CN104926942B - 结合b7h6的单克隆抗体及其用途 - Google Patents

结合b7h6的单克隆抗体及其用途 Download PDF

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Publication number
CN104926942B
CN104926942B CN201510169548.3A CN201510169548A CN104926942B CN 104926942 B CN104926942 B CN 104926942B CN 201510169548 A CN201510169548 A CN 201510169548A CN 104926942 B CN104926942 B CN 104926942B
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antibody
human
cells
antibodies
antigen
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CN104926942A (zh
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M·佩雷斯
E·维维尔
M·巴拉廷
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National Institute Of Health And Medicine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201510169548.3A 2009-12-09 2010-12-08 结合b7h6的单克隆抗体及其用途 Active CN104926942B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28501809P 2009-12-09 2009-12-09
US61/285,018 2009-12-09
CN201080063065.0A CN102741290B (zh) 2009-12-09 2010-12-08 结合b7h6的单克隆抗体及其用途

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CN104926942A CN104926942A (zh) 2015-09-23
CN104926942B true CN104926942B (zh) 2018-09-14

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CN201080063065.0A Active CN102741290B (zh) 2009-12-09 2010-12-08 结合b7h6的单克隆抗体及其用途

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US (2) US8822652B2 (https=)
EP (1) EP2510011B2 (https=)
JP (2) JP2013513380A (https=)
CN (2) CN104926942B (https=)
BR (1) BR112012013975B8 (https=)
CA (1) CA2783740C (https=)
DK (1) DK2510011T3 (https=)
EA (1) EA024629B1 (https=)
ES (1) ES2523472T3 (https=)
HR (1) HRP20141170T1 (https=)
IN (1) IN2012DN04908A (https=)
MX (1) MX2012006443A (https=)
PL (1) PL2510011T3 (https=)
PT (1) PT2510011E (https=)
RS (1) RS53667B1 (https=)
SI (1) SI2510011T1 (https=)
SM (1) SMT201400184B (https=)
WO (1) WO2011070443A1 (https=)

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US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
EP2510011B2 (en) 2009-12-09 2021-03-31 Institut National de la Santé et de la Recherche Médicale Monoclonal antibodies that bind b7h6 and uses thereof
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
JP2014534165A (ja) * 2011-09-13 2014-12-18 ドイチェス クレブスフォルシュンクスツェントルム Ｂ７−ｈ６ポリペプチドに対するｂ７−ｈ６治療活性モノクローナル抗体
ES2719495T5 (en) 2012-05-07 2025-09-10 Dartmouth College Anti-b7-h6 antibody, fusion proteins, and methods of using the same
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US11034767B2 (en) * 2016-04-15 2021-06-15 Trustees Of Dartmouth College High affinity B7-H6 antibodies and antibody fragments
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US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
EP3818083A2 (en) 2018-07-03 2021-05-12 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
JP7710373B2 (ja) 2019-02-21 2025-07-18 マレンゴ・セラピューティクス，インコーポレーテッド Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用
AU2020224681A1 (en) 2019-02-21 2021-09-16 Marengo Therapeutics, Inc. Antibody molecules that bind to NKp30 and uses thereof
CN116234829A (zh) 2020-01-03 2023-06-06 马伦戈治疗公司 抗tcr抗体分子及其用途
WO2021143858A1 (en) * 2020-01-17 2021-07-22 Beigene, Ltd. ANTI-NKp30 ANTIBODIES AND METHODS OF USE
MX2023011310A (es) 2021-03-26 2023-10-05 Innate Pharma Anclajes de citocina para proteinas de celulas nk de union a nkp46.
BR112023025331A2 (pt) 2021-06-09 2024-02-27 Innate Pharma Proteína multiespecífica, composição farmacêutica, célula recombinante, ácido nucleico ou conjunto de ácidos nucleicos, uso de uma proteína ou composição, métodos ou uso
WO2022258691A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a
WO2022258678A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a
CN114395044B (zh) * 2021-12-07 2023-12-29 合肥天港免疫药物有限公司 重组抗体及其应用
CN114395043B (zh) * 2021-12-07 2023-07-11 合肥天港免疫药物有限公司 Ncr3lg1抗体及其应用
CN114395045B (zh) * 2021-12-07 2023-06-09 合肥天港免疫药物有限公司 B7h6抗体及其应用
CN114395047B (zh) * 2021-12-07 2023-11-07 合肥天港免疫药物有限公司 双特异性抗体及其应用
CN114634574B (zh) * 2022-04-18 2022-12-20 先进生物(苏州)有限公司 抗B7H6的scFv抗体、其编码基因及其应用
WO2024005422A1 (ko) * 2022-06-29 2024-01-04 고려대학교 산학협력단 Nkp30 결합력이 향상된 b7-h6 변이체
EP4619509A1 (en) * 2022-11-16 2025-09-24 Deutsches Krebsforschungszentrum T cell-nk cell interaction inhibitors for use in disease treatment
WO2024208818A1 (en) 2023-04-04 2024-10-10 Innate Pharma Modular chimeric antigen receptor

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US8822652B2 (en) 2014-09-02
JP2017031147A (ja) 2017-02-09
EA201270654A1 (ru) 2013-02-28
BR112012013975B1 (pt) 2021-01-12
SI2510011T1 (sl) 2014-12-31
CN102741290B (zh) 2015-04-22
US20130004432A1 (en) 2013-01-03
JP6212181B2 (ja) 2017-10-11
PT2510011E (pt) 2014-12-12
PL2510011T3 (pl) 2015-02-27
EP2510011A1 (en) 2012-10-17
US20150056214A1 (en) 2015-02-26
BR112012013975A2 (pt) 2017-01-10
US9663577B2 (en) 2017-05-30
DK2510011T3 (en) 2014-12-01
CN102741290A (zh) 2012-10-17
JP2013513380A (ja) 2013-04-22
RS53667B1 (sr) 2015-04-30
BR112012013975B8 (pt) 2021-05-25
ES2523472T3 (es) 2014-11-26
CA2783740A1 (en) 2011-06-16
CN104926942A (zh) 2015-09-23
HRP20141170T1 (hr) 2015-01-30
WO2011070443A1 (en) 2011-06-16
EP2510011B2 (en) 2021-03-31
EP2510011B1 (en) 2014-09-17
CA2783740C (en) 2020-03-10
EA024629B1 (ru) 2016-10-31
SMT201400184B (it) 2015-01-15
IN2012DN04908A (https=) 2015-09-25
MX2012006443A (es) 2012-06-28

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