JP6234471B2 - スピロ環状イソキサゾリン誘導体の合成 - Google Patents

スピロ環状イソキサゾリン誘導体の合成 Download PDF

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JP6234471B2
JP6234471B2 JP2015544110A JP2015544110A JP6234471B2 JP 6234471 B2 JP6234471 B2 JP 6234471B2 JP 2015544110 A JP2015544110 A JP 2015544110A JP 2015544110 A JP2015544110 A JP 2015544110A JP 6234471 B2 JP6234471 B2 JP 6234471B2
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formula
compound
concentrated
aqueous base
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JP2016500106A (ja
JP2016500106A5 (enExample
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グリーンウッド，ショーン・ディー・ダブリュー
ストゥク，ティモシー・エル
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ゾエティス・サービシーズ・エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015544110A 2012-11-21 2013-11-20 スピロ環状イソキサゾリン誘導体の合成 Active JP6234471B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261729022P 2012-11-21 2012-11-21
US61/729,022 2012-11-21
PCT/US2013/070959 WO2014081800A1 (en) 2012-11-21 2013-11-20 Synthesis of spirocyclic isoxazoline derivatives

Publications (3)

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JP2016500106A JP2016500106A (ja) 2016-01-07
JP2016500106A5 JP2016500106A5 (enExample) 2016-10-06
JP6234471B2 true JP6234471B2 (ja) 2017-11-22

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JP2015544110A Active JP6234471B2 (ja) 2012-11-21 2013-11-20 スピロ環状イソキサゾリン誘導体の合成

Country Status (11)

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US (1) US9593126B2 (enExample)
EP (2) EP4056572A1 (enExample)
JP (1) JP6234471B2 (enExample)
CN (1) CN104918944B (enExample)
AU (1) AU2013348091B2 (enExample)
BR (1) BR112015011740B1 (enExample)
CA (1) CA2892344C (enExample)
ES (1) ES2916805T3 (enExample)
MX (1) MX368078B (enExample)
PL (1) PL2922854T3 (enExample)
WO (1) WO2014081800A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2881844A1 (en) * 2012-09-07 2014-03-13 Zoetis Llc Spirocyclic derivatives as antiparasitic agents
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
CN108699075A (zh) 2016-03-09 2018-10-23 巴斯夫欧洲公司 螺环衍生物
SG11201808756XA (en) 2016-04-06 2018-11-29 Merial Inc Process for the preparation of isoxazoline compounds
WO2017201134A1 (en) * 2016-05-20 2017-11-23 Avista Pharma Solutions, Inc. Synthetic process and novel intermediates
CN110381738B (zh) 2016-10-14 2021-07-16 勃林格殷格翰动物保健美国公司 农药的和杀寄生物的乙烯基异噁唑啉化合物
WO2018162312A1 (en) * 2017-03-10 2018-09-13 Basf Se Spirocyclic derivatives
JP2020530850A (ja) 2017-08-14 2020-10-29 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 殺有害生物および殺寄生生物ピラゾール−イソキサゾリン化合物
BR112021007784A2 (pt) * 2018-11-06 2021-07-27 Basf Se processo para preparar compostos de isoxazolina opticamente enriquecidos
JP7724845B2 (ja) 2020-07-24 2025-08-18 エランコ・ユーエス・インコーポレイテッド イソオキサゾリン化合物及びその中間体を作製するための方法
CN113548989A (zh) * 2021-07-14 2021-10-26 浙江倍合德制药有限公司 一种4-硝基苯基-2-甲磺酰基乙酸酯的制备工艺及其生产线
KR20240046112A (ko) 2021-08-11 2024-04-08 엘랑코 유에스 인코포레이티드 디아릴 이속사졸린 유도체의 제조 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091432A (en) * 1990-03-28 1992-02-25 Glasky Alvin J 9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use
MXPA05013227A (es) 2003-06-20 2006-03-09 Celltech R&D Ltd Derivados de tienopiridona como inhibidores de cinasa.
JP5409968B2 (ja) * 2010-08-05 2014-02-05 ゾエティス・エルエルシー 駆虫剤としてのイソオキサゾリン誘導体
MX2013010336A (es) 2011-03-10 2013-10-03 Zoetis Llc Derivados espirociclicos de isoxazolina como agentes antiparasitarios.
US9167013B2 (en) * 2011-03-10 2015-10-20 Telefonaktiebolaget L M Ericsson (Publ) Method and apparatus for prioritizing media within an electronic conference according to utilization settings at respective conference participants
AR086113A1 (es) * 2011-04-30 2013-11-20 Abbott Lab Isoxazolinas como agentes terapeuticos
TWM424868U (en) 2011-09-02 2012-03-21 yi-zhen Huang Baby walker

Also Published As

Publication number Publication date
EP2922854A1 (en) 2015-09-30
WO2014081800A1 (en) 2014-05-30
EP2922854B1 (en) 2022-05-04
CA2892344C (en) 2017-06-06
JP2016500106A (ja) 2016-01-07
AU2013348091A8 (en) 2015-07-09
CA2892344A1 (en) 2014-05-30
MX2015006458A (es) 2015-08-14
MX368078B (es) 2019-09-17
AU2013348091B2 (en) 2017-04-13
BR112015011740A2 (pt) 2017-07-11
ES2916805T3 (es) 2022-07-06
US9593126B2 (en) 2017-03-14
PL2922854T3 (pl) 2022-07-18
BR112015011740B1 (pt) 2020-04-14
EP4056572A1 (en) 2022-09-14
AU2013348091A1 (en) 2015-06-04
CN104918944B (zh) 2017-05-10
US20150291612A1 (en) 2015-10-15
CN104918944A (zh) 2015-09-16

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