CN104918944B - 螺环异噁唑啉衍生物的合成 - Google Patents
螺环异噁唑啉衍生物的合成 Download PDFInfo
- Publication number
- CN104918944B CN104918944B CN201380060755.4A CN201380060755A CN104918944B CN 104918944 B CN104918944 B CN 104918944B CN 201380060755 A CN201380060755 A CN 201380060755A CN 104918944 B CN104918944 B CN 104918944B
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- alkyl
- group
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QIFOIAXXLKQGJD-UHFFFAOYSA-N CS(CC(Oc(cc1)ccc1[N+]([O-])=O)=O)(=O)=O Chemical compound CS(CC(Oc(cc1)ccc1[N+]([O-])=O)=O)(=O)=O QIFOIAXXLKQGJD-UHFFFAOYSA-N 0.000 description 1
- 0 FC([C@](C1)(c(cc2Cl)cc(Cl)c2F)ON=C1c1ccc(C2(CNC2)OC2)*2c1)(F)F Chemical compound FC([C@](C1)(c(cc2Cl)cc(Cl)c2F)ON=C1c1ccc(C2(CNC2)OC2)*2c1)(F)F 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261729022P | 2012-11-21 | 2012-11-21 | |
| US61/729,022 | 2012-11-21 | ||
| PCT/US2013/070959 WO2014081800A1 (en) | 2012-11-21 | 2013-11-20 | Synthesis of spirocyclic isoxazoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104918944A CN104918944A (zh) | 2015-09-16 |
| CN104918944B true CN104918944B (zh) | 2017-05-10 |
Family
ID=49753486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380060755.4A Active CN104918944B (zh) | 2012-11-21 | 2013-11-20 | 螺环异噁唑啉衍生物的合成 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9593126B2 (enExample) |
| EP (2) | EP2922854B1 (enExample) |
| JP (1) | JP6234471B2 (enExample) |
| CN (1) | CN104918944B (enExample) |
| AU (1) | AU2013348091B2 (enExample) |
| BR (1) | BR112015011740B1 (enExample) |
| CA (1) | CA2892344C (enExample) |
| ES (1) | ES2916805T3 (enExample) |
| MX (1) | MX368078B (enExample) |
| PL (1) | PL2922854T3 (enExample) |
| WO (1) | WO2014081800A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1210472A1 (en) * | 2012-09-07 | 2016-04-22 | Zoetis Services Llc | Spirocyclic derivatives as antiparasitic agents |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| BR112018068034A2 (pt) | 2016-03-09 | 2019-01-08 | Basf Se | compostos espiro da fórmula i, composição, composição agrícola para combater pragas animais, método de combate ou controle de pragas invertebradas, método de proteção de plantas, semente e uso dos compostos |
| DK3440062T3 (da) | 2016-04-06 | 2022-01-03 | Boehringer Ingelheim Animal Health Usa Inc | Fremgangsmåde til fremstillingen af enantiomerisk berigede isoxazolinforbindelser - krystallinsk toluensolvat af (s)-afoxolaner |
| WO2017201134A1 (en) * | 2016-05-20 | 2017-11-23 | Avista Pharma Solutions, Inc. | Synthetic process and novel intermediates |
| MX380497B (es) | 2016-10-14 | 2025-03-11 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de vinil isoxazolina pesticidas y parasiticidas. |
| WO2018162312A1 (en) * | 2017-03-10 | 2018-09-13 | Basf Se | Spirocyclic derivatives |
| MX2020001724A (es) | 2017-08-14 | 2020-07-29 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas. |
| AU2019376282A1 (en) * | 2018-11-06 | 2021-05-20 | Basf Se | Process for preparation of optically enriched isoxazolines |
| KR20230043904A (ko) | 2020-07-24 | 2023-03-31 | 엘랑코 유에스 인코포레이티드 | 이속사졸린 화합물 및 이의 중간체의 제조 공정 |
| CN113548989A (zh) * | 2021-07-14 | 2021-10-26 | 浙江倍合德制药有限公司 | 一种4-硝基苯基-2-甲磺酰基乙酸酯的制备工艺及其生产线 |
