CN104918944B - 螺环异噁唑啉衍生物的合成 - Google Patents
螺环异噁唑啉衍生物的合成 Download PDFInfo
- Publication number
- CN104918944B CN104918944B CN201380060755.4A CN201380060755A CN104918944B CN 104918944 B CN104918944 B CN 104918944B CN 201380060755 A CN201380060755 A CN 201380060755A CN 104918944 B CN104918944 B CN 104918944B
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- alkyl
- group
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- QIFOIAXXLKQGJD-UHFFFAOYSA-N CS(CC(Oc(cc1)ccc1[N+]([O-])=O)=O)(=O)=O Chemical compound CS(CC(Oc(cc1)ccc1[N+]([O-])=O)=O)(=O)=O QIFOIAXXLKQGJD-UHFFFAOYSA-N 0.000 description 1
- 0 FC([C@](C1)(c(cc2Cl)cc(Cl)c2F)ON=C1c1ccc(C2(CNC2)OC2)*2c1)(F)F Chemical compound FC([C@](C1)(c(cc2Cl)cc(Cl)c2F)ON=C1c1ccc(C2(CNC2)OC2)*2c1)(F)F 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261729022P | 2012-11-21 | 2012-11-21 | |
| US61/729,022 | 2012-11-21 | ||
| PCT/US2013/070959 WO2014081800A1 (en) | 2012-11-21 | 2013-11-20 | Synthesis of spirocyclic isoxazoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104918944A CN104918944A (zh) | 2015-09-16 |
| CN104918944B true CN104918944B (zh) | 2017-05-10 |
Family
ID=49753486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380060755.4A Active CN104918944B (zh) | 2012-11-21 | 2013-11-20 | 螺环异噁唑啉衍生物的合成 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9593126B2 (enExample) |
| EP (2) | EP4056572A1 (enExample) |
| JP (1) | JP6234471B2 (enExample) |
| CN (1) | CN104918944B (enExample) |
| AU (1) | AU2013348091B2 (enExample) |
| BR (1) | BR112015011740B1 (enExample) |
| CA (1) | CA2892344C (enExample) |
| ES (1) | ES2916805T3 (enExample) |
| MX (1) | MX368078B (enExample) |
| PL (1) | PL2922854T3 (enExample) |
| WO (1) | WO2014081800A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015004826A2 (pt) * | 2012-09-07 | 2017-07-04 | Zoetis Llc | derivados espirocíclicos como agentes antiparasíticos |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| US20190077809A1 (en) | 2016-03-09 | 2019-03-14 | Basf Se | Spirocyclic Derivatives |
| CA3019947A1 (en) | 2016-04-06 | 2017-10-12 | Merial, Inc. | Process for the preparation of enantiomerically enriched isoxazoline compounds crystalline toluene solvate of (s)-afoxolaner |
| US10556909B2 (en) | 2016-05-20 | 2020-02-11 | Avista Pharma Solutions, Inc. | Synthetic process and intermediates |
| CN110381738B (zh) | 2016-10-14 | 2021-07-16 | 勃林格殷格翰动物保健美国公司 | 农药的和杀寄生物的乙烯基异噁唑啉化合物 |
| WO2018162312A1 (en) * | 2017-03-10 | 2018-09-13 | Basf Se | Spirocyclic derivatives |
| WO2019036407A1 (en) | 2017-08-14 | 2019-02-21 | Merial, Inc. | PYRAZOLE-ISOXAZOLINE COMPOUNDS WITH PESTICIDE AND PARASITICIDE ACTIVITY |
| US20210380569A1 (en) * | 2018-11-06 | 2021-12-09 | Basf Se | Process for Preparation of Optically Enriched Isoxazolines |
| US20230257370A1 (en) | 2020-07-24 | 2023-08-17 | Elanco Us Inc. | Process for making an isoxazoline compound and intermediate thereof |
| CN113548989A (zh) * | 2021-07-14 | 2021-10-26 | 浙江倍合德制药有限公司 | 一种4-硝基苯基-2-甲磺酰基乙酸酯的制备工艺及其生产线 |
| AU2022326468A1 (en) | 2021-08-11 | 2023-11-30 | ELANCO US, Inc. | Process for making diaryl isoxazoline derivative |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012120399A1 (en) * | 2011-03-10 | 2012-09-13 | Pfizer Inc. | Spirocyclic isoxazoline derivatives as antiparasitic agents |
| WO2012151158A1 (en) * | 2011-04-30 | 2012-11-08 | Abbott Laboratories | Isoxazolines as therapeutic agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091432A (en) * | 1990-03-28 | 1992-02-25 | Glasky Alvin J | 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use |
| US7521460B2 (en) * | 2003-06-20 | 2009-04-21 | Ucb Pharma S.A. | Thienopyridone derivatives as kinase inhibitors |
| CA2807005C (en) * | 2010-08-05 | 2015-04-07 | Ah Usa 42 Llc | Isoxazoline derivatives as antiparasitic agents |
| EP2684346B1 (en) * | 2011-03-10 | 2014-12-03 | Telefonaktiebolaget L M Ericsson (PUBL) | Method and apparatus for prioritizing media within an electronic conference according to utilization settings at respective conference participants |
| TWM424868U (en) | 2011-09-02 | 2012-03-21 | yi-zhen Huang | Baby walker |
-
2013
- 2013-11-20 CN CN201380060755.4A patent/CN104918944B/zh active Active
- 2013-11-20 ES ES13802788T patent/ES2916805T3/es active Active
- 2013-11-20 AU AU2013348091A patent/AU2013348091B2/en active Active
- 2013-11-20 US US14/439,091 patent/US9593126B2/en active Active
- 2013-11-20 EP EP22170224.4A patent/EP4056572A1/en not_active Withdrawn
- 2013-11-20 PL PL13802788.3T patent/PL2922854T3/pl unknown
- 2013-11-20 BR BR112015011740A patent/BR112015011740B1/pt active IP Right Grant
- 2013-11-20 EP EP13802788.3A patent/EP2922854B1/en active Active
- 2013-11-20 JP JP2015544110A patent/JP6234471B2/ja active Active
- 2013-11-20 CA CA2892344A patent/CA2892344C/en active Active
- 2013-11-20 MX MX2015006458A patent/MX368078B/es active IP Right Grant
- 2013-11-20 WO PCT/US2013/070959 patent/WO2014081800A1/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012120399A1 (en) * | 2011-03-10 | 2012-09-13 | Pfizer Inc. | Spirocyclic isoxazoline derivatives as antiparasitic agents |
| WO2012151158A1 (en) * | 2011-04-30 | 2012-11-08 | Abbott Laboratories | Isoxazolines as therapeutic agents |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016500106A (ja) | 2016-01-07 |
| AU2013348091B2 (en) | 2017-04-13 |
| EP2922854A1 (en) | 2015-09-30 |
| MX368078B (es) | 2019-09-17 |
| CA2892344A1 (en) | 2014-05-30 |
| JP6234471B2 (ja) | 2017-11-22 |
| EP4056572A1 (en) | 2022-09-14 |
| AU2013348091A8 (en) | 2015-07-09 |
| WO2014081800A1 (en) | 2014-05-30 |
| CN104918944A (zh) | 2015-09-16 |
| MX2015006458A (es) | 2015-08-14 |
| US20150291612A1 (en) | 2015-10-15 |
| CA2892344C (en) | 2017-06-06 |
| BR112015011740A2 (pt) | 2017-07-11 |
| PL2922854T3 (pl) | 2022-07-18 |
| AU2013348091A1 (en) | 2015-06-04 |
| US9593126B2 (en) | 2017-03-14 |
| BR112015011740B1 (pt) | 2020-04-14 |
| ES2916805T3 (es) | 2022-07-06 |
| EP2922854B1 (en) | 2022-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104918944B (zh) | 螺环异噁唑啉衍生物的合成 | |
| TWI760919B (zh) | 一種嘧啶並環衍生物及其在醫藥上的應用 | |
| CN111386276B (zh) | 制备取代的多环吡啶酮衍生物的立体选择性方法 | |
| CA2577525C (en) | Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same | |
| CN112585126B (zh) | 四环化合物的制备方法 | |
| BR112019017915A2 (pt) | Processos para a preparação de compostos fungicidas | |
| CN107522698A (zh) | 一种曲贝替定的制备方法及其中间体 | |
| WO2018045157A1 (en) | Process for preparing indole carboxamide compounds | |
| CN104837817B (zh) | 制备3‑氨基‑哌啶化合物的合成路线 | |
| EP4249077A1 (en) | Novel acridinium salt and method for producing same | |
| EP4662326A1 (en) | Ligand-enabled transannular c-h functionalization of cycloalkane carboxylic acids | |
| CN103709101A (zh) | 一类renierramycin G的合成中间体及其制备方法 | |
| HK1213547B (en) | Synthesis of spirocyclic isoxazoline derivatives | |
| CN103153947B (zh) | 非对映选择性制备双环[2.2.2]辛-2-酮化合物 | |
| JP7587862B2 (ja) | Ｌ－エリトロ－ビオプテリン類化合物の製造方法 | |
| CN119490501A (zh) | 咪唑双环化合物及其制备方法和用途 | |
| RU2346947C1 (ru) | Способ получения фурилгетарилметанов, содержащих тиено[2,3-b]пиридиновый фрагмент | |
| KR20170080190A (ko) | 1,5-쌍극자의 [5+3] 고리화 첨가 반응을 이용한 8원 헤테로 고리 화합물의 제조 방법 및 이에 의해 제조된 8원 헤테로 고리 화합물 | |
| HK40051429A (en) | Method of producing tetracyclic compound | |
| HK40051429B (zh) | 四环化合物的制备方法 | |
| WO2014133416A2 (ru) | Замещенная (r)-3-(4-метилкарбамоил-3-фторфениламино)тетрагидрофуран-3-енкарбоновая кислота (варианты) и ее эфир, способ получения и применения | |
| Kovganko et al. | Synthesis of Substituted Benzyl Ethers of 1-(4-Hydroxyphenyl) oct-2-en-1-one | |
| BR112018003171B1 (pt) | Compostos de tetrahidrooxepinopiridina, composição farmacêutica compreendendo os ditos compostos e uso terapêutico dos mesmos | |
| HK40028700B (en) | Method for stereoselectively producing substituted polycyclic pyridone derivative | |
| AU2016308406A1 (en) | Tetrahydrooxepinopyridine compound |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |