized in that the part by weight of described kitasamycin and auxiliary material is (25-40): (75-60); Starch in the auxiliary material: dextrin: sweet mellow wine=85: (10-7): (5-8).
4, the production method of a kind of enteric-coated kitasamycin for feed according to claim 1 is characterized in that described art for coating condition is as follows: blower frequency: 27.5Hz; Whiff pressure: 0.2MPa; Hydrojet flow velocity: 1 ml/min; Stream temperature: 33 ℃.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104686808A (en) * | 2015-03-26 | 2015-06-10 | 无锡正大畜禽有限公司 | 50% enteric package zinc oxide nanoparticle preparation method |
| CN104938791A (en) * | 2015-06-11 | 2015-09-30 | 深圳市裕农科技股份有限公司 | Fodder baking soda stomach-pass sustained-release agent and preparation method thereof |
| CN105534950A (en) * | 2016-01-05 | 2016-05-04 | 无锡华诺威动物保健品有限公司 | Production method for kitasamycin solid micro-capsules for feed |
| CN106265595A (en) * | 2016-09-29 | 2017-01-04 | 甘肃瑞和祥生物科技有限公司 | A kind of enteric kitasamycin sustained-release micro-spheres and preparation method thereof |
| CN106260599A (en) * | 2016-08-12 | 2017-01-04 | 广汉隆达饲料有限公司 | Enteric zinc oxide micropill |
| CN107518175A (en) * | 2016-06-29 | 2017-12-29 | 湖南晶天科技实业有限公司 | A kind of feed addictive coating aliphatic acid copper and preparation method thereof and a kind of feed |
| CN108902476A (en) * | 2018-07-26 | 2018-11-30 | 湖南普菲克生物科技有限公司 | A kind of sustained release sodium butyrate and preparation method thereof suitable for different livestock and poultry |
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| CN100431515C (en) * | 2005-05-24 | 2008-11-12 | 浙江大学 | Method for preparing additive of stable micronized medication |
| CN101045064A (en) * | 2007-01-30 | 2007-10-03 | 佛山市海纳川药业有限公司 | Gitamycin slow-release micro-ball preparation and its preparing process |
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2009
- 2009-07-16 CN CN2009101814186A patent/CN101611766B/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104686808A (en) * | 2015-03-26 | 2015-06-10 | 无锡正大畜禽有限公司 | 50% enteric package zinc oxide nanoparticle preparation method |
| CN104938791A (en) * | 2015-06-11 | 2015-09-30 | 深圳市裕农科技股份有限公司 | Fodder baking soda stomach-pass sustained-release agent and preparation method thereof |
| CN104938791B (en) * | 2015-06-11 | 2018-03-13 | 深圳市裕农科技股份有限公司 | A kind of feed crosses stomach sustained release agent and preparation method thereof with sodium bicarbonate |
| CN105534950A (en) * | 2016-01-05 | 2016-05-04 | 无锡华诺威动物保健品有限公司 | Production method for kitasamycin solid micro-capsules for feed |
| CN107518175A (en) * | 2016-06-29 | 2017-12-29 | 湖南晶天科技实业有限公司 | A kind of feed addictive coating aliphatic acid copper and preparation method thereof and a kind of feed |
| CN106260599A (en) * | 2016-08-12 | 2017-01-04 | 广汉隆达饲料有限公司 | Enteric zinc oxide micropill |
| CN106265595A (en) * | 2016-09-29 | 2017-01-04 | 甘肃瑞和祥生物科技有限公司 | A kind of enteric kitasamycin sustained-release micro-spheres and preparation method thereof |
| CN108902476A (en) * | 2018-07-26 | 2018-11-30 | 湖南普菲克生物科技有限公司 | A kind of sustained release sodium butyrate and preparation method thereof suitable for different livestock and poultry |
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| CN101611766B (en) | 2012-06-06 |
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Inventor after: Zhou Ling Inventor after: Ye Fengxian Inventor after: Feng Jingbo Inventor before: Zhou Ling Inventor before: Ye Fengxian |
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Address after: Wuxi new Mei Cun Qun Xing Lu 214112 Jiangsu city of Wuxi province No. 51 Patentee after: WUXI ZHENGDA BIOLOGY CO., LTD. Address before: Wuxi new Mei Cun Qun Xing Lu 214112 Jiangsu city of Wuxi province No. 51 Patentee before: Wuxi Zhengda Poultry Co., Ltd. |