CN104938484A - Application of 2,4-di-tert-butylphenol and acaricide - Google Patents
Application of 2,4-di-tert-butylphenol and acaricide Download PDFInfo
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- CN104938484A CN104938484A CN201510354183.1A CN201510354183A CN104938484A CN 104938484 A CN104938484 A CN 104938484A CN 201510354183 A CN201510354183 A CN 201510354183A CN 104938484 A CN104938484 A CN 104938484A
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- butylphenol compounds
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Abstract
The invention provides application of 2,4-di-tert-butylphenol and acaricide. The acaricide is composed of 2,4-di-tert-butylphenol and conventional excipients, wherein the mass of the 2,4-di-tert-butylphenol accounts for 0.05-99% that of the acaricide, and the mass of the conventional excipients account for 1-99.95% that of the acaricide. The novel harmonious acaricide is safe to people and livestock and environmentally friendly and has profound significance in ecological environmental protection, human health and comprehensive treatment on diseases.
Description
Technical field
The present invention relates to a kind of technical field of pesticide, concrete, what relate to is a kind of purposes and miticide of 2,4-DTBP.
Background technology
The crops of phytophagous mites all over the world are all found, it has, and volume are little, breeding is fast, strong adaptability and the feature such as easily to develop immunity to drugs, be the pest communities of generally acknowledged very difficult control.The most dependence on import of miticide used on the pesticide market of current China, the acaricidal expense of import accounts for 88.8% of general import agricultural chemicals expense.And the loss that mite class causes crop, within 30 years, there is obvious increase in the past.Main cause is intensive monoculture and uses non-specific insecticide.Next is because the growth time of a generation of mite class is shorter, can produce resistance rapidly to original miticide.These insecticides often acaricidal activity are not high, eliminated mite class natural enemy while killing mite class yet.At present, 3R problem i.e. residual (Residue), resistance (Resistance) and the pest resurgence (Resurgence) of chemical pesticide generally receives the concern of people, the understanding of the mankind to agricultural chemicals is also more and more deep, the use of agricultural chemicals is not focused on killing off the insect pests, but more focuses on regulating.Therefore, use obligate miticide to become the major measure of control phytophagous mites, the inevitable biopesticide towards efficient, wide spectrum, low toxicity, safety of acaricidal development and insect hormone type agricultural chemicals future development, meet the demand in market.
2,4-DTBP is called for short the tertiary phenol of 2,4-bis-, and being extensively present in plant, is also the important intermediate of fine chemical product, mainly for the preparation of helping antioxidant 168, also for producing polyisobutene, polyamide, Merlon etc.; Still can be used for producing antioxidant (300,314), ultra-violet absorber, light stabilizer 120, dyestuff and textile auxiliary, 2402 resins.In addition, also for the synthesis of spices, activator 460, initator TBCP, farm chemical emulgent, especially additive.In addition, now studies have reported that it has very strong biological action, comprise antioxidation, kill bacterial action and cytotoxicity.
Through finding existing technical literature retrieval, there is no 2,4-DTBP at present and preparing the application report in miticide; There is no at present a kind of, harmonious miticide to mammalian safe good with environment compatibility yet.
Summary of the invention
The present invention is directed to prior art above shortcomings, provide that a kind of efficient, noresidue, production cost are low, economical and practical, the purposes of a kind of 2,4-DTBP of environmental friendliness, high comprehensive performance and miticide.
The present invention seeks to be achieved through the following technical solutions:
The invention provides a kind of purposes of 2,4-DTBP, be applied to by 2,4-DTBP and prepare miticide.
Preferably, the plants such as described mite can be Tetranychus cinnabarinus, Tetranychus urticae evil mite.
The invention provides a kind of 2,4-DI-tert-butylphenol compounds miticide, described miticide is by 2,4-DI-tert-butylphenol compounds (i.e. bulk drug) and customary adjuvant form, wherein the quality of 2,4-DTBP accounts for the 0.05%-99% of 2,4-DTBP miticide quality, customary adjuvant accounts for the 1%-99.95% of 2,4-DTBP miticide quality.
Preferably, described customary adjuvant be solubilizer, synergist, emulsifier, bleeding agent etc. one or more.
Preferably, described solubilizer is neopelex, Potassium dodecylbenzenesulfonate, polysorbate, polyethylene glycol, sorbierite polyoxy ether, lignosulfonates, tea are withered, take Chinese honey locust etc. all in one or more.
Preferably, described emulsifier be in spans, Tweens, glycol ester class, propylene glycol ester class and/or polyethylene glycol type non-ionic surface active agent etc. one or more.
Preferably, described synergist be in Tea Saponin, APEO etc. one or more.
Preferably, described bleeding agent is azone etc.
Take certain 2,4-DI-tert-butylphenol compounds dissolution with solvents, selection adds various auxiliary material, picture as, solubilizer, synergist, emulsifier, bleeding agent etc., according to various technique, make various forms of miticide, such as: pulvis, missible oil, suspending agent, dry suspending agent, emulsifiable concentrate, sustained release agent, aqueous emulsion, spray etc.Wherein, solvent can be one or more in all organic solvents such as water, ethanol, methyl alcohol, acetone, cyclohexanone, benzinum, petroleum aromatic, purified petroleum benzin, ethyl acetate, toluene, dimethylbenzene.
The invention provides a kind of above-mentioned 2, the acaricidal application of 4-DI-tert-butylphenol compounds, is specially: joined by water in 2,4-DTBP miticide under stirring at normal temperature, make it be diluted to after 2,4-DTBP and bulk drug account for the concentration of 0.5-30wt% to spray to use.
Compared with prior art, the present invention has following beneficial effect:
The invention provides a kind of to person poultry safety, environmentally friendly novel harmonious miticide, all there is profound significance to the comprehensive regulation of ecological environmental protection, human health and disease.Compared with traditional agricultural chemicals, the present invention has following characteristics and advantage:
(1) features such as 2,4-DTBP is a kind of natural products, has nontoxic, easy degraded are friendly for people, animal and ecotope, safety;
(2) 2,4-DTBP source is easily, and esterification can be utilized to synthesize, also can from plant extracting directly, method is simple, can carry out large-scale industrial production;
(3) the present invention is that Late Cambrian 2,4-DTBP has and kills mite biologically active, and is mixed with miticide first.Through experiment, 96.7%. can be reached to Tetranychus cinnabarinus preventive effect
Embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.Following examples will contribute to those skilled in the art and understand the present invention further, but not limit the present invention in any form.It should be pointed out that to those skilled in the art, without departing from the inventive concept of the premise, some distortion and improvement can also be made.These all belong to protection scope of the present invention.
Embodiment 1
Take 2,4-DTBP 18g, use 300g dissolve with ethanol solution, add 167g Tween-80, dissolve, conveniently technique, makes the present invention 2,4-DI-tert-butylphenol compounds miticide, then thin up in made 2,4-DTBP miticide, makes 2,4-DI-tert-butylphenol compounds, namely the concentration of bulk drug is 1%.Finally, the 2,4-DTBP miticide after dilution is carried out indoor biological determination of activity to Tetranychus cinnabarinus, method is carried out according to the raw tetranychid leaching stem infusion process surveyed in SOP in the southern pesticides discovery center of country.The life or death borer population that 24 hours " Invest, Then Investigate "s respectively process, its preventive effect is 80.3%.
Embodiment 2
Take 2,4-DI-tert-butylphenol compounds 66g, uses 12g acetic acid ethyl dissolution, adds the 3.9g such as emulsifier wherein, conveniently technique, make 2,4-DTBP miticide of the present invention, then made 2, thin up in 4-DI-tert-butylphenol compounds miticide, make 2,4-DTBP, namely the concentration of bulk drug is 15%.Finally, the 2,4-DTBP miticide after dilution is carried out indoor biological determination of activity to Tetranychus cinnabarinus, method is carried out according to the raw tetranychid leaching stem infusion process surveyed in SOP in the southern pesticides discovery center of country.The life or death borer population that 24 hours " Invest, Then Investigate "s respectively process, its preventive effect is 95.87%.
Embodiment 3
Take 2,4-DI-tert-butylphenol compounds 82g, dissolve with 101g ethanol, add 90g such as emulsifier span-20 grade wherein, conveniently technique, make the present invention 2,4-DI-tert-butylphenol compounds miticide, then thin up in made 2,4-DTBP miticide, the concentration of 2,4-DTBP and bulk drug is made to be 29%.Finally, adopt indoor pot method to give birth to survey to Tetranychus cinnabarinus the 2,4-DTBP miticide after dilution, add up lethality after 24 hours, its preventive effect is 96.2%.
Embodiment 4
Take 2,4-DI-tert-butylphenol compounds 200g, dissolves with 150g methyl alcohol, adds emulsifier tween-245 wherein, the 49g such as Arlacel-20, conveniently technique, makes 2,4-DTBP miticide of the present invention, then made 2, thin up in 4-DI-tert-butylphenol compounds miticide, makes the concentration of 2,4-DTBP and bulk drug be 23%.Finally, adopt indoor pot method to give birth to survey to Tetranychus cinnabarinus the 2,4-DTBP miticide after dilution, add up lethality after 24 hours, its preventive effect is 96.7%.
Embodiment 5
Take 2,4-DI-tert-butylphenol compounds 500g, use 80g petroleum ether dissolution, add the auxiliary material 64g such as emulsifier, synergist, solubilizer wherein, conveniently technique, make the present invention 2,4-DI-tert-butylphenol compounds miticide, then thin up in made 2,4-DTBP miticide, the concentration of 2,4-DTBP and bulk drug is made to be 8%.Finally, the 2,4-DTBP miticide after dilution is adopted field plot experiment to Tetranychus cinnabarinus and carries out field control effectiveness test, add up lethality after 48 hours, preventive effect reaches 93.2%.
Above specific embodiments of the invention are described.It is to be appreciated that the present invention is not limited to above-mentioned particular implementation, those skilled in the art can make various distortion or amendment within the scope of the claims, and this does not affect flesh and blood of the present invention.
Claims (9)
1. a purposes for 2,4-DTBP, is characterized in that, is applied to by 2,4-DTBP and prepares miticide.
2. the purposes of 2,4-DTBP according to claim 1, is characterized in that, described mite is Tetranychus cinnabarinus or Tetranychus urticae.
3. one kind 2,4-DI-tert-butylphenol compounds miticide, it is characterized in that, described miticide is made up of 2,4-DTBP and customary adjuvant, and wherein 2, the quality of 4-DI-tert-butylphenol compounds accounts for 2, the 0.05%-99% of 4-DI-tert-butylphenol compounds miticide quality, customary adjuvant accounts for the 1%-99.95% of 2,4-DTBP miticide quality.
4. 2,4-DTBP miticide according to claim 3, is characterized in that, described customary adjuvant to refer in solubilizer, synergist, emulsifier, bleeding agent one or more.
5. according to claim 42,4-DI-tert-butylphenol compounds miticide, it is characterized in that, described solubilizer is neopelex, Potassium dodecylbenzenesulfonate, polysorbate, polyethylene glycol, sorbierite polyoxy ether, lignosulfonates, tea are withered, take in Chinese honey locust one or more.
6. 2,4-DTBP miticide according to claim 4, is characterized in that, described emulsifier is one or more in spans, Tweens, glycol ester class, propylene glycol ester class and/or polyethylene glycol type non-ionic surface active agent.
7. 2,4-DTBP miticide according to claim 4, is characterized in that, described synergist is one or more in Tea Saponin, APEO.
8. 2,4-DTBP miticide according to claim 4, is characterized in that, described bleeding agent is azone.
9. described in an any one of claim 3-8 2, the acaricidal application of 4-DI-tert-butylphenol compounds, it is characterized in that, under stirring at normal temperature, water is joined 2, in 4-DI-tert-butylphenol compounds miticide, make it be diluted to after 2,4-DTBP and bulk drug account for the concentration of 0.5-30wt% to spray to use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510354183.1A CN104938484A (en) | 2015-06-23 | 2015-06-23 | Application of 2,4-di-tert-butylphenol and acaricide |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510354183.1A CN104938484A (en) | 2015-06-23 | 2015-06-23 | Application of 2,4-di-tert-butylphenol and acaricide |
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| CN104938484A true CN104938484A (en) | 2015-09-30 |
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| CN201510354183.1A Pending CN104938484A (en) | 2015-06-23 | 2015-06-23 | Application of 2,4-di-tert-butylphenol and acaricide |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105010334A (en) * | 2015-07-09 | 2015-11-04 | 上海交通大学 | Pesticide for controlling plant aphids, and preparation method and application thereof |
| CN111228245A (en) * | 2020-02-27 | 2020-06-05 | 华侨大学 | Application of phenolic compound and pharmaceutically acceptable salt thereof in preparation of anti-hepatitis B virus medicine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3364106A (en) * | 1963-01-30 | 1968-01-16 | Dow Chemical Co | 5-tert-butyl-2-chlorophenyl nmethylcarbamate and its use as an insecticide |
| US4255447A (en) * | 1978-09-12 | 1981-03-10 | Nissan Chemical Industries Limited | Acaricidal compounds of cyclopropane carboxylic acid derivatives |
-
2015
- 2015-06-23 CN CN201510354183.1A patent/CN104938484A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3364106A (en) * | 1963-01-30 | 1968-01-16 | Dow Chemical Co | 5-tert-butyl-2-chlorophenyl nmethylcarbamate and its use as an insecticide |
| US4255447A (en) * | 1978-09-12 | 1981-03-10 | Nissan Chemical Industries Limited | Acaricidal compounds of cyclopropane carboxylic acid derivatives |
Non-Patent Citations (2)
| Title |
|---|
| JUN-RAN KIM ET AL: "Contact and Fumigant Toxicity of Hiba Oil Consituents and Efficacy of Spray Formulations Containing the Oil to American House Dust Mite and Copra Mite", 《ENTOMOLOGY AND CONSILIENCE》 * |
| YI JUAN CHEN ET AL: "Acaricidal activity of compounds from Cinnamomum camphora (L.) Presl against the carmine spider mite, Tetranychus cinnabarinus", 《PEST MANAG SCI》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105010334A (en) * | 2015-07-09 | 2015-11-04 | 上海交通大学 | Pesticide for controlling plant aphids, and preparation method and application thereof |
| CN105010334B (en) * | 2015-07-09 | 2017-03-15 | 上海交通大学 | A kind of insecticide of control plant aphids and its preparation and application |
| CN111228245A (en) * | 2020-02-27 | 2020-06-05 | 华侨大学 | Application of phenolic compound and pharmaceutically acceptable salt thereof in preparation of anti-hepatitis B virus medicine |
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Application publication date: 20150930 |
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