CN104918629A - Sp肽或其衍生物在制备降低il-13水平的药物中的应用 - Google Patents

Sp肽或其衍生物在制备降低il-13水平的药物中的应用 Download PDF

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Publication number
CN104918629A
CN104918629A CN201380070423.4A CN201380070423A CN104918629A CN 104918629 A CN104918629 A CN 104918629A CN 201380070423 A CN201380070423 A CN 201380070423A CN 104918629 A CN104918629 A CN 104918629A
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derivatives
peptide
group
gly
peptides
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CN104918629B (zh
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程云
虞瑞鹤
赵万洲
李红
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

本发明提供了一种SP肽或其衍生物在制备降低患者IL-13水平的药物中的应用，所述肽或其衍生物为如式I所示的SP肽或其药学上可接受的盐或酯。本发明的研究证实，所述肽或其衍生物可有效降低患者IL-13水平。Xaa1-Gln-Xaa2-Xaa3-Thr-Ser-Gly-Xaa4 (式I)其中，Xaa1为缺失、Ala、Gly、Val、Leu或Ile，Xaa2为Thr或Ser，Xaa3为Tyr、Phe或Trp，而且Xaa4为缺失、Ala、Gly、Val、Leu、Ile或Pro。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201380070423.4A 2013-02-07 2013-02-07 Sp肽或其衍生物在制备降低il‑13水平的药物中的应用 Active CN104918629B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2013/071525 WO2014121492A1 (zh) 2013-02-07 2013-02-07 Sp肽或其衍生物在制备降低il-13水平的药物中的应用

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CN104918629A true CN104918629A (zh) 2015-09-16
CN104918629B CN104918629B (zh) 2017-12-26

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CN (1) CN104918629B (zh)
WO (1) WO2014121492A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230203095A1 (en) * 2019-11-21 2023-06-29 Shanghai Institute of Pharmaceutical Industry Co., Ltd. Biological peptide for treating lung diseases and application thereof
CN112824428B (zh) * 2019-11-21 2022-08-16 上海医药工业研究院 一种治疗肺疾病的生物肽及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101559217A (zh) * 2008-04-18 2009-10-21 程云 7p肽的口服给药途径及其在预防或治疗肾炎中的应用
CN101822816A (zh) * 2010-05-27 2010-09-08 程云 7p肽在预防或治疗肺炎中的应用
CN101336110B (zh) * 2006-06-01 2011-06-01 程云 预防或治疗肝损伤的肽及其衍生物及其应用
CN104955469A (zh) * 2012-12-18 2015-09-30 程云 Sp肽或其衍生物在制备预防或治疗哮喘的药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1194986C (zh) * 2003-01-24 2005-03-30 程云 丙型肝炎病毒高变区1合成肽及其应用
CN102178926B (zh) * 2006-06-01 2012-07-25 程云 预防或治疗肝损伤的肽

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101336110B (zh) * 2006-06-01 2011-06-01 程云 预防或治疗肝损伤的肽及其衍生物及其应用
CN101559217A (zh) * 2008-04-18 2009-10-21 程云 7p肽的口服给药途径及其在预防或治疗肾炎中的应用
CN101822816A (zh) * 2010-05-27 2010-09-08 程云 7p肽在预防或治疗肺炎中的应用
CN104955469A (zh) * 2012-12-18 2015-09-30 程云 Sp肽或其衍生物在制备预防或治疗哮喘的药物中的应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
潘有禄等: "肺纤维化发生机制及治疗研究进展", 《中国药学杂志》 *
辛冰牧等: "肾纤维化发病机制及治疗学研究进展", 《国际药学研究杂志》 *

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WO2014121492A1 (zh) 2014-08-14
CN104918629B (zh) 2017-12-26

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