| MX2023014962A (es) | 2021-08-11 | 2024-02-13 | Elanco Us Inc | Proceso para elaborar derivado de diaril isoxazolina. |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012120399A1 (en) * | 2011-03-10 | 2012-09-13 | Pfizer Inc. | Spirocyclic isoxazoline derivatives as antiparasitic agents |
| WO2012151158A1 (en) * | 2011-04-30 | 2012-11-08 | Abbott Laboratories | Isoxazolines as therapeutic agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091432A (en) * | 1990-03-28 | 1992-02-25 | Glasky Alvin J | 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use |
| BRPI0410653A (pt) * | 2003-06-20 | 2006-07-04 | Celltech R&D Ltd | composto, composição farmacêutica, e, uso de um composto ou um sal, solvato, hidrato ou n-óxido farmaceuticamente aceitável do mesmo |
| PH12013500164A1 (en) * | 2010-08-05 | 2015-07-08 | Zoetis Services Llc | Isoxazoline derivatives as antiparasitic agents |
| US9167013B2 (en) * | 2011-03-10 | 2015-10-20 | Telefonaktiebolaget L M Ericsson (Publ) | Method and apparatus for prioritizing media within an electronic conference according to utilization settings at respective conference participants |
| TWM424868U (en) | 2011-09-02 | 2012-03-21 | yi-zhen Huang | Baby walker |
-
2013
- 2013-11-20 WO PCT/US2013/070959 patent/WO2014081800A1/en not_active Ceased
- 2013-11-20 US US14/439,091 patent/US9593126B2/en active Active
- 2013-11-20 EP EP13802788.3A patent/EP2922854B1/en active Active
- 2013-11-20 PL PL13802788.3T patent/PL2922854T3/pl unknown
- 2013-11-20 MX MX2015006458A patent/MX368078B/es active IP Right Grant
- 2013-11-20 JP JP2015544110A patent/JP6234471B2/ja active Active
- 2013-11-20 CA CA2892344A patent/CA2892344C/en active Active
- 2013-11-20 CN CN201380060755.4A patent/CN104918944B/zh active Active
- 2013-11-20 AU AU2013348091A patent/AU2013348091B2/en active Active
- 2013-11-20 EP EP22170224.4A patent/EP4056572A1/en not_active Withdrawn
- 2013-11-20 BR BR112015011740A patent/BR112015011740B1/pt active IP Right Grant
- 2013-11-20 ES ES13802788T patent/ES2916805T3/es active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012120399A1 (en) * | 2011-03-10 | 2012-09-13 | Pfizer Inc. | Spirocyclic isoxazoline derivatives as antiparasitic agents |
| WO2012151158A1 (en) * | 2011-04-30 | 2012-11-08 | Abbott Laboratories | Isoxazolines as therapeutic agents |
Also Published As
| Publication number | Publication date |
|---|---|
| MX368078B (es) | 2019-09-17 |
| ES2916805T3 (es) | 2022-07-06 |
| US20150291612A1 (en) | 2015-10-15 |
| EP4056572A1 (en) | 2022-09-14 |
| JP2016500106A (ja) | 2016-01-07 |
| MX2015006458A (es) | 2015-08-14 |
| EP2922854A1 (en) | 2015-09-30 |
| EP2922854B1 (en) | 2022-05-04 |
| CA2892344A1 (en) | 2014-05-30 |
| AU2013348091A1 (en) | 2015-06-04 |
| BR112015011740B1 (pt) | 2020-04-14 |
| AU2013348091B2 (en) | 2017-04-13 |
| CA2892344C (en) | 2017-06-06 |
| PL2922854T3 (pl) | 2022-07-18 |
| AU2013348091A8 (en) | 2015-07-09 |
| CN104918944A (zh) | 2015-09-16 |
| WO2014081800A1 (en) | 2014-05-30 |
| US9593126B2 (en) | 2017-03-14 |
| BR112015011740A2 (pt) | 2017-07-11 |
| JP6234471B2 (ja) | 2017-11-22 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |